{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:46:51Z","timestamp":1793742411748,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.chroma.2025.466418","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:03:02Z","timestamp":1758978182000},"page":"466418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Simultaneous determination of 12 lipophilic shellfish toxins in human plasma, serum, and urine using UPLC\u2013MS\/MS combined with PRiME HLB \u03bcElution platform"],"prefix":"10.1016","volume":"1762","author":[{"given":"Jiangang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3384-1506","authenticated-orcid":false,"given":"Li","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-3446","authenticated-orcid":false,"given":"Sudan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9055-4097","authenticated-orcid":false,"given":"Liangjiao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8579-4813","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466418_bib0001","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.marpolbul.2015.10.038","article-title":"Determination of typical lipophilic marine toxins in marine sediments from three coastal bays of China using liquid chromatography\u2013tandem mass spectrometry after accelerated solvent extraction","volume":"101","author":"Wang","year":"2015","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chroma.2025.466418_bib0002","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cofs.2018.10.006","article-title":"Outbreaks, toxicology, and analytical methods of marine toxins in seafood","volume":"24","author":"Daguer","year":"2018","journal-title":"Curr. Opin. Food Sci."},{"key":"10.1016\/j.chroma.2025.466418_bib0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gfs.2017.03.002","article-title":"Marine biotoxins and associated outbreaks following seafood consumption: prevention and surveillance in the 21st century","volume":"15","author":"Nicolas","year":"2017","journal-title":"Glob. Food Secur."},{"key":"10.1016\/j.chroma.2025.466418_bib0004","first-page":"41","article-title":"Contamination status and origins of lipophilic marine toxins in Qinhuangdao coastal waters","volume":"47","author":"Sun","year":"2023","journal-title":"Mar. Sci."},{"key":"10.1016\/j.chroma.2025.466418_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins10080324","article-title":"Human poisoning from marine toxins: unknowns for optimal consumer protection","volume":"10","author":"Vilari\u00f1o","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.chroma.2025.466418_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/1560-7917.ES.2019.24.35.1900513","article-title":"Outbreak of diarrhetic shellfish poisoning associated with consumption of mussels, United Kingdom, May to June 2019","volume":"24","author":"Young","year":"2019","journal-title":"Euro Surveill."},{"key":"10.1016\/j.chroma.2025.466418_bib0007","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.chroma.2015.08.066","article-title":"Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography\u2013tandem mass spectrometry","volume":"1416","author":"Wang","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0008","first-page":"1","article-title":"Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity","volume":"366","author":"Luis","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.chroma.2025.466418_bib0009","first-page":"1","article-title":"EU-harmonised standard operating procedure for determination of lipophilic marine biotoxins in molluscs by LC-MS\/MS","volume":"5","year":"2015","journal-title":"Version"},{"key":"10.1016\/j.chroma.2025.466418_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2024.464795","article-title":"Determination of lipophilic marine biotoxins (azaspiracids, brevetoxins, and okadaic acid group) and domoic acid in mussels by solid-phase extraction and reversed-phase liquid chromatography with tandem mass spectrometry","volume":"1720","author":"Ochi","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0011","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2015.11.016","article-title":"Determination of multiple toxins in whelk and clam samples collected from the Chukchi and Bering seas","volume":"109","author":"Li","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.chroma.2025.466418_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2021.461902","article-title":"Determination of lipophilic marine biotoxins by liquid chromatography-tandem mass spectrometry in five shellfish species from Washington State, USA","volume":"1639","author":"Wang","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2020.128374","article-title":"Simple determination of six groups of lipophilic marine algal toxins in seawater by automated on-line solid phase extraction coupled to liquid chromatography\u2013tandem mass spectrometry","volume":"262","author":"Wang","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.chroma.2025.466418_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2023.137995","article-title":"Marine toxins in seafood: recent updates on sample pretreatment and determination techniques","volume":"438","author":"Bian","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2025.466418_bib0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3724\/SP.J.1123.2020.11001","article-title":"Simultaneous determination of 12 lipophilic shellfish toxins in plasma and urine by ultra-high performance liquid chromatography\u2013tandem mass spectrometry","volume":"39","author":"Lin","year":"2024","journal-title":"Chin. J. Chromatogr."},{"key":"10.1016\/j.chroma.2025.466418_bib0016","first-page":"510","article-title":"Quantification of human plasma 18-hydroxycorticosterone by isotope dilution ultra-performance liquid chromatography tandem mass spectrometry","volume":"2","author":"Yin","year":"2021","journal-title":"Med. J. Pek. Union Med. College"},{"key":"10.1016\/j.chroma.2025.466418_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins8010001","article-title":"A simple and high-throughput analysis of amatoxins and phallotoxins in human plasma, serum and urine using UPLC-MS\/MS combined with PRiME HLB \u03bcElution platform","volume":"8","author":"Zhang","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.chroma.2025.466418_bib0018","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/17576180.2024.2349422","article-title":"Optimized LC-MS\/MS methods for quantifying antibody\u2013drug conjugate payloads in cell culture media containing phenol red","volume":"16","author":"Foreman","year":"2024","journal-title":"Bioanalysis"},{"key":"10.1016\/j.chroma.2025.466418_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpba.2021.114274","article-title":"Development and validation of an LC-MS\/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: application to cerebral microdialysis study","volume":"204","author":"Nair","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2025.466418_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22206-y","article-title":"Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS\/MS method","volume":"8","author":"Deng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chroma.2025.466418_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rcm.10086","article-title":"Development and validation of a liquid chromatography high-resolution mass spectrometry method for blood desmopressin quantification and its application in hemophilia A patients","volume":"39","author":"Hodin","year":"2025","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.chroma.2025.466418_bib0022","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5740\/jaoacint.SGEBrana","article-title":"Intra-laboratory validation of a fast and sensitive UHPLC-MS\/MS method with fast polarity switching for the analysis of lipophilic shellfish toxins","volume":"97","author":"Bra\u00f1a-Magdalena","year":"2014","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.chroma.2025.466418_bib0023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/toxins10090375","article-title":"Extended targeted and non-targeted strategies for the analysis of marine toxins in mussels and oysters by LC-HRMS","volume":"10","author":"Dom","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.chroma.2025.466418_bib0024","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chroma.2015.08.064","article-title":"High-resolution mass spectrometry for quantitative analysis and untargeted screening of algal toxins in mussels and passive samplers","volume":"1416","author":"Zendong","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0025","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1007\/s00216-014-7958-6","article-title":"Validation of a confirmatory method for lipophilic marine toxins in shellfish using HPLC-HR-Orbitrap MS","volume":"406","author":"Orellana","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2025.466418_bib0026","first-page":"624","article-title":"Determination of lipophilic marine toxins in shellfish by high performance liquid chromatography-tandem mass spectrometry with solid phase extraction","volume":"27","author":"Chen","year":"2015","journal-title":"Chin. J. Food Hyg."},{"key":"10.1016\/j.chroma.2025.466418_bib0027","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2015.11.016","article-title":"Determination of multiple toxins in whelk and clam samples collected from the Chukchi and Bering seas","volume":"109","author":"Li","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.chroma.2025.466418_bib0028","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/md19020099","article-title":"Lipophilic toxins in wild bivalves from the southern Gulf of California, Mexico","volume":"19","author":"Leyva-Valencia","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.chroma.2025.466418_bib0029","article-title":"Method performance verification for the combined detection and quantitation of the marine neurotoxin cyclic imines and brevetoxin shellfish metabolites in mussels (Mytilus edulis) and oysters (Crassostrea gigas) by UHPLC-MS\/MS","volume":"1179","author":"O\u2019Neill","year":"2021","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2025.466418_bib0030","unstructured":"J.P. Danaceau, E.E. Chambers, K.J. Fountain, Analysis of synthetic cannabinoids from urine for forensic toxicology using Oasis HLB \u03bcElution plates and Cortecs UPLC columns, Waters application note P\/N 720004780EN."},{"key":"10.1016\/j.chroma.2025.466418_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.127072","article-title":"Customized anion-exchange covalent organic frameworks for efficient extraction of natural products","volume":"342","author":"Zhang","year":"2024","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.chroma.2025.466418_bib0032","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s44211-022-00190-8","article-title":"A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis","volume":"38","author":"Badawy","year":"2022","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2025.466418_bib0033","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3390\/molecules25133047","article-title":"Compensate for or minimize matrix effects? Strategies for overcoming matrix effects in liquid chromatography-mass spectrometry technique: a tutorial review","volume":"25","author":"Cortese","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2025.466418_bib0034","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxicon.2020.10.002","article-title":"Evaluation of different strategies to minimize the matrix effects on LC\u2013MS\/MS analysis of multiple lipophilic shellfish toxins in both acidic and alkaline chromatographic conditions","volume":"188","author":"Qiu","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.chroma.2025.466418_bib0035","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/j.chroma.2010.09.020","article-title":"Strategies for the elimination of matrix effects in the liquid chromatography tandem mass spectrometry analysis of the lipophilic toxins okadaic acid and azaspiracid-1 in molluscan shellfish","volume":"1217","author":"Kilcoyne","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0036","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/md20020143","article-title":"Quantitation overcoming matrix effects of lipophilic toxins in Mytilus galloprovincialis by liquid chromatography-full scan high resolution mass spectrometry analysis (LC-HR-MS)","volume":"20","author":"Costa","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.chroma.2025.466418_bib0037","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00216-007-1542-2","article-title":"A liquid chromatography\/tandem mass spectrometric multi-mycotoxin method for quantification of 87 analytes and its application to semi-quantitative screening of moldy food samples","volume":"389","author":"Sulyok","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466418_bib0038","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC\u2013MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466418_bib0039","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1016\/j.chroma.2011.05.005","article-title":"Multi-mycotoxin analysis in eggs using a QuEChERS-based extraction procedure and ultra-high-pressure liquid chromatography coupled to triple quadrupole mass spectrometry","volume":"1218","author":"Frenich","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466418_bib0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aca.2004.08.055","article-title":"The ion suppression phenomenon in liquid chromatography\u2013mass spectrometry and its consequences in the field of residue analysis","volume":"529","author":"Antignac","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2025.466418_bib0041","article-title":"M10 Bioanalytical method validation and study sample analysis guidance for industry","year":"2022","journal-title":"ICH"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325007629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325007629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:23:08Z","timestamp":1761963788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325007629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"alternative-id":["S0021967325007629"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466418","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of 12 lipophilic shellfish toxins in human plasma, serum, and urine using UPLC\u2013MS\/MS combined with PRiME HLB \u03bcElution platform","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466418"}}