{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:12:46Z","timestamp":1786986766535,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008257","name":"Tarbiat Modares University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.cimid.2020.101413","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T16:26:03Z","timestamp":1578500763000},"page":"101413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Vaccination with a novel multi-epitope ROP8 DNA vaccine against acute Toxoplasma gondii infection induces strong B and T cell responses in mice"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-7217","authenticated-orcid":false,"given":"Masoud","family":"Foroutan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-8214","authenticated-orcid":false,"given":"Fatemeh","family":"Ghaffarifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-7659","authenticated-orcid":false,"given":"Zohreh","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-5513","authenticated-orcid":false,"given":"Abdolhosein","family":"Dalimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cimid.2020.101413_bib0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.vetpar.2017.07.013","article-title":"The global seroprevalence of Toxoplasma gondii among wild boars: a systematic review and meta-analysis","volume":"244","author":"Rostami","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.cimid.2020.101413_bib0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","article-title":"The history of Toxoplasma gondii--the first 100 years","volume":"55","author":"Dubey","year":"2008","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.cimid.2020.101413_bib0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/00071668.2013.763899","article-title":"Detection and genotyping of Toxoplasma gondii strains isolated from birds in the southwest of Iran","volume":"54","author":"Khademvatan","year":"2013","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.cimid.2020.101413_bib0020","first-page":"147","article-title":"Sur une infection \u00e0 corps de Leishman (ou organismes voisins) du gondi","author":"Nicolle","year":"1908","journal-title":"CR Acad Sci"},{"key":"10.1016\/j.cimid.2020.101413_bib0025","first-page":"389","article-title":"Toxoplasma gondii infection in immunocompromised patients: a systematic review and meta-analysis","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cimid.2020.101413_bib0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jogoh.2017.12.003","article-title":"An updated literature review on maternal-fetal and reproductive disorders of Toxoplasma gondii infection","volume":"47","author":"Fallahi","year":"2018","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.cimid.2020.101413_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007807","article-title":"Acute Toxoplasma infection in pregnant women worldwide: a systematic review and meta-analysis","volume":"13","author":"Rostami","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cimid.2020.101413_bib0040","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.biopha.2016.05.041","article-title":"Human toxoplasmosis-Searching for novel chemotherapeutics","volume":"82","author":"Antczak","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cimid.2020.101413_bib0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/DDDT.S60973","article-title":"Drugs in development for toxoplasmosis: advances, challenges, and current status","volume":"11","author":"Alday","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.cimid.2020.101413_bib0050","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1017\/S0031182011001776","article-title":"The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures","volume":"139","author":"Kropf","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.cimid.2020.101413_bib0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7774\/cevr.2018.7.1.24","article-title":"Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine","volume":"7","author":"Foroutan","year":"2018","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1586\/erv.09.27","article-title":"Current status of toxoplasmosis vaccine development","volume":"8","author":"Kur","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.cimid.2020.101413_bib0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.7774\/cevr.2018.7.2.93","article-title":"Recent progress in microneme-based vaccines development against Toxoplasma gondii","volume":"7","author":"Foroutan","year":"2018","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7774\/cevr.2019.8.1.4","article-title":"Rhoptry antigens as Toxoplasma gondii vaccine target","volume":"8","author":"Foroutan","year":"2019","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0075","first-page":"259","article-title":"Rhomboid antigens are promising targets in the vaccine development against Toxoplasma gondii","volume":"18","author":"Foroutan","year":"2019","journal-title":"EXCLI J."},{"key":"10.1016\/j.cimid.2020.101413_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2019.105696","article-title":"A systematic review on the role of GRA proteins of Toxoplasma gondii in host immunization","volume":"165","author":"Rezaei","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.cimid.2020.101413_bib0085","article-title":"Toxoplasma rhoptries: unique secretory organelles and source of promising vaccine proteins for immunoprevention of toxoplasmosis","volume":"2008","author":"Dlugonska","year":"2008","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.cimid.2020.101413_bib0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.meegid.2018.04.033","article-title":"Bioinformatics analysis of ROP8 protein to improve vaccine design against Toxoplasma gondii","volume":"62","author":"Foroutan","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.cimid.2020.101413_bib0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jmr.893","article-title":"Predicting linear B-cell epitopes using string kernels","volume":"21","author":"El-Manzalawy","year":"2008","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.cimid.2020.101413_bib0100","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.cimid.2020.101413_bib0105","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cimid.2020.101413_bib0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4939-2343-4_9","article-title":"Eukaryotic glycosylation: online methods for site prediction on protein sequences","volume":"1273","author":"Joshi","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cimid.2020.101413_bib0115","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/bioinformatics\/bti130","article-title":"Prediction of N-terminal acetylation sites","volume":"21","author":"Kiemer","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2020.101413_bib0120","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1006\/jmbi.1999.3310","article-title":"Sequence and structure-based prediction of eukaryotic protein phosphorylation sites","volume":"294","author":"Blom","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cimid.2020.101413_bib0125","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0076-6879(96)66034-0","article-title":"GOR method for predicting protein secondary structure from amino acid sequence","volume":"266","author":"Garnier","year":"1996","journal-title":"Methods Enzymol"},{"issue":"Suppl 1","key":"10.1016\/j.cimid.2020.101413_bib0130","first-page":"S162","article-title":"Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective","volume":"30","author":"Guex","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.cimid.2020.101413_bib0135","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.bpj.2011.10.024","article-title":"Improving the physical realism and structural accuracy of protein models by a two-step atomic-level energy minimization","volume":"101","author":"Xu","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.cimid.2020.101413_bib0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: phi,psi and Cbeta deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.cimid.2020.101413_bib0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0150","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/jvi.55.3.836-839.1985","article-title":"Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"key":"10.1016\/j.cimid.2020.101413_bib0155","first-page":"45","article-title":"Prediction of the secondary structure of proteins from their amino acid sequence","volume":"47","author":"Chou","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"10.1016\/j.cimid.2020.101413_bib0160","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01195768","article-title":"Prediction of chain flexibility in proteinsa - Tool for the Selection of Peptide Antigens","volume":"72","author":"Karplus","year":"1985","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.cimid.2020.101413_bib0165","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","article-title":"New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites","volume":"25","author":"Parker","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.cimid.2020.101413_bib0170","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cimid.2020.101413_bib0175","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cimid.2020.101413_bib0180","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1093\/bioinformatics\/btq551","article-title":"High-throughput prediction of protein antigenicity using protein microarray data","volume":"26","author":"Magnan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2020.101413_bib0185","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cimid.2020.101413_bib0190","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkl343","article-title":"AlgPred: prediction of allergenic proteins and mapping of IgE epitopes","volume":"34","author":"Saha","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0195","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/bioinformatics\/btp386","article-title":"Accurate sequence-based prediction of protein solubility","volume":"25","author":"Magnan","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2020.101413_bib0200","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0205","first-page":"392","article-title":"Expression of plasmid encoded GRA4 gene of toxoplasma gondii RH strain in CHO eukaryotic cells","volume":"13","author":"Aghdasi","year":"2018","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.cimid.2020.101413_bib0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3103\/S0891416819010099","article-title":"Evaluation of Anti-Toxoplasma gondii immune responses in BALB\/c mice induced by DNA vaccines encoding surface antigen 1 (SAG1) and 3 (SAG3)","volume":"34","author":"Sobati","year":"2019","journal-title":"Mol. Genet. Microbiol. Virol."},{"key":"10.1016\/j.cimid.2020.101413_bib0215","first-page":"590","article-title":"Evaluation of immunogenicity of cocktail DNA vaccine containing plasmids encoding complete GRA5, SAG1, and ROP2 antigens of toxoplasma gondii in BALB\/C mice","volume":"10","author":"Naserifar","year":"2015","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.cimid.2020.101413_bib0220","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1016\/j.vaccine.2015.10.077","article-title":"Toxoplasma gondii: vaccination with a DNA vaccine encoding T- and B-cell epitopes of SAG1, GRA2, GRA7 and ROP16 elicits protection against acute toxoplasmosis in mice","volume":"33","author":"Cao","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2020.101413_bib0225","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/20477724.2018.1446773","article-title":"Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design","volume":"112","author":"Kazi","year":"2018","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.cimid.2020.101413_bib0230","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.mib.2007.09.013","article-title":"Rhoptries: an arsenal of secreted virulence factors","volume":"10","author":"Bradley","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.cimid.2020.101413_bib0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrmicro1800","article-title":"Kiss and spit: the dual roles of Toxoplasma rhoptries","volume":"6","author":"Boothroyd","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cimid.2020.101413_bib0240","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1462-5822.2007.00909.x","article-title":"Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction","volume":"9","author":"Dubremetz","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cimid.2020.101413_bib0245","doi-asserted-by":"crossref","first-page":"34245","DOI":"10.1074\/jbc.M504158200","article-title":"Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii","volume":"280","author":"Bradley","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cimid.2020.101413_bib0250","series-title":"Fundamentai Immunology","first-page":"235","article-title":"Immunogenicity and antigen structure","author":"Berzofsky","year":"1993"},{"key":"10.1016\/j.cimid.2020.101413_bib0255","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1756-0500-2-111","article-title":"A comprehensive resource for integrating and displaying protein post-translational modifications","volume":"2","author":"Lee","year":"2009","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.cimid.2020.101413_bib0260","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00436-015-4824-1","article-title":"Review on the identification and role of Toxoplasma gondii antigenic epitopes","volume":"115","author":"Wang","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.cimid.2020.101413_bib0265","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1358\/dot.2018.54.5.2807864","article-title":"Plasmid DNA vaccines: where are we now?","volume":"54","author":"Ghaffarifar","year":"2018","journal-title":"Drugs Today"},{"key":"10.1016\/j.cimid.2020.101413_bib0270","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/IAI.68.3.1026-1033.2000","article-title":"B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii","volume":"68","author":"Sayles","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cimid.2020.101413_bib0275","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.3128869","article-title":"Interferon-gamma: the major mediator of resistance against Toxoplasma gondii","volume":"240","author":"Suzuki","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cimid.2020.101413_bib0280","first-page":"17","article-title":"T-cell immunity in human chronic toxoplasmosis","volume":"41","author":"El-Kady","year":"2011","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/j.cimid.2020.101413_bib0285","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1586\/14760584.2016.1124762","article-title":"Molecular mechanisms for enhanced DNA vaccine immunogenicity","volume":"15","author":"Li","year":"2016","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.cimid.2020.101413_bib0290","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbaexp.2003.11.005","article-title":"Intramuscular plasmid DNA electrotransfer: biodistribution and degradation","volume":"1676","author":"Bureau","year":"2004","journal-title":"Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression"},{"key":"10.1016\/j.cimid.2020.101413_bib0295","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.vaccine.2010.11.012","article-title":"Evaluation of the immune response induced by DNA vaccine cocktail expressing complete SAG1 and ROP2 genes against toxoplasmosis","volume":"29","author":"Hoseinian Khosroshahi","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2020.101413_bib0300","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/pim.12306","article-title":"Evaluation of immune responses induced by rhoptry protein 5 and rhoptry protein 7 DNA vaccines against Toxoplasma gondii","volume":"38","author":"Wang","year":"2016","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.cimid.2020.101413_bib0305","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.exppara.2014.02.016","article-title":"Toxoplasma gondii: protective immunity induced by rhoptry protein 9 (TgROP9) against acute toxoplasmosis","volume":"139","author":"Chen","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.cimid.2020.101413_bib0310","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/CVI.00397-12","article-title":"Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice","volume":"19","author":"Wang","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.cimid.2020.101413_bib0315","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/CVI.00312-10","article-title":"Protective immunity induced by Toxoplasma gondii rhoptry protein 16 against toxoplasmosis in mice","volume":"18","author":"Yuan","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.cimid.2020.101413_bib0320","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1051\/parasite\/2016004","article-title":"DNA vaccination with a gene encoding Toxoplasma gondii Rhoptry Protein 17 induces partial protective immunity against lethal challenge in mice","volume":"23","author":"Wang","year":"2016","journal-title":"Parasite"},{"key":"10.1016\/j.cimid.2020.101413_bib0325","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.vaccine.2011.06.110","article-title":"Protective effect against toxoplasmosis in mice induced by DNA immunization with gene encoding Toxoplasma gondii ROP18","volume":"29","author":"Yuan","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2020.101413_bib0330","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.actatropica.2017.09.007","article-title":"Vaccination with a DNA vaccine encoding Toxoplasma gondii ROP54 induces protective immunity against toxoplasmosis in mice","volume":"176","author":"Yang","year":"2017","journal-title":"Acta Trop."}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957120300011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957120300011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:44:08Z","timestamp":1758955448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957120300011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":66,"alternative-id":["S0147957120300011"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2020.101413","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccination with a novel multi-epitope ROP8 DNA vaccine against acute Toxoplasma gondii infection induces strong B and T cell responses in mice","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2020.101413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101413"}}