{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:32:26Z","timestamp":1790141546526,"version":"4.0.1"},"reference-count":183,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.cimid.2017.02.001","type":"journal-article","created":{"date-parts":[[2017,3,12]],"date-time":"2017-03-12T06:48:12Z","timestamp":1489301292000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-\u03b2"],"prefix":"10.1016","volume":"51","author":[{"given":"Amir","family":"Abdoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Maspi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ghaffarifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0005","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(07)70209-8","article-title":"Cutaneous leishmaniasis","volume":"7","author":"Reithinger","year":"2007","journal-title":"Lancet Infect. Dis."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0015","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/pim.12007","article-title":"Tissue damage and immunity in cutaneous leishmaniasis","volume":"34","author":"Nylen","year":"2012","journal-title":"Parasite Immunol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.clindermatol.2006.05.008","article-title":"Cutaneous leishmaniasis","volume":"25","author":"Bailey","year":"2007","journal-title":"Clin. Dermatol."},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1365-3024.2009.01148.x","article-title":"Foxp3 expression in lesions of the different clinical forms of American tegumentary leishmaniasis","volume":"31","author":"Carneiro","year":"2009","journal-title":"Parasite Immunol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.immuni.2008.11.013","article-title":"Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin","volume":"30","author":"McLachlan","year":"2009","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0035","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.1994.tb06043.x","article-title":"Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis","volume":"96","author":"Kemp","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0040","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fimmu.2012.00128","article-title":"Protective immunity and vaccination against cutaneous leishmaniasis","volume":"3","author":"Okwor","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0045","first-page":"1","article-title":"Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review","author":"Maspi","year":"2016","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.cimid.2017.02.001_bib0050","series-title":"Skin: Structure and Function, Dermatology in Clinical Practice","first-page":"1","author":"Zaidi","year":"2010"},{"key":"10.1016\/j.cimid.2017.02.001_bib0055","first-page":"1","volume":"vol. 119","author":"Walters","year":"2002"},{"issue":"7193","key":"10.1016\/j.cimid.2017.02.001_bib0060","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"issue":"265","key":"10.1016\/j.cimid.2017.02.001_bib0065","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"6212","key":"10.1016\/j.cimid.2017.02.001_bib0070","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1253836","article-title":"Advances in skin grafting and treatment of cutaneous wounds","volume":"346","author":"Sun","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cimid.2017.02.001_bib0075","series-title":"Wound Healing and Wound Care","author":"Gauglitz","year":"2013"},{"issue":"3\u20134","key":"10.1016\/j.cimid.2017.02.001_bib0080","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.imbio.2007.11.010","article-title":"Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor","volume":"213","author":"Laskay","year":"2008","journal-title":"Immunobiology"},{"issue":"5891","key":"10.1016\/j.cimid.2017.02.001_bib0085","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1159194","article-title":"In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies","volume":"321","author":"Peters","year":"2008","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0090","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.4049\/jimmunol.172.7.4454","article-title":"Macrophage interactions with neutrophils regulate Leishmania major infection","volume":"72","author":"Ribeiro-Gomes","year":"2004","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0095","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.4049\/jimmunol.173.11.6521","article-title":"Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages","volume":"173","author":"van Zandbergen","year":"2004","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-4632.2010.04419.x","article-title":"Leishmaniasis recidivans among school children in Bam, South-east Iran, 1994\u20132006","volume":"49","author":"Sharifi","year":"2010","journal-title":"Int. J. Dermatol."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0105","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4049\/jimmunol.132.5.2603","article-title":"Monocyte suppression of antigen-specific lymphocyte responses in diffuse cutaneous leishmaniasis patients from the Dominican Republic","volume":"132","author":"Petersen","year":"1984","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0110","doi-asserted-by":"crossref","first-page":"743","DOI":"10.4269\/ajtmh.1994.50.743","article-title":"American cutaneous leishmaniasis: in situ characterization of the cellular immune response with time","volume":"50","author":"Lima","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"6225","key":"10.1016\/j.cimid.2017.02.001_bib0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/339544a0","article-title":"Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions","volume":"339","author":"Modlin","year":"1989","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0120","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.immuni.2007.01.017","article-title":"Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania","volume":"6","author":"Leon","year":"2007","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0125","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1038\/jid.2009.176","article-title":"Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis","volume":"29","author":"Kim","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/1523-1747.ep12262597","article-title":"Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes","volume":"83","author":"Basham","year":"1984","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0135","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6215-13-58","article-title":"Thermotherapy. An alternative for the treatment of American cutaneous leishmaniasis","volume":"13","author":"L\u00f3pez","year":"2012","journal-title":"Trials"},{"issue":"6915","key":"10.1016\/j.cimid.2017.02.001_bib0140","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature01152","article-title":"CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity","volume":"20","author":"Belkaid","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0145","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4269\/ajtmh.1995.52.438","article-title":"The pathology of cutaneous leishmaniasis due to Leishmania major in Sudan","volume":"52","author":"Gaafar","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0150","doi-asserted-by":"crossref","first-page":"e1171","DOI":"10.1371\/journal.pntd.0001171","article-title":"Foxp3 and IL-10 expression correlates with parasite burden in lesional tissues of post kala azar dermal leishmaniasis (PKDL) patients","volume":"5","author":"Katara","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0155","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4049\/jimmunol.145.3.940","article-title":"Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma","volume":"145","author":"Ding","year":"1990","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0160","first-page":"115","article-title":"Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity","volume":"17","author":"Von Stebut","year":"2007","journal-title":"Eur. J. Dermatol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0165","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4049\/jimmunol.165.2.969","article-title":"A natural model of Leishmania major infection reveals a prolonged silent phase of parasite amplification in the skin before the onset of lesion formation and immunity","volume":"165","author":"Belkaid","year":"2000","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0170","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/j.1462-5822.2009.01348.x","article-title":"The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis","volume":"11","author":"Peters","year":"2009","journal-title":"Cell. Microbiol."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0175","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri.2016.72","article-title":"Cutaneous leishmaniasis: immune responses in protection and pathogenesis","volume":"16","author":"Scott","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/bmb\/ldl003","article-title":"Current understandings on the immunology of leishmaniasis and recent developments in prevention and treatment","volume":"75\u201376","author":"Roberts","year":"2005","journal-title":"Br. Med. Bull."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0185","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nri957","article-title":"A blast from the past: clearance of apoptotic cells regulates immune responses","volume":"2","author":"Savill","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"16","key":"10.1016\/j.cimid.2017.02.001_bib0190","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimaraes-Costa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0195","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.4049\/jimmunol.0713598","article-title":"IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice","volume":"82","author":"Lopez Kostka","year":"2009","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0200","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00430-012-0261-2","article-title":"Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance","volume":"201","author":"Kautz-Neu","year":"2012","journal-title":"Med. Microbiol. Immunol."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0205","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1084\/jem.20101751","article-title":"Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection","volume":"208","author":"Goncalves","year":"2011","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0210","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0215","doi-asserted-by":"crossref","first-page":"754965","DOI":"10.1155\/2014\/754965","article-title":"Innate immunity to Leishmaniainfection: within phagocytes","volume":"2014","author":"Lopes","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.cimid.2017.02.001_bib0220","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.cimid.2017.02.001_bib0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004300100084","article-title":"Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice","volume":"190","author":"Muller","year":"2001","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-065X.1991.tb00607.x","article-title":"Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro","volume":"123","author":"Kelso","year":"1991","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0235","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/IAI.66.8.3968-3970.1998","article-title":"Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice","volume":"6","author":"Huber","year":"1998","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0240","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/intimm\/3.6.587","article-title":"Establishment of resistance to Leishmania major infection in susceptible BALB\/c mice requires parasite-specific CD8+ T cells","volume":"3","author":"Muller","year":"1991","journal-title":"Int. Immunol."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0245","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.4049\/jimmunol.168.8.3992","article-title":"CD8+ T cells are required for primary immunity in C57BL\/6 mice following low-dose, intradermal challenge with Leishmania major","volume":"168","author":"Belkaid","year":"2002","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0250","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1084\/jem.20040172","article-title":"Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon \u03b3-producing CD8(+) T cells","volume":"199","author":"Uzonna","year":"2004","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-3024.1995.tb00962.x","article-title":"Cytotoxicity in human mucosal and cutaneous leishmaniasis","volume":"17","author":"Barral-Netto","year":"1995","journal-title":"Parasite Immunol."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0260","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.4049\/jimmunol.159.9.4467","article-title":"Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis","volume":"159","author":"Brodskyn","year":"1997","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0265","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00062752-200101000-00009","article-title":"Th1 and Th2 cells","volume":"8","author":"Dong","year":"2001","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0270","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Ann. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1081-1206(10)62426-X","article-title":"T-cell subsets (Th1 versus Th2)","volume":"85","author":"Romagnani","year":"2000","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0280","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/317537","article-title":"Type 1\/Type 2 immunity in infectious diseases","volume":"32","author":"Spellberg","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cimid.2017.02.001_bib0285","doi-asserted-by":"crossref","first-page":"719361","DOI":"10.1155\/2010\/719361","article-title":"The prominent role of neutrophils during the initial phase of infection by Leishmania parasites","volume":"2010","author":"Charmoy","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"80","key":"10.1016\/j.cimid.2017.02.001_bib0290","article-title":"T Helper1\/T Helper2Cells and resistance\/susceptibility to Leishmania infection: is this paradigm still relevant?","volume":"3","author":"Alexander","year":"2012","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0295","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0300","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nri1485","article-title":"Regulatory T cells: friend or foe in immunity to infection?","volume":"4","author":"Mills","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0305","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2008.03.003","article-title":"Contextual regulation of inflammation: a duet by transforming growth factor-\u03b2 and interleukin-10","volume":"28","author":"Li","year":"2008","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0310","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1084\/jem.20030159","article-title":"Interleukin 1\u00f6 promotes Th(1) differentiation and inhibits disease progression in Leishmania major\u2013susceptible BALB\/c mice","volume":"198","author":"von Stebut","year":"2003","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0315","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"Sacks","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0320","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1034\/j.1600-065X.2000.917307.x","article-title":"The role of nitric oxide in innate immunity","volume":"173","author":"Bogdan","year":"2000","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0325","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1096\/fj.04-3416fje","article-title":"Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo","volume":"19","author":"Kropf","year":"2005","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0330","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1002\/eji.1830211216","article-title":"Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages","volume":"21","author":"Liew","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0335","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2012.00083","article-title":"The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response","volume":"2","author":"Liu","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0340","first-page":"165","article-title":"The role of CD4 and CD8T cells in human cutaneous leishmaniasis","volume":"2","author":"da Silva Santos","year":"2014","journal-title":"FrontPublic Health"},{"key":"10.1016\/j.cimid.2017.02.001_bib0345","first-page":"1","article-title":"Immune responses during cutaneous and visceral leishmaniasis","author":"Kedzierski","year":"2014","journal-title":"Parasitology"},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0350","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0355","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1128\/IAI.69.12.7453-7460.2001","article-title":"Differences in gamma interferon production in vitro predict the pace of the In vivo response to Leishmania amazonensis in healthy volunteers","volume":"9","author":"Pompeu","year":"2001","journal-title":"Infect. Immun."},{"issue":"8\/9","key":"10.1016\/j.cimid.2017.02.001_bib0360","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-3024.2012.01372.x","article-title":"Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?","volume":"34","author":"Nicodemo","year":"2012","journal-title":"Parasit. Immunol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0365","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S0074-02761991000100009","article-title":"Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis","volume":"6","author":"Bittencourt","year":"1991","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0370","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1590\/S0074-02762013000100003","article-title":"Inflammation in disseminated lesions: an analysis of CD4+, CD20+, CD68+, CD31+ and vW+ cells in non-ulcerated lesions of disseminated leishmaniasis","volume":"108","author":"Mendes","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"8\u20139","key":"10.1016\/j.cimid.2017.02.001_bib0375","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-3024.2012.01372.x","article-title":"Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?","volume":"34","author":"Nicodemo","year":"2012","journal-title":"Parasite Immunol."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0380","doi-asserted-by":"crossref","first-page":"E69","DOI":"10.1086\/340526","article-title":"Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer","volume":"4","author":"Machado","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0385","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4269\/ajtmh.2001.65.87","article-title":"Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony","volume":"65","author":"Lessa","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0390","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1086\/511643","article-title":"Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis","volume":"44","author":"Machado","year":"2007","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0395","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1086\/502980","article-title":"CD4+CD25+T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells","volume":"93","author":"Campanelli","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0400","first-page":"e54","article-title":"Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection","volume":"4","author":"Ivonise","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0405","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0410","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"1","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0415","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-\u03b2 and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell\u2013mediated pathology","volume":"8","author":"McGeachy","year":"2007","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0420","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0425","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1128\/IAI.00047-11","article-title":"Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens","volume":"79","author":"Cyktor","year":"2011","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0430","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","article-title":"TH1 cells control themselves by producing interleukin-10","volume":"7","author":"O\u2019Garra","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0435","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1084\/jem.194.10.f53","article-title":"Regulatory role of T cells producing both interferon \u03b3 and interleukin 10 in persistent infection","volume":"194","author":"Trinchieri","year":"2001","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0440","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.20070104","article-title":"Interleukin-10 production by effector T cells: Th1 cells show self control","volume":"204","author":"Trinchieri","year":"2007","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0445","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/wound.2013.0461","article-title":"Regenerative wound healing: the role of interleukin-10","volume":"3","author":"King","year":"2014","journal-title":"Adv. Wound Care (New Rochelle)"},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0450","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00403-013-1314-0","article-title":"Protection against TGF-\u03b21-induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring","volume":"305","author":"Shi","year":"2013","journal-title":"Arch. Dermatol. Res."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0455","doi-asserted-by":"crossref","first-page":"e98228","DOI":"10.1371\/journal.pone.0098228","article-title":"Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3 K\/AKT and STAT3 signaling pathways in scar-forming fibroblasts","volume":"9","author":"Shi","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0460","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/bbrc.1999.1455","article-title":"Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing","volume":"265","author":"Sato","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0465","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/wrr.12169","article-title":"Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring","volume":"22","author":"Wise","year":"2014","journal-title":"Wound Rep. Regener."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0470","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1099\/vir.0.18978-0","article-title":"Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells","volume":"84","author":"Lateef","year":"2003","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0475","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1099\/vir.0.82238-0","article-title":"Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10","volume":"87","author":"Chan","year":"2006","journal-title":"J. Gen. Virol."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0480","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.jid.5701232","article-title":"IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation","volume":"128","author":"Peranteau","year":"2008","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0485","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1524-475X.2007.00326.x","article-title":"Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation","volume":"6","author":"Gordon","year":"2008","journal-title":"Wound Rep. Regener."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0490","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.4049\/jimmunol.1103180","article-title":"IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration","volume":"189","author":"Deng","year":"2012","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0495","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/hep.510280621","article-title":"Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice","volume":"28","author":"Louis","year":"1998","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0500","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jhsa.2008.07.020","article-title":"Effect of interleukin-10 overexpression on the properties of healing tendon in a murine patellar tendon model","volume":"3","author":"Ricchetti","year":"2008","journal-title":"J. Hand Surg."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0505","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1529-8027.2007.00148.x","article-title":"Interleukin-10 reduces scarring and enhances regeneration at a site of sciatic nerve repair","volume":"12","author":"Atkins","year":"2007","journal-title":"J. Peripher. Nerv. Syst."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0510","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCULATIONAHA.112.112185","article-title":"Interleukin-10 treatment attenuates pressure overload\u2013induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3\u2013dependent inhibition of nuclear factor-\u03baB","volume":"126","author":"Verma","year":"2012","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0515","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/thx.2005.056317","article-title":"In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-\u03b2 in the lung","volume":"61","author":"Nakagome","year":"2006","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0520","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1053\/jpsu.2000.6868","article-title":"Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair","volume":"35","author":"Liechty","year":"2000","journal-title":"J. Pediatr. Surg."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0525","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2353\/ajpath.2007.060370","article-title":"Accelerated wound closure in mice deficient for interleukin-10","volume":"170","author":"Eming","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0530","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/wrr.12043","article-title":"Interleukin-10 reduces scar formation in both animal and human cutaneous wounds: results of two preclinical and phase II randomized control studies","volume":"21","author":"Kieran","year":"2013","journal-title":"Wound Rep. Regener."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0535","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1172\/JCI116570","article-title":"Interleukin 10 production correlates with pathology in human Leishmania donovani infections","volume":"92","author":"Ghalib","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0540","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.166.2.1141","article-title":"The role of IL-10 in promoting disease progression in leishmaniasis","volume":"166","author":"Kane","year":"2001","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0545","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.4049\/jimmunol.162.3.1723","article-title":"A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells","volume":"162","author":"Groux","year":"1999","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0550","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.4049\/jimmunol.171.7.3705","article-title":"The role of interleukin-10 in susceptibility of BALB\/c mice to infection with Leishmania mexicana and Leishmania a mazonensis","volume":"171","author":"Padigel","year":"2003","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0555","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.194.10.1497","article-title":"The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure","volume":"194","author":"Belkaid","year":"2001","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0560","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1084\/jem.20061886","article-title":"CD4+ CD25- Foxp3- Th1 cells are the source of IL-10\u2013mediated immune suppression in chronic cutaneous leishmaniasis","volume":"204","author":"Anderson","year":"2007","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0565","doi-asserted-by":"crossref","first-page":"e1003476","DOI":"10.1371\/journal.ppat.1003476","article-title":"T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine","volume":"9","author":"Schwarz","year":"2013","journal-title":"PLoS Pathog."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0570","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1128\/IAI.71.8.4278-4288.2003","article-title":"Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis","volume":"71","author":"Ji","year":"2003","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0575","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1084\/jem.20092532","article-title":"IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform","volume":"207","author":"Darrah","year":"2010","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0580","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.4049\/jimmunol.175.4.2517","article-title":"IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection","volume":"75","author":"Stober","year":"2005","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.cimid.2017.02.001_bib0585","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.4049\/jimmunol.180.9.6139","article-title":"Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis","volume":"180","author":"Salhi","year":"2008","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0590","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1086\/324665","article-title":"High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment","volume":"184","author":"Bourreau","year":"2001","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0595","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1128\/IAI.73.12.7853-7859.2005","article-title":"Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis","volume":"3","author":"Faria","year":"2005","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0600","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.2007.03436.x","article-title":"Can interferon-\u03b3 and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection?","volume":"149","author":"Gomes-Silva","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0605","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1046\/j.1365-2249.1998.00468.x","article-title":"High levels of plasma IL-10 and expression of IL-10 by keratinocytes during viscera leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis","volume":"111","author":"Gasim","year":"1998","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0610","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1086\/588387","article-title":"Increased levels of interleukin-10 and IgG3 are hallmarks of Indian post-kala-azar dermal leishmaniasis","volume":"197","author":"Ganguly","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"999","key":"10.1016\/j.cimid.2017.02.001_bib0615","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/pgmj.2008.069831","article-title":"Transforming growth factor \u03b21 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance","volume":"85","author":"Klass","year":"2009","journal-title":"Postgrad. Med. J."},{"issue":"6397","key":"10.1016\/j.cimid.2017.02.001_bib0620","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-\u03b21 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0625","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","article-title":"Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death","volume":"90","author":"Kulkarni","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0630","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0882-4010(91)90022-3","article-title":"Transforming growth factor beta (TGF-b 1) plays a detrimental role in the progression of experimental Mycobacterium avium infection; in vivo and in vitro evidence","volume":"11","author":"Denis","year":"1991","journal-title":"Microb. Pathog."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0635","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.4049\/jimmunol.179.8.5592","article-title":"IL-10-and TGF-\u03b2-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India","volume":"179","author":"Saha","year":"2007","journal-title":"J. Immunol."},{"issue":"5069","key":"10.1016\/j.cimid.2017.02.001_bib0640","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/science.1636092","article-title":"Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism","volume":"257","author":"Barral-Netto","year":"1992","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0645","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2005.08.006","article-title":"Upregulation of TGF-\u03b2, FOXP3, and CD4+ CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection","volume":"23","author":"Walther","year":"2005","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0650","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-\u03b2 signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0655","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1083\/jcb.114.6.1285","article-title":"Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10","volume":"114","author":"Bradham","year":"1991","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0660","first-page":"244","article-title":"Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts","volume":"57","author":"Gillery","year":"1992","journal-title":"Eur. J. Cell Biol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0665","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jcp.1041480119","article-title":"Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing","volume":"148","author":"Kane","year":"1991","journal-title":"J. Cell. Physiol."},{"issue":"16","key":"10.1016\/j.cimid.2017.02.001_bib0670","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0675","first-page":"485","article-title":"Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar","volume":"152","author":"Schmid","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0680","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00006534-200108000-00022","article-title":"Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts","volume":"108","author":"Chin","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"issue":"4820","key":"10.1016\/j.cimid.2017.02.001_bib0685","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1126\/science.2442813","article-title":"Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta","volume":"237","author":"Mustoe","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.cimid.2017.02.001_bib0690","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/14756366.2016.1161620","article-title":"Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs","volume":"31","author":"Jab\u0142o\u0144ska-Trypu\u0107","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0695","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regener."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0700","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-4781(00)00002-6","article-title":"Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription","volume":"1490","author":"White","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"18","key":"10.1016\/j.cimid.2017.02.001_bib0705","doi-asserted-by":"crossref","first-page":"10917","DOI":"10.1074\/jbc.271.18.10917","article-title":"Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes","volume":"71","author":"Mauviel","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.cimid.2017.02.001_bib0710","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1043-4666(03)00253-9","article-title":"Hypoxia modulates the effects of transforming growth factor-beta isoforms on matrix-formation by primary human lung fibroblasts","volume":"24","author":"Papakonstantinou","year":"2003","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0715","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/excr.1996.0326","article-title":"Endogenous TGF-beta activity is modified during cellular aging: effects on metalloproteinase and TIMP-1 expression","volume":"228","author":"Zeng","year":"1996","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0720","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/1523-1747.ep12481258","article-title":"Transforming growth factor-beta improves healing of radiation-impaired wounds","volume":"97","author":"Bernstein","year":"1991","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0725","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/bjd.12843","article-title":"Topical photodynamic therapy following excisional wounding of human skin increases production of transforming growth factor-\u03b23 and matrix metalloproteinases 1 and 9, with associated improvement in dermal matrix organization","volume":"171","author":"Mills","year":"2014","journal-title":"Br. J. Dermatol."},{"issue":"22","key":"10.1016\/j.cimid.2017.02.001_bib0730","doi-asserted-by":"crossref","first-page":"23098","DOI":"10.1074\/jbc.M311430200","article-title":"Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK\/ERK","volume":"279","author":"Xu","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0735","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1002\/art.23134","article-title":"Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts","volume":"56","author":"Shi-wen","year":"2007","journal-title":"Arthritis Rheumatol."},{"issue":"13","key":"10.1016\/j.cimid.2017.02.001_bib0740","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1096\/fasebj.13.13.1774","article-title":"Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP","volume":"13","author":"Duncan","year":"1999","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0745","first-page":"18","article-title":"The role of the TGF-\u03b2 family in wound healing, burns and scarring: a review","volume":"2","author":"Penn","year":"2012","journal-title":"Int. J. Burns Trauma"},{"issue":"3\u20134","key":"10.1016\/j.cimid.2017.02.001_bib0750","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2119\/molmed.2009.00149","article-title":"Attenuation of the transforming growth factor \u03b2-signaling pathway in chronic venous ulcers","volume":"16","author":"Pastar","year":"2010","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0755","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jcp.10301","article-title":"Fibroblasts from chronic wounds show altered TGF-\u03b2-signaling and decreased TGF-\u03b2 Type II Receptor expression","volume":"195","author":"Kim","year":"2003","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0760","first-page":"3","article-title":"Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease","volume":"143","author":"Kulkarni","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cimid.2017.02.001_bib0765","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ki.1997.185","article-title":"Biology of TGF-bold beta in knockout and transgenic mouse models","volume":"51","author":"B\u00f6ttinger","year":"1997","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0770","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/jcs.107.5.1137","article-title":"Neutralising antibody to TGF-beta 1, 2 reduces cutaneous scarring in adult rodents","volume":"107","author":"Shah","year":"1994","journal-title":"J. Cell Sci."},{"issue":"8787","key":"10.1016\/j.cimid.2017.02.001_bib0775","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0140-6736(92)90009-R","article-title":"Control of scarring in adult wounds by neutralising antibody to transforming growth factor \u03b2","volume":"339","author":"Shah","year":"1992","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0780","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.4049\/jimmunol.163.10.5693","article-title":"Anti-TGF-\u03b2 treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma","volume":"163","author":"McCormick","year":"1999","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.cimid.2017.02.001_bib0785","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"6179","key":"10.1016\/j.cimid.2017.02.001_bib0790","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/334260a0","article-title":"Deactivation of macrophages by transforming growth factor-beta","volume":"34","author":"Tsunawaki","year":"1988","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0795","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1749-6632.1993.tb35934.x","article-title":"Modulation of macrophage function by transforming growth factor \u03b2, interleukin-4, and interleukin-10a","volume":"685","author":"Bogdan","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.cimid.2017.02.001_bib0800","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.cimid.2017.02.001_bib0805","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17Cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.cimid.2017.02.001_bib0810","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1172\/JCI70064","article-title":"Dendritic epidermal T cells regulate skin antimicrobial barrier function","volume":"123","author":"MacLeod","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0815","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.4049\/jimmunol.1303297","article-title":"Skin-resident T cells sense ultraviolet radiation\u2013induced injury and contribute to DNA repair","volume":"192","author":"MacLeod","year":"2014","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0820","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.4049\/jimmunol.1003235","article-title":"Lack of Th17 cell generation in patients with severe burn injuries","volume":"187","author":"Inatsu","year":"2011","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.cimid.2017.02.001_bib0825","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.463","article-title":"IL-22 promotes fibroblast-mediated wound repair in the skin","volume":"133","author":"McGee","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0830","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/wound.2014.0608","article-title":"The innate immune system in acute and chronic wounds","volume":"5","author":"MacLeod","year":"2016","journal-title":"Adv. Wound Care"},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0835","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1084\/jem.20081787","article-title":"A role for human skin-resident T cells in wound healing","volume":"06","author":"Toulon","year":"2009","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0840","first-page":"947","article-title":"Transforming growth factor-beta in human cutaneous leishmaniasis","volume":"147","author":"Barral","year":"1995","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0845","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1073\/pnas.90.8.3442","article-title":"Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis","volume":"90","author":"Barral","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0850","first-page":"16","article-title":"Interleukin-10 and transforming growth factor-\u03b2 in early and late lesions of patients with Leishmania major induced cutaneous leishmaniasis","volume":"7","author":"Hejazi","year":"2012","journal-title":"Iran. J. Parasitol."},{"issue":"4","key":"10.1016\/j.cimid.2017.02.001_bib0855","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.vetimm.2008.11.020","article-title":"Expression of IFN-\u03b3, TNF-\u03b1, IL-10 and TGF-\u03b2 in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi","volume":"128","author":"Alves","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0860","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/IAI.62.3.837-842.1994","article-title":"Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis","volume":"62","author":"Melby","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cimid.2017.02.001_bib0865","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cellimm.2016.07.004","article-title":"Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines","volume":"309","author":"Banerjee","year":"2016","journal-title":"Cell. Immunol."},{"issue":"7090","key":"10.1016\/j.cimid.2017.02.001_bib0870","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"issue":"7090","key":"10.1016\/j.cimid.2017.02.001_bib0875","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"41","author":"Mangan","year":"2006","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0880","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology","volume":"8","author":"McGeachy","year":"2007","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.cimid.2017.02.001_bib0885","doi-asserted-by":"crossref","first-page":"e1003243","DOI":"10.1371\/journal.ppat.1003243","article-title":"IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection","volume":"9","author":"Gonzalez-Lombana","year":"2013","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.cimid.2017.02.001_bib0890","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1086\/599380","article-title":"Interleukin 17 production among patients with american cutaneous leishmaniasis","volume":"200","author":"Bacellar","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.cimid.2017.02.001_bib0895","doi-asserted-by":"crossref","first-page":"e0134698","DOI":"10.1371\/journal.pone.0134698","article-title":"IL-22 protects against tissue damage during cutaneous leishmaniasis","volume":"10","author":"Gimblet","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0900","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2013.12.016","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis","volume":"6","author":"Oliveira","year":"2014","journal-title":"Cytokine"},{"issue":"12","key":"10.1016\/j.cimid.2017.02.001_bib0905","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1084\/jem.185.12.2101","article-title":"Altered immune responses in interleukin 10 transgenic mice","volume":"185","author":"Hagenbaugh","year":"1997","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.cimid.2017.02.001_bib0910","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1086\/515297","article-title":"Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major","volume":"177","author":"Louzir","year":"1998","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.cimid.2017.02.001_bib0915","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.162.2.974","article-title":"Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production","volume":"62","author":"Li","year":"1999","journal-title":"J. Immunol."}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957117300103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957117300103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:06:21Z","timestamp":1692705981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957117300103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":183,"alternative-id":["S0147957117300103"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2017.02.001","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-\u03b2","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2017.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}