{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:50:43Z","timestamp":1782157843692,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chroma.2026.467071","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:52:27Z","timestamp":1778136747000},"page":"467071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Uncertainty-driven model-based search methods for method development in liquid chromatography"],"prefix":"10.1016","volume":"1781","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-9228","authenticated-orcid":false,"given":"Leon E.","family":"Niezen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5801","authenticated-orcid":false,"given":"Deirdre","family":"Cabooter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-7184","authenticated-orcid":false,"given":"Gert","family":"Desmet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467071_bib0001","doi-asserted-by":"crossref","DOI":"10.1021\/ac9001244","article-title":"Effect of pressure, particle size, and time on optimizing performance in liquid chromatography","volume":"81","author":"Carr","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0002","series-title":"Introduction to Modern Liquid Chromatography","author":"Snyder","year":"2010"},{"key":"10.1016\/j.chroma.2026.467071_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2013.08.045","article-title":"Influence of pressure and temperature on molar volume and retention properties of peptides in ultra-high pressure liquid chromatography","volume":"1311","author":"Fekete","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9673(99)00767-0","article-title":"Reversed-phase liquid chromatographic separation of complex samples by optimizing temperature and gradient timeII. Two-run assay procedures","volume":"857","author":"Dolan","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2008.04.019","article-title":"Combined effect of solvent content, temperature and pH on the chromatographic behaviour of ionisable compounds. II: benefits of the simultaneous optimisation","volume":"1193","author":"Pous-Torres","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0006","doi-asserted-by":"crossref","first-page":"13699","DOI":"10.1021\/acs.analchem.4c02700","article-title":"Assisted active learning for model-based method development in liquid chromatography","volume":"96","author":"Bosten","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0007","article-title":"Gradient elution in liquid chromatography. I. The influence of the composition of the mobile phase on the capacity ratio (retention volume, band width, and resolution) in isocratic elution - theoretical considerations","volume":"91","author":"Jandera","year":"1974","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0008","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0021-9673(01)97902-6","article-title":"Gradient elution in liquid chromatography. II. Retention characteristics (retention volume, band width, resolution, plate number) in solvent-programmed chromatography - theoretical considerations","volume":"91","author":"Jandera","year":"1974","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0009","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chroma.2014.08.014","article-title":"A universal comparison study of chromatographic response functions","volume":"1361","author":"Tyteca","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465626","article-title":"Comparison of optimization algorithms for automated method development of gradient profiles","volume":"1742","author":"van Henten","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465008","article-title":"A new chromatographic response function with automatically adapting weight factor for automated method development","volume":"1727","author":"Niezen","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0012","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chroma.2011.12.082","article-title":"A new chromatographic response function for assessing the separation quality in comprehensive two-dimensional liquid chromatography","volume":"1225","author":"Duarte","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0013","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1021\/ac101420f","article-title":"Comprehensive study on the optimization of online two-dimensional liquid chromatographic systems considering losses in theoretical peak capacity in first- and second-dimensions: a pareto-optimality approach","volume":"82","author":"Viv\u00f3-Truyols","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0014","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jssc.201700863","article-title":"Optimizing separations in online comprehensive two-dimensional liquid chromatography","volume":"41","author":"Pirok","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467071_bib0015","doi-asserted-by":"crossref","DOI":"10.1007\/BF02688488","article-title":"Computer simulation as a means of developing an optimized reversed-phase gradient-elution separation","volume":"24","author":"Dolan","year":"1987","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467071_bib0016","doi-asserted-by":"crossref","first-page":"16060","DOI":"10.1021\/acs.analchem.2c03160","article-title":"Chemometric strategies for fully automated interpretive method development in liquid chromatography","volume":"94","author":"Bos","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461435","article-title":"Application of evolutionary algorithms to optimise one- and two-dimensional gradient chromatographic separations","volume":"1628","author":"Huygens","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2006.01.005","article-title":"Multilinear gradient elution optimisation in reversed-phase liquid chromatography using genetic algorithms","volume":"1120","author":"Nikitas","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2014.12.085","article-title":"Computer-assisted multi-segment gradient optimization in ion chromatography","volume":"1381","author":"Tyteca","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464768","article-title":"Deep reinforcement learning for the direct optimization of gradient separations in liquid chromatography","volume":"1720","author":"Kensert","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0021","article-title":"Reinforcement learning for automated method development in liquid chromatography: insights in the reward strategy and experimental budget selection","author":"Niezen","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.340789","article-title":"Closed-loop automatic gradient design for liquid chromatography using bayesian optimization","volume":"1242","author":"Boelrijk","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467071_bib0023","article-title":"Operator-free HPLC automated method development guided by bayesian optimization","volume":"3","author":"Dixon","year":"2024","journal-title":"Digit. Discov."},{"key":"10.1016\/j.chroma.2026.467071_bib0024","series-title":"High-Performance Gradient Elution: The Practical Application of the Linear-Solvent-Strength Model","author":"Snyder","year":"2006"},{"key":"10.1016\/j.chroma.2026.467071_bib0025","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jssc.202000905","article-title":"Recent applications of retention modelling in liquid chromatography","volume":"44","author":"den Uijl","year":"2021","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467071_bib0026","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.chroma.2008.09.051","article-title":"Retention models for isocratic and gradient elution in reversed-phase liquid chromatography","volume":"1216","author":"Nikitas","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chroma.2019.03.057","article-title":"Migration and elution equations in gradient liquid chromatography","volume":"1599","author":"Blumberg","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0028","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10337-013-2555-y","article-title":"Theory of gradient elution liquid chromatography with linear solvent strength: part 1. migration and elution parameters of a solute band","volume":"77","author":"Blumberg","year":"2014","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467071_bib0029","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0021-9673(00)81008-0","article-title":"Gradient selection in reversed-phase liquid chromatography","volume":"149","author":"Schoenmakers","year":"1978","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0030","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1016\/j.chroma.2010.04.023","article-title":"Improved reversed-phase gradient retention modeling","volume":"1217","author":"Neue","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0031","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chroma.2006.01.104","article-title":"Peak compression in reversed-phase gradient elution","volume":"1111","author":"Neue","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0032","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chroma.2003.08.043","article-title":"Enhanced calculation of optimal gradient programs in reversed-phase liquid chromatography","volume":"1018","author":"Viv\u00f3-Truyols","year":"2003","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0033","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-9673(00)81641-6","article-title":"Peak width in solvent-programmed chromatography. I. General description of peak broadening in solvent-programmed elution","volume":"204","author":"Poppe","year":"1981","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464019","article-title":"Peak width in liquid chromatography with exponential retention and linear program preceded by isocratic hold","volume":"1699","author":"Blumberg","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9673(01)89133-0","article-title":"Drylab\u00ae computer simulation for high-performance liquid chromatographic method development. I. Isocratic elution","volume":"485","author":"Snyder","year":"1989","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9673(01)89134-2","article-title":"Drylab\u00ae computer simulation for high-performance liquid chromatographic method development. II. Gradient elution","volume":"485","author":"Dolan","year":"1989","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2011.05.028","article-title":"A systematic approach to development of liquid chromatographic impurity methods for pharmaceutical analysis","volume":"56","author":"Stafford","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.467071_bib0038","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.chroma.2005.12.042","article-title":"Implementation of a rapid and automated high performance liquid chromatography method development strategy for pharmaceutical drug candidates","volume":"1107","author":"Hewitt","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0039","doi-asserted-by":"crossref","DOI":"10.1021\/acs.analchem.2c02034","article-title":"Toward the general mechanistic model of liquid chromatographic retention","volume":"94","author":"Kamedulska","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0040","doi-asserted-by":"crossref","DOI":"10.1021\/acs.analchem.3c04697","article-title":"Comparison of chromatographic stationary phases using a Bayesian-based multilevel model","volume":"96","author":"Wiczling","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0041","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0021-9673(01)89129-9","article-title":"Simplex optimization of high-performance liquid chromatographic separations","volume":"485","author":"Berridge","year":"1989","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(00)80117-X","article-title":"Unattended optimisation of reversed-phase high-performance liquid chromatographic separations using the modified simplex algorithm","volume":"244","author":"Berridge","year":"1982","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0043","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/bioinformatics\/btu740","article-title":"MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS\/MS analysis","volume":"31","author":"Bradbury","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chroma.2026.467071_bib0044","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0169-7439(01)00148-4","article-title":"A hybrid genetic algorithm with local search: I. Discrete variables: optimisation of complementary mobile phases","volume":"59","author":"Viv\u00f3-Truyols","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.chroma.2026.467071_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464570","article-title":"A perspective on the use of deep deterministic policy gradient reinforcement learning for retention time modeling in reversed-phase liquid chromatography","volume":"1713","author":"Kensert","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461180","article-title":"Testing experimental designs in liquid chromatography (I): development and validation of a method for the comprehensive inspection of experimental designs","volume":"1624","author":"Navarro-Huerta","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462458","article-title":"Testing experimental designs in liquid chromatography (II): influence of the design geometry on the prediction performance of retention models","volume":"1654","author":"Gisbert-Alonso","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2007.11.045","article-title":"Optimal experimental design in chromatography","volume":"1177","author":"Atkinson","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0049","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1021\/ac301331g","article-title":"Predictive elution window stretching and shifting as a generic search strategy for automated method development for liquid chromatography","volume":"84","author":"Tyteca","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467071_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/sscp.201700037","article-title":"Evaluation of sequential Bayesian-based method development procedures for chromatographic problems involving one, two, and three analytes","volume":"1","author":"Wiczling","year":"2018","journal-title":"Sep. Sci. Plus"},{"key":"10.1016\/j.chroma.2026.467071_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.461900","article-title":"Deep Q-learning for the selection of optimal isocratic scouting runs in liquid chromatography","volume":"1638","author":"Kensert","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0052","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1042\/bj0351358","article-title":"A new form of chromatogram employing two liquid phases. 1. A theory of chromatography 2. Application to the micro-determination of the higher monoamino-acids in proteins","volume":"35","author":"Martin","year":"1941","journal-title":"Biochem. J."},{"key":"10.1016\/j.chroma.2026.467071_bib0053","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.chroma.2014.06.010","article-title":"Gradient-elution parameters in capillary liquid chromatography for high-speed separations of peptides and intact proteins","volume":"1355","author":"Vaast","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467071_bib0054","doi-asserted-by":"crossref","DOI":"10.1007\/s10337-021-04112-0","article-title":"Peak fraction purity and chromatographic resolution: gaussian peaks revisited","volume":"85","author":"Striegel","year":"2022","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467071_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0003-2670(99)00368-2","article-title":"Evaluation of several global resolution functions for liquid chromatography","volume":"396","author":"Carda-Broch","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467071_bib0056","series-title":"Analytical Separation Science","author":"Pirok","year":"2025"},{"key":"10.1016\/j.chroma.2026.467071_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2015.05.031","article-title":"On the inherent data fitting problems encountered in modelingretention behavior of analytes with dual retention mechanism","volume":"1403","author":"Tyteca","year":"2015","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326004000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326004000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:14:23Z","timestamp":1779927263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326004000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":57,"alternative-id":["S0021967326004000"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467071","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncertainty-driven model-based search methods for method development in liquid chromatography","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467071"}}