{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:30:32Z","timestamp":1792438232934,"version":"4.5.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.chroma.2026.466798","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:41:22Z","timestamp":1770828082000},"page":"466798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Advances in LC\u2013MS\/MS methods and sample preparation strategies for therapeutic drug monitoring of immunosuppressive drugs"],"prefix":"10.1016","volume":"1773","author":[{"given":"Selen","family":"Al","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet","family":"Dincel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-0939","authenticated-orcid":false,"given":"Aykut","family":"Kul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olcay","family":"Sagirli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1056\/NEJM200007063430107","article-title":"The immune system","volume":"343","author":"Delves","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.chroma.2026.466798_bib0002","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nri3227","article-title":"Regulatory immune cells in transplantation","volume":"12","author":"Wood","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"suppl_1","key":"10.1016\/j.chroma.2026.466798_bib0003","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/bja\/aer384","article-title":"Organ transplantation: historical perspective and current practice","volume":"108","author":"Watson","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.chroma.2026.466798_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-015-0332-8","article-title":"Immunosuppressive drugs and fertility","volume":"10","author":"Leroy","year":"2015","journal-title":"Orphanet. J. Rare Dis."},{"key":"10.1016\/j.chroma.2026.466798_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124996","article-title":"Overview of therapeutic drug monitoring and clinical practice","volume":"266","author":"Fang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.466798_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114315","article-title":"Overview of therapeutic drug monitoring of immunosuppressive drugs: analytical and clinical practices","volume":"205","author":"Seyfinejad","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.466798_bib0007","first-page":"1","article-title":"An ultra-fast method for therapeutic drug monitoring of tacrolimus, sirolimus and cyclosporine A","author":"Lv","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0008","first-page":"726","article-title":"Immunosuppressive drugs","author":"Hussain","year":"2022","journal-title":"Encycl. Infect. Immun."},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0009","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/1091581810374654","article-title":"Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia","volume":"29","author":"Bugelski","year":"2010","journal-title":"Int. J. Toxicol."},{"issue":"9","key":"10.1016\/j.chroma.2026.466798_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015487","article-title":"Immunosuppressive drug therapy","volume":"3","author":"Hartono","year":"2013","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"issue":"4","key":"10.1016\/j.chroma.2026.466798_bib0011","doi-asserted-by":"crossref","first-page":"14","DOI":"10.29245\/2578-3009\/2019\/4.1178","article-title":"Immunosuppressive drugs in organ transplantation to prevent allograft rejection: mode of action and side effects","volume":"3","author":"Claeys","year":"2019","journal-title":"J. Immunol. Sci."},{"key":"10.1016\/j.chroma.2026.466798_bib0012","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s12072-020-10091-5","article-title":"Immunosuppressive regimens for adult liver transplant recipients in real-life practice: consensus recommendations from an Italian working group","volume":"14","author":"Cillo","year":"2020","journal-title":"Hepatol. Int."},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0013","doi-asserted-by":"crossref","first-page":"119S","DOI":"10.1002\/j.1875-9114.1991.tb02641.x","article-title":"Complications associated with immunosuppressive therapy and their management","volume":"11","author":"Min","year":"1991","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0014","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1742-7843.2010.00602.x","article-title":"Clinical pharmacology in research, teaching and health care: considerations by IUPHAR, the International union of basic and clinical pharmacology","volume":"107","author":"Birkett","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"7","key":"10.1016\/j.chroma.2026.466798_bib0015","first-page":"601","article-title":"Pharmacokinetic drug-drug interaction and their implication in clinical management","volume":"18","author":"Palleria","year":"2013","journal-title":"J. Res. Med. Sci. Off. J. Isfahan Univ. Med. Sci."},{"key":"10.1016\/j.chroma.2026.466798_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344018","article-title":"the role of automation in improving the performance and throughput of microsample bioanalysis","author":"Protti","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466798_bib0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00228-013-1504-x","article-title":"Therapeutic drug monitoring for tomorrow","volume":"69","author":"Eliasson","year":"2013","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"15","key":"10.1016\/j.chroma.2026.466798_bib0018","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.3390\/molecules30153139","article-title":"Therapeutic drug monitoring of everolimus using volumetric absorptive microsampling and quantitative dried blood spot methods with LC-MS\/MS in adult solid organ transplant recipients: an analytical and clinical comparative study","volume":"30","author":"Kocur","year":"2025","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.chroma.2026.466798_bib0019","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.tibtech.2020.03.001","article-title":"On-site therapeutic drug monitoring","volume":"38","author":"Ates","year":"2020","journal-title":"Trends Biotechnol."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0020","article-title":"Therapeutic drug monitoring: which drugs, why, when and how to do it","volume":"31","author":"Ghiculescu","year":"2008","journal-title":"Aust. Prescr."},{"key":"10.1016\/j.chroma.2026.466798_bib0021","article-title":"Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology","volume":"54","author":"Udomkarnjananun","year":"2021","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.chroma.2026.466798_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/frtra.2025.1716789","article-title":"Comparative evaluation of five tacrolimus assays in transplant recipients: implications for optimizing therapeutic drug monitoring","volume":"4","author":"SahBandar","year":"2025","journal-title":"Front. Transplant."},{"key":"10.1016\/j.chroma.2026.466798_bib0023","first-page":"1097","article-title":"Alternate sampling matrices for therapeutic drug monitoring of immunosuppressants","volume":"10","author":"Sallustio","year":"2022","journal-title":"Ther. Drug Monit."},{"issue":"3","key":"10.1016\/j.chroma.2026.466798_bib0024","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jala.2010.02.001","article-title":"Matrix effects\u2014a challenge toward automation of molecular analysis","volume":"15","author":"Chiu","year":"2010","journal-title":"JALA J. Assoc. Lab. Autom."},{"issue":"6","key":"10.1016\/j.chroma.2026.466798_bib0025","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jaad.2010.02.063","article-title":"The use of cyclosporine in dermatology: part I","volume":"63","author":"Amor","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.chroma.2026.466798_bib0026","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s13346-019-00650-1","article-title":"Recent advances in cyclosporine drug delivery: challenges and opportunities","volume":"9","author":"Patel","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0027","article-title":"Cyclosporine: a review","volume":"2012","author":"Tedesco","year":"2012","journal-title":"J. Transplant."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0028","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.proghi.2004.04.001","article-title":"Cyclosporine A and adverse effects on organs: histochemical studies","volume":"39","author":"Rezzani","year":"2004","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1016\/j.chroma.2026.466798_bib0029","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.1016\/j.transproceed.2004.01.028","article-title":"Cyclosporine nephrotoxicity","author":"Fellstr\u00f6m","year":"2004","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.chroma.2026.466798_bib0030","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1016\/j.transproceed.2003.12.047","article-title":"The use of cyclosporine in renal transplantation","author":"Hesselink","year":"2004","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.chroma.2026.466798_bib0031","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/OAEM.S241501","article-title":"Cyclosporine-a-based immunosuppressive therapy-induced neurotoxicity: a case report","author":"Teimouri","year":"2020","journal-title":"Open Access Emerg. Med."},{"key":"10.1016\/j.chroma.2026.466798_bib0032","doi-asserted-by":"crossref","first-page":"S396","DOI":"10.1016\/j.transproceed.2004.01.013","article-title":"Therapeutic drug monitoring of cyclosporine","author":"Jorga","year":"2004","journal-title":"Transplant. Proc."},{"issue":"10","key":"10.1016\/j.chroma.2026.466798_bib0033","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/FPC.0b013e328364db84","article-title":"PharmGKB summary: cyclosporine and tacrolimus pathways","volume":"23","author":"Barbarino","year":"2013","journal-title":"Pharmacogenet. Genom."},{"issue":"4","key":"10.1016\/j.chroma.2026.466798_bib0034","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1517\/14656566.9.4.635","article-title":"The role of tacrolimus in renal transplantation","volume":"9","author":"Bowman","year":"2008","journal-title":"Expert Opin. PharmacOther"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1432-2277.2000.tb01040.x","article-title":"Treatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver transplant recipients","volume":"13","author":"Emre","year":"2000","journal-title":"Transpl. Int."},{"issue":"3","key":"10.1016\/j.chroma.2026.466798_bib0036","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/TP.0000000000003350","article-title":"Thirty years of tacrolimus in clinical practice","volume":"105","author":"Ong","year":"2021","journal-title":"Transplantation"},{"issue":"9","key":"10.1016\/j.chroma.2026.466798_bib0037","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1097\/01.TP.0000126926.61434.A5","article-title":"Tacrolimus and transplantation: a decade in review","volume":"77","author":"Fung","year":"2004","journal-title":"Transplantation"},{"issue":"12","key":"10.1016\/j.chroma.2026.466798_bib0038","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2165\/00003495-200363120-00006","article-title":"Tacrolimus: a further update of its use in the management of organ transplantation","volume":"63","author":"Scott","year":"2003","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.chroma.2026.466798_bib0039","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1517\/14656566.2.11.1903","article-title":"Sirolimus: a comprehensive review","volume":"2","author":"Kahan","year":"2001","journal-title":"Expert Opin. PharmacOther"},{"key":"10.1016\/j.chroma.2026.466798_bib0040","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0041-1345(03)00211-2","article-title":"Sirolimus: its discovery, biological properties, and mechanism of action","author":"Sehgal","year":"2003","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.chroma.2026.466798_bib0041","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2165\/00003088-200140080-00002","article-title":"Clinical pharmacokinetics of sirolimus","volume":"40","author":"Mahalati","year":"2001","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.chroma.2026.466798_bib0042","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2165\/00003088-200544080-00001","article-title":"Sirolimus: the evidence for clinical pharmacokinetic monitoring","volume":"44","author":"Stenton","year":"2005","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.chroma.2026.466798_bib0043","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2165\/00003495-200767030-00004","article-title":"Use of sirolimus in solid organ transplantation","volume":"67","author":"Augustine","year":"2007","journal-title":"Drugs"},{"issue":"8S","key":"10.1016\/j.chroma.2026.466798_bib0044","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/TP.0b013e3181a05b7a","article-title":"Management of side effects of sirolimus therapy","volume":"87","author":"Stallone","year":"2009","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0045","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1158\/1078-0432.CCR-09-1314","article-title":"Everolimus","volume":"16","author":"Houghton","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chroma.2026.466798_bib0046","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00003088-200443020-00002","article-title":"Clinical pharmacokinetics of everolimus","volume":"43","author":"Kirchner","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.chroma.2026.466798_bib0047","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2165\/00003495-200464080-00005","article-title":"Everolimus","volume":"64","author":"Chapman","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.chroma.2026.466798_bib0048","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-3-642-54490-3_23","article-title":"Everolimus","author":"Hasskarl","year":"2014","journal-title":"Small Mol. Oncol."},{"issue":"12","key":"10.1016\/j.chroma.2026.466798_bib0049","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1517\/13543784.11.12.1845","article-title":"Review of the proliferation inhibitor everolimus","volume":"11","author":"Nashan","year":"2002","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.chroma.2026.466798_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10549-013-2630-y","article-title":"Everolimus: side effect profile and management of toxicities in breast cancer","volume":"140","author":"Paplomata","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"issue":"2-3","key":"10.1016\/j.chroma.2026.466798_bib0051","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0162-3109(00)00188-0","article-title":"Mycophenolate mofetil and its mechanisms of action","volume":"47","author":"Allison","year":"2000","journal-title":"Immunopharmacology"},{"issue":"02","key":"10.1016\/j.chroma.2026.466798_bib0052","doi-asserted-by":"crossref","first-page":"042","DOI":"10.1055\/s-0035-1556743","article-title":"Update on the teratogenicity of maternal mycophenolate mofetil","volume":"4","author":"Coscia","year":"2015","journal-title":"J. Pediatr. Genet."},{"issue":"7","key":"10.1016\/j.chroma.2026.466798_bib0053","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1358\/dot.2009.45.7.1384878","article-title":"Mycophenolate mofetil: an update","volume":"45","author":"Villarroel","year":"2009","journal-title":"Drugs Today"},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0054","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.54054","article-title":"Effectiveness of mycophenolate mofetil among patients with progressive IgA nephropathy: a randomized clinical trial","volume":"6","author":"Hou","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73882-8","article-title":"Efficacy and safety of mycophenolate mofetil therapy in neuromyelitis optica spectrum disorders: a systematic review and meta-analysis","volume":"10","author":"Songwisit","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0056","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.ftd.0000199358.80013.bd","article-title":"Therapeutic drug monitoring of mycophenolate mofetil in transplantation","volume":"28","author":"Van Gelder","year":"2006","journal-title":"Ther. Drug Monit."},{"issue":"8","key":"10.1016\/j.chroma.2026.466798_bib0057","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1172\/JCI200318384","article-title":"Azathioprine: old drug, new actions","volume":"111","author":"Maltzman","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.chroma.2026.466798_bib0058","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jaad.2005.07.059","article-title":"Azathioprine in dermatology: the past, the present, and the future","volume":"55","author":"Patel","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"issue":"8","key":"10.1016\/j.chroma.2026.466798_bib0059","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2036.2004.02197.x","article-title":"Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases","volume":"20","author":"Weersma","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.chroma.2026.466798_bib0060","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1046\/j.1365-2036.2002.01297.x","article-title":"Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine","volume":"16","author":"Fraser","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0061","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaad.2010.04.041","article-title":"The cutaneous and systemic manifestations of azathioprine hypersensitivity syndrome","volume":"65","author":"Bidinger","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"issue":"10","key":"10.1016\/j.chroma.2026.466798_bib0062","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1365-2036.2008.03843.x","article-title":"Azathioprine treatment during lactation","volume":"28","author":"Christensen","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.chroma.2026.466798_bib0063","series-title":"Handbook of Analytical Separations","first-page":"97","article-title":"Immunoassays for therapeutic drug monitoring and clinical toxicology","author":"Clarke","year":"2020"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0064","article-title":"UHPLC-MS\/MS method for simultaneous determination of tacrolimus, Cyclosporine A, sirolimus and Everolimus in human blood and clinical application","volume":"53","author":"Jiaqing","year":"2025","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116064","article-title":"Conjugating immunoassays to mass spectrometry: solutions to contemporary challenges in clinical diagnostics","volume":"132","author":"Stevens","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0066","first-page":"105","article-title":"Interferences in immunoassay","volume":"25","author":"Tate","year":"2004","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.chroma.2026.466798_bib0067","doi-asserted-by":"crossref","unstructured":"P. Jannetto, Therapeutic drug monitoring using mass spectrometry, Mass spectrometry for the clinical laboratory (2017) 165-179.","DOI":"10.1016\/B978-0-12-800871-3.00008-0"},{"key":"10.1016\/j.chroma.2026.466798_bib0068","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.trac.2016.03.019","article-title":"The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine","volume":"84","author":"Decosterd","year":"2016","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0069","series-title":"Therapeutic Drug Monitoring","first-page":"67","article-title":"Analytical techniques used in therapeutic drug monitoring","author":"Milone","year":"2024"},{"issue":"17","key":"10.1016\/j.chroma.2026.466798_bib0070","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.4155\/bio.11.201","article-title":"Sample treatment based on extraction techniques in biological matrices","volume":"3","author":"Ashri","year":"2011","journal-title":"Bioanalysis"},{"key":"10.1016\/j.chroma.2026.466798_bib0071","series-title":"Mass Spectrometry For The Clinical Laboratory","first-page":"37","article-title":"Sample preparation techniques for mass spectrometry in the clinical laboratory","author":"Stone","year":"2017"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0072","doi-asserted-by":"crossref","first-page":"e4137","DOI":"10.1002\/bmc.4137","article-title":"Sample preparation for large-scale bioanalytical studies based on liquid chromatographic techniques","volume":"32","author":"Medvedovici","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2026.466798_bib0073","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.acc.2016.09.003","article-title":"Advances in clinical mass spectrometry","volume":"79","author":"French","year":"2017","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0074","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.acc.2021.07.003","article-title":"Amino acids in inflammatory bowel diseases: modern diagnostic tools and methodologies","volume":"107","author":"Piestansky","year":"2022","journal-title":"Adv. Clin. Chem."},{"issue":"1-2","key":"10.1016\/j.chroma.2026.466798_bib0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2009.10.004","article-title":"A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation","volume":"656","author":"Nov\u00e1kov\u00e1","year":"2009","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0076","article-title":"Solid phase extraction technique\u2013trends, opportunities and applications","volume":"15","author":"\u017bwir-Ferenc","year":"2006","journal-title":"Pol. J. Environ. Stud."},{"issue":"6","key":"10.1016\/j.chroma.2026.466798_bib0077","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0165-9936(03)00605-8","article-title":"New trends in solid-phase extraction","volume":"22","author":"Poole","year":"2003","journal-title":"TrAC Trends Anal. Chem."},{"issue":"3","key":"10.1016\/j.chroma.2026.466798_bib0078","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/07373937.2011.645413","article-title":"Past, present, and future of solid phase extraction: a review","volume":"42","author":"Buszewski","year":"2012","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"12","key":"10.1016\/j.chroma.2026.466798_bib0079","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s44211-022-00190-8","article-title":"A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis","volume":"38","author":"Badawy","year":"2022","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.466798_bib0080","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/9783527678129.assep056","article-title":"Dispersive solid-phase extraction","author":"Socas-Rodr\u00edguez","year":"2015","journal-title":"Anal. Sep. Sci."},{"issue":"21","key":"10.1016\/j.chroma.2026.466798_bib0081","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.3390\/molecules25214869","article-title":"Recent materials developed for dispersive solid phase extraction","volume":"25","author":"\u015acigalski","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0082","article-title":"Dispersive solid phase extraction for the analysis of veterinary drugs applied to food samples: a review","volume":"2017","author":"Islas","year":"2017","journal-title":"Int. J. Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.115893","article-title":"Functionalized nanomaterials in dispersive solid phase extraction: advances & prospects","volume":"127","author":"B\u00fcy\u00fcktiryaki","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0084","article-title":"Advances in dispersive solid-phase extraction techniques for analytical quantification of fluoroquinolone antibiotics","volume":"193","author":"Shukri","year":"2023","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2026.466798_bib0085","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.trac.2019.04.018","article-title":"Current trends in QuEChERS method. A versatile procedure for food, environmental and biological analysis","volume":"116","author":"Santana-Mayor","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0086","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.trac.2019.06.012","article-title":"The application of the QuEChERS methodology in the determination of antibiotics in food: a review","volume":"118","author":"Zhang","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.teac.2019.e00063","article-title":"Review of the QuEChERS method for the analysis of organic pollutants: persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals","volume":"22","author":"Kim","year":"2019","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0088","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2019.02.036","article-title":"QuEChERS-fundamentals, relevant improvements, applications and future trends","volume":"1070","author":"Perestrelo","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466798_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2019.103314","article-title":"Recent developments and applications of QuEChERS based techniques on food samples during pesticide analysis","volume":"84","author":"Musarurwa","year":"2019","journal-title":"J. Food Compos. Anal."},{"issue":"28","key":"10.1016\/j.chroma.2026.466798_bib0090","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1007\/s00216-024-05525-0","article-title":"SWIEET\u2014a salt-free alternative to QuEChERS","volume":"416","author":"Kalinke","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"issue":"19","key":"10.1016\/j.chroma.2026.466798_bib0091","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1021\/ac00218a019","article-title":"Solid phase microextraction with thermal desorption using fused silica optical fibers","volume":"62","author":"Arthur","year":"1990","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0092","series-title":"Handbook of Solid Phase Microextraction","first-page":"13","article-title":"Theory of solid-phase microextraction","author":"Pawliszyn","year":"2012"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0093","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1021\/acs.analchem.7b04502","article-title":"Advances in solid phase microextraction and perspective on future directions","volume":"90","author":"Reyes-Garces","year":"2017","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0094","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.aca.2007.12.041","article-title":"Development of a dynamic headspace solid-phase microextraction procedure coupled to GC\u2013qMSD for evaluation the chemical profile in alcoholic beverages","volume":"609","author":"Rodrigues","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466798_bib0095","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.trac.2012.10.006","article-title":"Recent trends in SPME concerning sorbent materials, configurations and in vivo applications","volume":"43","author":"Silva","year":"2013","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0096","doi-asserted-by":"crossref","unstructured":"J. Pawliszyn, Solid phase microextraction, Headspace Analysis of Foods and Flavors: Theory and Practice (2001) 73-87.","DOI":"10.1007\/978-1-4615-1247-9_6"},{"issue":"4","key":"10.1016\/j.chroma.2026.466798_bib0097","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1021\/cr100203t","article-title":"Nondestructive sampling of living systems using in vivo solid-phase microextraction","volume":"111","author":"Ouyang","year":"2011","journal-title":"Chem. Rev."},{"issue":"52","key":"10.1016\/j.chroma.2026.466798_bib0098","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1002\/anie.201407057","article-title":"Development of coated blade spray ionization mass spectrometry for the quantitation of target analytes present in complex matrices","volume":"53","author":"G\u00f3mez-R\u00edos","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"issue":"45","key":"10.1016\/j.chroma.2026.466798_bib0099","doi-asserted-by":"crossref","first-page":"15879","DOI":"10.1021\/acs.analchem.2c04003","article-title":"Coated blade spray with a barrier: improving negative electrospray ionization and sample preparation","volume":"94","author":"Zhou","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466798_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342244","article-title":"Perspective on SPME-MS: Green and high-performance methods for rapid screening","volume":"1291","author":"Zhou","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"38","key":"10.1016\/j.chroma.2026.466798_bib0101","doi-asserted-by":"crossref","first-page":"27608","DOI":"10.1039\/D4RA03251A","article-title":"Recent advances in solid phase microextraction with various geometries in environmental analysis","volume":"14","author":"Keerthana","year":"2024","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0102","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/FTD.0b013e3181c49a00","article-title":"Ultra fast liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of cyclosporin A, tacrolimus, sirolimus, and everolimus in whole blood using deuterated internal standards for cyclosporin A and everolimus","volume":"32","author":"Meinitzer","year":"2010","journal-title":"Ther. Drug Monit."},{"issue":"2-3","key":"10.1016\/j.chroma.2026.466798_bib0103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clinbiochem.2010.10.005","article-title":"Comparison of blood sirolimus, tacrolimus and everolimus concentrations measured by LC-MS\/MS, HPLC-UV and immunoassay methods","volume":"44","author":"Sallustio","year":"2011","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0104","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/FTD.0b013e318246d515","article-title":"Analytical performance of a new liquid chromatography\/tandem mass spectrometric method for determination of everolimus concentrations in whole blood","volume":"34","author":"McMillin","year":"2012","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.chroma.2026.466798_bib0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jchromb.2011.07.021","article-title":"A high-throughput U-HPLC\u2013MS\/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine","volume":"883","author":"Klepacki","year":"2012","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0106","article-title":"Simultaneous determination of cyclosporine A, tacrolimus, sirolimus, and everolimus in whole-blood samples by LC-MS\/MS","volume":"2012","author":"Karapirli","year":"2012","journal-title":"Sci. World J."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0107","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/FTD.0b013e31824b0bfb","article-title":"Quantification of tacrolimus and three demethylated metabolites in human whole blood using LC\u2013ESI\u2013MS\/MS","volume":"34","author":"Dubbelboer","year":"2012","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.chroma.2026.466798_bib0108","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jchromb.2011.10.034","article-title":"Successful and cost-efficient replacement of immunoassays by tandem mass spectrometry for the quantification of immunosuppressants in the clinical laboratory","volume":"883","author":"H\u00e9tu","year":"2012","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0109","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/FTD.0b013e318274827d","article-title":"Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography\u2013tandem mass spectrometric assay","volume":"35","author":"Becker","year":"2013","journal-title":"Ther. Drug Monit."},{"issue":"16-17","key":"10.1016\/j.chroma.2026.466798_bib0110","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.clinbiochem.2013.08.013","article-title":"Immunosuppressant therapeutic drug monitoring by LC-MS\/MS: workflow optimization through automated processing of whole blood samples","volume":"46","author":"Marinova","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.chroma.2026.466798_bib0111","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aca.2013.10.051","article-title":"Ultra-fast cyclosporin A quantitation in whole blood by laser diode thermal desorption\u2013tandem mass spectrometry; comparison with high performance liquid chromatography\u2013tandem mass spectrometry","volume":"805","author":"Jourdil","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466798_bib0112","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2013.01.017","article-title":"Simultaneous online SPE\u2013HPLC\u2013MS\/MS analysis of docetaxel, temsirolimus and sirolimus in whole blood and human plasma","volume":"921","author":"Navarrete","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466798_bib0113","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jchromb.2013.03.014","article-title":"Two rapid ultra performance liquid chromatography\/tandem mass spectrometry (UPLC\/MS\/MS) methods with common sample pretreatment for therapeutic drug monitoring of immunosuppressants compared to immunoassay","volume":"928","author":"Tszyrsznic","year":"2013","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"10.1016\/j.chroma.2026.466798_bib0114","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/FTD.0000000000000006","article-title":"A direct method for the measurement of everolimus and sirolimus in whole blood by LC\u2013MS\/MS using an isotopic everolimus internal standard","volume":"36","author":"Morgan","year":"2014","journal-title":"Ther. Drug Monit."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2116\/analsci.30.293","article-title":"Quantitative determination of cyclosporine in human whole blood by ultra-performance liquid chromatography with triple quadrupole tandem mass spectrometry","volume":"30","author":"Jung","year":"2014","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.466798_bib0116","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s10337-015-2981-0","article-title":"Simultaneous measurement of cyclosporine A, everolimus, sirolimus and tacrolimus concentrations in human blood by UPLC\u2013MS\/MS","volume":"78","author":"Rigo-Bonnin","year":"2015","journal-title":"Chromatographia"},{"issue":"6","key":"10.1016\/j.chroma.2026.466798_bib0117","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/bmc.3628","article-title":"Use of a small particle solid-core packing for improved efficiency and rapid measurement of sirolimus and everolimus by LC-MS\/MS","volume":"30","author":"Morgan","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2026.466798_bib0118","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jchromb.2016.10.035","article-title":"Development and validation of LC\u2013MS\/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: correlation with genetic polymorphism","volume":"1038","author":"Al-Ghobashy","year":"2016","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0119","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5530\/jyp.2017.9.20","article-title":"A novel and rapid LC\u2013MS\/MS assay for the determination of mycophenolate and mycophenolic acid in human plasma","volume":"9","author":"Maddela","year":"2017","journal-title":"J. Young Pharm."},{"issue":"10","key":"10.1016\/j.chroma.2026.466798_bib0120","doi-asserted-by":"crossref","first-page":"e3976","DOI":"10.1002\/bmc.3976","article-title":"Free mycophenolic acid determination in human plasma ultrafiltrate by a validated liquid chromatography\u2013tandem mass spectrometry method","volume":"31","author":"\u0141uszczy\u0144ska","year":"2017","journal-title":"Biomed. Chromatogr."},{"issue":"4","key":"10.1016\/j.chroma.2026.466798_bib0121","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5582\/bst.2017.01121","article-title":"A comparison of liquid chromatography-tandem mass spectrometry (LC-MS\/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the cyclosporin A concentration in whole blood from Chinese patients","volume":"11","author":"Li","year":"2017","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.chroma.2026.466798_bib0122","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jchromb.2018.04.028","article-title":"Simultaneous determination of cyclosporine and tacrolimus in human whole blood by ultra-high performance liquid chromatography tandem mass spectrometry and comparison with a chemiluminescence microparticle immunoassay","volume":"1087","author":"Mei","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466798_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121772","article-title":"A new HPLC-MS\/MS method for simultaneous determination of cyclosporine A, tacrolimus, sirolimus and everolimus for routine therapeutic drug monitoring","volume":"1128","author":"Krn\u00e1\u010d","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466798_bib0124","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jchromb.2018.11.026","article-title":"Isotope\u2013labeled versus analog internal standard in LC\u2013MS\/MS method for tacrolimus determination in human whole blood samples\u2013A compensation of matrix effects","volume":"1104","author":"Bodnar-Broniarczyk","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466798_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121802","article-title":"Highly sensitive and rapid determination of azathioprine metabolites in whole blood lysate by liquid chromatography\u2013tandem mass spectrometry","volume":"1136","author":"Miao","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466798_bib0126","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.transproceed.2020.01.077","article-title":"Simultaneous determination of everolimus, sirolimus, tacrolimus, and cyclosporine-A by mass spectrometry","author":"Perez","year":"2020","journal-title":"Transplant. Proc."},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0127","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/FTD.0000000000000861","article-title":"Comparison of a point-of-care testing with enzyme-multiplied immunoassay technique and liquid chromatography combined with tandem mass spectrometry methods for therapeutic drug monitoring of mycophenolic acid: a preliminary study","volume":"43","author":"Zhou","year":"2021","journal-title":"Ther. Drug Monit."},{"issue":"13","key":"10.1016\/j.chroma.2026.466798_bib0128","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.3390\/molecules27134087","article-title":"Simultaneous determination of six immunosuppressants in human whole blood by HPLC-MS\/MS using a modified QuEChERS method","volume":"27","author":"Zheng","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2026.466798_bib0129","article-title":"Comparison of LC-MS\/MS and EMIT methods for the precise determination of blood sirolimus in children with vascular anomalies","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chroma.2026.466798_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123907","article-title":"Bimetallic metal\u2013organic framework as an efficient sorbent for the extraction of tacrolimus and cyclosporine from plasma before HPLC-MS\/MS analysis","volume":"1231","author":"Mehrvarz","year":"2023","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.chroma.2026.466798_bib0131","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3892\/etm.2023.12041","article-title":"A simple and accurate LC\u2011MS\/MS method for monitoring cyclosporin A that is suitable for high throughput analysis","volume":"26","author":"Yuan","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.chroma.2026.466798_bib0132","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jmsacl.2024.06.001","article-title":"Therapeutic drug monitoring of mycophenolic acid and azole antifungals on two distinct LC-MS\/MS instruments","volume":"33","author":"Wolken","year":"2024","journal-title":"J. Mass Spectrom. Adv. Clin. Lab"},{"issue":"13","key":"10.1016\/j.chroma.2026.466798_bib0133","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.3390\/ijms26136358","article-title":"Analytical validation of an LC-MS\/MS method for simultaneous quantification of multiple immunosuppressants in microvolume whole blood","volume":"26","author":"Aizawa","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.chroma.2026.466798_bib0134","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/FTD.0000000000001341","article-title":"An offline SPE-LC-MS\/MS method for simultaneous quantification of tacrolimus, cyclosporine a, kynurenine, tryptophan, and creatinine using volumetric absorptive microsampling device mitra","volume":"47","author":"Nierychlewski","year":"2025","journal-title":"Ther. Drug Monit."},{"issue":"2","key":"10.1016\/j.chroma.2026.466798_bib0135","doi-asserted-by":"crossref","first-page":"e9932","DOI":"10.1002\/rcm.9932","article-title":"Development and validation of a rapid HPLC-MS\/MS method for simultaneous determination of cyclosporine A and tacrolimus in whole blood for routine therapeutic drug monitoring in organ transplantation","volume":"39","author":"Han","year":"2025","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"6","key":"10.1016\/j.chroma.2026.466798_bib0136","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10337-020-03893-0","article-title":"Rapid separation and screening of mycophenolate mofetil and mycophenolic acid with a novel (vinyl ester) resin molecular imprinted monolithic column","volume":"83","author":"Feng","year":"2020","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.466798_bib0137","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1134\/S1061934813120046","article-title":"RP-HPLC Method for the Estimation of 6-Mercaptopurine in spiked human plasma and pharmaceutical formulations","volume":"68","author":"Naik","year":"2013","journal-title":"J. Anal. Chem."},{"issue":"8","key":"10.1016\/j.chroma.2026.466798_bib0138","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/00365513.2016.1230775","article-title":"Simultaneous determination of mycophenolate and its metabolite mycophenolate-7-o-glucuronide with an isocratic HPLC-UV-based method in human plasma and stability evaluation","volume":"76","author":"Rissling","year":"2016","journal-title":"Scand. J. Clin. Lab Invest."},{"key":"10.1016\/j.chroma.2026.466798_bib0139","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jmsacl.2023.03.002","article-title":"Mass spectrometry quantitation of immunosuppressive drugs in clinical specimens using online solid-phase extraction and accurate-mass full scan-single ion monitoring","volume":"28","author":"Yeung","year":"2023","journal-title":"J. Mass Spectrom. Adv. Clin. Lab"},{"key":"10.1016\/j.chroma.2026.466798_bib0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aca.2017.10.016","article-title":"Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS\/MS)","volume":"999","author":"G\u00f3mez-R\u00edos","year":"2018","journal-title":"Anal. Chim. Acta"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326001287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326001287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:32:04Z","timestamp":1773048724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326001287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":140,"alternative-id":["S0021967326001287"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466798","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in LC\u2013MS\/MS methods and sample preparation strategies for therapeutic drug monitoring of immunosuppressive drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466798"}}