{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:34:04Z","timestamp":1793223244089,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006482","name":"Council on Ocean Affairs Science and Technology, California State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019471","name":"Mitsubishi Chemical Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography A"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.chroma.2026.467509","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:58:49Z","timestamp":1790693929000},"page":"467509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["End-group-selective size-exclusion chromatography\u2013mass spectrometry of poly(lactic acid) and poly(lactide-co-glycolide) polymers"],"prefix":"10.1016","volume":"1789","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4608-3699","authenticated-orcid":false,"given":"Masashi","family":"Serizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-0480","authenticated-orcid":false,"given":"Rick","family":"van den Hurk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-7436","authenticated-orcid":false,"given":"Stefan","family":"van Berkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9467","authenticated-orcid":false,"given":"Pieter","family":"van Delft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-3778","authenticated-orcid":false,"given":"Bob W.J.","family":"Pirok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-1465","authenticated-orcid":false,"given":"Ron A.H.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-7716","authenticated-orcid":false,"given":"Peter J.","family":"Schoenmakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-7341","authenticated-orcid":false,"given":"Andrea F.G.","family":"Gargano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chroma.2026.467509_bib0001","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.3390\/ijms15033640","article-title":"An overview of Poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering","volume":"15","author":"Gentile","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chroma.2026.467509_bib0002","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/10717544.2021.1943056","article-title":"Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review","volume":"28","author":"Hua","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.chroma.2026.467509_bib0003","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s40005-019-00453-z","article-title":"Poly(lactic acid)\/poly(lactic-co-glycolic acid)-based microparticles: an overview","volume":"49","author":"Blasi","year":"2019","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.chroma.2026.467509_bib0004","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-Glycolic Acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.chroma.2026.467509_bib0005","first-page":"7969","article-title":"Biodegradable compatibilizers for poly(hydroxyalkanoate)\/poly(\u03f5-caprolactone) blends through click reactions with end-functionalized microbial poly(hydroxyalkanoate)s, ACS Sustain","volume":"7","author":"Oyama","year":"2019","journal-title":"Chem. Eng."},{"key":"10.1016\/j.chroma.2026.467509_bib0006","doi-asserted-by":"crossref","first-page":"9779","DOI":"10.1021\/ma3016739","article-title":"Multidimensional characterization of \u03b1,\u03c9-telechelic poly(\u03b5-caprolactone)s via online coupling of 2D chromatographic methods (LC\/SEC) and ESI-TOF\/MALDI-TOF-MS","volume":"45","author":"Barqawi","year":"2012","journal-title":"Macromolecules"},{"key":"10.1016\/j.chroma.2026.467509_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2019.04.023","article-title":"Encapsulation and release of doxycycline from electrospray-generated PLGA microspheres: effect of polymer end groups","volume":"564","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.chroma.2026.467509_bib0008","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.actbio.2013.12.039","article-title":"Degradation mechanisms of bioresorbable polyesters. Part 1. Effects of random scission, end scission and autocatalysis","volume":"10","author":"Gleadall","year":"2014","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.chroma.2026.467509_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120468","article-title":"Biomaterials applications of cyclic polymers","volume":"267","author":"Golba","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.chroma.2026.467509_bib0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41557-020-0440-5","article-title":"The synthesis, properties and potential applications of cyclic polymers","volume":"12","author":"Haque","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.chroma.2026.467509_bib0011","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/polym10070713","article-title":"Organocatalytic stereoselective cyclic polylactide synthesis in supercritical carbon dioxide under plasticizing conditions","volume":"10","author":"Mase","year":"2018","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.chroma.2026.467509_bib0012","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0142-9612(02)00323-X","article-title":"Removal of dihydroxy-terminated components from monomethoxy-terminated poly(ethylene glycol)","volume":"24","author":"Lee","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.chroma.2026.467509_bib0013","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/S0032-3861(02)00078-2","article-title":"Termini and main-chain composition of monomethoxy-terminated poly(ethylene glycol) studied by two-dimensional column chromatography","volume":"43","author":"Lee","year":"2002","journal-title":"Polym. (Guildf.)"},{"key":"10.1016\/j.chroma.2026.467509_bib0014","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jssc.202000768","article-title":"Detection challenges in quantitative polymer analysis by liquid chromatography","volume":"44","author":"Knol","year":"2021","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.chroma.2026.467509_bib0015","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/jbm.b.33920","article-title":"Mapping intermediate degradation products of poly(lactic-co-glycolic acid) in vitro","volume":"106","author":"Li","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.chroma.2026.467509_bib0016","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1021\/jasms.1c00085","article-title":"Electrospray ionization-mass spectrometry of synthetic polymers functionalized with carboxylic acid end-groups","volume":"32","author":"Nitsche","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.467509_bib0017","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1016\/j.polymer.2007.07.041","article-title":"Electrospray ionization mass spectrometric end-group analysis of PMMA produced by radical polymerization using diacyl peroxide initiators","volume":"48","author":"Buback","year":"2007","journal-title":"Polym. (Guildf.)"},{"key":"10.1016\/j.chroma.2026.467509_bib0018","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.polymer.2006.01.021","article-title":"Hydrolytic degradation of poly(d,l-lactide) as a function of end group: carboxylic acid vs. hydroxyl","volume":"47","author":"Wiggins","year":"2006","journal-title":"Polym. (Guildf.)"},{"key":"10.1016\/j.chroma.2026.467509_bib0019","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/jasms.0c00137","article-title":"Mass spectrometry-based analytical strategy for comprehensive molecular characterization of biodegradable poly(lactic-co-glycolic Acid) copolymers","volume":"31","author":"Fouquet","year":"2020","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.467509_bib0020","series-title":"Multiple Detection in Size-Exclusion Chromatography","first-page":"196","article-title":"Size-exclusion chromatography coupled to mass spectrometry and tandem mass spectrometry for oligomer analysis","author":"Prokai","year":"2005"},{"key":"10.1016\/j.chroma.2026.467509_bib0021","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/jasms.4c00447","article-title":"Size-exclusion chromatography-electrospray-ionization mass spectrometry to characterize end group and chemical distribution of poly(lactide-co-glycolide) copolymers","volume":"36","author":"Serizawa","year":"2025","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.467509_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.465137","article-title":"Functionality-type and chemical-composition separation of poly(lactide-co-glycolide) using gradient elution normal-phase liquid chromatography with basic and acidic additives","volume":"1730","author":"Serizawa","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chroma.2026.467509_bib0023","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpha.2019.01.004","article-title":"Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC","volume":"9","author":"Pourasghar","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.chroma.2026.467509_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8652","article-title":"MSPolyCalc: a web-based app for polymer mass spectrometry data interpretation. the case study of a pharmaceutical excipient","volume":"34","author":"Desport","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.467509_bib0025","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1039\/D4RA07881K","article-title":"Optimizing solvent systems for electrospun PLGA scaffolds: effects on microstructure and mechanical properties for biomedical applications","volume":"15","author":"Salimbeigi","year":"2025","journal-title":"RSC Adv"},{"key":"10.1016\/j.chroma.2026.467509_bib0026","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-3659(97)01647-7","article-title":"Microencapsulation techniques using ethyl acetate as a dispersed solvent: effects of its extraction rate on the characteristics of PLGA microspheres","volume":"47","author":"Sah","year":"1997","journal-title":"J. Control. Release"},{"key":"10.1016\/j.chroma.2026.467509_bib0027","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1021\/ma900755z","article-title":"Fast and accurate determination of absolute individual molecular weight distributions from mixtures of polymers via size exclusion chromatography- electrospray ionization mass spectrometry","volume":"42","author":"Gruendling","year":"2009","journal-title":"Macromolecules"},{"key":"10.1016\/j.chroma.2026.467509_bib0028","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijpharm.2008.12.019","article-title":"Injectable in situ forming depot systems: PEG-DAE as novel solvent for improved PLGA storage stability","volume":"371","author":"Schoenhammer","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.chroma.2026.467509_bib0031","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/jms.1110","article-title":"Characterization of linear and cyclic polylactic acids and their solvolysis products by electrospray ionization mass spectrometry","volume":"41","author":"Osaka","year":"2006","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.chroma.2026.467509_bib0029","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00216-015-9198-9","article-title":"Novel behavior of the chromatographic separation of linear and cyclic polymers","volume":"408","author":"Montenegro-Burke","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chroma.2026.467509_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/macp.201700114","article-title":"Transesterification in the solid State of cyclic and linear poly(l-lactide)s","volume":"218","author":"Weidner","year":"2017","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.chroma.2026.467509_bib0032","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/mabi.200500062","article-title":"Poly(lactide) stereocomplexes: formation, structure, properties, degradation, and applications","volume":"5","author":"Tsuji","year":"2005","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.chroma.2026.467509_bib0033","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1021\/ja200895s","article-title":"Exploiting sequence to control the hydrolysis behavior of biodegradable PLGA copolymers","volume":"133","author":"Li","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chroma.2026.467509_bib0034","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.polymdegradstab.2011.05.022","article-title":"Hydrolytic degradation of poly(d,l-lactide-co-glycolide 50\/50)-di-acrylate network as studied by liquid chromatography-mass spectrometry","volume":"96","author":"Peters","year":"2011","journal-title":"Polym. Degrad. Stab."},{"key":"10.1016\/j.chroma.2026.467509_bib0035","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1021\/acs.macromol.5c03061","article-title":"Quantifying poly(lactide-co-glycolide) residual dimer-alternating structure and block-length distribution using controlled chemical degradation and reverse-phase liquid chromatography\u2013Mass spectrometry analysis","volume":"59","author":"Serizawa","year":"2026","journal-title":"Macromolecules"}],"container-title":["Journal of Chromatography A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021967326008356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:04:41Z","timestamp":1793221481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021967326008356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S0021967326008356"],"URL":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467509","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.15007490\/v1","asserted-by":"object"}]},"ISSN":["0021-9673"],"issn-type":[{"value":"0021-9673","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"End-group-selective size-exclusion chromatography\u2013mass spectrometry of poly(lactic acid) and poly(lactide-co-glycolide) polymers","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography A","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chroma.2026.467509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"467509"}}