{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:10:29Z","timestamp":1782875429954,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.cimid.2025.102358","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T17:39:00Z","timestamp":1746985140000},"page":"102358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["First report on the molecular characterization and phylogenetic analysis of meq oncogene from virulent serotype-1 Marek's disease virus in laying hen flocks and broiler breeders in Algeria"],"prefix":"10.1016","volume":"120","author":[{"given":"Samia","family":"Ameziane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Salhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Hammami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Amraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Bensalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Tahraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Ouchene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadjet Amina","family":"Khelifi Touhami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Hireche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Agabou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cimid.2025.102358_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/03079457.2011.646238","article-title":"The long view: 40 years of Marek's disease research and Avian Pathology","volume":"41","author":"Biggs","year":"2012","journal-title":"Avian Pathol."},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/cancers12030647","article-title":"Latest insights into Marek\u2019s disease virus pathogenesis and tumorigenesis","volume":"12","author":"Bertzbach","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.cimid.2025.102358_bib3","series-title":"Marek's Disease: An Evolving Problem","first-page":"49","article-title":"Marek's disease: a worldwide problem","author":"Morrow","year":"2004"},{"key":"10.1016\/j.cimid.2025.102358_bib4","series-title":"Current Topics in Microbiology and Immunology","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-642-56863-3_2","article-title":"Pathogenesis of Marek\u2019s disease virus infection","author":"Calnek","year":"2001"},{"key":"10.1016\/j.cimid.2025.102358_bib5","series-title":"Veterinary Virology","first-page":"301","author":"Frederick","year":"1999"},{"issue":"5","key":"10.1016\/j.cimid.2025.102358_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/03079459808419376","article-title":"Central nervous system lesions induced experimentally by a very virulent strain of Marek\u2019s disease virus in Marek\u2019s disease-resistant chickens","volume":"27","author":"Cho","year":"1998","journal-title":"Avian Pathol."},{"key":"10.1016\/j.cimid.2025.102358_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2307\/1592455","article-title":"Increased virulence of Marek's disease virus field isolates","volume":"41","author":"Witter","year":"1997","journal-title":"Avian Dis."},{"key":"10.1016\/j.cimid.2025.102358_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1586\/14760584.4.1.77","article-title":"Use of Marek\u2019s disease vaccines: could they be driving the virus to increasing virulence?","volume":"4","author":"Davison","year":"2005","journal-title":"Expert. Rev. Vaccin."},{"key":"10.1016\/j.cimid.2025.102358_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/03079450500059255","article-title":"Classification of Marek\u2019s disease viruses according to pathotype: philosophy and methodology","volume":"34","author":"Witter","year":"2005","journal-title":"Avian Pathol."},{"issue":"11","key":"10.1016\/j.cimid.2025.102358_bib10","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.14202\/vetworld.2021.3021-3027","article-title":"Occurrence of Marek\u2019s disease in vaccinated Algerian broiler breeder flocks: a histopathological survey","volume":"14","author":"Lounas","year":"2021","journal-title":"Vet. World"},{"key":"10.1016\/j.cimid.2025.102358_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-015-0493-7","article-title":"Outbreak of Marek\u2019s disease in a vaccinated broiler breeding flock during its peak egg-laying period in China","volume":"11","author":"Zhuang","year":"2015","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.cimid.2025.102358_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12917-021-03130-2","article-title":"First report of serotype-1 Marek\u2019s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study","volume":"18","author":"Ongor","year":"2022","journal-title":"BMC Vet. Res"},{"issue":"1992","key":"10.1016\/j.cimid.2025.102358_bib13","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1073\/pnas.89.9.4042","article-title":"Marek\u2019s disease virus encodes a basic-leucine zipper gene resembling the fos\/jun oncogenes that is highly expressed in lymphoblastoid tumors","volume":"89","author":"Jones","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cimid.2025.102358_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetmic.2004.06.007","article-title":"Comparative analysis of Marek's disease virus (MDV) glycoprotein-, lytic antigen pp38- and transformation antigen Meq-encoding genes: association of meq mutations with MDVs of high virulence","volume":"102","author":"Shamblin","year":"2004","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.cimid.2025.102358_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/03079457.2012.656077","article-title":"Pathotyping of Australian isolates of Marek\u2019s disease virus and association of pathogenicity with meq gene polymorphism","volume":"41","author":"Renz","year":"2012","journal-title":"Avian Pathol."},{"key":"10.1016\/j.cimid.2025.102358_bib16","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.3382\/ps\/pez095","article-title":"Molecular characterization of the meq gene of Marek\u2019s disease viruses detected in unvaccinated backyard chickens reveals the circu-lation of low- and high-virulence strains","volume":"98","author":"Mescolini","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.cimid.2025.102358_bib17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/ani12050540","article-title":"A review on the Marek\u2019s disease out-break and its virulence-related meq genovariation in Asia between 2011\u20132021","volume":"12","author":"Song","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.cimid.2025.102358_bib18","unstructured":"S.A.N. Group Biotech Germany GmbH. Kylt\u00ae RNA\/DNA Purification Manual: Purification Kit for RNA and DNA from Veterinary Samples [Internet]. H\u00f6ltinghausen (Germany): SAN Group Biotech Germany GmbH; 2020. Available from: \u3008https:\/\/www.kylt.eu\/templates\/images\/products\/168_1_pdf\/Kylt_RNA-DNA-Purification9\u3009."},{"key":"10.1016\/j.cimid.2025.102358_bib19","unstructured":"S.A.N. Group Biotech Germany GmbH. Kylt\u00ae MDV & Rispens DIVA Real-Time PCR Detection Manual [Internet]. H\u00f6ltinghausen (Germany): SAN Group Biotech Germany GmbH; 2019. Available from: \u3008https:\/\/www.kylt.eu\/kylt-mdv-rispens-diva-en\u3009."},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00705-021-05355-w","article-title":"A highly pathogenic Marek\u2019s disease virus isolate from chickens immunized with a bivalent vaccine in China","volume":"167","author":"Li","year":"2022","journal-title":"Arch. Virol."},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib21","doi-asserted-by":"crossref","first-page":"C31","DOI":"10.1016\/j.vaccine.2008.04.009","article-title":"Marek's disease vaccines: a solution for today but a worry for tomorrow","volume":"18:26","author":"Gimeno","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.cimid.2025.102358_bib22","series-title":"Avian Medicine","first-page":"266","article-title":"Viral diseases","author":"Wernery","year":"2000"},{"issue":"1","key":"10.1016\/j.cimid.2025.102358_bib23","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1038\/s41598-023-37636-6","article-title":"Application of structural equation modelling to inform best management strategies for Marek\u2019s disease in Amhara region, Ethiopia","volume":"13","author":"Birhan","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cimid.2025.102358_bib24","article-title":"Marek\u2019s disease is a threat for large scale poultry production. In Updates on Veterinary Anatomy and Physiology","author":"Kozdru\u0144","year":"2021","journal-title":"IntechOpen"},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5958\/0973-970X.2022.00033.5","article-title":"Diagnosis of Marek\u2019s disease through histological, immunohistochemical, and molecular applications: a comparative study","volume":"46","author":"Reddy","year":"2022","journal-title":"Indian J. Vet. Pathol."},{"key":"10.1016\/j.cimid.2025.102358_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1637\/7273-090704R1.1","article-title":"Examination of the effect of a naturally occurring mutations in glycoprotein L on Marek\u2019s disease virus pathogenesis","volume":"80","author":"Santin","year":"2006","journal-title":"Avian Dis."},{"key":"10.1016\/j.cimid.2025.102358_bib27","first-page":"181","article-title":"Pathological investigation of Marek\u2019s disease in a pullet farm in Bangladesh and detection of Marek\u2019s disease virus by PCR. SAARC Journal of Agriculture","volume":"16","author":"Biswas","year":"2018"},{"key":"10.1016\/j.cimid.2025.102358_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/9781119650522.ch10","article-title":"Musculoskeletal system","author":"Kim","year":"2024","journal-title":"Pathol. Pet. Aviary Birds"},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib29","first-page":"345","article-title":"Histological and ELISA investigations to uncover subclinical and clinical Marek\u2019s disease in broiler chickens in Jordan","volume":"55","author":"Hayajneh","year":"2021","journal-title":"Agrociencia"},{"key":"10.1016\/j.cimid.2025.102358_bib30","article-title":"May). Diagnosis of Marek\u2019s Disease in Isa Brown Layer Chicken based on Anatomical Pathology and Histopathological Examination. In","volume":"1174","author":"Aliza","year":"2023"},{"key":"10.1016\/j.cimid.2025.102358_bib31","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3390\/ani10081280","article-title":"Morphological and immunohistochemical examination of lymphoproliferative lesions caused by Marek\u2019s disease virus in breeder chickens","volume":"10","author":"Stamilla","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.cimid.2025.102358_bib32","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.19045\/bspab.2021.100107","article-title":"Histological study of broiler chicken liver infected with Marek\u2019s disease (MDV)","volume":"10","author":"Khan","year":"2021","journal-title":"Pure Appl. Biol."},{"key":"10.1016\/j.cimid.2025.102358_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/03079457.2017.1375079","article-title":"Characterizing the histopathology of natural co-infection with Marek\u2019s disease virus and subgroup J avian leucosis virus in egg-laying hens","volume":"47","author":"Wen","year":"2018","journal-title":"Avian Pathol."},{"key":"10.1016\/j.cimid.2025.102358_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1439-0450.2004.00728.x","article-title":"An enzyme-linked immunosorbent assay (ELISA) for detection of Marek's disease virus-specific antibodies and its application in an experimental vaccine trial","volume":"51","author":"Zelnik","year":"2004","journal-title":"J. Vet. Med. B: Infect. Dis. Vet. Public Health"},{"issue":"8","key":"10.1016\/j.cimid.2025.102358_bib35","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3390\/v14081651","article-title":"Pathogenicity and pathotype analysis of Henan isolates of Marek\u2019s disease virus reveal long-term circulation of highly virulent MDV variant in China","volume":"14","author":"Teng","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.cimid.2025.102358_bib36","unstructured":"Islam, M.M. (2023). Pathological and Molecular Investigation of Hepatomegaly and Splenomegaly Syndrome in Poultry in Chattogram (Doctoral dissertation, Chattogram Veterinary and Animal Sciences University, Khulshi-Chattogram-4225)."},{"key":"10.1016\/j.cimid.2025.102358_bib37","first-page":"52","article-title":"Pathological studies on acute Marek\u2019s disease in native and crossbred chickens of an organized poultry farm","volume":"14","author":"Makwana","year":"2018","journal-title":"Indian J. Vet. Sci. Biotechnol."},{"key":"10.1016\/j.cimid.2025.102358_bib38","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3923\/ijps.2007.372.377","article-title":"Occurrence of Marek\u2019s disease in vaccinated poultry flocks of Haryana (India)","volume":"6","author":"Kamaldeep","year":"2007","journal-title":"Int. J. Poult. Sci."},{"key":"10.1016\/j.cimid.2025.102358_bib39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4149\/av_2018_221","article-title":"Molecular characterization and phylogenetic analysis of oncogenes from virulent serotype-1 Marek's disease virus in India","volume":"62","author":"Prathibha","year":"2018","journal-title":"Acta Virol."},{"key":"10.1016\/j.cimid.2025.102358_bib40","first-page":"2319","article-title":"Occurrence of Marek\u2019s disease in commercial layer chicken. International","volume":"8","author":"Ravikumar","year":"2019","journal-title":"J. Curr. Microbiol. Appl. Sci."},{"issue":"12","key":"10.1016\/j.cimid.2025.102358_bib41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1292\/jvms.64.1097","article-title":"Diversity (polymorphism) of the meq gene in the attenuated Marek\u2019s disease virus (MDV) serotype 1 and MDV-transformed cell lines","volume":"64","author":"Chang","year":"2002","journal-title":"J. Vet. Med Sci."},{"issue":"1","key":"10.1016\/j.cimid.2025.102358_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01652176.2024.2318198","article-title":"Molecular characterization of the meq oncogene of Marek's disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains","volume":"44","author":"Chac\u00f3n","year":"2024","journal-title":"Vet. Q"},{"issue":"2","key":"10.1016\/j.cimid.2025.102358_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tvjl.2004.05.009","article-title":"Evolution of Marek's disease -- a paradigm for incessant race between the pathogen and the host","volume":"170","author":"Nair","year":"2005","journal-title":"Vet. J."},{"issue":"17","key":"10.1016\/j.cimid.2025.102358_bib44","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1128\/JVI.74.17.7980-7988.2000","article-title":"The genome of a very virulent Marek's disease virus","volume":"74","author":"Tulman","year":"2000","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.cimid.2025.102358_bib45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11262-007-0157-1","article-title":"Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek's disease virus","volume":"35","author":"Spatz","year":"2007","journal-title":"Virus Genes"},{"key":"10.1016\/j.cimid.2025.102358_bib46","first-page":"57","article-title":"Protective efficacy of Marek's disease vaccines","volume":"255","author":"Witter","year":"2001","journal-title":"Curr. Top. Microbiol Immunol."},{"issue":"2","key":"10.1016\/j.cimid.2025.102358_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1637\/9579-101510-Reg.1","article-title":"Effect of Diluting Marek\u2019s disease vaccines on the outcomes of Marek\u2019s disease virus infection when challenged with highly virulent Marek\u2019s disease viruses","volume":"55","author":"Gimeno","year":"2011","journal-title":"Avian Dis."}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957125000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957125000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T20:39:54Z","timestamp":1748723994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957125000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":47,"alternative-id":["S0147957125000669"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2025.102358","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First report on the molecular characterization and phylogenetic analysis of meq oncogene from virulent serotype-1 Marek's disease virus in laying hen flocks and broiler breeders in Algeria","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2025.102358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102358"}}