{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:44:14Z","timestamp":1788666254422,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Programa de Desarrollo de las Ciencias B\u00e1sicas"},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Innovaci\u00f3n e Investigaci\u00f3n","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["01.10.0783.04"],"award-info":[{"award-number":["01.10.0783.04"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.cimid.2016.01.004","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T17:15:40Z","timestamp":1453569340000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Quillaja brasiliensis saponins induce robust humoral and cellular responses in a bovine viral diarrhea virus vaccine in mice"],"prefix":"10.1016","volume":"45","author":[{"given":"Samuel Paulo","family":"Cibulski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Mourglia-Ettlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Fumaco","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helton Fernandes","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina","family":"Yendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"de Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Germano","family":"Fett-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-8312","authenticated-orcid":false,"given":"Grace","family":"Gosmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Michel","family":"Roehe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cimid.2016.01.004_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01652176.2003.9695140","article-title":"Bovine viral diarrhoea virus infections and its control. A review","volume":"25","author":"Lindberg","year":"2003","journal-title":"Vet. Q."},{"key":"10.1016\/j.cimid.2016.01.004_bib0135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/0300985813520250","article-title":"Bovine viral diarrhea virus infections: manifestations of infection and recent advances in understanding pathogenesis and control","volume":"51","author":"Brodersen","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.00005-07","article-title":"Current status of veterinary vaccines","volume":"20","author":"Meeusen","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"issue":"Suppl 2","key":"10.1016\/j.cimid.2016.01.004_bib0145","doi-asserted-by":"crossref","first-page":"B14","DOI":"10.1016\/j.vaccine.2015.01.088","article-title":"New generation adjuvants \u2013 from empiricism to rational design","volume":"33","author":"O\u2019Hagan","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0150","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cimid.2016.01.004_bib0155","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.vaccine.2009.01.091","article-title":"Advances in saponin-based adjuvants","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jep.2004.05.016","article-title":"Biological activities and distribution of plant saponins","volume":"94","author":"Sparg","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0165","doi-asserted-by":"crossref","first-page":"e105374","DOI":"10.1371\/journal.pone.0105374","article-title":"Alternative inactivated poliovirus vaccines adjuvanted with Quillaja brasiliensis or Quil-A saponins are equally effective in inducing specific immune responses","volume":"9","author":"de Costa","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.cimid.2016.01.004_bib0170","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.1016\/j.vaccine.2011.09.137","article-title":"Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation","volume":"29","author":"Silveira","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0175","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1016\/j.vaccine.2006.06.059","article-title":"Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice","volume":"24","author":"Fleck","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0180","series-title":"Animal Cell Culture: A Practical Approach","author":"Freshney","year":"1992"},{"key":"10.1016\/j.cimid.2016.01.004_bib0185","first-page":"37","article-title":"An overview of the inactivation of FMDV and the implications when residual virus is present in vaccines","volume":"75","author":"Brown","year":"1991","journal-title":"Dev. Biol. Stand."},{"key":"10.1016\/j.cimid.2016.01.004_bib0190","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/ptr.3454","article-title":"Alum-type adjuvant effect of non-haemolytic saponins purified from Ilex and Passiflora spp","volume":"25","author":"Silveira","year":"2011","journal-title":"Phytother. Res.: PTR"},{"key":"10.1016\/j.cimid.2016.01.004_bib0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vaccine.2006.07.011","article-title":"Genital CD8+ T cell response to HIV-1 gag in mice immunized by mucosal routes with a recombinant simian adenovirus","volume":"25","author":"de Souza","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0200","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/138955711796575470","article-title":"Immunoadjuvant and anti-inflammatory plant saponins: characteristics and biotechnological approaches towards sustainable production","volume":"11","author":"de Costa","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.cimid.2016.01.004_bib0205","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.4049\/jimmunol.138.11.3688","article-title":"Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones","volume":"138","author":"Cher","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri3803","article-title":"A brief history of T cell help to B cells","volume":"15","author":"Crotty","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0215","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.drudis.2014.02.015","article-title":"New Th2 adjuvants for preventive and active immunotherapy of neurodegenerative proteinopathies","volume":"19","author":"Marciani","year":"2014","journal-title":"Drug Discov. Today"},{"issue":"Suppl 2","key":"10.1016\/j.cimid.2016.01.004_bib0220","doi-asserted-by":"crossref","first-page":"B21","DOI":"10.1016\/j.vaccine.2014.12.082","article-title":"Beyond adjuvants: immunomodulation strategies to enhance T cell immunity","volume":"33","author":"Kamphorst","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2016.01.004_bib0225","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0952-7915(99)80050-8","article-title":"Cytotoxic T lymphocyte activation by cross-priming","volume":"11","author":"Heath","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0230","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-065X.1995.tb00686.x","article-title":"Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance","volume":"146","author":"Kagi","year":"1995","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cimid.2016.01.004_bib0235","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/smim.1997.0065","article-title":"Functions of CD8 T-cell subsets secreting different cytokine patterns","volume":"9","author":"Mosmann","year":"1997","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cimid.2016.01.004_bib0240","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/viro.2000.0442","article-title":"Cytokine-mediated control of viral infections","volume":"273","author":"Guidotti","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.cimid.2016.01.004_bib0245","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.plaphy.2013.02.003","article-title":"Accumulation of a bioactive triterpene saponin fraction of Quillaja brasiliensis leaves is associated with abiotic and biotic stresses","volume":"66","author":"de Costa","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.cimid.2016.01.004_bib0250","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12033-010-9257-6","article-title":"Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields","volume":"46","author":"Yendo","year":"2010","journal-title":"Mol. Biotechnol."}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957116300030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957116300030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T16:05:59Z","timestamp":1692201959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957116300030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":25,"alternative-id":["S0147957116300030"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2016.01.004","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quillaja brasiliensis saponins induce robust humoral and cellular responses in a bovine viral diarrhea virus vaccine in mice","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2016.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}