{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:23:55Z","timestamp":1783729435032,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J199"],"award-info":[{"award-number":["2022J199"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["202003N4168"],"award-info":[{"award-number":["202003N4168"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","award":["2025HY0914&gt;"],"award-info":[{"award-number":["2025HY0914&gt;"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.chroma.2026.466802","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:41:23Z","timestamp":1770828083000},"page":"466802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Halloysite nanotubes-incorporated ionic liquid-modified organic polymer monolith for the spin-tip solid-phase extraction of dexmedetomidine from whole blood"],"prefix":"10.1016","volume":"1773","author":[{"given":"Menglin","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-7012","authenticated-orcid":false,"given":"Xiaoqiang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-2049","authenticated-orcid":false,"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.466802_bib0001","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.2147\/JIR.S346089","article-title":"Recent advances in the clinical value and potential of dexmedetomidine","volume":"14","author":"Liu","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.chroma.2026.466802_bib0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210391","article-title":"Determination of blood dexmedetomidine in dried blood spots by LC-MS\/MS to screen therapeutic levels in paediatric patients","volume":"14","author":"Rivera-Espinosa","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.chroma.2026.466802_bib0003","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jpba.2018.03.015","article-title":"Determination of dexmedetomidine by UHPLC-MS\/MS and its application to evaluate the effect of dexmedetomidine concentration on the target-controlled infusion concentration of propofol","volume":"154","author":"Zheng","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.466802_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122381","article-title":"Determination of dexmedetomidine using high performance liquid chromatography coupled with tandem mass spectrometric (HPLC-MS\/MS) assay combined with microdialysis technique: Application to a pharmacokinetic study","volume":"1160","author":"Chang","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466802_bib0005","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jchromb.2017.12.006","article-title":"An improved liquid chromatography tandem mass spectrometry (LC-MS\/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma","volume":"1073","author":"Moosavi","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chroma.2026.466802_bib0006","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/00480169.2016.1237313","article-title":"Pharmacokinetics and sedative effects of dexmedetomidine in dairy calves","volume":"65","author":"Cagnardi","year":"2017","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.chroma.2026.466802_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114853","article-title":"Simultaneous detection of a panel of nine sedatives and metabolites in plasma from critically ill pediatric patients via UPLC-MS\/MS","volume":"218","author":"Birabaharan","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.466802_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.07.025","article-title":"Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients","volume":"175","author":"Yang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.466802_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464224","article-title":"Rapid extraction of osimertinib and its active metabolite in urine by miniaturized centrifugal spin-column extraction using ionic liquid hybrid hierarchical porous adsorbent","volume":"1705","author":"Han","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123779","article-title":"A rapid capillary-channeled polymer (C-CP) fiber spin-down tip approach for the isolation of plant-derived extracellular vesicles (PDEVs) from 20 common fruit and vegetable sources","volume":"252","author":"Jackson","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.466802_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.463787","article-title":"Honeycomb resin-based spin-column solid-phase extraction for efficient determination of alectinib and its metabolite in human urine","volume":"1690","author":"Zhao","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124150","article-title":"N, N'-methylene bisacrylamide\/divinyl benzene based-highly cross-linked hybrid monolithic column: Production and its applications for powerful capture of four chlorophenols","volume":"254","author":"Wang","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.466802_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.463959","article-title":"Rapid and simple determination of organophosphorus pesticides in urine using polydopamine-modified monolithic spin column extraction combined with liquid chromatography-mass spectrometry","volume":"1696","author":"Zhang","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0014","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1021\/acs.analchem.6b00701","article-title":"Preparation of polypropylene spin tips filled with immobilized titanium (IV) ion monolithic adsorbent for robust phosphoproteome analysis","volume":"88","author":"Liu","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0015","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1039\/D1CC05529A","article-title":"Bottom-up\/cross-linking mass spectrometry via simplified sample processing on anion-exchange solid-phase extraction spin column","volume":"58","author":"Takemori","year":"2022","journal-title":"Chem. Commun."},{"key":"10.1016\/j.chroma.2026.466802_bib0016","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1021\/acs.analchem.9b05355","article-title":"Probing protein-protein interactions with label-free mass spectrometry quantification in combination with affinity purification by spin-tip affinity columns","volume":"92","author":"Liu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464518","article-title":"Organic-silica hybrid monolithic sorbents for sample preparation techniques: A review on advances in synthesis, characterization, and applications","volume":"1713","author":"Souza","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343332","article-title":"Hierarchically porous covalent organic framework doped monolithic column for on-line chip-based array microextraction of nonsteroidal anti-inflammatory drugs in microlitre volume of blood","volume":"1331","author":"Zhang","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466802_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147112","article-title":"Modification of halloysite nanotube using chitosan\/zinc hydroxystannate to mimic coral for excellent flame retardancy and mechanical properties of PVC","volume":"325","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.chroma.2026.466802_bib0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.colsurfa.2012.12.048","article-title":"Physicochemical and adsorptive properties of a heat-treated and acid-leached Algerian halloysite","volume":"421","author":"Belkassa","year":"2013","journal-title":"Colloids Surf. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140205","article-title":"A novel halloysite nanotubes-based hybrid monolith for in-tube solid-phase microextraction of polar cationic pesticides","volume":"458","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.339632","article-title":"Ionic liquid-based magnetic nanoparticles for magnetic dispersive solid-phase extraction: A review","volume":"1201","author":"Chen","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.466802_bib0023","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chroma.2018.04.063","article-title":"On-line coupling of hydrophilic ionic liquids-based polymer monolith microextraction to capillary liquid chromatography with amperometric detection: An ultrasensitive residue analysis method for glycopeptide antibiotics","volume":"1556","author":"Tang","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465540","article-title":"Rapid analysis of six cytokinins in tomato plants using phenylboronic acid and ionic liquid functionalized monolithic capillary column combined with UHPLC-MS\/MS","volume":"1739","author":"Deng","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0025","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1039\/D3AY00400G","article-title":"Sodium hexametaphosphate-treated halloysite based solid-phase extraction of biguanides from dietary supplements","volume":"15","author":"Huang","year":"2023","journal-title":"Anal. Methods"},{"key":"10.1016\/j.chroma.2026.466802_bib0026","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/bmc.2870","article-title":"Development of a stable isotope dilution UPLC-MS\/MS method for quantification of dexmedetomidine in a small amount of human plasma","volume":"27","author":"Inoue","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2026.466802_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144480","article-title":"Nanozyme mediated Raman-NLISA dual-modal immunosensor for accurate and sensitive detection of microcystin-LR","volume":"485","author":"Zeng","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0028","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1021\/acsapm.3c02295","article-title":"Disposable saliva sensors for early cancer diagnosis using hyper-cross-linked molecularly imprinted polymeric electrocatalysts","volume":"5","author":"Athar","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.chroma.2026.466802_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143440","article-title":"A halloysite nanotubes-based hybrid fluorous monolith as the mixed-mode sorbent for hydrophilic and hydrophobic interactions and its application for analysis of antibiotics from milk powder and milk samples","volume":"476","author":"Lin","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.fluid.2022.113404","article-title":"Influence of alkyl chain length of imidazolium-based ionic liquid on the crude oil-aqueous solution IFT under different ionic strengths","volume":"556","author":"Barari","year":"2022","journal-title":"Fluid Phase Equilib."},{"key":"10.1016\/j.chroma.2026.466802_bib0031","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.catcom.2014.10.026","article-title":"Supported imidazole as heterogeneous catalyst for the synthesis of cyclic carbonates from epoxides and CO2","volume":"59","author":"Sankar","year":"2015","journal-title":"Catal. Commun."},{"key":"10.1016\/j.chroma.2026.466802_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137982","article-title":"Preparation of monolith-based adsorbent mingled with metal organic framework for field microextraction of organic pollutants with significantly distinct properties in water","volume":"491","author":"Zeng","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chroma.2026.466802_bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.70226","article-title":"Synthesis of perfluorooctyl-functionalized halloysite nanotubes for dispersive solid-phase extraction of antimalarial inhibitors in whole blood","volume":"48","author":"Wang","year":"2025","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.466802_bib0034","doi-asserted-by":"crossref","first-page":"30137","DOI":"10.1021\/acsami.4c05600","article-title":"An ultramicroporous graphene-based 3D structure derived from cellulose-based biomass for high-performance CO2 capture","volume":"16","author":"Park","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.chroma.2026.466802_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144182","article-title":"Ionic liquid-functionalized metal-organic frameworks adsorbents for effective extraction of dibutyl phthalate in edible oil: A new strategy for selectivity and low cost","volume":"482","author":"Yang","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0036","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chroma.2014.06.078","article-title":"Poly(ionic liquid) immobilized magnetic nanoparticles as new adsorbent for extraction and enrichment of organophosphorus pesticides from tea drinks","volume":"1358","author":"Zheng","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0037","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ijbiomac.2012.06.022","article-title":"Chitosan\/halloysite nanotubes bionanocomposites: Structure, mechanical properties and biocompatibility","volume":"51","author":"Liu","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.chroma.2026.466802_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.466237","article-title":"Enhanced by ionic liquids: Magnetic molecularly imprinted polymers-magnetic solid-phase extraction-UHPLC-UV for sensitive detection of benzimidazoles in multiple food matrices","volume":"1759","author":"Xue","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466802_bib0039","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/00000542-200612000-00009","article-title":"A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children","volume":"105","author":"Petroz","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.chroma.2026.466802_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3184759","article-title":"LC-MS\/MS method for simultaneous quantification of dexmedetomidine, dezocine, and midazolam in rat plasma and its application to their pharmacokinetic study","volume":"2018","author":"Cui","year":"2018","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.chroma.2026.466802_bib0041","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jchromb.2016.04.051","article-title":"Determination of dexmedetomidine in children's plasma by ultra-performance liquid chromatography tandem mass spectrometry and application to pharmacokinetic study","volume":"1023\u20131024","author":"Liu","year":"2016","journal-title":"J. Chromatogr. B"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326001329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326001329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:16:53Z","timestamp":1776125813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326001329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":41,"alternative-id":["S0021967326001329"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466802","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Halloysite nanotubes-incorporated ionic liquid-modified organic polymer monolith for the spin-tip solid-phase extraction of dexmedetomidine from whole blood","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466802"}}