{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:18:28Z","timestamp":1783106308721,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science & Technology Development","doi-asserted-by":"publisher","award":["104.04\\u20132021.38"],"award-info":[{"award-number":["104.04\\u20132021.38"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chroma.2026.467064","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:41:40Z","timestamp":1777732900000},"page":"467064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Analysis of weight-loss compounds in health supplements by ultrasonic extraction, dispersive sorbent cleanup, and liquid chromatography tandem mass spectrometry quantification"],"prefix":"10.1016","volume":"1780","author":[{"given":"Khanh Hung","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Quoc","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Trang","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Phuong","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-3199","authenticated-orcid":false,"given":"Viet Ngan","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Hung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong Khanh","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viet Chien","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Oanh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Huy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Anh Huong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Hong Hao","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467064_bib0001","doi-asserted-by":"crossref","DOI":"10.1124\/pharmrev.123.001045","article-title":"Emerging pharmacotherapies for obesity: a systematic review","volume":"77","author":"Kokkorakis","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.chroma.2026.467064_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101882","article-title":"Pharmacotherapy of obesity: an update on the available medications and drugs under investigation","volume":"58","author":"Chakhtoura","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.chroma.2026.467064_bib0003","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3810\/pgm.2011.01.2243","article-title":"The Pharmacological Treatment and Management of Obesity","volume":"123","author":"Hussain","year":"2011","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.chroma.2026.467064_bib0004","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.2174\/0929867326666190215114359","article-title":"Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: a Review","volume":"27","author":"Qiu","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.chroma.2026.467064_bib0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-022-01149-x","article-title":"Signaling pathways in obesity: mechanisms and therapeutic interventions","volume":"7","author":"Wen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.chroma.2026.467064_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.crbiot.2024.100259","article-title":"A review: anti-obesity drug discovery from natural plant metabolites and endogenous peptides","volume":"8","author":"Zhu","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"10.1016\/j.chroma.2026.467064_bib0007","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2174\/156802609788897862","article-title":"Anti-obesity Agents: a Focused Review on the Structural Classification of Therapeutic Entities","volume":"9","author":"Oh","year":"2009","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.chroma.2026.467064_bib0008","first-page":"E160","article-title":"Dietary supplements for obesity","volume":"63","author":"Bonetti","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"10.1016\/j.chroma.2026.467064_bib0009","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s13679-016-0214-y","article-title":"New Dietary Supplements for Obesity: what We Currently Know","volume":"5","author":"R\u00edos-Hoyo","year":"2016","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.chroma.2026.467064_bib0010","first-page":"1","article-title":"Sibutramine as a Cause of Sudden Cardiac Death","volume":"2021","author":"Rodriguez-Guerra","year":"2021","journal-title":"Case Rep. Cardiol."},{"key":"10.1016\/j.chroma.2026.467064_bib0011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(75)80086-2","article-title":"Fenfluramine poisoning","volume":"87","author":"Veltri","year":"1975","journal-title":"J. Pediatr."},{"key":"10.1016\/j.chroma.2026.467064_bib0012","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/bmj.289.6445.591","article-title":"Fatal overdosage of phenylpropanolamine","volume":"289","author":"Logie","year":"1984","journal-title":"BMJ"},{"key":"10.1016\/j.chroma.2026.467064_bib0013","first-page":"909","article-title":"Validation of an Analytical Method for Determination of Sibutramine Hydrochloride Monohydrate in Capsules by Uv-Vis Spectrophotometry","volume":"26","author":"Maluf","year":"2007","journal-title":"Lat. Am. J. Pharm."},{"key":"10.1016\/j.chroma.2026.467064_bib0014","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/elan.201800888","article-title":"Simple and Sensitive Determination of Sibutramine in Slimming Tea Beverages Using a Carbon Screen-printed Electrode with Adsorptive Stripping Voltammetry","volume":"31","author":"Lima","year":"2019","journal-title":"Electroanalysis"},{"key":"10.1016\/j.chroma.2026.467064_bib0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/dta.1524","article-title":"Simultaneous determination of pharmaceutical components in dietary supplements for weight loss by capillary electrophoresis tandem mass spectrometry","volume":"6","author":"Akamatsu","year":"2014","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.chroma.2026.467064_bib0016","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1039\/C5AY02973B","article-title":"Detection of sibutramine and phenolphthalein in functional foods using capillary electrophoresis","volume":"8","author":"Wang","year":"2016","journal-title":"Analytical Methods"},{"key":"10.1016\/j.chroma.2026.467064_bib0017","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10337-018-3502-8","article-title":"HPLC\u2013UV Chromatographic Methods for Detection and Quantification of Undeclared Withdrawn Synthetic Medications in Counterfeit Herbal Medicines with Confirmation by HPLC\u2013PDA and Mass Spectrometry","volume":"81","author":"Hemdan","year":"2018","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467064_bib0018","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jpba.2013.08.031","article-title":"Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry","volume":"88","author":"Song","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.467064_bib0019","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12272-015-0665-9","article-title":"Development and validation of UPLC and LC-MS\/MS methods for the simultaneous determination of anti-obesity drugs in foods and dietary supplements","volume":"39","author":"Kim","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.chroma.2026.467064_bib0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/02652030802641880","article-title":"Determination of synthetic drugs used to adulterate botanical dietary supplements using QTRAP LC-MS\/MS","volume":"26","author":"Chen","year":"2009","journal-title":"Food Additives and Contaminants - Part A"},{"key":"10.1016\/j.chroma.2026.467064_bib0021","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/jssc.202101030","article-title":"Application of liquid chromatography-high resolution mass spectrometry and liquid chromatography-tandem mass spectrometry methods to 45 weight loss compounds in health functional food, food, and illegal drug","volume":"45","author":"Lee","year":"2022","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467064_bib0022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/dta.1846","article-title":"Analysis of 40 weight loss compounds adulterated in health supplements by liquid chromatography quadrupole linear ion trap mass spectrometry","volume":"8","author":"Zeng","year":"2016","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.chroma.2026.467064_bib0023","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/s25030762","article-title":"PULSE: a Fast Portable Unit for Lab-on-Site Electrochemistry","volume":"25","author":"Ferreira","year":"2025","journal-title":"Sensors"},{"key":"10.1016\/j.chroma.2026.467064_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.115037","article-title":"Capillary electrophoresis with contactless conductivity detection as an affordable and versatile tool for screening illegal synthetic compounds in herbal-based products and nutrition supplements","volume":"217","author":"Nguyen","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2026.467064_bib0025","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.microc.2015.12.010","article-title":"On-site determination of Pb2+ and Cd2+ in seawater by double stripping voltammetry with bismuth-modified working electrodes","volume":"126","author":"Zhang","year":"2016","journal-title":"Microchem. J."},{"key":"10.1016\/j.chroma.2026.467064_bib0026","doi-asserted-by":"crossref","DOI":"10.1088\/0957-0233\/24\/4\/042001","article-title":"Review on the development of truly portable and in-situ capillary electrophoresis systems","volume":"24","author":"Lewis","year":"2013","journal-title":"Meas. Sci. Technol."},{"key":"10.1016\/j.chroma.2026.467064_bib0027","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/bmc.1248","article-title":"Simultaneous determination of anti-diabetes\/anti-obesity drugs by LC\/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC\/MS\/MS","volume":"23","author":"Kim","year":"2009","journal-title":"Biomed. Chromatograp."},{"key":"10.1016\/j.chroma.2026.467064_bib0028","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/19440049.2014.888497","article-title":"Monitoring of 29 weight loss compounds in foods and dietary supplements by LC-MS\/MS","volume":"31","author":"Kim","year":"2014","journal-title":"Food Addit. Contaminants - Part A"},{"key":"10.1016\/j.chroma.2026.467064_bib0031","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/02652030801946553","article-title":"Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS","volume":"25","author":"Wang","year":"2008","journal-title":"Food Additives & Contaminants: Part A"},{"key":"10.1016\/j.chroma.2026.467064_bib0032","first-page":"15","article-title":"Method Validation for the Analysis of Multiple Weight Loss Drugs in Dietary Supplement Materials by LC-MS\/MS","volume":"02","author":"Tran","year":"2015","journal-title":"J. Regulat. Sci."},{"key":"10.1016\/j.chroma.2026.467064_bib0033","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1080\/10826076.2017.1343730","article-title":"Simultaneous determination of eight adulterants in weight management supplements and herbs by HPLC\u2013DAD and LC\u2013MS\/MS","volume":"40","author":"Zhong","year":"2017","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2026.467064_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462102","article-title":"A multi-analytical strategy for evaluation of quality and authenticity of artichoke food supplements for overweight control","volume":"1647","author":"Mena-Garc\u00eda","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467064_bib0035","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.3390\/nu16244369","article-title":"Label accuracy and quality of select weight-loss dietary supplements sold on or near US military bases","volume":"16","author":"Crawford","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.chroma.2026.467064_bib0036","first-page":"58","article-title":"Simultaneous Determination of 80 Unapproved Compounds using HPLC and LC-MS\/MS in Dietary Supplements","volume":"13","author":"Kwon","year":"2022","journal-title":"Mass Spectro. Lett."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326003936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326003936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:45:48Z","timestamp":1783104348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326003936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"alternative-id":["S0021967326003936"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467064","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of weight-loss compounds in health supplements by ultrasonic extraction, dispersive sorbent cleanup, and liquid chromatography tandem mass spectrometry quantification","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467064"}}