{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:53:11Z","timestamp":1791636791540,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018601","name":"Guangdong Special Support Plan","doi-asserted-by":"publisher","award":["2023JC07L096"],"award-info":[{"award-number":["2023JC07L096"]}],"id":[{"id":"10.13039\/501100018601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0303000007"],"award-info":[{"award-number":["2023B0303000007"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025B515130001"],"award-info":[{"award-number":["2025B515130001"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010960"],"award-info":[{"award-number":["2025A1515010960"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.chroma.2026.467504","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:08:56Z","timestamp":1790546936000},"page":"467504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Expanding environmental monitoring of psychotropic drugs by incorporating human metabolites through tandem solid-phase extraction"],"prefix":"10.1016","volume":"1788","author":[{"given":"An-Guo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2019an","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467504_bib0001","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.chemosphere.2015.07.002","article-title":"Occurrence and fate of psychiatric pharmaceuticals in the urban water system of Shanghai, China","volume":"138","author":"Wu","year":"2015","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.chroma.2026.467504_bib0002","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11126-025-10122-0","article-title":"International trends in antidepressant consumption: a 10-year comparative analysis (2010-2020)","volume":"96","author":"Peano","year":"2025","journal-title":"Psychiatr. Q."},{"key":"10.1016\/j.chroma.2026.467504_bib0003","series-title":"Drug Metabolism in MSD Manual Professional Edition","author":"Le","year":"2022"},{"issue":"22","key":"10.1016\/j.chroma.2026.467504_bib0004","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1021\/acs.est.4c00968","article-title":"How wastewater reflects human metabolism-suspect screening of pharmaceutical metabolites in wastewater influent","volume":"58","author":"Meyer","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.chroma.2026.467504_bib0005","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/j.1552-4604.1992.tb03875.x","article-title":"Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O-desmethyl metabolite","volume":"32","author":"Klamerus","year":"1992","journal-title":"J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.chroma.2026.467504_bib0006","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/pharmaceutics16060737","article-title":"Applying physiologically based pharmacokinetic modeling to interpret carbamazepine\u2019s nonlinear pharmacokinetics and its induction potential on cytochrome P450 3A4 and cytochrome P450 2C9 enzymes","volume":"16","author":"Yin","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.chroma.2026.467504_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2025.123292","article-title":"Fate and transformation of psychotropic drugs in urban wastewater systems and receiving rivers via the integration of targeted and suspect screening analysis","volume":"276","author":"Wang","year":"2025","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.chroma.2026.467504_bib0008","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/acsestwater.0c00081","article-title":"Occurrence and fate of psychiatric pharmaceuticals in wastewater treatment plants in Hong Kong: enantiomeric profiling and preliminary risk assessment","volume":"1","author":"Wu","year":"2021","journal-title":"ACS ES&T Water."},{"issue":"8","key":"10.1016\/j.chroma.2026.467504_bib0009","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world's rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.chroma.2026.467504_bib0010","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1021\/es5024493","article-title":"Transformation of oxcarbazepine and Human metabolites of carbamazepine and oxcarbazepine in wastewater treatment and sand filters","volume":"48","author":"Kaiser","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"6743","key":"10.1016\/j.chroma.2026.467504_bib0011","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.adp7174","article-title":"Pharmaceutical pollution influences river-to-sea migration in Atlantic salmon (Salmo salar)","volume":"388","author":"Brand","year":"2025","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.chroma.2026.467504_bib0012","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/acsmedchemlett.0c00202","article-title":"Biotransformation: impact and application of metabolism in drug discovery","volume":"11","author":"Shanu-Wilson","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.chroma.2026.467504_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106467","article-title":"The metabolites could not be ignored: a comparative study of the metabolite norfluoxetine with its parent fluoxetine on zebrafish (Danio rerio)","volume":"257","author":"Yan","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chroma.2026.467504_bib0014","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.watres.2018.08.034","article-title":"Distribution and fate of pharmaceuticals and their metabolite conjugates in a municipal wastewater treatment plant","volume":"144","author":"Brown","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chroma.2026.467504_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.463896","article-title":"Wastewater surveillance of 105 pharmaceutical drugs and metabolites by means of ultra-high-performance liquid-chromatography-tandem high resolution mass spectrometry","volume":"1693","author":"Massano","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467504_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464627","article-title":"Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS\/MS)","volume":"1715","author":"Wang","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467504_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142648","article-title":"Occurrence, fate and mass loading of benzodiazepines and their transformation products in eleven wastewater treatment plants in Guangdong province","volume":"755","author":"Lei","year":"2021","journal-title":"China. Sci. Total Environ."},{"issue":"23","key":"10.1016\/j.chroma.2026.467504_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312808","article-title":"Cytochrome P450 enzymes and drug metabolism in humans","volume":"22","author":"Zhao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.chroma.2026.467504_bib0019","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/cbdv.200690111","article-title":"The biochemistry of drug metabolism - an introduction - part 1. Principles and overview","volume":"3","author":"Testa","year":"2006","journal-title":"Chem. Biodivers."},{"issue":"1","key":"10.1016\/j.chroma.2026.467504_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03602532.2025.2582864","article-title":"Phase II metabolism in xenobiotic biotransformation: general mechanisms and the underestimated role of microbial systems","volume":"58","author":"Pietrzak","year":"2026","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.chroma.2026.467504_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463237","article-title":"Development of sol-gel silica-based mixed-mode zwitterionic sorbents for determining drugs in environmental water samples","volume":"1676","author":"Moral","year":"2022","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467504_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460531","article-title":"Mixed-mode ion-exchange polymeric sorbents in environmental analysis","volume":"1609","author":"Fontanals","year":"2020","journal-title":"J. Chromatogr. A"},{"issue":"14","key":"10.1016\/j.chroma.2026.467504_bib0023","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1007\/s00216-022-04066-8","article-title":"Solid-phase extraction and fractionation of multiclass pollutants from wastewater followed by liquid chromatography tandem-mass spectrometry analysis","volume":"414","author":"Fernandez-Fernandez","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2026.467504_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462715","article-title":"Hypercrosslinked polymer microspheres decorated with anion- and cation-exchange groups for the simultaneous solid-phase extraction of acidic and basic analytes from environmental waters","volume":"1661","author":"Nadal","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.chroma.2026.467504_bib0025","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/acs.est.3c07244","article-title":"Embedding mixed sorbents in binder: solid-phase microextraction coating with wide extraction coverage and its application in environmental water analysis","volume":"58","author":"Zhou","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chroma.2026.467504_bib0026","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chroma.2018.07.045","article-title":"Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by ultra-high performance liquid chromatography-tandem mass spectrometry","volume":"1569","author":"Gonz\u00e1lez-Mari\u00f1o","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"7","key":"10.1016\/j.chroma.2026.467504_bib0027","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/acs.chemrestox.2c00067","article-title":"Commandeuring\" xenobiotic metabolism: advances in understanding xenobiotic metabolism","volume":"35","author":"van Vugt-Lussenburg","year":"2022","journal-title":"Chem. Res. Toxicol."},{"issue":"12","key":"10.1016\/j.chroma.2026.467504_bib0028","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s44211-022-00190-8","article-title":"A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis","volume":"38","author":"Badawy","year":"2022","journal-title":"Anal. Sci."},{"key":"10.1016\/j.chroma.2026.467504_bib0029","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.chroma.2017.12.025","article-title":"Simultaneous analysis of opioid analgesics and their metabolites in municipal wastewaters and river water by liquid chromatography-tandem mass spectrometry","volume":"1533","author":"Krizman-Matasic","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"17","key":"10.1016\/j.chroma.2026.467504_bib0030","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1007\/s00216-014-7753-4","article-title":"Retention and selectivity of basic drugs on solid-phase extraction sorbents: application to direct determination of \u03b2-blockers in urine","volume":"406","author":"Boonjob","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"issue":"19","key":"10.1016\/j.chroma.2026.467504_bib0031","doi-asserted-by":"crossref","first-page":"10308","DOI":"10.1021\/acs.est.6b03338","article-title":"Mind the gap: persistent and mobile organic compounds water contaminants that slip through","volume":"50","author":"Reemtsma","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.chroma.2026.467504_bib0032","first-page":"918","article-title":"Selectivity of solid phase extraction of freshwater dissolved organic matter and its effect on ultrahigh resolution mass spectra","volume":"18","author":"Raeke","year":"2016","journal-title":"Environ. Sci."},{"issue":"2","key":"10.1016\/j.chroma.2026.467504_bib0033","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1021\/ci300487z","article-title":"How do metabolites differ from their parent molecules and how are they excreted?","volume":"53","author":"Kirchmair","year":"2013","journal-title":"J. Chem. Inf. Model."},{"issue":"6","key":"10.1016\/j.chroma.2026.467504_bib0034","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41929-026-01548-1","article-title":"Conformation-driven C3-C(sp3)-H arylation of saturated azacycles using Pd catalyst","volume":"9","author":"Chen","year":"2026","journal-title":"Nat. Catal."},{"issue":"20","key":"10.1016\/j.chroma.2026.467504_bib0035","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1021\/acs.jmedchem.9b00179","article-title":"Hydroxyl groups in synthetic and natural-product-derived therapeutics: a perspective on a common functional group","volume":"62","author":"Cramer","year":"2019","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.chroma.2026.467504_bib0036","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1021\/jo4002867","article-title":"Thermochemical studies of epoxides and related compounds","volume":"78","author":"Morgan","year":"2013","journal-title":"J. Org. Chem."},{"issue":"24","key":"10.1016\/j.chroma.2026.467504_bib0037","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1021\/acs.analchem.1c00357","article-title":"Correction of matrix effects for reliable non-target screening LC-ESI-MS analysis of wastewater","volume":"93","author":"Tisler","year":"2021","journal-title":"Anal. Chem."},{"issue":"13","key":"10.1016\/j.chroma.2026.467504_bib0038","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal. Chem."},{"issue":"20","key":"10.1016\/j.chroma.2026.467504_bib0039","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1039\/D1AN01047F","article-title":"Overview, consequences, and strategies for overcoming matrix effects in LC-MS analysis: a critical review","volume":"146","author":"Nasiri","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.chroma.2026.467504_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122933","article-title":"High-throughput multi-residue quantification of contaminants of emerging concern in wastewaters enabled using direct injection liquid chromatography-tandem mass spectrometry","volume":"398","author":"Ng","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"27","key":"10.1016\/j.chroma.2026.467504_bib0041","doi-asserted-by":"crossref","first-page":"19535","DOI":"10.1021\/acs.est.6c02538","article-title":"Mood altering waters: multidimensional profiling and chiral characterization of antidepressants in effluent-impacted waterways","volume":"60","author":"Vincent","year":"2026","journal-title":"Environ. Sci. Technol."}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:04:08Z","timestamp":1791633848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326008307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S0021967326008307"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467504","relation":{},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expanding environmental monitoring of psychotropic drugs by incorporating human metabolites through tandem solid-phase extraction","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467504","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"467504"}}