{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:43:24Z","timestamp":1780101804109,"version":"3.54.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["4002943"],"award-info":[{"award-number":["4002943"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["P2022AJA7H8"],"award-info":[{"award-number":["P2022AJA7H8"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.chroma.2025.466460","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:55Z","timestamp":1760163895000},"page":"466460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Expanding the use of green solvents for the isolation of melittin from honeybee venom"],"prefix":"10.1016","volume":"1763","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4796-1186","authenticated-orcid":false,"given":"Amin","family":"Tabesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-3287","authenticated-orcid":false,"given":"Chiara","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-8563","authenticated-orcid":false,"given":"Amirmohammad","family":"Faraji Shovey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1587-6330","authenticated-orcid":false,"given":"Rachele","family":"Canton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-8766","authenticated-orcid":false,"given":"Martina","family":"Catani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-0871","authenticated-orcid":false,"given":"Alberto","family":"Cavazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-8303","authenticated-orcid":false,"given":"Hassan","family":"Rezadoost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0039-1032","authenticated-orcid":false,"given":"Chiara","family":"Nosengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-2074","authenticated-orcid":false,"given":"Simona","family":"Felletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466460_bib0001","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1055\/s-0030-1270904","article-title":"Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures","volume":"77","author":"Gertsch","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.chroma.2025.466460_bib0002","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-021-00503-z","article-title":"In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria","volume":"22","author":"Askari","year":"2021","journal-title":"BMC. Pharmacol. Toxicol."},{"key":"10.1016\/j.chroma.2025.466460_bib0003","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/exd.12384","article-title":"Cationic membrane-active peptides - anticancer and antifungal activity as well as penetration into human skin","volume":"23","author":"Do","year":"2014","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.chroma.2025.466460_bib0004","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/toxins7041126","article-title":"Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan","volume":"7","author":"Moreno","year":"2015","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.chroma.2025.466460_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00412","article-title":"Therapeutic properties of bioactive compounds from different honeybee products","volume":"8","author":"Cornara","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chroma.2025.466460_bib0006","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fct.2016.06.008","article-title":"Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal","volume":"94","author":"Sobral","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chroma.2025.466460_bib0007","unstructured":"F. Sengul, H. Vatansev, Overview of apitherapy products: anti-cancer effects of bee venom used In apitherapy, 2021."},{"key":"10.1016\/j.chroma.2025.466460_bib0008","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tifs.2020.04.026","article-title":"Honeybee products: an updated review of neurological actions","volume":"101","author":"El-Seedi","year":"2020","journal-title":"Trends. Food Sci. Technol."},{"key":"10.1016\/j.chroma.2025.466460_bib0009","first-page":"11","article-title":"Potential therapeutic applications of bee venom on skin disease and its mechanisms: a literature review","author":"Kim","year":"2019","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.chroma.2025.466460_bib0010","first-page":"13","article-title":"Cosmetic applications of bee venom","author":"El-Wahed","year":"2021","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.chroma.2025.466460_bib0011","article-title":"Therapeutic use of bee venom and potential applications in veterinary medicine","volume":"10","author":"Bava","year":"2023","journal-title":"Vet. Sci."},{"key":"10.1016\/j.chroma.2025.466460_bib0012","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.intimp.2007.04.005","article-title":"Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia","volume":"7","author":"Moon","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.chroma.2025.466460_bib0013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0003-2697(82)90144-0","article-title":"Purification from bee venom of melittin devoid of phospholipase A2 contamination","volume":"127","author":"Maulet","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chroma.2025.466460_bib0014","doi-asserted-by":"crossref","unstructured":"X. Vila-Farr\u00e9s, E. Giralt, J. Vila, Update of peptides with antibacterial activity, 2012.","DOI":"10.2174\/0929867311209066188"},{"key":"10.1016\/j.chroma.2025.466460_bib0015","first-page":"12","article-title":"Therapeutic effects of apamin as a bee venom component for non-neoplastic disease","author":"Gu","year":"2020","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.chroma.2025.466460_bib0016","article-title":"New N-terminal fatty-acid-modified melittin analogs with potent biological activity","volume":"25","author":"Huang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chroma.2025.466460_bib0017","article-title":"Standardization of the manufacturing process of Bee Venom pharmacopuncture containing melittin as the active ingredient","volume":"2018","author":"Lee","year":"2018","journal-title":"Eviden.-Based Complem. Altern. Med."},{"key":"10.1016\/j.chroma.2025.466460_bib0018","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4014\/jmb.1608.08042","article-title":"One-step purification of melittin derived from Apis mellifera bee venom","volume":"27","author":"Teoh","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.chroma.2025.466460_bib0019","doi-asserted-by":"crossref","DOI":"10.1021\/bi00395a010","article-title":"Solid-phase synthesis of Melittin: purification and functional characterization","author":"Tosteson","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.chroma.2025.466460_bib0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/00313029500169782","article-title":"A high efficiency method for purification and assay of bee venom phospholipase A2","volume":"27","author":"Ameratunga","year":"1995","journal-title":"Pathology."},{"key":"10.1016\/j.chroma.2025.466460_bib0021","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10989-017-9641-1","article-title":"Apoptotic effect of melittin purified from Iranian honey Bee venom on Human cervical cancer HeLa cell line","volume":"24","author":"Zarrinnahad","year":"2018","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.chroma.2025.466460_bib0022","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jcma.2015.06.008","article-title":"First report on the isolation of melittin from Iranian honey bee venom and evaluation of its toxicity on gastric cancer AGS cells","volume":"78","author":"Mahmoodzadeh","year":"2015","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.chroma.2025.466460_bib0023","article-title":"Preparative chromatography","author":"Schmidt-Traub","year":"2020","journal-title":"Wiley-VCH"},{"key":"10.1016\/j.chroma.2025.466460_bib0024","series-title":"FUNDAMENTALS of Preparative and Nonlinear Chromatography","author":"Guiochon","year":"2006"},{"key":"10.1016\/j.chroma.2025.466460_bib0025","first-page":"1616","article-title":"Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography","author":"De Luca","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466460_bib0026","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.chroma.2006.04.073","article-title":"Retention modelling in ternary solvent-strength gradient elution reversed-phase chromatography using 30 mm columns","volume":"1121","author":"Euerby","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466460_bib0027","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1002\/cssc.201701120","article-title":"Nanofiltration-enabled In situ solvent and reagent recycle for sustainable continuous-flow synthesis","volume":"10","author":"Fodi","year":"2017","journal-title":"ChemSusChem."},{"key":"10.1016\/j.chroma.2025.466460_bib0028","unstructured":"European Chemicals Bureau Existing Substances European Union Risk Assessment Report - acetonitrile, 2002."},{"key":"10.1016\/j.chroma.2025.466460_bib0029","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals Human Use, impurities: guideline for residual solvents Q3C(R9), Available from (https:\/\/www.Ich.Org\/Fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/QualIty\/Q3C_R9\/Step4\/Q3C_R9_Guideline.Pdf). (2024) 1\u201311, (2024)."},{"key":"10.1016\/j.chroma.2025.466460_bib0030","series-title":"Handbook of Green Analytical Chemistry","article-title":"The concept of green analytical chemistry","author":"De La Guardia","year":"2012"},{"key":"10.1016\/j.chroma.2025.466460_bib0031","doi-asserted-by":"crossref","unstructured":"D. Prat, A. Wells, J. Hayler, H. Sneddon, C.R. McElroy, S. Abou-Shehada, P.J. Dunn, CHEM21 selection guide of classical- and less classical-solvents, Green. Chem.. 18 (2015) 288\u2013296. https:\/\/doi.org\/10.1039\/c5gc01008j.","DOI":"10.1039\/C5GC01008J"},{"key":"10.1016\/j.chroma.2025.466460_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464530","article-title":"Dimethyl carbonate as a green alternative to acetonitrile in reversed-phase liquid chromatography. Part II: purification of a therapeutic peptide","volume":"1713","author":"Bozza","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466460_bib0033","doi-asserted-by":"crossref","DOI":"10.1039\/D5GC01158B","article-title":"Replace, reduce, and reuse organic solvents in peptide downstream processing: the benefits of dimethyl carbonate over acetonitrile","author":"De Luca","year":"2025","journal-title":"Green. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.118007","article-title":"Exploring the potential of green chemistry in reversed-phase liquid chromatography: a review of sustainable solvents","volume":"181","author":"Kalisz","year":"2024","journal-title":"TrAC - Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464477","article-title":"Dimethyl carbonate as a green alternative to acetonitrile in reversed-phase liquid chromatography. Part I: separation of small molecules","volume":"1712","author":"Felletti","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466460_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051065","article-title":"Greening reversed-phase liquid chromatography methods using alternative solvents for pharmaceutical analysis","volume":"23","author":"Yabr\u00e9","year":"2018","journal-title":"Molecules."},{"key":"10.1016\/j.chroma.2025.466460_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/separations10020070","article-title":"Dimethyl carbonate as a mobile-phase modifier for normal-phase and hydrophilic interaction liquid chromatography","volume":"10","author":"Boes","year":"2023","journal-title":"Separations."},{"key":"10.1016\/j.chroma.2025.466460_bib0038","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jpba.2012.11.045","article-title":"Greening pharmaceutical applications of liquid chromatography through using propylene carbonate\u2013ethanol mixtures instead of acetonitrile as organic modifier in the mobile phases","volume":"75","author":"Tache","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2025.466460_bib0039","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.trac.2013.04.010","article-title":"The 12 principles of green analytical chemistry and the SIGNIFICANCE mnemonic of green analytical practices","volume":"50","author":"Ga\u0142uszka","year":"2013","journal-title":"TrAC - Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0040","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","article-title":"AGREE - analytical GREEnness metric approach and software","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0041","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.70175","article-title":"Continuous depletion of tetrahydrocannabinol from cannabis extract through simulated moving bed chromatography using green mobile phase","author":"Compagnin","year":"2025","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2025.466460_bib0042","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1039\/C8GC03875A","article-title":"Making the move towards modernized greener separations: introduction of the analytical method greenness score (AMGS) calculator","volume":"21","author":"Hicks","year":"2019","journal-title":"Green. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0043","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/D4GC04300F","article-title":"In silico modeling enables greener analytical and preparative chromatographic methods","volume":"27","author":"Handlovic","year":"2024","journal-title":"Green. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.greeac.2023.100065","article-title":"ChlorTox Base \u2013 a useful source of information on popular reagents in terms of chemical hazards and greenness assessment","volume":"6","author":"Nowak","year":"2023","journal-title":"Green Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.greeac.2023.100056","article-title":"How to evaluate methods used in chemical laboratories in terms of the total chemical risk? \u2013 a ChlorTox scale","volume":"5","author":"Nowak","year":"2023","journal-title":"Green Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0046","year":"2025"},{"key":"10.1016\/j.chroma.2025.466460_bib0047","doi-asserted-by":"crossref","DOI":"10.1002\/etc.5620160237","article-title":"A screening method for ranking and scoring chemicals by potential human health and environmental impacts","volume":"16","author":"Swanson","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0048","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ecoenv.2015.05.043","article-title":"Scoring of solvents used in analytical laboratories by their toxicological and exposure hazards","volume":"120","author":"Tobiszewski","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chroma.2025.466460_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10100583","article-title":"Africanized Bee venom (Apis mellifera Linnaeus): neuroprotective effects in a Parkinson\u2019s Disease mouse model induced by 6-hydroxydopamine","volume":"10","author":"Dantas","year":"2022","journal-title":"Toxics."},{"key":"10.1016\/j.chroma.2025.466460_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2022.04.006","article-title":"Chemical profiling and antimicrobial effect of Anatolian honey bee venom","volume":"213","author":"Sonmez","year":"2022","journal-title":"Toxicon."},{"key":"10.1016\/j.chroma.2025.466460_bib0051","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1007\/s12010-022-04284-x","article-title":"Apis mellifera anatoliaca venom exerted anti-inflammatory activity on LPS-stimulated mammalian macrophages by reducing the production of the inflammatory cytokines","volume":"195","author":"Sevin","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.chroma.2025.466460_bib0052","doi-asserted-by":"crossref","DOI":"10.1007\/s10989-024-10631-9","article-title":"The cytotoxic effects of Turkish bee venom (Apis mellifera) on selected cancer cell lines","volume":"30","author":"Babayeva","year":"2024","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.chroma.2025.466460_bib0053","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1039\/D4GC05737F","article-title":"Performance evaluation of green and conventional solvents in reversed-phase liquid chromatography based on the separation of non-polar and polar substances","volume":"27","author":"Kalisz","year":"2025","journal-title":"Green. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116051","article-title":"Modern trends in downstream processing of biotherapeutics through continuous chromatography: the potential of Multicolumn Countercurrent Solvent Gradient purification","volume":"132","author":"De Luca","year":"2020","journal-title":"TrAC - Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2025.466460_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465440","article-title":"Integrated multidimensional chromatography on preparative scale for oligonucleotides purification","volume":"1737","author":"Nosengo","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2025.466460_bib0056","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1039\/c0gc00918k","article-title":"Expanding GSK\u2019s solvent selection guide \u2013 embedding sustainability into solvent selection starting at medicinal chemistry","volume":"13","author":"Henderson","year":"2011","journal-title":"Green. Chem."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325008040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325008040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T01:23:38Z","timestamp":1763774618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325008040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":56,"alternative-id":["S0021967325008040"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466460","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expanding the use of green solvents for the isolation of melittin from honeybee venom","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"466460"}}