{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:09:03Z","timestamp":1788786543676,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374060"],"award-info":[{"award-number":["22374060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.chroma.2026.467372","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:43:23Z","timestamp":1787240603000},"page":"467372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deep eutectic solvents as primary separation media in capillary electrokinetic chromatography: A case study using Proline:Urea and cyclodextrins"],"prefix":"10.1016","volume":"1786","author":[{"given":"Song","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanhao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-486X","authenticated-orcid":false,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467372_bib0001","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1021\/acs.analchem.4c00857","article-title":"Capillary electrophoresis: a three-year literature review","volume":"96","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202518366","article-title":"Intact proteoform analysis by capillary electrophoresis\u2013mass spectrometry. Are we there yet?","volume":"65","author":"Gould","year":"2026","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chroma.2026.467372_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344323","article-title":"Separation and analysis of proteins by capillary electromigration methods in the period mid- 2021 \u2212 2024","volume":"1368","author":"\u0160t\u011bp\u00e1nov\u00e1","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467372_bib0004","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpha.2023.03.003","article-title":"A chiral metal-organic framework {(HQA)(ZnCl2)(2\u00b75H2O)}n for the enantioseparation of chiral amino acids and drugs","volume":"13","author":"Zheng","year":"2023","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.chroma.2026.467372_bib0005","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1021\/acs.analchem.5c00553","article-title":"Chiral separation enhancement in capillary electrophoresis by electrophoretic mobility differences without electroosmosis","volume":"97","author":"Qian","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.129471","article-title":"Constructing a composite interface on in situ grown MOF scaffolds for efficient separation of D,L-dmlno acids via chiral ligand-exchange capillary electrochromatography","volume":"303","author":"Wang","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467372_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465589","article-title":"Microchip capillary electrophoresis-mass spectrometry for high-throughput simultaneous analysis of B-complex vitamins","volume":"1740","author":"Yang","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2026.345371","article-title":"Separation and detection of hemicellulose and insights into chemical heterogeneity through capillary electrophoresis","volume":"1401","author":"Najjoum","year":"2026","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467372_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465992","article-title":"Influence of descriptor database selection on modeling retention factors in capillary micellar and microemulsion electrokinetic chromatography using the solvation parameter model","volume":"1753","author":"Atapattu","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124556","article-title":"Chiral separation by capillary electrokinetic chromatography with hydrophobic deep eutectic solvents as pseudo-stationary phases","volume":"260","author":"Xu","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467372_bib0011","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s00216-025-05783-6","article-title":"Investigating drug-liposome interactions using liposomal electrokinetic chromatography","volume":"417","author":"\u0160imonov\u00e1","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340693","article-title":"A feasibility study on the use of hydrophobic eutectic solvents as pseudo-stationary phases in capillary electrophoresis for chiral separations","volume":"1239","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467372_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343025","article-title":"Identification of 3-hydroxyaspartate with two chiral centers by capillary electrophoresis-mass spectrometry and vibrational circular dichroism independent of single enantiomer standard","volume":"1323","author":"Yang","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467372_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116532","article-title":"Separation of tolperisone and its degradation products by a dual cyclodextrin capillary electrophoresis system to study their potential role in allergic events","volume":"252","author":"Lakatos","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.chroma.2026.467372_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132369","article-title":"Controlled release and antibacterial properties of PEO\/casein nanofibers loaded with Thymol\/\u03b2-cyclodextrin inclusion complexes in beef preservation","volume":"382","author":"Dai","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0016","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1002\/jsfa.12527","article-title":"Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-beta-cyclodextrin and Soluplus\u00ae nanoparticles based on electrospray technology","volume":"103","author":"Xue","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.chroma.2026.467372_bib0017","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.xphs.2022.03.021","article-title":"Liquiritin-hydroxypropyl-beta-cyclodextrin inclusion complex: preparation, characterization, bioavailability and antitumor activity evaluation","volume":"111","author":"Wang","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.chroma.2026.467372_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465781","article-title":"Amino-\u03b2-cyclodextrin derivatives with different chain lengths as chiral selectors for separation of dansyl amino acid enantiomers by capillary electrophoresis","volume":"1746","author":"Fu","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465597","article-title":"Simultaneous stereoisomeric preconcentration and determination of alkaloids and stereoisomers in Uncariae ramulus cum uncis using field enhanced sample injection and dynamic pH junction sweeping method by cyclodextrin electrokinetic chromatography","volume":"1740","author":"Liu","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0020","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/elps.202400150","article-title":"A new empirical equation to take into account the influence of ionic strength on electrophoretic mobility and determination of binding constants of ester betulin derivatives with sulfated \u03b2-cyclodextrin by affinity capillary electrophoresis","volume":"46","author":"Sursyakova","year":"2025","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2026.467372_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.116987","article-title":"Cyclodextrins as chiral selectors in capillary electrophoresis: recent trends in mechanistic studies","volume":"160","author":"Chankvetadze","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460519","article-title":"Investigation of the synergistic effect of chiral ionic liquids as additives in non-aqueous capillary electrophoresis for enantioseparation","volume":"1609","author":"Ren","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0023","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/elps.202100173","article-title":"Electrophoretic mobility of ester betulin derivatives and their complexation with \u03b3-cyclodextrin studied by capillary electrophoresis in aqueous solutions at different pH values","volume":"43","author":"Sursyakova","year":"2022","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2026.467372_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126126","article-title":"Deep eutectic solvents as a green alternative to organic solvents for \u03b2-cyclodextrin pseudo-stationary phase in capillary electrophoresis","volume":"275","author":"Ding","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467372_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128117","article-title":"Cyclodextrin mediated non-aqueous electrophoresis for chiral separations of anionic boron clusters","volume":"293","author":"Hor\u00e1\u010dek","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467372_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.460854","article-title":"A sensitive two-step stacking by coupling field-enhanced sample injection and micelle to cyclodextrin stacking for the determination of neutral analytes","volume":"1618","author":"Liu","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0027","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0165-9936(98)00032-6","article-title":"Analyte\u2013additive interactions in nonaqueous capillary electrophoresis: a critical review","volume":"17","author":"Bowser","year":"1998","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0028","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202418957","article-title":"Sustainable synthesis of functional materials assisted by deep eutectic solvents for biomedical, environmental, and energy applications","volume":"35","author":"Nie","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.chroma.2026.467372_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2025.133126","article-title":"Metallic deep eutectic solvent derived chiral carbon dots functionalized MOF@silica composite: a new and highly efficient column packing material","volume":"369","author":"Zhang","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.chroma.2026.467372_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.105963","article-title":"Efficient synthesis of isoamyl acetate in deep eutectic solvent utilizing in-situ aqueous phase immobilized lipase biocatalyst","volume":"64","author":"Zhang","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.chroma.2026.467372_bib0031","doi-asserted-by":"crossref","first-page":"8248","DOI":"10.1111\/1750-3841.17545","article-title":"Physical field-assisted deep eutectic solvent processing: a green and water-saving extraction and separation technology","volume":"89","author":"Zhou","year":"2024","journal-title":"J. Food Sci."},{"key":"10.1016\/j.chroma.2026.467372_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.147453","article-title":"Deep eutectic solvent-extracted lignin as a natural emulsifier for ultrasound-assisted ginger oil nanoemulsions with enhanced antioxidant and antimicrobial activities","volume":"503","author":"Mukhtar","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0033","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1039\/D4GC06386D","article-title":"Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond","volume":"27","author":"Cheve-Kools","year":"2025","journal-title":"Green Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2024.129329","article-title":"Mildly expanded graphite with exceptional performance from waste lithium ion batteries by space-confined intercalation of deep eutectic solvent","volume":"354","author":"Wang","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.chroma.2026.467372_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2025.107350","article-title":"Deep eutectic solvent-modified multi-walled carbon nanotubes as QuEChERS adsorbents coupled with gas chromatography-mass spectrometry for the determination of pesticide residues in Lycium barbarum","volume":"141","author":"Liu","year":"2025","journal-title":"J. Food Compost. Anal."},{"key":"10.1016\/j.chroma.2026.467372_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117649","article-title":"Recent advances towards the use of deep eutectic solvents and cyclodextrins in the extraction of food contaminants: from traditional sample pretreatment techniques to green microextraction and beyond","volume":"173","author":"Kalogiouri","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467372_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344686","article-title":"Natural deep eutectic solvent as extractor and support for determination of metals by laser induced breakdown spectroscopy","volume":"1378","author":"Soares","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467372_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2025.111866","article-title":"Deep eutectic solvent: a promising way to enhance the physicomechanical and antimicrobial properties of pullulan\/carboxymethyl chitosan films impregnated with zein\u2013nisin nanofillers for sustainable food packaging","volume":"171","author":"Ashraf","year":"2026","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.chroma.2026.467372_bib0039","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1111\/1750-3841.17339","article-title":"Synergistic effect of drying methods and ultrasonication on natural deep eutectic solvent extraction of phytochemicals from African spinach (Amaranthus hybridus) stem","volume":"89","author":"Okonkwo","year":"2024","journal-title":"J. Food Sci."},{"key":"10.1016\/j.chroma.2026.467372_bib0040","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/elps.201900067","article-title":"Investigation of deep eutectic solvents as additives to \u03b2-CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE","volume":"40","author":"Mu","year":"2019","journal-title":"Electrophoresis"},{"key":"10.1016\/j.chroma.2026.467372_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121419","article-title":"Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solvents","volume":"220","author":"Deng","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467372_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465388","article-title":"Clindamycin phosphate-based deep eutectic solvent as a chiral selector for enantioseparation of amino alcohol drugs in nonaqueous capillary electrophoresis","volume":"1736","author":"Ma","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2026.466970","article-title":"(Deep) eutectic solvents in chromatographic and electromigration techniques","volume":"1777","author":"Zhang","year":"2026","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464644","article-title":"Capillary electrophoresis separations with deep eutectic solvents as greener separation media: a proof-of-concept study","volume":"1716","author":"Ding","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9673(01)00794-4","article-title":"Optimizing separation conditions for polycyclic aromatic hydrocarbons in micellar electrokinetic chromatography","volume":"924","author":"Hsieh","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0046","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0021-9673(01)01271-7","article-title":"Separation of polycyclic aromatic hydrocarbons with sodium dodecylbenzenesulfonate in electrokinetic chromatography","volume":"949","author":"Kavran","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467372_bib0047","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.talanta.2005.10.025","article-title":"Effect of cetyltrimethylammonium bromide on the migration of polyaromatic hydrocarbons in capillary electrokinetic chromatography","volume":"69","author":"Belin","year":"2006","journal-title":"Talanta"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326007004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326007004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:23:02Z","timestamp":1788783782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326007004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S0021967326007004"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467372","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep eutectic solvents as primary separation media in capillary electrokinetic chromatography: A case study using Proline:Urea and cyclodextrins","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467372"}}