{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:03:53Z","timestamp":1779930233521,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chroma.2026.467029","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:55:53Z","timestamp":1776873353000},"page":"467029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Establishment of an integrated profiling-fingerprinting-chemometrics strategy for quality control and mechanistic investigation of Fuhuo Capsule"],"prefix":"10.1016","volume":"1781","author":[{"given":"Shuang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.chroma.2026.467029_bib0001","first-page":"2657","article-title":"Pharmacodynamic study of Fuxing Pill","volume":"31","author":"Yang","year":"2009","journal-title":"Hebei Med. J."},{"issue":"3","key":"10.1016\/j.chroma.2026.467029_bib0002","first-page":"344","article-title":"Research on the preparation technology of Resurrection Capsules","volume":"31","author":"Yang","year":"2009","journal-title":"Hebei Med. J."},{"key":"10.1016\/j.chroma.2026.467029_bib0003","article-title":"Research on the preparation process and quality standards of Revival Capsules","author":"Chang","year":"2007","journal-title":"Hebei Med. Univ."},{"key":"10.1016\/j.chroma.2026.467029_bib0004","first-page":"A8","article-title":"Development of Fuhuo Capsule and clinical observation in 421 cases","volume":"27","author":"Xuan","year":"2005","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.chroma.2026.467029_bib0005","first-page":"306","article-title":"Preparation and clinical observation of Fuhuo Capsule for osteonecrosis of the femoral head","volume":"27","author":"Yang","year":"2005","journal-title":"Hebei Med. J."},{"issue":"1","key":"10.1016\/j.chroma.2026.467029_bib0006","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jssc.201900365","article-title":"Quality evaluation of traditional Chinese medicines based on fingerprinting","volume":"43","author":"Liu","year":"2020","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467029_bib0007","doi-asserted-by":"crossref","first-page":"1265178","DOI":"10.3389\/fphar.2023.1265178","article-title":"Advancing herbal medicine: enhancing product quality and safety through robust quality control practices","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.chroma.2026.467029_bib0008","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/ph17091113","article-title":"Botany, traditional use, phytochemistry, pharmacology and quality control of Taraxaci Herba: comprehensive review","volume":"17","author":"Wu","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.chroma.2026.467029_bib0009","doi-asserted-by":"crossref","first-page":"1475297","DOI":"10.3389\/fphar.2025.1475297","article-title":"Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives","volume":"16","author":"Dubale","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.chroma.2026.467029_bib0010","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/molecules30081825","article-title":"Multi-component characterization and quality evaluation strategy of Sarcandrae herba by combining dual-column tandem HPLC fingerprint and UPLC-Q-TOF-MS\/MS","volume":"30","author":"Zhong","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.chroma.2026.467029_bib0011","doi-asserted-by":"crossref","first-page":"466510","DOI":"10.1016\/j.chroma.2025.466510","article-title":"Comprehensive evaluation of quality consistency of Kangshou Pills using digital fingerprinting, dissolution behavior and antioxidant spectrum-effect relationship","volume":"1764","author":"Li","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467029_bib0012","doi-asserted-by":"crossref","first-page":"115546","DOI":"10.1016\/j.jpba.2023.115546","article-title":"Chemometrics and antioxidant activity assisted nontargeted metabolomics for the identification of ginger species","volume":"234","author":"Tang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.chroma.2026.467029_bib0013","first-page":"178","article-title":"Research progress on the relationship between hepatitis B virus and liver lipid metabolism","volume":"36","author":"Shan","year":"2023","journal-title":"Infect. Dis. Inf."},{"issue":"21","key":"10.1016\/j.chroma.2026.467029_bib0014","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1007\/s00216-024-05453-z","article-title":"In situ metabolomic analysis of osteonecrosis of the femoral head (ONFH) using MALDI MSI","volume":"416","author":"Li","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"10.1016\/j.chroma.2026.467029_bib0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/biom14060667","article-title":"Advances in the pathogenesis of steroid-associated osteonecrosis of the femoral head","volume":"14","author":"Zhang","year":"2024","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.chroma.2026.467029_bib0016","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.3390\/molecules27103196","article-title":"Comparative analysis of volatile constituents in root tuber and rhizome of Curcuma longa L. using fingerprints and chemometrics approaches on gas chromatography\u2013mass spectrometry","volume":"27","author":"Tang","year":"2022","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.chroma.2026.467029_bib0017","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1080\/14786419.2011.637217","article-title":"Study on the phenolic constituents of the flowers and leaves of Trifolium repens L","volume":"26","author":"Kicel","year":"2012","journal-title":"Nat. Prod. Res."},{"issue":"12","key":"10.1016\/j.chroma.2026.467029_bib0018","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3390\/antiox12122037","article-title":"The antioxidant and anti-inflammatory properties of Merremia umbellata extract","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.chroma.2026.467029_bib0019","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/bmc.3413","article-title":"In vitro and in vivo identification of metabolites of magnoflorine by LC LTQ-Orbitrap MS and its potential pharmacokinetic interaction in Coptidis Rhizoma decoction in rat","volume":"29","author":"Xue","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.chroma.2026.467029_bib0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jchromb.2016.03.027","article-title":"Metabolic profile of esculin in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry","volume":"1020","author":"Wang","year":"2016","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"10.1016\/j.chroma.2026.467029_bib0021","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jfda.2018.01.011","article-title":"Quantitative and qualitative analyses of cytotoxic triterpenoids in the rhizomes of Anemone raddeana using HPLC and HPLC-ESI-Q\/TOF-MS","volume":"26","author":"Zhao","year":"2018","journal-title":"J. Food Drug Anal."},{"issue":"1","key":"10.1016\/j.chroma.2026.467029_bib0022","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13020-023-00836-3","article-title":"Quality evaluation methods of Chinese medicine based on scientific supervision: recent research progress and prospects","volume":"18","author":"Chen","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.chroma.2026.467029_bib0023","article-title":"Study on the preparation and quality standards of Fuhuo capsules","author":"Chang","year":"2007","journal-title":"Hebei Med. Univ."},{"issue":"2","key":"10.1016\/j.chroma.2026.467029_bib0024","doi-asserted-by":"crossref","first-page":"bbad518","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief. Bioinform."},{"issue":"4","key":"10.1016\/j.chroma.2026.467029_bib0025","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00198-019-04835-9","article-title":"Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han population","volume":"30","author":"Yu","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.chroma.2026.467029_bib0026","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.4110\/in.2022.22.e25","article-title":"IL-34 aggravates steroid-induced osteonecrosis of the femoral head via promoting osteoclast differentiation","volume":"22","author":"Wang","year":"2022","journal-title":"Immune Netw."},{"issue":"6","key":"10.1016\/j.chroma.2026.467029_bib0027","first-page":"3559","article-title":"Duhuo Jisheng decoction inhibits the activity of osteoclasts in osteonecrosis of the femoral head via regulation of the RELA\/AKT1 axis","volume":"14","author":"Xing","year":"2022","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.chroma.2026.467029_bib0028","doi-asserted-by":"crossref","first-page":"21634","DOI":"10.1038\/s41598-024-72941-8","article-title":"Identification and validation of endoplasmic reticulum stress-related genes in patients with steroid-induced osteonecrosis of the femoral head","volume":"14","author":"Wu","year":"2024","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.chroma.2026.467029_bib0029","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1021\/acs.jafc.4c09284","article-title":"Astaxanthin prevents glucocorticoid-induced femoral head osteonecrosis by targeting ferroptosis through the JAK2\/STAT3 signaling pathway","volume":"73","author":"Lin","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.chroma.2026.467029_bib0030","first-page":"195","article-title":"Regulation of JAK2\/STAT3 signaling pathway by polydatin in the treatment of hormone-induced femoral head necrosis in rats","volume":"38","author":"Yang","year":"2025","journal-title":"China J. Orthop. Traumatol."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326003596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326003596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:13:18Z","timestamp":1779927198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326003596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S0021967326003596"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467029","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of an integrated profiling-fingerprinting-chemometrics strategy for quality control and mechanistic investigation of Fuhuo Capsule","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467029"}}