{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:53:51Z","timestamp":1791636831016,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104115"],"award-info":[{"award-number":["82104115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20262BAC200266"],"award-info":[{"award-number":["20262BAC200266"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21626407"],"award-info":[{"award-number":["21626407"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.chroma.2026.467494","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:11:55Z","timestamp":1790291515000},"page":"467494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of sulfonium versus ammonium groups in zwitterions on hydrophilic interaction chromatographic separation performance"],"prefix":"10.1016","volume":"1788","author":[{"given":"Yuanyuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesara","family":"Ar-sanork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-4331","authenticated-orcid":false,"given":"Zhengjin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467494_bib0001","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0021-9673(00)96972-3","article-title":"Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds","volume":"499","author":"Alpert","year":"1990","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.125121","article-title":"Rapid fabrication of versatile zwitterionic super-hydrophilic polymers by sole-monomer system for biomolecules separation","volume":"396","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"issue":"17","key":"10.1016\/j.chroma.2026.467494_bib0003","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.chroma.2011.02.024","article-title":"Preparation and application of hydrophilic monolithic columns","volume":"1218","author":"Jiang","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0004","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chroma.2016.09.059","article-title":"The effect of charged groups on hydrophilic monolithic stationary phases on their chromatographic properties","volume":"1469","author":"Li","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.463785","article-title":"Comprehensive evaluation of zwitterionic hydrophilic liquid chromatography stationary phases for oligonucleotide characterization","volume":"1690","author":"Lardeux","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s44211-023-00430-5","article-title":"A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation","volume":"40","author":"Lai","year":"2024","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467494_bib0007","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2017.06.034","article-title":"Preparation and evaluation of 400\u03bcm I.D. polymer-based hydrophilic interaction chromatography monolithic columns with high column efficiency","volume":"1509","author":"Liu","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0008","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.langmuir.8b01789","article-title":"Molecular design of zwitterionic polymer interfaces: searching for the difference","volume":"35","author":"Laschewsky","year":"2019","journal-title":"Langmuir"},{"key":"10.1016\/j.chroma.2026.467494_bib0009","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actbio.2016.03.038","article-title":"Zwitterionic materials for antifouling membrane surface construction","volume":"40","author":"He","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.chroma.2026.467494_bib0010","first-page":"294","article-title":"Structures, properties, and applications of zwitterionic polymers","volume":"1","author":"Qu","year":"2022","journal-title":"Chem. Phys. Mater."},{"issue":"14","key":"10.1016\/j.chroma.2026.467494_bib0011","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1021\/acs.langmuir.4c00343","article-title":"Electrified interactions of polyzwitterions with charged surfaces: role of dipole orientation and surface potentials","volume":"40","author":"Lin","year":"2024","journal-title":"Langmuir"},{"key":"10.1016\/j.chroma.2026.467494_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcoa.2025.100258","article-title":"Interaction properties and separation potential of zwitterionic stationary phases in hydrophilic interaction liquid chromatography","volume":"8","author":"Vos\u00e1hlov\u00e1","year":"2025","journal-title":"J. Chromatogr. Open"},{"key":"10.1016\/j.chroma.2026.467494_bib0013","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.talanta.2015.12.066","article-title":"Chromatographic behavior of 12 polar pteridines in hydrophilic interaction chromatography using five different HILIC columns coupled with tandem mass spectrometry","volume":"150","author":"Xiong","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.chroma.2026.467494_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464864","article-title":"Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation","volume":"1722","author":"Lai","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0015","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1021\/ac103312e","article-title":"Zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC and ZIC-cHILIC) provide high resolution separation and increase sensitivity in proteome analysis","volume":"83","author":"Palma","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465917","article-title":"Fabrication and evaluation of a dual-zwitterionic functionalized hydrophilic monolith for chromatographic separation","volume":"1751","author":"Lai","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0017","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.aca.2017.11.032","article-title":"Hydrophilic polymeric monoliths containing choline phosphate for separation science applications","volume":"999","author":"Wang","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chroma.2026.467494_bib0018","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jpha.2022.05.008","article-title":"Rapid fabrication of zwitterionic sulfobetaine vinylimidazole-based monoliths via photoinitiated copolymerization for hydrophilic interaction chromatography","volume":"12","author":"Wang","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.chroma.2026.467494_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465316","article-title":"Effect of anionic groups in zwitterionic hydrophilic stationary phases on their chromatographic characteristics","volume":"1734","author":"Lai","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0020","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1021\/jacs.1c09902","article-title":"Comparative analysis of sulfonium-\u03c0, ammonium-\u03c0, and sulfur-\u03c0 interactions and relevance to SAM-Dependent methyltransferases","volume":"144","author":"Albanese","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"10.1016\/j.chroma.2026.467494_bib0021","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1021\/acsapm.4c00461","article-title":"Ammonium, phosphonium, and sulfonium polymers for antimicrobial applications: a comparative study","volume":"6","author":"Gong","year":"2024","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.chroma.2026.467494_bib0022","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/pola.28359","article-title":"Reactive polymer zwitterions: sulfonium sulfonates","volume":"55","author":"Chalarca","year":"2017","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0023","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chroma.2014.11.007","article-title":"Influence of the crosslinker type on the chromatographic properties of hydrophilic sulfoalkylbetaine-type monolithic columns","volume":"1373","author":"Liu","year":"2014","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.chroma.2026.467494_bib0024","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00216-011-5308-5","article-title":"Hydrophilic interaction liquid chromatography (HILIC)-a powerful separation technique","volume":"402","author":"Buszewski","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"issue":"25","key":"10.1016\/j.chroma.2026.467494_bib0025","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1002\/anie.201201096","article-title":"A molecular dynamics study on the partitioning mechanism in hydrophilic interaction chromatography","volume":"51","author":"Melnikov","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chroma.2026.467494_bib0026","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/jssc.201200682","article-title":"Preparation and application of novel zwitterionic monolithic column for hydrophilic interaction chromatography","volume":"36","author":"Liu","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467494_bib0027","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00216-011-4767-z","article-title":"Comparison of stationary phases for packed column supercritical fluid chromatography based upon ionic liquid motifs: a study of cation and anion effects","volume":"400","author":"Smuts","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0028","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1021\/jo049766y","article-title":"Determination of solvation descriptors for ionic species: hydrogen bond acidity and basicity","volume":"69","author":"Abraham","year":"2004","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0029","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1021\/ic00141a005","article-title":"Electronegativities of elements in valence states and their applications. 1. Electronegativities of elements in valence states","volume":"21","author":"Zhang","year":"1982","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0030","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1039\/D4CC03388D","article-title":"Controlling and predicting alkyl-onium electronic structure","volume":"60","author":"Tompkins","year":"2024","journal-title":"Chem. Commun."},{"key":"10.1016\/j.chroma.2026.467494_bib0031","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1021\/jo01123a002","article-title":"The SN mechanism in aromatic compounds. Part XIII","volume":"20","author":"Bolto","year":"1955","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.chroma.2026.467494_bib0032","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3390\/pharmaceutics13050734","article-title":"Combined use of structure analysis, studies of molecular association in solution, and molecular modelling to understand the different propensities of dihydroxybenzoic acids to form solid phases","volume":"13","author":"Trimdale","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.chroma.2026.467494_bib0033","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1016\/j.chroma.2011.01.066","article-title":"Hydrophilic interaction chromatography of nucleoside triphosphates with temperature as a separation parameter","volume":"1218","author":"Johnsen","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467494_bib0034","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1039\/D3SC01977B","article-title":"Hydration behaviors of nonfouling zwitterionic materials","volume":"14","author":"Sarker","year":"2023","journal-title":"Chem. Sci."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:08:11Z","timestamp":1791634091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326008204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0021967326008204"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467494","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of sulfonium versus ammonium groups in zwitterions on hydrophilic interaction chromatographic separation performance","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"467494"}}