{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:42:35Z","timestamp":1778560955623,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cirug\u00eda y Cirujanos"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.circir.2015.05.010","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T21:55:52Z","timestamp":1434578152000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enfermedad de von Willebrand, biolog\u00eda molecular y diagn\u00f3stico"],"prefix":"10.1016","volume":"83","author":[{"given":"Edgar","family":"Hern\u00e1ndez-Zamora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Zavala-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Quintana-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba","family":"Reyes-Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.circir.2015.05.010_bib0230","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood.V70.4.895.895","article-title":"Von Willebrand factor and von Willebrand disease","volume":"70","author":"Ruggeri","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.circir.2015.05.010_bib0235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1040-8428(98)00045-6","article-title":"Von Willebrand factor: From cell biology to the clinical management of von Willebrand's disease","volume":"30","author":"Vischer","year":"1999","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.circir.2015.05.010_bib0240","doi-asserted-by":"crossref","first-page":"22777","DOI":"10.1016\/S0021-9258(18)54418-5","article-title":"Von Willebrand factor","volume":"266","author":"Sadler","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.circir.2015.05.010_bib0245","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1182\/blood.V46.3.417.417","article-title":"Studies of the human factor VIII\/von Willebrand's factor protein II. Identification and characterization of the von Willebrand protein","volume":"46","author":"Gralnick","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.circir.2015.05.010_bib0250","unstructured":"Kasper CK; Hemophilia of Georgia, U.S.A. Protocols for the treatment of hemophilia and von Willebrand disease. 3th ed. Georgia, U.S.A.: Haemophilia of Georgia; 2008. p. 84-93."},{"key":"10.1016\/j.circir.2015.05.010_bib0255","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1093\/nar\/13.13.4699","article-title":"Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene","volume":"13","author":"Verweij","year":"1985","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.circir.2015.05.010_bib0260","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1073\/pnas.84.13.4393","article-title":"Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site","volume":"84","author":"Collins","year":"1987","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.circir.2015.05.010_bib0265","doi-asserted-by":"crossref","first-page":"18554","DOI":"10.1074\/jbc.271.31.18554","article-title":"Analysis of the megakaryocyte glycoprotein IX promoter identifies positive and negative regulatory domains and functional GATA and Ets sites","volume":"271","author":"Bastian","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.circir.2015.05.010_bib0270","doi-asserted-by":"crossref","first-page":"19514","DOI":"10.1016\/S0021-9258(19)47144-5","article-title":"Structure of the gene for human von Willebrand factor","volume":"264","author":"Mancuso","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.circir.2015.05.010_bib0275","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/bi00215a036","article-title":"Human von Willebrand factor gene and pseudogene: Structural analysis and differentiation by polymerase chain reaction","volume":"30","author":"Mancuso","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.circir.2015.05.010_bib0280","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.pcl.2008.01.008","article-title":"Pediat","volume":"55","author":"Robertson","year":"2008","journal-title":"Clin North Am"},{"key":"10.1016\/j.circir.2015.05.010_bib0285","doi-asserted-by":"crossref","first-page":"15647","DOI":"10.1073\/pnas.0705175104","article-title":"Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi","volume":"104","author":"Purvis","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.circir.2015.05.010_bib0290","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1538-7836.2008.03211.x","article-title":"Protein synthesis by platelets: Historical and new perspectives","volume":"7","author":"Weyrich","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0295","doi-asserted-by":"crossref","first-page":"24180","DOI":"10.1074\/jbc.M110.215194","article-title":"Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease","volume":"286","author":"Wang","year":"2011","journal-title":"J Biol Chem"},{"issue":"Suppl 5","key":"10.1016\/j.circir.2015.05.010_bib0300","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2516.2008.01848.x","article-title":"Function of von Willebrand factor in haemostasis and thrombosis","volume":"14","author":"Reininger","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.circir.2015.05.010_bib0305","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/GIM.0b013e3182035931","article-title":"Von Willebrand disease","volume":"13","author":"James","year":"2011","journal-title":"Genet Med"},{"issue":"Suppl 1","key":"10.1016\/j.circir.2015.05.010_bib0310","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1538-7836.2011.04320.x","article-title":"Biology and physics of von Willebrand factor concatamers","volume":"9","author":"Springer","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0315","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1182\/blood.V94.5.1637","article-title":"Evidence for extracellular processing of pro-von Willebrand factor after infusion in animals with and without severe von Willebrand disease","volume":"94","author":"Turecek","year":"1999","journal-title":"Blood"},{"issue":"Suppl 6","key":"10.1016\/j.circir.2015.05.010_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2516.2012.02925.x","article-title":"Von Willebrand's disease: A report from a meeting in the \u00c5land islands","volume":"18","author":"Berntorp","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.circir.2015.05.010_bib0325","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1055\/s-0037-1614330","article-title":"Inconsistency of association between type 1 von Willebrand disease phenotype and genotype in families identified in an epidemiological investigation","volume":"82","author":"Castaman","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0330","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0031-1280567","article-title":"Von Willebrand disease: Local diagnosis management of a globally distributed bleeding disorder","volume":"37","author":"Favaloro","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0335","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/hae.12016","article-title":"Von Willebrand's disease in Mexico: A pilot study","volume":"19","author":"Majluf-Cruz","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.circir.2015.05.010_bib0340","first-page":"49","article-title":"Treatment of patients with von Willebrand disease","volume":"2","author":"Tuohy","year":"2011","journal-title":"J Blood Med"},{"key":"10.1016\/j.circir.2015.05.010_bib0345","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/asheducation-2009.1.113","article-title":"Optimizing treatment of von Willebrand disease by using phenotypic and molecular data","volume":"1","author":"Rodeghiero","year":"2009","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.circir.2015.05.010_bib0350","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0038-1642471","article-title":"A revised classification of von Willebrand disease for the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"71","author":"Sadler","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0355","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1160\/TH04-10-0670","article-title":"North American Specialized Coagulation Laboratory Association Variability in clinical laboratory practice in testing for disorders of platelet function: Results of two surveys of the North American Specialized Coagulation Laboratory Association","volume":"93","author":"Moffat","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0360","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1055\/s-0032-1326780","article-title":"Laboratory investigations for bleeding disorders","volume":"38","author":"Hayward","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0365","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0025-6196(12)61202-6","article-title":"Laboratory diagnosis of von Willebrand's disease","volume":"66","author":"Triplett","year":"1991","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.circir.2015.05.010_bib0370","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0037-1613992","article-title":"Impact, diagnosis and treatment of von Willebrand disease","volume":"84","author":"Sadler","year":"2000","journal-title":"Thromb Haemost"},{"issue":"Suppl 5","key":"10.1016\/j.circir.2015.05.010_bib0375","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2516.2010.02295.x","article-title":"New developments in laboratory diagnosis and monitoring","volume":"16","author":"Kitchen","year":"2010","journal-title":"Haemophilia"},{"key":"10.1016\/j.circir.2015.05.010_bib0380","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0038-1653759","article-title":"The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: Improved specificity and reliability","volume":"73","author":"Verbruggen","year":"1995","journal-title":"Thromb Haemost"},{"issue":"Suppl 1","key":"10.1016\/j.circir.2015.05.010_bib0385","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1002\/ajh.23142","article-title":"Von Willebrand disease: Clinical and laboratory lessons learned from the large von Willebrand disease studies","volume":"87","author":"James","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.circir.2015.05.010_bib0390","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/asheducation-2013.1.254","article-title":"Von Willebrand disease: Advances in pathogenetic understanding, diagnosis, and therapy","volume":"2013","author":"Lillicrap","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.circir.2015.05.010_bib0395","first-page":"1261","article-title":"Diagnosis and management of von Willebrand disease: Guidelines for primary care","volume":"80","author":"Yawn","year":"2009","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.circir.2015.05.010_bib0400","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0038-1650567","article-title":"Factor VIII binding assay of von Willebrand factor and the diagnosis of type 2N von Willebrand disease-results of an international survey. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTH","volume":"76","author":"Mazurier","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0405","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0950-3536(96)80060-6","article-title":"Molecular basis of von Willebrand disease","volume":"9","author":"Mazurier","year":"1996","journal-title":"Baillieres Clin Haematol"},{"key":"10.1016\/j.circir.2015.05.010_bib0410","first-page":"55","article-title":"Type 2N von Willebrand disease (Normandy)","volume":"46","author":"Morales-de la Vega","year":"2008","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"10.1016\/j.circir.2015.05.010_bib0415","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3324\/haematol.10606","article-title":"Mutational analysis of the von Willebrand factor gene in type 1 von Willebrand disease using conformation sensitive gel electrophoresis: a comparison of fluorescent and manual techniques","volume":"92","author":"Hashemi Soteh","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.circir.2015.05.010_bib0420","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1182\/blood-2006-05-020784","article-title":"Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)","volume":"109","author":"Goodeve","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.circir.2015.05.010_bib0425","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1182\/blood-2007-09-110940","article-title":"Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD)","volume":"111","author":"Haberichter","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.circir.2015.05.010_bib0430","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-2006-947870","article-title":"Genetic testing for von Willebrand disease: The Canadian experience","volume":"32","author":"James","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.circir.2015.05.010_bib0435","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bcmd.2007.06.007","article-title":"Molecular study of VWF gene from Mexican Mestizo patients with von Willebrand disease, and the finding of three new mutations","volume":"39","author":"Melo-Nava","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.circir.2015.05.010_bib0440","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/MOH.0b013e328363c11f","article-title":"New development in von Willebrand disease","volume":"20","author":"Castaman","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.circir.2015.05.010_bib0445","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2516.2004.00886.x","article-title":"Management of von Willebrand disease: A guideline from the UK Haemophilia Centre Doctors\u2019 Organization","volume":"10","author":"Pasi","year":"2004","journal-title":"Haemophilia"},{"key":"10.1016\/j.circir.2015.05.010_bib0450","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"Von Willebrand disease (VWD): Evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"}],"container-title":["Cirug\u00eda y Cirujanos"],"original-title":[],"language":"es","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0009741115000687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0009741115000687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T20:45:03Z","timestamp":1652474703000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009741115000687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0009741115000687"],"URL":"https:\/\/doi.org\/10.1016\/j.circir.2015.05.010","relation":{},"ISSN":["0009-7411"],"issn-type":[{"value":"0009-7411","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enfermedad de von Willebrand, biolog\u00eda molecular y diagn\u00f3stico","name":"articletitle","label":"Article Title"},{"value":"Cirug\u00eda y Cirujanos","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.circir.2015.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Academia Mexicana de Cirug\u00eda A.C. Published by Masson Doyma M\u00e9xico S.A.","name":"copyright","label":"Copyright"}]}}