{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:15:17Z","timestamp":1788236117665,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019125","name":"National Institute of Pharmaceutical Education and Research Ahmedabad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.chroma.2026.466986","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:55:18Z","timestamp":1775782518000},"page":"466986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["HPLC\u2013PDA and LC\u2013HRMS\/MS-based quantitative and qualitative analysis of Glycosmis pentaphylla alkaloids, and investigation of their anticancer potential through network pharmacology"],"prefix":"10.1016","volume":"1778","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0882-0394","authenticated-orcid":false,"given":"Soham","family":"Rajyaguru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parusu Kavya","family":"Teja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuvaraaj","family":"V K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyeeta","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Madavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-3146","authenticated-orcid":false,"given":"Nitish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7974-2231","authenticated-orcid":false,"given":"Siddheshwar K.","family":"Chauthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.466986_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114313","article-title":"Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: a review","volume":"278","author":"Khandokar","year":"2021","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.chroma.2026.466986_bib0002","first-page":"2723","article-title":"A review on the pharmacology and phytochemistry of traditional medicinal plant, Glycosmis pentaphylla (Retz.) Correa","volume":"5","author":"Sreejith","year":"2012","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.chroma.2026.466986_bib0003","first-page":"70","article-title":"Review on ethnomedicinal claims and pharmacological activity of Asvashakhotah (Glycosmis pentaphylla [Retz.] A. DC): an extrapharmacopoeial plant of Ayurveda","volume":"18","author":"Ramavat","year":"2024","journal-title":"J. Ayu."},{"key":"10.1016\/j.chroma.2026.466986_bib0004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0031-9422(00)90802-1","article-title":"Sulphur-containing amides from Glycosmis species with different antifungal activity","volume":"34","author":"Greger","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.chroma.2026.466986_bib0005","doi-asserted-by":"crossref","first-page":"112865","DOI":"10.1016\/j.phytochem.2021.112865","article-title":"Traditional uses, phytochemistry, pharmacology, toxicology and formulation aspects of Glycosmis species: A systematic review","volume":"190","author":"Teja","year":"2021","journal-title":"Phytochemistry"},{"key":"10.1016\/j.chroma.2026.466986_bib0006","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/hlca.201200027","article-title":"Alkaloids from the stems of Glycosmis pentaphylla","volume":"95","author":"Yang","year":"2012","journal-title":"Helv. Chim. Acta."},{"key":"10.1016\/j.chroma.2026.466986_bib0007","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1039\/C5OB00695C","article-title":"Glycosmisines A and B: isolation of two new carbazole\u2013indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities","volume":"13","author":"Chen","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.chroma.2026.466986_bib0008","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1080\/10286020.2014.918961","article-title":"Glycoborinine induces apoptosis through mitochondrial pathway in HepG2 cells","volume":"16","author":"Yang","year":"2014","journal-title":"J. Asian Nat. Prod. Res"},{"key":"10.1016\/j.chroma.2026.466986_bib0009","first-page":"29","article-title":"Phytochemical and physicochemical assessment of diversity in the leaves of Glycosmis pentaphylla (Retz.) DC","volume":"8","author":"Babu","year":"2019","journal-title":"Pharma. Innov. J."},{"key":"10.1016\/j.chroma.2026.466986_bib0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.26656\/fr.2017.6(4).468","article-title":"Current authentication methods of herbs and herbal products: a systematic review","volume":"4","author":"Pauzi","year":"2022","journal-title":"Food. Res."},{"key":"10.1016\/j.chroma.2026.466986_bib0011","series-title":"Evidence-based Validation of Herbal Medicine","first-page":"405","article-title":"Applications of high performance liquid chromatography in the analysis of herbal products","author":"Sarker","year":"2015"},{"key":"10.1016\/j.chroma.2026.466986_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/5533646","article-title":"A fast and validated HPLC method for the simultaneous analysis of five 5-HT3 receptor antagonists via the quantitative analysis of multicomponents by a single marker","volume":"2021","author":"Chen","year":"2021","journal-title":"Int. J. Anal. Chem."},{"key":"10.1016\/j.chroma.2026.466986_bib0014","doi-asserted-by":"crossref","first-page":"11201","DOI":"10.1021\/acsomega.2c08100","article-title":"Isolation, characterization of undescribed alkaloids, and semisynthetic modifications of cytotoxic pyranoacridone alkaloids from Glycosmis pentaphylla","volume":"8","author":"Teja","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.chroma.2026.466986_bib0015","doi-asserted-by":"crossref","first-page":"105962","DOI":"10.1016\/j.fitote.2024.105962","article-title":"Isolation and characterization of bioactive alkaloids and GC\u2013MS based identification of volatile oil metabolites from fruits of Glycosmis pentaphylla and evaluation of their cytotoxic activity","volume":"175","author":"Teja","year":"2024","journal-title":"Fitoterapia"},{"key":"10.1016\/j.chroma.2026.466986_bib0016","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1039\/D4MD00317A","article-title":"Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective","volume":"15","author":"Arora","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.chroma.2026.466986_bib0017","first-page":"53","article-title":"Chemical constituents from Glycosmis pentaphylla stems","volume":"47","author":"Chokchaisiri","year":"2019","journal-title":"KKU Sci. J."},{"key":"10.1016\/j.chroma.2026.466986_bib0018","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fpubh.2020.00176","article-title":"Glycosmis pentaphylla (Rutaceae): a natural candidate for the isolation of potential bioactive arborine and skimmianine compounds for controlling multidrug-resistant Staphylococcus aureus","volume":"8","author":"Murugan","year":"2020","journal-title":"Front. Public Health"},{"key":"10.1016\/j.chroma.2026.466986_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22452\/mjs.vol41no3.1","article-title":"Bioautography, combination effects and photo-activated enzymatic restriction inhibitory activity of antimicrobial alkaloids from Glycosmis pentaphylla (Retz.) DC","volume":"41","author":"Md Taib","year":"2022","journal-title":"Malays. J. Sci."},{"key":"10.1016\/j.chroma.2026.466986_bib0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/pca.927","article-title":"HPLC quantification of alkaloids from Haplophyllum extracts and comparison with their cytotoxic properties","volume":"17","author":"Fiot","year":"2006","journal-title":"Phytochem. Anal"},{"key":"10.1016\/j.chroma.2026.466986_bib0021","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/1570193X20666221026162904","article-title":"Genus acronychia: an extensive review on phytochemistry and pharmacological activities","volume":"20","author":"Son","year":"2023","journal-title":"Mini. Rev. Org. Chem."},{"key":"10.1016\/j.chroma.2026.466986_bib0022","doi-asserted-by":"crossref","first-page":"9061","DOI":"10.1007\/s00210-025-03834-4","article-title":"Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach","volume":"398","author":"Shaala","year":"2025","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol"},{"key":"10.1016\/j.chroma.2026.466986_bib0023","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1186\/s12885-025-14066-3","article-title":"Combining network pharmacology and experimental verification to explore the inhibitory effects of Deoxyelephantopin (DET) against non-small cell lung cancer (NSCLC)","volume":"25","author":"Wu","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.chroma.2026.466986_bib0024","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.chroma.2026.466986_bib0025","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.chroma.2026.466986_bib0026","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/acs.jnatprod.4c00843","article-title":"Semisynthesis of Glycosmis pentaphylla alkaloid derivatives: Pyranoacridone-hydroxamic acid cytotoxic conjugates with HDAC and topoisomerase II\u03b1 dual inhibitory activity","volume":"88","author":"Teja","year":"2025","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.chroma.2026.466986_bib0027","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.chroma.2026.466986_bib0028","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.chroma.2026.466986_bib0029","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.chroma.2007.03.119","article-title":"Chromatographic classification and comparison of commercially available reversed-phase liquid chromatographic columns containing phenyl moieties using principal component analysis","volume":"1154","author":"Euerby","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466986_bib0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0021-9673(93)80808-L","article-title":"Shape selectivity in reversed-phase liquid chromatography for the separation of planar and non-planar solutes","volume":"656","author":"Sander","year":"1993","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466986_bib0031","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1365\/s10337-006-0794-x","article-title":"Insights into the retention mechanism on a pentafluorophenylpropylsiloxane-bonded silica stationary phase (Discovery HS F5) in RP-LC","volume":"63","author":"Kiridena","year":"2006","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.466986_bib0032","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0021-9673(01)01321-8","article-title":"Temperature selectivity in reversed-phase high performance liquid chromatography","volume":"965","author":"Dolan","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.466986_bib0033","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1039\/C5NP00073D","article-title":"Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products","volume":"33","author":"Demarque","year":"2016","journal-title":"Nat. Prod. Rep"},{"key":"10.1016\/j.chroma.2026.466986_bib0034","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.9330","article-title":"Investigation on the binary ionization choices for large conjugated amines during electrospray ionization","volume":"36","author":"Tan","year":"2022","journal-title":"Rapid. Commun. Mass. Spectrom."},{"key":"10.1016\/j.chroma.2026.466986_bib0035","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.3390\/molecules29194715","article-title":"Acridone derivatives for near-UV radical polymerization: one-component type II vs. multicomponent behaviors","volume":"29","author":"Noon","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2026.466986_bib0036","doi-asserted-by":"crossref","first-page":"12377","DOI":"10.1039\/D2TC02270B","article-title":"Acridone and quinacridone derivatives with carbazole or phenoxazine substituents: synthesis, electrochemistry, photophysics and application as TADF electroluminophores","volume":"10","author":"Kulszewicz-Bajer","year":"2022","journal-title":"J. Mater. Chem. C. Mater."},{"key":"10.1016\/j.chroma.2026.466986_bib0037","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijms.2007.01.008","article-title":"Characteristic fragmentation behavior of some novel anti-calmodulin acridone derivatives studied by electrospray ionization tandem mass spectrometry","volume":"263","author":"Prasad","year":"2007","journal-title":"Int. J. Mass. Spectrom."},{"key":"10.1016\/j.chroma.2026.466986_bib0038","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s13361-018-1997-8","article-title":"Experimental and theoretical studies on gas-phase fragmentation reactions of protonated methyl benzoate:\u2009concomitant neutral eliminations of benzene, carbon dioxide, and methanol","volume":"29","author":"Xia","year":"2018","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.466986_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338874","article-title":"A targeted prenylation analysis by a combination of IT-MS and HR-MS: identification of prenyl number, configuration, and position in different subclasses of (iso)flavonoids","volume":"1180","author":"van Dinteren","year":"2021","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/j.chroma.2026.466986_bib0040","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/chromsci\/45.8.458","article-title":"Gas chromatography-mass spectrometry analysis of regioisomeric ring substituted methoxy methyl phenylacetones","volume":"45","author":"Awad","year":"2007","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.chroma.2026.466986_bib0041","first-page":"1","article-title":"Specialized structures and developmental mechanisms of secondary metabolite-synthesizing organs and tissues in medicinal plants","volume":"00","author":"Fu","year":"2026","journal-title":"J. Integr. Plant. Biol."},{"key":"10.1016\/j.chroma.2026.466986_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.stress.2023.100154","article-title":"Role of plant secondary metabolites in defence and transcriptional regulation in response to biotic stress","volume":"8","author":"Anjali","year":"2023","journal-title":"Plant. Stress."},{"key":"10.1016\/j.chroma.2026.466986_bib0043","doi-asserted-by":"crossref","first-page":"172","DOI":"10.33545\/26649926.2024.v6.i1c.428","article-title":"Role of plant secondary metabolites in biotic interactions and defense","volume":"6","author":"Iyer","year":"2024","journal-title":"Int. J. Biol. Sci"},{"key":"10.1016\/j.chroma.2026.466986_bib0044","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/plants14142146","article-title":"Secondary metabolites in plants","volume":"14","author":"Palazon","year":"2025","journal-title":"Plants"},{"key":"10.1016\/j.chroma.2026.466986_bib0045","series-title":"Biodiversity and Chemotaxonomy","first-page":"121","article-title":"Chemotaxonomic significance of alkaloids in plants","author":"Singh","year":"2019"},{"key":"10.1016\/j.chroma.2026.466986_bib0046","first-page":"13","article-title":"A comprehensive review of the Rutaceae family: taxonomy, phytochemistry, pharmacology, and applied aspects","volume":"5","author":"Kiran","year":"2025","journal-title":"J. Med. Plants. Stud."},{"key":"10.1016\/j.chroma.2026.466986_bib0047","doi-asserted-by":"crossref","unstructured":"N. Zaman, M. Rizwan, A. Iqbal, A. Rauf, Y.S. Al-Awthan, O. Bahattab, Phytochemistry and medicinal uses of the family Rutaceae, in: Phytochemical and Pharmacological Investigation of the Family Rutaceae, Apple Academic Press, New York, 2024: pp. 51\u201369. https:\/\/doi.org\/10.1201\/9781003401469-4.","DOI":"10.1201\/9781003401469-4"},{"key":"10.1016\/j.chroma.2026.466986_bib0048","first-page":"622","article-title":"Alkaloids of the Australian Rutaceae: Acronychia baueri . II. some reactions of the alkaloid acronycine","volume":"2","author":"Brown","year":"1949","journal-title":"Austrl. J. Sci. Res. A."},{"key":"10.1016\/j.chroma.2026.466986_bib0049","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.3390\/plants14142234","article-title":"Chemotaxonomy, an efficient tool for medicinal plant identification: current trends and limitations","volume":"14","author":"Amin","year":"2025","journal-title":"Plants"},{"key":"10.1016\/j.chroma.2026.466986_bib0050","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10265-024-01566-9","article-title":"Chemotaxonomy compared to morphological and anatomical taxonomy of five Hibiscus species","volume":"137","author":"Abdelfattah","year":"2024","journal-title":"J. Plant Res."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732600316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002196732600316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:03:41Z","timestamp":1777550621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002196732600316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":49,"alternative-id":["S002196732600316X"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466986","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPLC\u2013PDA and LC\u2013HRMS\/MS-based quantitative and qualitative analysis of Glycosmis pentaphylla alkaloids, and investigation of their anticancer potential through network pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.466986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"466986"}}