{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:32:22Z","timestamp":1783035142555,"version":"3.54.6"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504105"],"award-info":[{"award-number":["2023YFC3504105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.chroma.2025.466630","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:57:39Z","timestamp":1765814259000},"page":"466630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Digital fingerprinting and quantitative analysis: A systematic strategy for differentiating bear bile powder from pig bile adulterants using UPLC-QTOF-MS and UPLC-QQQ-MS"],"prefix":"10.1016","volume":"1767","author":[{"given":"Haonan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangliang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2025.466630_bib0001","first-page":"5433","article-title":"Ancient and modern application of bile drugs","volume":"37","author":"Zhu","year":"2022","journal-title":"C J T C M P"},{"key":"10.1016\/j.chroma.2025.466630_bib0002","first-page":"1555","article-title":"Research progress in quality control of Bile-derived medicinal materials","volume":"27","author":"Wu","year":"2025","journal-title":"Mod. Chin. Med."},{"key":"10.1016\/j.chroma.2025.466630_bib0003","article-title":"Substitutes for Bear Bile for the Treatment of Liver Diseases: Research Progress and Future Perspective","volume":"2016","author":"Li","year":"2016","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.chroma.2025.466630_bib0004","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1746-4269-5-2","article-title":"Bear bile: dilemma of traditional medicinal use and animal protection","volume":"5","author":"Feng","year":"2009","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.chroma.2025.466630_bib0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2468-1253(19)30343-7","article-title":"Current and potential treatments for primary biliary cholangitis","volume":"5","author":"Shah","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.chroma.2025.466630_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106340","article-title":"Sequence and structure-guided discovery of a novel NADH-dependent 7\u03b2-hydroxysteroid dehydrogenase for efficient biosynthesis of ursodeoxycholic acid","volume":"131","author":"Huang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.chroma.2025.466630_bib0007","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2021.09.021","article-title":"From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders","volume":"99","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.chroma.2025.466630_bib0008","article-title":"Dried bear bile exerts its antidepressant effect by modulating adrenal FXR to reduce peripheral glucocorticoid levels","volume":"41","author":"Tao","year":"2024","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.chroma.2025.466630_bib0009","article-title":"Bear bile powder ameliorates type 2 diabetes via modulation of metabolic profiles, gut microbiota, and metabolites","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chroma.2025.466630_bib0010","doi-asserted-by":"crossref","DOI":"10.1002\/ansa.70040","article-title":"Comprehensive Analysis of Bile-derived Medicinal Materials Based on Ultra-High-Performance Liquid Chromatography Coupled With Charged Aerosol Detection and Chemometrics","volume":"6","author":"Wu","year":"2025","journal-title":"Anal. Sci. Adv."},{"key":"10.1016\/j.chroma.2025.466630_bib0011","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.3390\/molecules29133144","article-title":"A Comprehensive Analysis of Fel Ursi and Its Common Adulterants Based on UHPLC-QTOF-MSE and Chemometrics","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules."},{"key":"10.1016\/j.chroma.2025.466630_bib0012","doi-asserted-by":"crossref","first-page":"43264","DOI":"10.1021\/acsomega.4c08260","article-title":"Comprehensive Analysis of Bile Medicines Based on UHPLC-QTOF-MSE and Machine Learning","volume":"9","author":"Wang","year":"2024","journal-title":"ACS. Omega"},{"key":"10.1016\/j.chroma.2025.466630_bib0013","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1007\/s00216-023-04740-5","article-title":"Performance evaluation of E-nose and E-tongue combined with machine learning for qualitative and quantitative assessment of bear bile powder","volume":"415","author":"Lei","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2025.466630_bib0014","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00216-022-04413-9","article-title":"Rapid discrimination of the authenticity and geographical origin of bear bile powder using stable isotope ratio and elemental analysis","volume":"415","author":"Yuan","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2025.466630_bib0015","first-page":"1064","article-title":"[DNA fingerprinting identification of bile power(bile)medicines]","volume":"45","author":"Tian","year":"2020","journal-title":"Zhongguo Zhong. Yao Za Zhi."},{"key":"10.1016\/j.chroma.2025.466630_bib0016","doi-asserted-by":"crossref","first-page":"e5164","DOI":"10.1002\/jms.5164","article-title":"Analysis of Saposhnikoviae Radix and Libonotidis Radix Based on \u201cCharacteristic Ion Set\u201d and Chemometrics","volume":"60","author":"Wang","year":"2025","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.chroma.2025.466630_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/ansa.70014","article-title":"Identification of Rubiae Radix et Rhizoma and Its Adulterants Based on \u201cMass Spectrometry Matrix","volume":"6","author":"Wang","year":"2025","journal-title":"Anal. Sci. Adv."},{"key":"10.1016\/j.chroma.2025.466630_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1438321","article-title":"Digital identification and adulteration analysis of Codonopsis Radix and Stellariae Radix based on the \u201cdigital identity\u201d of chemical compositions","volume":"12","author":"Wang","year":"2024","journal-title":"Front. Chem."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325009744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967325009744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:05:14Z","timestamp":1773925514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967325009744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"alternative-id":["S0021967325009744"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466630","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Digital fingerprinting and quantitative analysis: A systematic strategy for differentiating bear bile powder from pig bile adulterants using UPLC-QTOF-MS and UPLC-QQQ-MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2025.466630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466630"}}