{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:42:19Z","timestamp":1793371339611,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3304203"],"award-info":[{"award-number":["2023YFC3304203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023CSJGG1800"],"award-info":[{"award-number":["2023CSJGG1800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2023Z132"],"award-info":[{"award-number":["2023Z132"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2023S151"],"award-info":[{"award-number":["2023S151"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2024S047"],"award-info":[{"award-number":["2024S047"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2024Z230"],"award-info":[{"award-number":["2024Z230"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2022Z241"],"award-info":[{"award-number":["2022Z241"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["2023Z168"],"award-info":[{"award-number":["2023Z168"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03101"],"award-info":[{"award-number":["2024C03101"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03266"],"award-info":[{"award-number":["2024C03266"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.chroma.2025.466011","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:10:20Z","timestamp":1745925020000},"page":"466011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Rapid screening of illicit drugs in wastewater based on-site automated solid phase extraction and portable mass spectrometry techniques"],"prefix":"10.1016","volume":"1753","author":[{"given":"Liangming","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466011_bib0001","unstructured":"UNODC, World drug report 2024, https:\/\/www.unodc.org\/unodc\/en\/data-and-analysis\/world-drug-report-2024.html. Accessed April 12, 2025."},{"issue":"1","key":"10.1016\/j.chroma.2025.466011_bib0002","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/molecules28010164","article-title":"From the streets to the judicial evidence: determination of traditional illicit substances in drug seizures by a rapid and sensitive UHPLC-MS\/MS-based platform","volume":"28","author":"Gosetti","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2025.466011_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.teac.2020.e00105","article-title":"Site- and event-specific wastewater-based epidemiology: current status and future perspectives","volume":"28","author":"Verov\u0161ek","year":"2020","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466011_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148047","article-title":"Current and future perspectives for wastewater-based epidemiology as a monitoring tool for pharmaceutical use","volume":"789","author":"Boogaerts","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0005","first-page":"348","article-title":"Illicit drugs in municipal sewage","volume":"791","author":"Daughton","year":"2001","journal-title":"Pharm. Care Prod. Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0006","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.scitotenv.2017.07.126","article-title":"Five-year monitoring of 19 illicit and legal substances of abuse at the inlet of a wastewater treatment plant in Barcelona (NE Spain) and estimation of drug consumption patterns and trends","volume":"609","author":"Mastroianni","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157353","article-title":"Pharmaceutical pollution of hospital effluents and municipal wastewaters of Eastern Canada","volume":"846","author":"Vaudreuil","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132914","article-title":"Ecological risk assessment of the typical anti-epidemic drugs in the Pearl River Delta by tracing their source and residual characteristics","volume":"463","author":"Wu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chroma.2025.466011_bib0009","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Wastewater analysis and drugs \u2014 a European multi-city study. https:\/\/www.euda.europa.eu, 2023. Accessed April 12, 2025."},{"key":"10.1016\/j.chroma.2025.466011_bib0010","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Assessing illicit drug in wastewater: advances in wastewater-based drug epidemiology. https:\/\/www.euda.europa.eu\/publications\/insights\/assessing-drugs-in-wastewater_en, 2016. Accessed April 12, 2025."},{"key":"10.1016\/j.chroma.2025.466011_bib0011","unstructured":"CREW (Centre of Expertise for Waters), Review of wastewater monitoring applications for public health and environmental surveillance, CREW, Scotland. https:\/\/www.crew.ac.uk\/sites\/www.crew.ac.uk\/files\/publication\/FINAL_REPORT_FOR_Review%20of%20wastewater%20monitoring%20applications.pdf, 2021. Accessed April 12, 2025."},{"key":"10.1016\/j.chroma.2025.466011_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2023.111672","article-title":"Sewage analysis as an alternative tool for assessing drug of abuse and new psychoactive substances in Tunisia","volume":"347","author":"Moslah","year":"2023","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.chroma.2025.466011_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.122977","article-title":"Solid chip-based detection of trace morphine in solutions via portable surface-enhanced Raman spectroscopy","volume":"302","author":"Zhao","year":"2023","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.chroma.2025.466011_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340025","article-title":"Microwave-prepared surface imprinted magnetic nanoparticles based electrochemical sensor for adsorption and determination of ketamine in sewage","volume":"1217","author":"Zou","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"11","key":"10.1016\/j.chroma.2025.466011_bib0015","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.chroma.2010.01.046","article-title":"Determination of drugs of abuse in water by solid-phase extraction, derivatisation and gas chromatography\u2013ion trap-tandem mass spectrometry","volume":"1217","author":"Gonz\u00e1lez-Mari\u00f1o","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"9","key":"10.1016\/j.chroma.2025.466011_bib0016","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/dta.3608","article-title":"Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods","volume":"16","author":"Frankenfeld","year":"2024","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.chroma.2025.466011_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.118000","article-title":"High resolution mass spectrometry (HRMS) determination of drugs in wastewater and wastewater based epidemiology in Cadiz Bay (Spain)","volume":"341","author":"Santana-Viera","year":"2023","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.chroma.2025.466011_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-4-14","article-title":"Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse","volume":"4","author":"Zuccato","year":"2005","journal-title":"Environ. Health"},{"key":"10.1016\/j.chroma.2025.466011_bib0019","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.scitotenv.2017.01.114","article-title":"Applying sewage epidemiology approach to estimate illicit drug consumption in a tropical context: bias related to sewage temperature and pH","volume":"584-585","author":"Devault","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.scitotenv.2013.12.054","article-title":"Assessment of stability of drug biomarkers in municipal wastewater as a factor influencing the estimation of drug consumption using sewage epidemiology","volume":"487","author":"Senta","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.chroma.2025.466011_bib0021","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1021\/acs.est.1c00396","article-title":"Systematic evaluation of the in-sample stability of selected pharmaceuticals, illicit drugs, and their metabolites in wastewater","volume":"55","author":"Lin","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2025.466011_bib0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jhazmat.2012.04.030","article-title":"The stability of illicit drugs and metabolites in wastewater, an important issue for sewage epidemiology?","volume":"239-240","author":"van Nuijs","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chroma.2025.466011_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115900","article-title":"In-sample stability and postsampling analysis of 21 illicit drugs, their metabolites and cotinine in wastewater","volume":"270","author":"Che","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chroma.2025.466011_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156888","article-title":"Rapid detection and speciation of illicit drugs via a thin-film microextraction approach for wastewater-based epidemiology study","volume":"842","author":"Chen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chroma.2025.466011_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121864","article-title":"Dilute-and-shoot approach for the high-throughput LC-MS\/MS determination of illicit drugs in the field of wastewater-based epidemiology","volume":"259","author":"Gracia-Mar\u00edn","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2025.466011_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.463980","article-title":"Rapid on-site detection of underground petroleum pipeline leaks and risk assessment using portable gas chromatography-mass spectrometry and solid phase microextraction","volume":"1696","author":"Wang","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466011_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.vacuum.2022.110889","article-title":"Review and prospect on portable mass spectrometer for recent applications","volume":"199","author":"Yang","year":"2022","journal-title":"Vacuum"},{"key":"10.1016\/j.chroma.2025.466011_bib0028","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.talanta.2018.01.013","article-title":"A new tool for the evaluation of the analytical procedure: green analytical procedure index","volume":"181","author":"P\u0142otka-Wasylka","year":"2018","journal-title":"Talanta"},{"issue":"14","key":"10.1016\/j.chroma.2025.466011_bib0029","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","article-title":"AGREE\u2014Analytical GREEnness metric approach and software","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"issue":"19","key":"10.1016\/j.chroma.2025.466011_bib0030","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1039\/D3GC02347H","article-title":"Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality","volume":"25","author":"Manousi","year":"2023","journal-title":"Green Chem."},{"issue":"6","key":"10.1016\/j.chroma.2025.466011_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27897","article-title":"Simultaneous determination of 28 illegal drugs in sewage by high throughput online SPE-ISTD-UHPLC-MS\/MS","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.chroma.2025.466011_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136750","article-title":"Zinc (\u2161) functionalized magnetic geopolymer as sorbents for rapid extraction of fluoroquinolones in food prior to quantification by UHPLC-MS\/MS","volume":"428","author":"Song","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2025.466011_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464703","article-title":"Magnetic solid-phase extraction based on polydopamine-coated magnetic nanoparticles for rapid and sensitive analysis of eleven illicit drugs and metabolites in wastewater with the aid of UHPLC-MS\/MS","volume":"1718","author":"Yuan","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466011_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463022","article-title":"Simultaneous determination of 12 illicit drugs in human plasma by the PRiME clover-shaped nano-titania functionalized covalent organic frameworks pass-through cleanup procedure followed by ultra-performance liquid chromatography-tandem mass spectrometry","volume":"1671","author":"Zhang","year":"2022","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466011_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465485","article-title":"Rapid on-site detection of illicit drugs in urine using C18 pipette-tip based solid-phase extraction coupled with a miniaturized mass spectrometer","volume":"1738","author":"Wu","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466011_bib0036","article-title":"Pretreatment-free, on-site separation and sensitive identification of methamphetamine in biological specimens by SERS-active hydrogel microbeads","volume":"263","author":"Ye","year":"2023","journal-title":"Anal. Chim. Actal."},{"key":"10.1016\/j.chroma.2025.466011_bib0037","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1021\/acs.analchem.4c05146","article-title":"Photothermal desorption and reagent-assisted low-temperature plasma ionization miniature IT-MS\/MS for on-site analysis of illicit drugs in saliva and urine","volume":"97","author":"Wu","year":"2025","journal-title":"Anal. Chem."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325003590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325003590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:03:42Z","timestamp":1762193022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325003590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"alternative-id":["S0021967325003590"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466011","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid screening of illicit drugs in wastewater based on-site automated solid phase extraction and portable mass spectrometry techniques","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466011"}}