{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:17:14Z","timestamp":1786947434838,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002753","name":"Universidad Nacional de Colombia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.chroma.2025.466173","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:38:21Z","timestamp":1750819101000},"page":"466173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Tetrahydrocannabinol separation from cannabis extracts using centrifugal partition chromatography"],"prefix":"10.1016","volume":"1757","author":[{"given":"Ada C.","family":"Gallo-Molina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-9582","authenticated-orcid":false,"given":"C\u00e9sar A.","family":"S\u00e1nchez-Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0638-0222","authenticated-orcid":false,"given":"Iv\u00e1n D.","family":"Gil-Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466173_bib0001","article-title":"Cannabis sativa: extraction methods for phytocannabinoids-an update","author":"Malabadi","year":"2024","journal-title":"Artic. World J. Biol. Pharm. Health Sci."},{"key":"10.1016\/j.chroma.2025.466173_bib0002","article-title":"Cannabinoides: una prometedora herramienta para el desarrollo de nuevas terapias","author":"Fraguas-S\u00e1nchez","year":"2014","journal-title":"An. Real Acad. Nac. Farm."},{"key":"10.1016\/j.chroma.2025.466173_bib0003","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.chroma.2025.466173_bib0004","unstructured":"OAS- CICAD, \u201cCannabis with a high concentration of tetrahydrocannabinol (THC) and synthetic cannabinoids in Latin America and the Caribbean,\u201d 2023."},{"key":"10.1016\/j.chroma.2025.466173_bib0005","unstructured":"Die Bundesregierung Deutschland, \u201cDrogen politik: FAQ zur legalisierung von Cannabis,\u201d 2024. https:\/\/www.bundesregierung.de\/breg-de\/aktuelles\/cannabis-legalisierung-2213640. (accessed 09 April 2025)."},{"key":"10.1016\/j.chroma.2025.466173_bib0006","unstructured":"Le S\u00e9nat de la r\u00e9publique fran\u00e7aise, \u201cLa d\u00e9p\u00e9nalisation et la l\u00e9galisation du cannabis,\u201d https:\/\/www.senat.fr\/lc\/lc306\/lc306.html. (accessed 09 April 2025)."},{"key":"10.1016\/j.chroma.2025.466173_bib0007","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), \u201cCannabis and Cannabis-derived compounds: quality considerations for clinical research | FDA guidance for industry,\u201d 2023. [Online]. Available: https:\/\/www.fda.gov\/drugs\/guidance-compliance-regulatory-information\/guidances-drugs. (accessed 09 April 2025)."},{"key":"10.1016\/j.chroma.2025.466173_bib0008","unstructured":"Fedlex: La plateforme de publication du droit f\u00e9d\u00e9ral, \u201cLoi f\u00e9d\u00e9rale sur les stup\u00e9fiants et les substances psychotropes,\u201d https:\/\/www.fedlex.admin.ch\/eli\/cc\/1952\/241_241_245\/fr. (accessed 09 April 2025)."},{"key":"10.1016\/j.chroma.2025.466173_bib0009","unstructured":"Gobierno de Peru - Ministerio de Desarrollo Agrario y Riego, \u201cDecreto supremo N\u00b0 0005-2019-SA\u201d."},{"key":"10.1016\/j.chroma.2025.466173_bib0010","unstructured":"Centro de Informaci\u00f3n Oficial - Gobierno de Uruguay, \u201cDecreto N\u00b0 298\/017: autorizacion de \u2018venta bajo receta profesional\u2019 para las especialidades farmaceuticas con cannabidiol como principio activo,\u201d pp. 1\u20131, Oct. 2017."},{"key":"10.1016\/j.chroma.2025.466173_bib0011","unstructured":"Ministerio de Salud y Protecci\u00f3n Social, \u201cDecreto 613 de 2017 que reglamenta el acceso seguro e informado al uso m\u00e9dico y cient\u00edfico del cannabis,\u201d p. 35, 2017, [Online]. Available: https:\/\/www.minsalud.gov.co\/Normatividad_Nuevo\/Decreto613de2017.pdf."},{"issue":"15","key":"10.1016\/j.chroma.2025.466173_bib0012","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1081\/JLC-200028170","article-title":"Preparative isolation of cannabinoids from cannabis sativa by centrifugal partition chromatography","volume":"27","author":"Hazekamp","year":"2004","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2025.466173_bib0013","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.chroma.2019.04.048","article-title":"Rapid isolation of acidic cannabinoids from Cannabis sativa L. using pH-zone-refining centrifugal partition chromatography","volume":"1599","author":"Popp","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.supflu.2019.01.020","article-title":"Extraction, isolation and purification of tetrahydrocannabinol from the Cannabis sativa L. plant using supercritical fluid extraction and solid phase extraction","volume":"146","author":"Gallo-Molina","year":"2019","journal-title":"J. Supercrit. Fluids."},{"key":"10.1016\/j.chroma.2025.466173_bib0015","unstructured":"Tan Xin, Zhang Ke, Gao Weibo, and Chang Tanran, \u201cMethod for extracting cannabidiol from cannabis,\u201d US 10, 301, 242 B2, 2019."},{"issue":"July","key":"10.1016\/j.chroma.2025.466173_bib0016","article-title":"Cannabidiol from inflorescences of Cannabis sativa L.: green extraction and purification processes","volume":"155","author":"Marzorati","year":"2020","journal-title":"Ind. Crops. Prod."},{"issue":"900","key":"10.1016\/j.chroma.2025.466173_bib0017","article-title":"Isolation, purification, and antimicrobial 2020","volume":"10","author":"Daniela","year":"2020","journal-title":"Biomolecules."},{"key":"10.1016\/j.chroma.2025.466173_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112726","article-title":"Approach for simultaneous cannabidiol isolation and pesticide removal from hemp extracts with liquid-liquid chromatography","volume":"155","author":"Luca","year":"2020","journal-title":"Ind. Crops. Prod."},{"key":"10.1016\/j.chroma.2025.466173_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462608","article-title":"Separation of minor cannabinoids from hemp extract with trapping multiple dual mode liquid-liquid chromatography","volume":"1658","author":"Luca","year":"2021","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.chroma.2025.466173_bib0020","first-page":"867","article-title":"Extraction and isolation of high quantities of cannabidiol, cannabinol, and delta-9- tetrahydrocannabinol from Cannabis sativa L","volume":"25","author":"Madaka","year":"2021","journal-title":"Malays. J. Anal. Sci."},{"key":"10.1016\/j.chroma.2025.466173_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ces.2023.119279","article-title":"Evaluation of advanced liquid\u2013liquid chromatography operating modes for the tetrahydrocannabinol-remediation of hemp extracts","volume":"282","author":"Luca","year":"2023","journal-title":"Chem. Eng. Sci."},{"issue":"19","key":"10.1016\/j.chroma.2025.466173_bib0022","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1007\/s00216-023-04782-9","article-title":"Effective isolation of cannabidiol and cannabidiolic acid free of psychotropic phytocannabinoids from hemp extract by fast centrifugal partition chromatography","volume":"415","author":"Maly","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2025.466173_bib0023","doi-asserted-by":"crossref","DOI":"10.1021\/acsagscitech.4c00462","article-title":"From hemp to CBD crystals: a scaled-up procedure for the selective extraction, isolation, and purification of cannabidiol","author":"Calmanti","year":"2025","journal-title":"ACS. Agric. Sci. Technol."},{"key":"10.1016\/j.chroma.2025.466173_bib0024","first-page":"1","article-title":"Pilot-scale preparation of broad-spectrum CBD: extraction optimization and purification using centrifugal partition chromatography","author":"Wongumpornpinit","year":"2025","journal-title":"Med. Cannabis. Cannabinoids."},{"issue":"C","key":"10.1016\/j.chroma.2025.466173_bib0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0021-9673(00)82022-1","article-title":"A new centrifugal counter-current chromatograph and its application","volume":"239","author":"Murayama","year":"1982","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0026","article-title":"Hydrophobic and hydrophilic interactions in countercurrent chromatography","author":"Zhang","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/9783527678129.assep046","article-title":"Separations with a liquid stationary phase: countercurrent chromatography or centrifugal partition chromatography","author":"Berthod","year":"2015","journal-title":"Anal. Sep. Sci."},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466173_bib0028","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9673(96)00880-1","article-title":"Preparative separation of anthocyanins by gradient elution centrifugal partition chromatograghy","volume":"763","author":"Renault","year":"1997","journal-title":"J. Chromatogr. A"},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466173_bib0029","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0021-9673(02)00355-2","article-title":"Preparative isolation of polyphenolic compounds from Vitis vinifera by centrifugal partition chromatography","volume":"964","author":"Delaunay","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0030","doi-asserted-by":"crossref","unstructured":"J.B. Friesen, J.B. McAlpine, S.N. Chen, and G.F. Pauli, \u201cCountercurrent separation of natural products: an update,\u201d 2015. doi: 10.1021\/np501065h.","DOI":"10.1021\/np501065h"},{"key":"10.1016\/j.chroma.2025.466173_bib0032","series-title":"Advances in Chromatography","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1201\/9781420060379.ch9","article-title":"Countercurrent chromatography: from the milligram to the kilogram","author":"Berthod","year":"2009"},{"issue":"2","key":"10.1016\/j.chroma.2025.466173_bib0033","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9673(98)00795-X","article-title":"Preparative purification of antibiotics for comparing hydrostatic and hydrodynamic mode counter-current chromatography and preparative high-performance liquid chromatography","volume":"831","author":"Menet","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2015.08.006","article-title":"Centrifugal partition chromatography in a biorefinery context: separation of monosaccharides from hydrolysed sugar beet pulp","author":"Ward","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466173_bib0035","article-title":"Solvent selection in countercurrent chromatography using small-volume hydrostatic columns","author":"Faure","year":"2013","journal-title":"LCGC N. Am."},{"issue":"12\u201313","key":"10.1016\/j.chroma.2025.466173_bib0037","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1081\/JLC-200063571","article-title":"Simple approach to the development of a CCC solvent selection protocol suitable for automation","volume":"28","author":"Garrard","year":"2005","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2025.466173_bib0038","unstructured":"F.G. Calvo, F. Mar\u00eda, and J. Monteagudo, \u201cGreen and BioBased solvents,\u201d 2018."},{"key":"10.1016\/j.chroma.2025.466173_bib0039","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cofs.2019.04.007","article-title":"ScienceDirect the relationship between cannabis \/hemp use in foods and processing methodology","volume":"28","author":"King","year":"2019","journal-title":"Curr. Opin. Food Sci."},{"key":"10.1016\/j.chroma.2025.466173_bib0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cofs.2019.04.007","article-title":"The relationship between cannabis\/hemp use in foods and processing methodology","volume":"28","author":"King","year":"2019","journal-title":"Curr. Opin. Food Sci."},{"issue":"1\u20132","key":"10.1016\/j.chroma.2025.466173_bib0041","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2004.01.001","article-title":"Determination of liquid-liquid partition coefficients by separation methods","volume":"1037","author":"Berthod","year":"2004","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.chroma.2025.466173_bib0042","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chroma.2004.12.044","article-title":"Golden rules and pitfalls in selecting optimum conditions for high-speed counter-current chromatography","volume":"1065","author":"Ito","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"17","key":"10.1016\/j.chroma.2025.466173_bib0043","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1080\/10826070500225234","article-title":"G.U.E.S.S. - A generally useful estimate of solvent systems in CCC","volume":"28","author":"Friesen","year":"2005","journal-title":"J. Liq. Chromatogr. Relat. Technol."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325005199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325005199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:27:43Z","timestamp":1761427663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325005199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"alternative-id":["S0021967325005199"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466173","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrahydrocannabinol separation from cannabis extracts using centrifugal partition chromatography","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466173"}}