{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:06:54Z","timestamp":1791230814633,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00276\/2025"],"award-info":[{"award-number":["UIDB\/00276\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UI\/BD\/153070\/2022"],"award-info":[{"award-number":["UI\/BD\/153070\/2022"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.06540"],"award-info":[{"award-number":["2020.06540"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0059\/2020"],"award-info":[{"award-number":["LA\/P\/0059\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cimid.2026.102477","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:28:35Z","timestamp":1778340515000},"page":"102477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Clonal and plasmid-mediated dissemination of mcr-1 in Escherichia coli strains at the human\u2013companion animal interface: Genomic characterisation of colistin resistance plasmids"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-5372","authenticated-orcid":false,"given":"Juliana","family":"Menezes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Moreira da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia J.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constan\u00e7a","family":"Pomba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cimid.2026.102477_bib1","unstructured":"EMA, Updated advice on the use of colistin products in animals within the European Union: development of resistance and possible impact on human and animal health, 2016."},{"key":"10.1016\/j.cimid.2026.102477_bib2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/22221751.2020.1754133","article-title":"Colistin and its role in the Era of antibiotic resistance: an extended review (2000\u20132019)","volume":"9","author":"El-Sayed Ahmed","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.cimid.2026.102477_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cimid.2026.102477_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/1560-7917.ES.2016.21.9.30155","article-title":"Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds","volume":"21","author":"Skov","year":"2016","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.cimid.2026.102477_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics14121213","article-title":"The public health risks of colistin resistance in dogs and cats: a one health perspective review","volume":"14","author":"Menezes","year":"2025","journal-title":"Antibiotics"},{"key":"10.1016\/j.cimid.2026.102477_bib6","first-page":"1","article-title":"Global impact of mcr-1-positive Enterobacteriaceae bacteria on \u201c one health","volume":"0","author":"Xiaomin","year":"2020","journal-title":"Crit. Rev. Microbiol"},{"key":"10.1016\/j.cimid.2026.102477_bib7","series-title":"Advanced Animal Health and Medical Products","first-page":"265","article-title":"The Public Health Risk of Companion Animal to Human Transmission of Antimicrobial Resistance During Different Types of Animal Infection","author":"Pomba","year":"2020"},{"key":"10.1016\/j.cimid.2026.102477_bib8","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jcpa.2015.03.004","article-title":"Bacterial Zoonoses Transmitted by Household Pets: State-of-the-Art and Future Perspectives for Targeted Research and Policy Actions","volume":"155","author":"Damborg","year":"2016","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.cimid.2026.102477_bib9","first-page":"1","article-title":"The global distribution and spread of the mobilized colistin resistance gene mcr-1","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cimid.2026.102477_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15539-7","article-title":"Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction","volume":"7","author":"Matamoros","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cimid.2026.102477_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2020.604067","article-title":"Characterization of the Complete Nucleotide Sequences of mcr-1-Encoding Plasmids From Enterobacterales Isolates in Retailed Raw Meat Products From the Czech Republic","volume":"11","author":"Zelendova","year":"2021","journal-title":"Front. Microbiol"},{"key":"10.1016\/j.cimid.2026.102477_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0180347","article-title":"Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada","volume":"12","author":"Tijet","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cimid.2026.102477_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2016.260","article-title":"Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production","volume":"2","author":"Wang","year":"2017","journal-title":"Nat. Microbiol"},{"key":"10.1016\/j.cimid.2026.102477_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jgar.2019.12.002","article-title":"Diverse Escherichia coli lineages from domestic animals carrying colistin resistance gene mcr-1 in an Ecuadorian household","volume":"22","author":"Loayza-Villa","year":"2020","journal-title":"J. Glob. Antimicrob. Resist"},{"key":"10.1016\/j.cimid.2026.102477_bib15","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2022.27.44.2101144","article-title":"mcr-1 sharing between co-habiting dogs and humans in the community, Lisbon, Portugal, 2018- 2020","author":"Menezes","year":"2022","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.cimid.2026.102477_bib16","unstructured":"S. Andrews, A quality control tool for high throughput sequence data, (2010). \u3008https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/\u3009 (accessed January 10, 2021)."},{"key":"10.1016\/j.cimid.2026.102477_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/bioinformatics\/btr026","article-title":"Quality control and preprocessing of metagenomic datasets","volume":"27","author":"Schmieder","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2026.102477_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: A new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.cimid.2026.102477_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112963","article-title":"Pilon: An integrated tool for comprehensive microbial variant detection and genome assembly improvement","volume":"9","author":"Walker","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cimid.2026.102477_bib20","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: Rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2026.102477_bib21","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/jac\/dkaa345","article-title":"ResFinder 4.0 for predictions of phenotypes from genotypes","volume":"75","author":"Bortolaia","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cimid.2026.102477_bib22","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In Silico Detection and Typing of Plasmids using PlasmidFinder and Plasmid Multilocus Sequence Typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cimid.2026.102477_bib23","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1128\/JCM.03617-13","article-title":"Real-Time Whole-Genome Sequencing for Routine Typing, Surveillance, and Outbreak Detection of Verotoxigenic Escherichia coli","volume":"52","author":"Joensen","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s10096-023-04629-2","article-title":"Longitudinal study of ESBL\/AmpC-producing Enterobacterales strains sharing between cohabiting healthy companion animals and humans in Portugal and in the United Kingdom","author":"Menezes","year":"2023","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.cimid.2026.102477_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0524-x","article-title":"The harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes","volume":"15","author":"Treangen","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cimid.2026.102477_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku1196","article-title":"Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins","volume":"43","author":"Croucher","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cimid.2026.102477_bib27","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1093\/bioinformatics\/btz305","article-title":"RAxML-NG: A fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference","volume":"35","author":"Kozlov","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cimid.2026.102477_bib28","unstructured":"T. Seemann, F. Kl\u00f6tzl, A.J. Page, snp-dists, (2021). \u3008https:\/\/github.com\/tseemann\/snp-dists\u3009 (accessed January 20, 2022)."},{"key":"10.1016\/j.cimid.2026.102477_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cmi.2017.12.016","article-title":"Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene\u2013based approaches","volume":"24","author":"Sch\u00fcrch","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.cimid.2026.102477_bib30","article-title":"Microreact: visualizing and sharing data for genomic epidemiology and phylogeography","volume":"2","author":"Argim\u00f3n","year":"2016","journal-title":"Microb. Genom."},{"key":"10.1016\/j.cimid.2026.102477_bib31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/antibiotics14050506","article-title":"One Health at Risk: Plasmid-Mediated Spread of mcr-1 Across Clinical, Agricultural, and Environmental Ecosystems","volume":"14","author":"Touati","year":"2025","journal-title":"Antibiotics"},{"key":"10.1016\/j.cimid.2026.102477_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03209-21","article-title":"PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli","volume":"13","author":"Yi","year":"2022","journal-title":"MBio"},{"key":"10.1016\/j.cimid.2026.102477_bib33","article-title":"Fitness Advantage of mcr-1\u2013Bearing IncI2 and IncX4 Plasmids in Vitro","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MTBP-0016-2017","article-title":"Fitness Costs of Plasmids: a Limit to Plasmid Transmission","volume":"5","author":"San Millan","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.cimid.2026.102477_bib35","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/jac\/dkx488","article-title":"Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae","volume":"73","author":"Rozwandowicz","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cimid.2026.102477_bib36","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1128\/AAC.00935-16","article-title":"Full-Length Nucleotide Sequences of mcr-1-Harboring Plasmids Isolated from Extended-Spectrum-\u03b2-Lactamase-Producing Escherichia coli Isolates of Different Origins","volume":"60","author":"Zurfluh","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cimid.2026.102477_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00991-17","article-title":"Complete Genome Sequence of Salmonella enterica subsp. enterica Serovar Paratyphi B Sequence Type 28 Harboring mcr-1","volume":"5","author":"Borowiak","year":"2017","journal-title":"Genome Announc"},{"key":"10.1016\/j.cimid.2026.102477_bib38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/mdr.2020.0109","article-title":"Colistin-Resistant Enterobacterales Isolated from Chicken Meat in Western Algeria","volume":"27","author":"Chaalal","year":"2021","journal-title":"Microb. Drug Resist"},{"key":"10.1016\/j.cimid.2026.102477_bib39","article-title":"A Novel mcr-1 Variant Carried by an IncI2-Type Plasmid Identified From a Multidrug Resistant Enterotoxigenic Escherichia coli","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib40","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tim.2018.02.006","article-title":"Towards Understanding MCR-like Colistin Resistance","volume":"26","author":"Sun","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib41","article-title":"Colistin Resistance and Molecular Characterization of the Genomes of mcr-1-Positive Escherichia coli Clinical Isolates","volume":"12","author":"Li","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib42","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1128\/AAC.01457-16","article-title":"A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1","volume":"60","author":"Snesrud","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cimid.2026.102477_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile Genetic Elements Associated with Antimicrobial Resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.cimid.2026.102477_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/mmi.13896","article-title":"Type IV secretion in Gram-negative and Gram-positive bacteria","volume":"107","author":"Grohmann","year":"2018","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cimid.2026.102477_bib45","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1128\/MMBR.00020-10","article-title":"Mobility of Plasmids","volume":"74","author":"Smillie","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cimid.2026.102477_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1142\/S168264851972003X","article-title":"Chromosomal locations of mcr-1 in Klebsiella pneumoniae and Enterobacter cloacae from dogs","volume":"45","author":"Chang","year":"2019","journal-title":"Taiwan Vet. J."},{"key":"10.1016\/j.cimid.2026.102477_bib47","article-title":"Draft Genome Sequence of Escherichia coli S51, a Chicken Isolate Harboring a Chromosomally Encoded mcr-1 Gene","volume":"4","author":"Zurfluh","year":"2016","journal-title":"Genome Announc"}],"container-title":["Comparative Immunology, Microbiology and Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957126000391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147957126000391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:30:48Z","timestamp":1784651448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147957126000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"alternative-id":["S0147957126000391"],"URL":"https:\/\/doi.org\/10.1016\/j.cimid.2026.102477","relation":{},"ISSN":["0147-9571"],"issn-type":[{"value":"0147-9571","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clonal and plasmid-mediated dissemination of mcr-1 in Escherichia coli strains at the human\u2013companion animal interface: Genomic characterisation of colistin resistance plasmids","name":"articletitle","label":"Article Title"},{"value":"Comparative Immunology, Microbiology and Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cimid.2026.102477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102477"}}