{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T21:21:57Z","timestamp":1786310517461,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.chroma.2025.466050","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:57:00Z","timestamp":1747148220000},"page":"466050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Supercritical fluid extraction assisted by magnetic solid-phase extraction method using MWCNTs\/Fe3O4@coPANI-PTH as preconcentration and gas chromatography mass spectrometry analysis for determining nitrosamines in Valsartan and Losartan tablets"],"prefix":"10.1016","volume":"1756","author":[{"given":"Seyed Hamid","family":"Bahrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Raofie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466050_bib0001","unstructured":"FDA Updates and Press Announcements on Angiotensin II Receptor Blocker (ARB) Recalls Valsartan, Losartan, and Irbesartan, 2019. https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm613916.htm (Last accessed: 13 November 2019)."},{"key":"10.1016\/j.chroma.2025.466050_bib0002","series-title":"CHMP List of questions - To be addressed by the API manufacturers for valsartan-containing medicinal products (Procedure number: EMEA\/H\/A-31\/1471)","year":"2018"},{"key":"10.1016\/j.chroma.2025.466050_bib0003","first-page":"151","article-title":"Simultaneous detection of nitrosamines and other sartan-related impurities in active pharmaceutical ingredients by supercritical fluid chromatography","volume":"174","author":"Schmidtsdorff","year":"2019","journal-title":"JPBA"},{"key":"10.1016\/j.chroma.2025.466050_bib0004","unstructured":"U.S. Food & Drug Administration, FDA provides update on its ongoing investigation into valsartan products; and reports on the finding of an additional impurity identified in one firm\u2019s already recalled products, 2018(Last accessed: 20. January 2019). https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm620499.htm."},{"key":"10.1016\/j.chroma.2025.466050_bib0005","unstructured":"M. Abdel-Tawab, R. Gr\u00f6ner, T. Kopp, J. Meins, J. W\u00fcbert, Valsartan: ZL find et NDMA in Tabletten, Pharm. (1856) 158 (2018) 2898\u20132902."},{"key":"10.1016\/j.chroma.2025.466050_bib0006","series-title":"EU Authorities Take Further Action in Ongoing Review of Sartans: Zhejiang Huahai Placed Under Increased Supervision; Aurobindo Pharma Stopped From Supplying Irbesartan to the EU","year":"2018"},{"key":"10.1016\/j.chroma.2025.466050_bib0007","volume":"17","year":"1978"},{"key":"10.1016\/j.chroma.2025.466050_bib0008","series-title":"N-Nitrosodimethylamine, Concise International Chemical","year":"2002"},{"key":"10.1016\/j.chroma.2025.466050_bib0009","series-title":"Federal Facilities Restoration and Reuse Office, Technical Fact Sheet - N-Nitrosodimethylamine","year":"2017"},{"key":"10.1016\/j.chroma.2025.466050_bib0010","unstructured":"U.S. Food & Drug Administration, Center for drug evaluation and research, GC\/MS headspace method for detection of NDMA in Valsartan Drug Substance, 2018 (Accessed: 27. February 2019). https:\/\/www.fda.gov\/media\/115965\/download."},{"key":"10.1016\/j.chroma.2025.466050_bib0011","unstructured":"European network of OMCLs, OMCLs release three methods for determination of NDMA in Sartans, Strasbourg, France (Accessed: 16 February 2019), 2018. https:\/\/www.edqm.eu\/en\/news\/omcls-release-three-methods-determination-ndma-sartans."},{"issue":"3","key":"10.1016\/j.chroma.2025.466050_bib0012","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1021\/jf062382j","article-title":"Method of determination of nitrosamines in sausages by CO2 supercritical fluid extraction (SFE) and micellar electrokinetic chromatography (MEKC)","volume":"55","author":"Sanches Filho","year":"2007","journal-title":"J. Agric. Food Chem."},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466050_bib0013","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0021-9673(02)00549-6","article-title":"Optimization of parameters for the supercritical fluid extraction in the determination of N-nitrosamines in rubbers","volume":"963","author":"Reche","year":"2002","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2025.466050_bib0014","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0021-9673(92)80343-S","article-title":"Effects of collection solvent parameters and extraction cell geometry on supercritical fluid extraction efficiencies","volume":"594","author":"Langenfeld","year":"1992","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2025.466050_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2015.03.038","article-title":"Supercritical fluid extraction with carbon nanotubes as a solid collection trap for the analysis of polycyclic aromatic hydrocarbons and their derivatives","volume":"1395","author":"Han","year":"2015","journal-title":"J. Chromatogr. A."},{"issue":"14","key":"10.1016\/j.chroma.2025.466050_bib0016","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1002\/app.13183","article-title":"Supercritical CO2 extraction of phthalate plasticizers from PVC","volume":"90","author":"Shieh","year":"2003","journal-title":"J. Appl. Polym. Sci."},{"issue":"6","key":"10.1016\/j.chroma.2025.466050_bib0017","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jssc.201900886","article-title":"Supercritical fluid extraction followed by supramolecular solvent microextraction as a fast and efficient preconcentration method for determination of polycyclic aromatic hydrocarbons in apple peels","volume":"43","author":"Falsafi","year":"2020","journal-title":"J. Sep. Sci."},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466050_bib0018","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0021-9673(02)00549-6","article-title":"Optimization of parameters for the supercritical fluid extraction in the determination of N-nitrosamines in rubbers","volume":"963","author":"Reche","year":"2002","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2025.466050_bib0019","first-page":"744","article-title":"Supercritical fluid extraction of N-nitrosamines in hams processed in elastic rubber nettings","volume":"78","author":"Pensabene","year":"1995","journal-title":"J. Assoc. Off. Anal. Chem. Int."},{"key":"10.1016\/j.chroma.2025.466050_bib0020","first-page":"895","article-title":"Supercritical fluid extraction of volatile N-nitrosamines in fried bacon and its drippings: method comparison","volume":"79","author":"Fiddler","year":"1996","journal-title":"J. Assoc. Off. Anal. Chem. Int."},{"key":"10.1016\/j.chroma.2025.466050_bib0021","series-title":"Tobacco-Specific N-Nitrosamines Recent Advances","first-page":"121","author":"Brunnemann","year":"2017"},{"issue":"3","key":"10.1016\/j.chroma.2025.466050_bib0022","article-title":"Study of Nicotiana tabacum L extraction, by methods of liquid and supercritical fluid extraction","volume":"17","author":"Ikhsanov","year":"2019","journal-title":"J. Appl. Eng. Sci."},{"issue":"5","key":"10.1016\/j.chroma.2025.466050_bib0023","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3390\/molecules29051147","article-title":"Extraction and Purification of Nicotine from Tobacco Rhizomes by Supercritical CO2","volume":"29","author":"Zheng","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2025.466050_bib0024","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.talanta.2011.08.064","article-title":"Optimization of supercritical fluid extraction combined with dispersive liquid\u2013liquid microextraction as an efficient sample preparation method for determination of 4-nitrotoluene and 3-nitrotoluene in a complex matrix","volume":"88","author":"Jowkarderis","year":"2012","journal-title":"Talanta"},{"issue":"41","key":"10.1016\/j.chroma.2025.466050_bib0025","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1039\/D1AY01211H","volume":"13","author":"Raofie","year":"2021","journal-title":"Analytical Methods (journal)"},{"issue":"1","key":"10.1016\/j.chroma.2025.466050_bib0026","doi-asserted-by":"crossref","first-page":"9904","DOI":"10.1038\/s41598-022-13727-8","article-title":"Production Ganoderma lucidum extract nanoparticles by expansion of supercritical fluid solution and evaluation of the antioxidant ability","volume":"12","author":"Karimi","year":"2022","journal-title":"J. Sci. Rep."},{"key":"10.1016\/j.chroma.2025.466050_bib0027","article-title":"Phenomenological modeling of supercritical fluid extraction of oil from Elaeagnus angustifolia seeds","volume":"35","author":"Ardestani","year":"2023","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"10.1016\/j.chroma.2025.466050_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.135313","article-title":"Co-extraction of turmeric (Curcuma longa L.) and dried coconut shreds by supercritical fluid extraction (SFE): chemical and bioactivity profile","volume":"382","author":"Sharma","year":"2023","journal-title":"J. Clean. Prod."},{"issue":"16","key":"10.1016\/j.chroma.2025.466050_bib0029","doi-asserted-by":"crossref","first-page":"14605","DOI":"10.1007\/s13399-022-02807-4","article-title":"Supercritical fluid extraction of essential oils from Citrus reticulata peels: optimization and characterization studies","volume":"13","author":"Rajput","year":"2023","journal-title":"Biomass Convers Biorefin"},{"key":"10.1016\/j.chroma.2025.466050_bib0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.envres.2017.12.025","article-title":"Nanoadsorbents based on conducting polymer nanocomposites with main focus on polyaniline and its derivatives for removal of heavy metal ions\/dyes: a review","volume":"162","author":"Zare","year":"2018","journal-title":"Environ Res"},{"key":"10.1016\/j.chroma.2025.466050_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.synthmet.2019.116266","article-title":"Conducting polymer composite aerogel with magnetic properties for organic dye removal","volume":"260","author":"Bober","year":"2020","journal-title":"Synth Met"},{"key":"10.1016\/j.chroma.2025.466050_bib0032","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.chemosphere.2016.11.109","article-title":"Comparison of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry with electron ionization for determination of N-nitrosamines in environmental water","volume":"168","author":"Chen","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chroma.2025.466050_bib0033","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00604-013-1144-y","article-title":"Polythiophene-coated Fe3O4 nanoparticles as a selective adsorbent for magnetic solid-phase extraction of silver (I), gold (III), copper (II) and palladium (II)","volume":"181","author":"Tahmasebi","year":"2014","journal-title":"Microchim. Acta."},{"issue":"9","key":"10.1016\/j.chroma.2025.466050_bib0034","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1021\/acs.jchemed.6b00060","article-title":"Chemical oxidative polymerization of polyaniline: a practical approach for preparation of smart conductive textiles","volume":"93","author":"Abu-Thabit","year":"2016","journal-title":"J. Chem. Educ."},{"issue":"11","key":"10.1016\/j.chroma.2025.466050_bib0035","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1002\/pc.25738","article-title":"Preparation and characterization of polyaniline-and polythiophene-based copolymer and its nanocomposite suitable for electro-optical devices","volume":"41","author":"Dey Sadhu","year":"2020","journal-title":"Polym Compos"},{"issue":"10","key":"10.1016\/j.chroma.2025.466050_bib0036","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00396-023-05141-x","article-title":"Mechanism and adsorptive performance of PANI\/PTh copolymer as a novel and highly efficient adsorbent for the elimination of textile pollutants from aqueous solutions","volume":"301","author":"Karadeniz","year":"2023","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.chroma.2025.466050_bib0037","first-page":"1007","article-title":"Chemically engineered PTh\u2013co-PANi\u2013Ti copolymer composite systems for photovoltaic application","volume":"27","author":"Takpire","year":"2016","journal-title":"J. Mater. Sci."},{"issue":"6","key":"10.1016\/j.chroma.2025.466050_bib0038","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1039\/C3TB21171A","article-title":"Preparation of core\u2013shell Fe3O4@ poly (dopamine) magnetic nanoparticles for biosensor construction","volume":"2","author":"Martin","year":"2014","journal-title":"J. Mater. Chem. B."},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466050_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmmm.2003.07.006","article-title":"Preparation and characterization of amino\u2013silane modified superparamagnetic silica nanospheres","volume":"270","author":"Liu","year":"2004","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.chroma.2025.466050_bib0040","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.microc.2018.08.037","article-title":"Determination of acidic, basic and amphoteric drugs in biological fluids and wastewater after their simultaneous dispersive micro-solid phase extraction using multiwalled carbon nanotubes\/magnetite nanoparticles@ poly (2-aminopyrimidine) composite","volume":"143","author":"Jalilian","year":"2018","journal-title":"Microchem J"},{"key":"10.1016\/j.chroma.2025.466050_bib0041","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chroma.2014.04.073","article-title":"Magnetic solid phase extraction based on magnetite\/reduced graphene oxide nanoparticles for determination of trace isocarbophos residues in different matrices","volume":"1347","author":"Yan","year":"2014","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2025.466050_bib0042","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chroma.2016.08.065","article-title":"Determination of six sulfonylurea herbicides in environmental water samples by magnetic solid-phase extraction using multi-walled carbon nanotubes as adsorbents coupled with high-performance liquid chromatography","volume":"1466","author":"Ma","year":"2016","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.chroma.2025.466050_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.138848","article-title":"Facile extraction and determination of organophosphorus pesticides using poly (8-hydroxyquinoline) functionalized magnetic multi-walled carbon nanotubes nanocomposite in water, fruits, and vegetables samples","volume":"447","author":"Shahsavani","year":"2024","journal-title":"J. Food Chem."},{"key":"10.1016\/j.chroma.2025.466050_bib0044","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pharma.2023.08.002","article-title":"LC-MS\/MS Investigation of nitrosamine impurities in certain Sartan group medicinal products available in Istanbul, T\u00fcrkiye","volume":"82","author":"\u00d6nc\u00fc","year":"2024","journal-title":"Ann. Pharm. Fr."},{"key":"10.1016\/j.chroma.2025.466050_bib0045","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1248\/bpb.b19-00006","article-title":"Analysis of an impurity, N-nitrosodimethylamine, in valsartan drug substances and associated products using GC\u2013MS","volume":"42","author":"Tsutsumi","year":"2019","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.chroma.2025.466050_bib0046","doi-asserted-by":"crossref","first-page":"11048","DOI":"10.1021\/acsomega.1c00982","article-title":"Development of a sensitive headspace gas chromatography\u2013mass spectrometry method for the simultaneous determination of nitrosamines in losar-tan active pharmaceutical ingredients","volume":"6","author":"Wichitnithad","year":"2021","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.chroma.2025.466050_bib0047","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.xphs.2023.01.005","article-title":"Investigation of carcinogenic impurities of N-nitrosamines in sartan pharmaceutical products marketed in brazil: development and validation of method based on high-performance liquid chromatography-tandem mass spectrometry","volume":"112","author":"Monteiro","year":"2023","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.chroma.2025.466050_bib0048","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/chromsci\/bmac059","article-title":"A multi-analyte LC\u2013MS\/MS method for determination and quantification of six nitrosamine impurities in sartans like azilsartan, valsartan, telmisartan, olmesartan, losartan and irbesartan","volume":"62","author":"R.Gopireddy","year":"2024","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2025.466050_bib0049","first-page":"1","article-title":"Water as a green solvent for sustainable sample preparation: single drop microextraction of N-nitrosamines from losartan tablets","author":"Pereira dos Santos","year":"2024","journal-title":"Anal Bioanal Chem"},{"issue":"17","key":"10.1016\/j.chroma.2025.466050_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300214","article-title":"Microextraction by packed sorbent of N-nitrosamines from Losartan tablets using a high-throughput robot platform followed by liquid chromatography-tandem mass spectrometry","volume":"46","author":"Pereira dos Santos","year":"2023","journal-title":"J. Sep. Sci."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732500398X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732500398X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:08:20Z","timestamp":1749456500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002196732500398X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"alternative-id":["S002196732500398X"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466050","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supercritical fluid extraction assisted by magnetic solid-phase extraction method using MWCNTs\/Fe3O4@coPANI-PTH as preconcentration and gas chromatography mass spectrometry analysis for determining nitrosamines in Valsartan and Losartan tablets","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"466050"}}