{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:17:31Z","timestamp":1783109851644,"version":"3.54.6"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP22K05160"],"award-info":[{"award-number":["JP22K05160"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.chroma.2026.467092","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:40:14Z","timestamp":1778712014000},"page":"467092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Correlation between chromatographic behavior and microfluidic phase distribution in the phase-separation mode of HPLC"],"prefix":"10.1016","volume":"1781","author":[{"given":"Hiyori","family":"Sakata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuto","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iharada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsukagoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467092_bib0001","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1039\/D4RA08232J","article-title":"Aqueous two-phase system (ATPS): from basic science to applications","volume":"15","author":"Zhang","year":"2025","journal-title":"RSC Adv"},{"key":"10.1016\/j.chroma.2026.467092_bib0002","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s43246-022-00249-z","article-title":"Ferrofluidic aqueous two-phase system with ultralow interfacial tension and micro-pattern formation","volume":"3","author":"Rigoni","year":"2022","journal-title":"Commun. Mater."},{"key":"10.1016\/j.chroma.2026.467092_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133856","article-title":"Review of recent applications and modifications of aqueous two-phase system for the separation of biomolecules","volume":"276","author":"Segaran","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.chroma.2026.467092_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117652","article-title":"Aqueous two-phase systems for the extraction, separation, and recovery of synthetic dyes","volume":"173","author":"Fideles","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467092_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/pr11010031","article-title":"Aqueous two-phase systems based on ionic liquids and deep eutectic solvents as a tool for the recovery of non-protein bioactive compounds: a review","volume":"11","author":"Buarque","year":"2023","journal-title":"Processes"},{"key":"10.1016\/j.chroma.2026.467092_bib0006","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2116\/analsci.27.793","article-title":"Tube radial distribution phenomenon of ternary mixed solvents in a microspace under laminar flow conditions","volume":"27","author":"Murakami","year":"2011","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0007","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1039\/C0AN00820F","article-title":"Fluorescence observation supporting capillary chromatography based on tube radial distribution of carrier solvents under laminar flow conditions","volume":"136","author":"Jinno","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.chroma.2026.467092_bib0008","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.talanta.2018.02.046","article-title":"Tube radial distribution chromatography system developed by combining commercially available HPLC system and open-tubular capillary as separation column","volume":"183","author":"Yamada","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467092_bib0009","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2116\/analsci.19A001","article-title":"Phase separation and collection of annular flow by phase transformation","volume":"35","author":"Yoshioka","year":"2019","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1017\/S0956792500004289","article-title":"Self-similar flows of multi-phase immiscible fluids","volume":"11","author":"Oztekin","year":"2000","journal-title":"Eur. J. Appl. Math."},{"key":"10.1016\/j.chroma.2026.467092_bib0011","doi-asserted-by":"crossref","DOI":"10.1115\/1.4050958","article-title":"Experimental visualization and analysis of multiphase immiscible flow in fractured micromodels using micro-particle image velocimetry","volume":"144","author":"Haque","year":"2022","journal-title":"J. Energy Resour. Technol."},{"key":"10.1016\/j.chroma.2026.467092_bib0012","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00231-018-2494-0","article-title":"Liquid\u2013liquid two-phase flow patterns in ultra-shallow straight and serpentine microchannels","volume":"55","author":"Wu","year":"2019","journal-title":"Heat Mass Transfer."},{"key":"10.1016\/j.chroma.2026.467092_bib0013","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/cjce.20108","article-title":"Oil\u2013water two-phase flow in microchannels: flow patterns and pressure drop measurements","volume":"86","author":"Salim","year":"2008","journal-title":"Can. J. Chem. Eng."},{"key":"10.1016\/j.chroma.2026.467092_bib0014","first-page":"302","article-title":"Flow characteristics of oil\u2013water mixtures in horizontal mini-channel","volume":"26","author":"Ami","year":"2012","journal-title":"Jpn. J. Multiph. Flow"},{"key":"10.1016\/j.chroma.2026.467092_bib0015","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.ijmultiphaseflow.2011.06.004","article-title":"Viscous oil\u2013water flows in a microchannel initially saturated with oil: flow patterns and pressure drop characteristics","volume":"37","author":"Foroughi","year":"2011","journal-title":"Int. J. Multiph. Flow"},{"key":"10.1016\/j.chroma.2026.467092_bib0016","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1039\/c2ay05813h","article-title":"Separation of dansyl-DL-amino acids by open-tubular capillary chromatography based on tube radial distribution phenomenon of the ternary mixed carrier solvents","volume":"4","author":"Kudo","year":"2012","journal-title":"Anal. Methods"},{"key":"10.1016\/j.chroma.2026.467092_bib0017","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/10826076.2013.873869","article-title":"Open-tubular capillary chromatography based on tube radial distribution of water\u2013acetonitrile containing sodium chloride mixture carrier solvents","volume":"38","author":"Kobayashi","year":"2015","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2026.467092_bib0018","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.talanta.2017.03.075","article-title":"Protein separation through preliminary experiments concerning pH and salt concentration by tube radial distribution chromatography based on phase separation multiphase flow using a polytetrafluoroethylene capillary tube","volume":"169","author":"Kan","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467092_bib0019","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2116\/analsci.18P105","article-title":"Phase separation multi-phase flow using an aqueous two-phase system of polyethylene glycol\/dextran mixed solution","volume":"34","author":"Imanishi","year":"2018","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0020","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2116\/analsci.28.423","article-title":"Mixing process of ternary solvents prepared through microchannels in a microchip under laminar flow conditions","volume":"28","author":"Nishiyama","year":"2012","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0021","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2116\/analsci.28.439","article-title":"The micro-flow reaction system featured the liquid\u2013liquid interface created with ternary mixed carrier solvents in a capillary tube","volume":"28","author":"Masuhara","year":"2012","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0022","first-page":"89","article-title":"Investigation of specific microfluidic flow with two-phase separation mixed solvent solutions and application to flow technology","volume":"32","author":"Tsukagoshi","year":"2015","journal-title":"J. Flow Inject. Anal."},{"key":"10.1016\/j.chroma.2026.467092_bib0023","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2116\/analsci.30.65","article-title":"Fundamental research and application of the specific fluidic behavior of mixed solvents in a microspace","volume":"30","author":"Tsukagoshi","year":"2014","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0024","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2116\/bunsekikagaku.71.25","article-title":"Discovery of phase-separated multiphase flows and attempts at academic and technical systematization","volume":"71","author":"Tsukagoshi","year":"2022","journal-title":"Bunseki Kagaku."},{"key":"10.1016\/j.chroma.2026.467092_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s44211-023-00442-1","article-title":"Phase-separation multiphase flow: preliminary application to analytical chemistry","volume":"40","author":"Tsukagoshi","year":"2024","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0026","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s44211-023-00290-z","article-title":"Development of HPLC system that uses phase-separation multiphase flow as an eluent","volume":"39","author":"Jallas","year":"2023","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0027","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s44211-023-00363-z","article-title":"Development of a HPLC system using a phase-separation multiphase flow as an eluent coupled to a silica-particle packed column","volume":"39","author":"Kinoshita","year":"2023","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0028","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s44211-024-00599-3","article-title":"Development of an HPLC device with water\/acetonitrile with NaCl mixed solution that induces a phase-separation multiphase flow as the eluent in the separation column","volume":"40","author":"Hirose","year":"2024","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0029","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/10826076.2025.2486457","article-title":"Application of a phase-separation multiphase flow as an eluent to a HPLC system using a core-shell silica-particle packed column","volume":"48","author":"Kimura","year":"2025","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2026.467092_bib0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10337-025-04392-w","article-title":"Effects of porous structure of separation columns on chromatograms obtained by phase-separation mode in HPLC","volume":"88","author":"Katayama","year":"2025","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467092_bib0031","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s44211-024-00636-1","article-title":"Development of a HPLC system using a phase-separation multiphase flow as an eluent: an influence of column pressure on phase separation and chromatogram at room temperature","volume":"40","author":"Takagi","year":"2024","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0032","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10337-025-04449-w","article-title":"Development and evaluation of a phase-separation mode in HPLC through the analysis of multicomponent analytes","volume":"88","author":"Hirose","year":"2025","journal-title":"Chromatographia"},{"key":"10.1016\/j.chroma.2026.467092_bib0033","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/10826076.2025.2578340","article-title":"Multicomponent analysis evaluation of the separation behavior of naphthalene derivatives in the phase-separation mode on HPLC using a ternary mixture eluent on a C18 column","volume":"48","author":"Rea","year":"2025","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.chroma.2026.467092_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2026.466734","article-title":"Phase-separation mode in HPLC: theoretical prediction and experimental evaluation of elution times","volume":"1770","author":"Hiramatsu","year":"2026","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467092_bib0035","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s44211-025-00830-9","article-title":"Direct visualization of phase-separation multiphase flow in a silica bead\u2013packed microchannel using fluorescence microscopy","volume":"41","author":"Yamashiro","year":"2025","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467092_bib0036","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2116\/analsci.32.455","article-title":"Consideration of inner and outer phase configuration in tube radial distribution phenomenon based on viscous dissipation in a microfluidic flow using various types of mixed solvent solutions","volume":"32","author":"Fujinaga","year":"2016","journal-title":"Anal. Sci."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326004218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326004218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:24:17Z","timestamp":1783106657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326004218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"alternative-id":["S0021967326004218"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467092","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation between chromatographic behavior and microfluidic phase distribution in the phase-separation mode of HPLC","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467092"}}