{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:52:59Z","timestamp":1774893179163,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.chroma.2025.465686","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T07:29:48Z","timestamp":1737098988000},"page":"465686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic conditions on cloud point extraction"],"prefix":"10.1016","volume":"1743","author":[{"given":"Bartosz","family":"Sznek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-8326","authenticated-orcid":false,"given":"Andrzej","family":"Czyrski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.465686_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117113","article-title":"Recent innovations in cloud point extraction towards a more efficient and environmentally friendly procedure","volume":"164","author":"Snigur","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.465686_bib0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/chromsci\/bmz064","article-title":"Cloud point extraction in the determination of drugs in biological matrices","volume":"58","author":"Kojro","year":"2020","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2025.465686_bib0003","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.trac.2005.01.013","article-title":"Micelle-mediated separation and cloud-point extraction","volume":"24","author":"Paleologos","year":"2005","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.465686_bib0004","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.talanta.2013.02.037","article-title":"Complex-forming organic ligands in cloud-point extraction of metal ions: a review","volume":"110","author":"Pytlakowska","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2025.465686_bib0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.trac.2009.02.002","article-title":"Microwave-assisted and cloud-point extraction in determination of drugs and other bioactive compounds","volume":"28","author":"Madej","year":"2009","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.465686_bib0006","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chroma.2015.10.076","article-title":"Cloud-point extraction is compatible with liquid chromatography coupled to electrospray ionization mass spectrometry for the determination of bisoprolol in human plasma","volume":"1423","author":"Giebu\u0142towicz","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.465686_bib0007","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/ph13120458","article-title":"Determination of antidepressants in human plasma by modified cloud-point extraction coupled with mass spectrometry","volume":"13","author":"Gniazdowska","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.chroma.2025.465686_bib0008","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jchromb.2008.06.052","article-title":"Determination of venlafaxine in human plasma by high-performance liquid chromatography using cloud-point extraction and spectrofluorimetric detection","volume":"872","author":"Qin","year":"2008","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chroma.2025.465686_bib0009","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/00387010.2013.790063","article-title":"Vortex-Assisted Acid-Induced Cloud Point Extraction Coupled With Spectrofluorometry for the Determination of Fluoroquinolones in Environmental Water Samples","volume":"47","author":"Xia","year":"2014","journal-title":"Spectroscopy Letters"},{"key":"10.1016\/j.chroma.2025.465686_bib0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-2670(02)00148-4","article-title":"Evaluation of the factors affecting extraction of organic compounds based on the acid-induced phase cloud point approach","volume":"460","author":"Sicilia","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2025.465686_bib0011","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.3390\/pharmaceutics15061774","article-title":"The chemometric evaluation of the factors influencing cloud point extraction for fluoroquinolones","volume":"15","author":"Micha\u0142owska","year":"2023","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.chroma.2025.465686_bib0012","doi-asserted-by":"crossref","first-page":"113","DOI":"10.17219\/pim\/196209","article-title":"Design of experiments and artificial neural networks as useful tools in the optimization of analytical procedure","volume":"54","author":"Sznek","year":"2024","journal-title":"Polim. Med."},{"key":"10.1016\/j.chroma.2025.465686_bib0013","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3390\/pr8040473","article-title":"Response surface methodology as a useful tool for evaluation of the recovery of the fluoroquinolones from plasma\u2014the study on applicability of box-behnken design, central composite design and Doehlert design","volume":"8","author":"Czyrski","year":"2020","journal-title":"Processes"},{"key":"10.1016\/j.chroma.2025.465686_bib0014","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.3390\/su131910660","article-title":"Modeling of 3R (reduce, reuse and recycle) for sustainable construction waste reduction: a partial least squares structural equation modeling (PLS-SEM)","volume":"13","author":"Mohammed","year":"2021","journal-title":"Sustainability"},{"key":"10.1016\/j.chroma.2025.465686_bib0015","unstructured":"ICH Q2(R2) Validation of analytical procedures - Scientific guideline | European Medicines Agency (EMA), (2024). https:\/\/www.ema.europa.eu\/en\/ich-q2r2-validation-analytical-procedures-scientific-guideline (accessed October 21, 2024)."},{"key":"10.1016\/j.chroma.2025.465686_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0236789","article-title":"Validation of the usefulness of artificial neural networks for risk prediction of adverse drug reactions used for individual patients in clinical practice","volume":"15","author":"Imai","year":"2020","journal-title":"PLoS. One"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325000354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325000354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T15:10:12Z","timestamp":1740237012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325000354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":16,"alternative-id":["S0021967325000354"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.465686","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic conditions on cloud point extraction","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.465686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"465686"}}