{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:56:47Z","timestamp":1782410207836,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.cimid.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T23:40:23Z","timestamp":1550706023000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites"],"prefix":"10.1016","volume":"64","author":[{"given":"Irwin Rose Alencar","family":"de Menezes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Henrique Sousa","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Augusti Boligon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Rol\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathia","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas","family":"Melo Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Socorro","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Relison","family":"Tintino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo Luiz","family":"Silva Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Rodrigues","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Roberto Guedes","family":"da Silva Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucindo Jos\u00e9","family":"Quintans-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cimid.2019.02.007_bib0005","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1371\/journal.pntd.0000256","article-title":"Neglected infections of poverty in the United States of America","volume":"2","author":"Hotez","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cimid.2019.02.007_bib0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1756-3305-4-197","article-title":"One health: the global challenge of epidemic and endemic leishmaniasis","volume":"4","author":"Palatnik-de-Sousa","year":"2011","journal-title":"Parasit. Vectors."},{"key":"10.1016\/j.cimid.2019.02.007_bib0015","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1590\/S0102-311X2008001200024","article-title":"Visceral leishmaniasis in Brazil: trends and challenges","volume":"24","author":"Maia-Elkhoury","year":"2008","journal-title":"Cad. Saude Publica."},{"key":"10.1016\/j.cimid.2019.02.007_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actatropica.2013.10.002","article-title":"Prevalence of Chagas disease in Brazil: a systematic review and meta-analysis","volume":"130","author":"Martins-Melo","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.cimid.2019.02.007_bib0025","first-page":"42","article-title":"Molecular mechanisms of antibiotic resistance","volume":"42","author":"Blair","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0030","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.cimid.2019.02.007_bib0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"Holmes","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.cimid.2019.02.007_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/nyas.12954","article-title":"Bioactive natural products from novel microbial sources","volume":"1354","author":"Challinor","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cimid.2019.02.007_bib0045","doi-asserted-by":"crossref","first-page":"E1715","DOI":"10.3390\/molecules22101715","article-title":"Screening a natural product-based library against kinetoplastid parasites","volume":"22","author":"Zulfiqar","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.cimid.2019.02.007_bib0050","first-page":"115","article-title":"Antitrypanosomal activity of flavonoid extracted from Ximenia americana stem bark","volume":"3","author":"Maikai","year":"2010","journal-title":"Int. J. Biol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0055","series-title":"Ximenia americana: Chemistry, Pharmacology and Biological Properties, a Review","author":"Monte","year":"2012"},{"key":"10.1016\/j.cimid.2019.02.007_bib0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0367-326X(02)00302-7","article-title":"Antimicrobial activity of Ximenia americana","volume":"74","author":"Omer","year":"2003","journal-title":"Fitoterapia"},{"key":"10.1016\/j.cimid.2019.02.007_bib0065","first-page":"104","article-title":"Antipyretic activity of aqueous extract from Ximenia americana","volume":"5","author":"Soro","year":"2015","journal-title":"Int. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0070","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S2222-1808(15)60957-4","article-title":"Evaluation of in vitro antioxidant and anti-inflammatory activities of Ximenia americana extracts","volume":"5","author":"Shettar","year":"2015","journal-title":"Asian Pacific J. Trop. Dis."},{"key":"10.1016\/j.cimid.2019.02.007_bib0075","first-page":"50","article-title":"In vitro and in vivo evaluation of anti-trypanosomal activity of stem bark of Ximenia americana","volume":"2","author":"Maikai","year":"2010","journal-title":"Int. J. Biol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2018.04.041","article-title":"HPLC profile and antiedematogenic activity of Ximenia americana L.(Olacaceae) in mice models of skin inflammation","volume":"119","author":"da Silva","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2015.06.022","article-title":"Ethnopharmacological study of plants sold for therapeutic purposes in public markets in Northeast Brazil","volume":"172","author":"de Carvalho Nilo Bitu","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0090","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1590\/1983-084X\/13_059","article-title":"Potencial terap\u00eautico e uso de plantas medicinais em uma \u00e1rea de Caatinga no estado do Cear\u00e1, nordeste do Brasil","volume":"16","author":"Ribeiro","year":"2014","journal-title":"Rev. Bras. Plantas Med."},{"key":"10.1016\/j.cimid.2019.02.007_bib0095","first-page":"491","article-title":"Therapeutic traditional practices: usage and knowledge of cerrado plants in the State of Pernambuco (Northeastern Brazil)","volume":"14","author":"Mac\u00eado","year":"2015","journal-title":"Bol. Latinoam. y del Caribe Plantas Med. y Aromat."},{"key":"10.1016\/j.cimid.2019.02.007_bib0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2014.09.001","article-title":"Ethnopharmacology of medicinal plants of carrasco, northeastern Brazil","volume":"157","author":"Souza","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0105","series-title":"Plantas medicinais: guia de sele\u00e7\u00e3o e emprego de plantas usadas em fitoterapia no Nordeste do Brasil","author":"Matos","year":"2007"},{"key":"10.1016\/j.cimid.2019.02.007_bib0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3923\/rjphyto.2012.84.91","article-title":"HPLC\/DAD profile and determination of total phenolics, flavonoids, tannins and alkaloids contents of Scutia buxifolia Reissek stem bark","volume":"6","author":"Boligon","year":"2012","journal-title":"Res. J. Phytochem."},{"key":"10.1016\/j.cimid.2019.02.007_bib0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nut.2013.10.005","article-title":"Brazilian nut consumption by healthy volunteers improves inflammatory parameters","volume":"30","author":"Colpo","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.cimid.2019.02.007_bib0120","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1590\/S0074-02762002000800006","article-title":"Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain","volume":"97","author":"Le-Senne","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"10.1016\/j.cimid.2019.02.007_bib0125","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.ejmech.2007.11.007","article-title":"Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies","volume":"43","author":"Roldos","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cimid.2019.02.007_bib0130","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/640682","article-title":"Modulation of the antibiotic activity by extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan","volume":"2013","author":"Figueredo","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.cimid.2019.02.007_bib0135","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1021\/jm9509410","article-title":"De Novo antimicrobial peptides with low mammalian cell toxicity","volume":"39","author":"Javadpour","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cimid.2019.02.007_bib0140","first-page":"239","article-title":"Studies of antimicrobial activity and chemical constituents of Ximenia americana","volume":"2","author":"Ogunleye","year":"2003","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.cimid.2019.02.007_bib0145","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jep.2011.12.031","article-title":"Bioactive polyphenols in Ximenia americana and the traditional use among Malian healers","volume":"139","author":"Le","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0150","first-page":"23","article-title":"Phytochemical screening and analgesic activity of methanolic extract of Ximenia americana","volume":"3","author":"Siddaiah","year":"2009","journal-title":"J. Pharm. Chem."},{"key":"10.1016\/j.cimid.2019.02.007_bib0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exppara.2012.01.015","article-title":"The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase","volume":"130","author":"da Silva","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cimid.2019.02.007_bib0160","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1590\/S0037-86822011000500007","article-title":"Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil","volume":"44","author":"Vila-Nova","year":"2011","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.cimid.2019.02.007_bib0165","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/jac\/dkn053","article-title":"Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity","volume":"61","author":"Sen","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cimid.2019.02.007_bib0170","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/np400193m","article-title":"Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes","volume":"76","author":"Fonseca-Silva","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.cimid.2019.02.007_bib0175","first-page":"30","article-title":"Antimicrobial properties of stem bark extracts of Ximenia americana","volume":"1","author":"Maikai","year":"2009","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.cimid.2019.02.007_bib0180","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3923\/jms.2007.284.288","article-title":"Phytochemical and antimicrobial investigation of the aqueous and methanolic extracts of Ximenia americana","volume":"7","author":"James","year":"2007","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.cimid.2019.02.007_bib0185","first-page":"92","article-title":"Modulation of the erythromycin resistance in Staphylococcus aureus by ethanolic extracts of Ximenia americana L and Schinopsis brasiliensis Engl","volume":"14","author":"Da Silva","year":"2015","journal-title":"Bol. Latinoam. y del Caribe Plantas Med. y Arom\u00e1ticas"},{"key":"10.1016\/j.cimid.2019.02.007_bib0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cimid.2019.02.007_bib0195","first-page":"8","article-title":"Composi\u00e7\u00e3o fen\u00f3lica e avalia\u00e7\u00e3o da atividade antioxidante e citoprotetora dos extratos de Psidium guajava L. var. pyrifera e Psidium guajava L. var. pom\u00edfera. Cad","volume":"13","author":"Leite","year":"2014","journal-title":"Cult e Ci\u00eancia"},{"key":"10.1016\/j.cimid.2019.02.007_bib0200","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1080\/10942912.2011.565905","article-title":"Association between food and drugs: antimicrobial and synergistic activity of Annona muricata L","volume":"16","author":"Bento","year":"2013","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.cimid.2019.02.007_bib0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fitote.2010.11.016","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"82","author":"Wagner","year":"2011","journal-title":"Fitoterapia"}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957119300414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957119300414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:43:27Z","timestamp":1758955407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957119300414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":41,"alternative-id":["S0147957119300414"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2019.02.007","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ximenia americana L. enhances the antibiotic activity and inhibit the development of kinetoplastid parasites","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}