{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:13:12Z","timestamp":1787739192285,"version":"build-2784847793"},"reference-count":150,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20488"],"award-info":[{"award-number":["U23A20488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017683","name":"Dalian Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["2023JJ11CG007"],"award-info":[{"award-number":["2023JJ11CG007"]}],"id":[{"id":"10.13039\/501100017683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017683","name":"Dalian Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["2023RJ005"],"award-info":[{"award-number":["2023RJ005"]}],"id":[{"id":"10.13039\/501100017683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017683","name":"Dalian Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["2022JJ12SN046"],"award-info":[{"award-number":["2022JJ12SN046"]}],"id":[{"id":"10.13039\/501100017683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["2023JH2\/101800011"],"award-info":[{"award-number":["2023JH2\/101800011"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["2021JH\/2\/10300071"],"award-info":[{"award-number":["2021JH\/2\/10300071"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["2023JH2\/101700075"],"award-info":[{"award-number":["2023JH2\/101700075"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Colloid and Interface Science"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cis.2026.103897","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:25:55Z","timestamp":1775755555000},"page":"103897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Advances in lipids design for LNP-mediated DNA and RNA delivery"],"prefix":"10.1016","volume":"354","author":[{"given":"Defu","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayinigeer","family":"Halemaimaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cis.2026.103897_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.cis.2026.103897_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12967-023-04834-9","article-title":"NCAPG2 promotes prostate cancer malignancy and stemness via STAT3\/c-MYC signaling","volume":"22","author":"Zhang","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.cis.2026.103897_bb0015","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1021\/mp500367k","article-title":"Stabilization of Ostwald ripening in low molecular weight amino lipid nanoparticles for systemic delivery of siRNA therapeutics","volume":"11","author":"Gindy","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0020","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41571-020-0413-z","article-title":"Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors","volume":"17","author":"Galluzzi","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.cis.2026.103897_bb0025","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41467-024-45666-5","article-title":"Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection","volume":"15","author":"Pattipeiluhu","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"Perez-Herrero","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.cis.2026.103897_bb0035","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.apsb.2019.08.003","article-title":"Recent progress in drug delivery","volume":"9","author":"Li","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.cis.2026.103897_bb0040","doi-asserted-by":"crossref","first-page":"9725","DOI":"10.1038\/s41598-020-66694-3","article-title":"Liposome-mediated delivery of challenging chemicals to aid environmental assessment of bioaccumulative (B) and toxic (T) properties","volume":"10","author":"Castro","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.cis.2026.103897_bb0045","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.2147\/IJN.S87148","article-title":"Nanotechnology-based drug delivery systems for the treatment of Alzheimer\u2019s disease","volume":"10","author":"Fonseca-Santos","year":"2015","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0050","doi-asserted-by":"crossref","first-page":"E781","DOI":"10.1002\/ijc.27361","article-title":"Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo","volume":"131","author":"Lee","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cis.2026.103897_bb0055","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/bm3019592","article-title":"Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia","volume":"14","author":"Pola","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.cis.2026.103897_bb0060","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acsabm.8b00526","article-title":"Polymeric micelle of a gelatin-oleylamine conjugate: a prominent drug delivery carrier for treating triple negative breast cancer cells","volume":"1","author":"Selestin Raja","year":"2018","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0065","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1038\/s41598-020-62501-1","article-title":"Optimization of docetaxel loading conditions in liposomes: proposing potential products for metastatic breast carcinoma chemotherapy","volume":"10","author":"Vakili-Ghartavol","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.cis.2026.103897_bb0070","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1021\/acs.langmuir.6b01088","article-title":"Synthesis and characterization of biodegradable lignin nanoparticles with tunable surface properties","volume":"32","author":"Richter","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.cis.2026.103897_bb0075","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1039\/c2cs35146c","article-title":"Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application","volume":"41","author":"Jager","year":"2012","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0080","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/acs.molpharmaceut.7b01055","article-title":"Systemic administration of siRNA with anti-HB-EGF antibody-modified lipid nanoparticles for the treatment of triple-negative breast cancer","volume":"15","author":"Okamoto","year":"2018","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0085","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1021\/mp800146j","article-title":"Antitumor activity of g3139 lipid nanoparticles (LNPs)","volume":"6","author":"Pan","year":"2009","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0090","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1023\/A:1014861900478","article-title":"A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity","volume":"16","author":"Fischer","year":"1999","journal-title":"Pharm Res"},{"key":"10.1016\/j.cis.2026.103897_bb0095","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0168-3659(01)00368-6","article-title":"Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats","volume":"75","author":"Takeuchi","year":"2001","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/187221111797200597","article-title":"New methods for lipid nanoparticles preparation","volume":"5","author":"Corrias","year":"2011","journal-title":"Recent Pat Drug Deliv Formul"},{"key":"10.1016\/j.cis.2026.103897_bb0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1517\/17425240903436479","article-title":"Polymeric micelles as a new drug carrier system and their required considerations for clinical trials","volume":"7","author":"Yokoyama","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.cis.2026.103897_bb0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1517\/17425240903380446","article-title":"Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction","volume":"7","author":"Kim","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.cis.2026.103897_bb0115","article-title":"Physiological barriers and strategies of lipid-based nanoparticles for nucleic acid drug delivery","volume":"36","author":"Hu","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0120","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11262-024-02102-6","article-title":"Advances in the study of LNPs for mRNA delivery and clinical applications","volume":"60","author":"Wang","year":"2024","journal-title":"Virus Genes"},{"key":"10.1016\/j.cis.2026.103897_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114416","article-title":"The role of lipid components in lipid nanoparticles for vaccines and gene therapy","volume":"188","author":"Hald Albertsen","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0130","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1021\/acsnano.8b01516","article-title":"On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA","volume":"12","author":"Kulkarni","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.cis.2026.103897_bb0135","article-title":"Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA","volume":"11","author":"Patel","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0140","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1021\/acs.jpcb.7b10795","article-title":"Structure of lipid nanoparticles containing siRNA or mRNA by dynamic nuclear polarization-enhanced NMR spectroscopy","volume":"122","author":"Viger-Gravel","year":"2018","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.cis.2026.103897_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002105","article-title":"Biotechnology: overcoming biological barriers to nucleic acid delivery using lipid nanoparticles","volume":"21","author":"Hamilton","year":"2023","journal-title":"PLoS Biol"},{"key":"10.1016\/j.cis.2026.103897_bb0150","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.175.4025.949","article-title":"Gene therapy for human genetic disease?","volume":"175","author":"Friedmann","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.cis.2026.103897_bb0155","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1021\/jm200237p","article-title":"Factors determining the superior performance of lipid\/DNA\/protammine nanoparticles over lipoplexes","volume":"54","author":"Caracciolo","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.cis.2026.103897_bb0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","article-title":"Knocking down barriers: advances in siRNA delivery","volume":"8","author":"Whitehead","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.cis.2026.103897_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11095-023-03471-7","article-title":"Lipid nanoparticles for nucleic acid delivery to endothelial cells","volume":"40","author":"Liu","year":"2023","journal-title":"Pharm Res"},{"key":"10.1016\/j.cis.2026.103897_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201903637","article-title":"Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery","volume":"31","author":"Kim","year":"2019","journal-title":"Adv Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0175","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0180","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1208\/s12248-010-9210-4","article-title":"Delivery of siRNA therapeutics: barriers and carriers","volume":"12","author":"Wang","year":"2010","journal-title":"AAPS J"},{"key":"10.1016\/j.cis.2026.103897_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081698","article-title":"Efficient delivery of DNA using lipid nanoparticles","volume":"14","author":"Cui","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cis.2026.103897_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081292","article-title":"Microfluidic formulation of DNA-loaded multicomponent lipid nanoparticles for gene delivery","volume":"13","author":"Quagliarini","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cis.2026.103897_bb0195","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.nano.2016.12.014","article-title":"Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA","volume":"13","author":"Kulkarni","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0200","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1039\/D2BM00168C","article-title":"In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression","volume":"10","author":"Algarni","year":"2022","journal-title":"Biomater Sci"},{"key":"10.1016\/j.cis.2026.103897_bb0205","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.2147\/IJN.S366962","article-title":"Ionizable lipid nanoparticle-mediated delivery of plasmid DNA in cardiomyocytes","volume":"17","author":"Scalzo","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0210","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1038\/s41598-020-65059-0","article-title":"Lipid nanoparticle formulation increases efficiency of DNA-vectored vaccines\/immunoprophylaxis in animals including transchromosomic bovines","volume":"10","author":"Mucker","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.cis.2026.103897_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122914","article-title":"Corosolic acid-modified lipid nanoparticles as delivery carriers for DNA vaccines against avian influenza","volume":"638","author":"Guo","year":"2023","journal-title":"Int J Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0220","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.lfs.2006.06.011","article-title":"Therapeutic potential of RNA interference for neurological disorders","volume":"79","author":"Sah","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.cis.2026.103897_bb0225","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41573-024-00977-6","article-title":"The 60-year evolution of lipid nanoparticles for nucleic acid delivery","volume":"23","author":"Cullis","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.cis.2026.103897_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202309225","article-title":"Nanoparticle-mediated delivery of anti-PU.1 siRNA via localized intracisternal administration reduces neuroinflammation","volume":"36","author":"Ralvenius","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0235","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9231641","article-title":"Design and in vitro evaluation of novel cationic lipids for siRNA delivery in breast cancer cell lines","volume":"2022","author":"Vaidya","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.cis.2026.103897_bb0240","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nbt.1602","article-title":"Rational design of cationic lipids for siRNA delivery","volume":"28","author":"Semple","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.cis.2026.103897_bb0245","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1002\/anie.201203263","article-title":"Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo","volume":"51","author":"Jayaraman","year":"2012","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.cis.2026.103897_bb0250","article-title":"Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA","volume":"1","author":"Belliveau","year":"2012","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0255","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1021\/acs.jpcb.5b02891","article-title":"Microfluidic mixing: a general method for encapsulating macromolecules in lipid nanoparticle systems","volume":"119","author":"Leung","year":"2015","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.cis.2026.103897_bb0260","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s00277-019-03713-y","article-title":"Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo","volume":"98","author":"Jyotsana","year":"2019","journal-title":"Ann Hematol"},{"key":"10.1016\/j.cis.2026.103897_bb0265","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/acsmedchemlett.8b00652","article-title":"Simplifying the chemical structure of cationic lipids for siRNA-lipid nanoparticles","volume":"10","author":"Kuboyama","year":"2019","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.cis.2026.103897_bb0270","article-title":"Lipid nanoparticle delivery of siRNA to silence neuronal gene expression in the brain","volume":"2","author":"Rungta","year":"2013","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0275","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2016.05.059","article-title":"Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA","volume":"235","author":"Chen","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0280","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1038\/ncomms5277","article-title":"Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity","volume":"5","author":"Whitehead","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0285","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/mt.2013.124","article-title":"Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics","volume":"21","author":"Maier","year":"2013","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0290","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/mt.2010.85","article-title":"Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms","volume":"18","author":"Akinc","year":"2010","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0295","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2014.09.025","article-title":"Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration","volume":"196","author":"Chen","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0300","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/s41467-020-16991-2","article-title":"Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation","volume":"11","author":"Barbier-Torres","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0305","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2012.09.009","article-title":"A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo","volume":"163","author":"Sato","year":"2012","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0310","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2016.01.042","article-title":"A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells","volume":"225","author":"Warashina","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0315","doi-asserted-by":"crossref","DOI":"10.1038\/srep37849","article-title":"Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines","volume":"6","author":"Nakamura","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.cis.2026.103897_bb0320","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jconrel.2019.01.001","article-title":"Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo","volume":"295","author":"Sato","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0325","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2020.07.001","article-title":"Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy","volume":"325","author":"Shobaki","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0330","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/10837450.2018.1469149","article-title":"The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells","volume":"24","author":"Uemura","year":"2018","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.cis.2026.103897_bb0335","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/acsami.7b15982","article-title":"Development of cationic quaternary ammonium sulfonamide amino lipids for nucleic acid delivery","volume":"10","author":"Miller","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.cis.2026.103897_bb0340","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jconrel.2015.10.024","article-title":"SiRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo","volume":"220","author":"Suzuki","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0345","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2017.01.016","article-title":"Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates","volume":"519","author":"Suzuki","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0350","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1021\/la201464k","article-title":"Interaction of cholesterol-conjugated ionizable amino lipids with biomembranes: lipid polymorphism, structure-activity relationship, and implications for siRNA delivery","volume":"27","author":"Zhang","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.cis.2026.103897_bb0355","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/mp3005337","article-title":"Assessing the heterogeneity level in lipid nanoparticles for siRNA delivery: size-based separation, compositional heterogeneity, and impact on bioperformance","volume":"10","author":"Zhang","year":"2013","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0360","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/mt.2009.208","article-title":"Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment","volume":"18","author":"Abrams","year":"2010","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0365","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/hr.2013.155","article-title":"Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension","volume":"37","author":"Olearczyk","year":"2014","journal-title":"Hypertens Res"},{"key":"10.1016\/j.cis.2026.103897_bb0370","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/acs.molpharmaceut.0c00087","article-title":"Improved stability of siRNA-loaded lipid nanoparticles prepared with a PEG-monoacyl fatty acid facilitates ligand-mediated siRNA delivery","volume":"17","author":"Sakurai","year":"2020","journal-title":"Mol Pharm"},{"key":"10.1016\/j.cis.2026.103897_bb0375","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.addr.2007.03.004","article-title":"Exogenous siRNA delivery using peptide transduction domains\/cell penetrating peptides","volume":"59","author":"Meade","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0380","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bbrc.2014.01.107","article-title":"Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery","volume":"444","author":"Asai","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0385","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1021\/acsami.5b12144","article-title":"Design of highly potent lipid-functionalized peptidomimetics for efficient in vivo siRNA delivery","volume":"8","author":"Xiao","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.cis.2026.103897_bb0390","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/molecules24183413","article-title":"Design of peptidomimetic functionalized cholesterol based lipid nanoparticles for efficient delivery of therapeutic nucleic acids","volume":"24","author":"Ehexige","year":"2019","journal-title":"Molecules"},{"issue":"15_suppl","key":"10.1016\/j.cis.2026.103897_bb0395","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2020.38.15_suppl.e15211","article-title":"R-DOTAP (Versamune): a novel enantiospecific cationic lipid nanoparticle that induces CD4 and CD8 cellular immune responses to whole protein and tumor-specific peptide antigens","volume":"38","author":"Wood","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cis.2026.103897_bb0400","doi-asserted-by":"crossref","first-page":"11329","DOI":"10.1039\/D5NR00433K","article-title":"PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanoparticle-mediated mRNA delivery","volume":"17","author":"Liu","year":"2025","journal-title":"Nanoscale"},{"key":"10.1016\/j.cis.2026.103897_bb0405","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41571-023-00811-9","article-title":"Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects","author":"Kon","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.cis.2026.103897_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2017.56","article-title":"Tools for translation: non-viral materials for therapeutic mRNA delivery","volume":"2","author":"Hajj","year":"2017","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0415","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.actbio.2023.12.009","article-title":"Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy","volume":"174","author":"Xu","year":"2024","journal-title":"Acta Biomater"},{"key":"10.1016\/j.cis.2026.103897_bb0420","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2015.08.007","article-title":"Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes","volume":"217","author":"Pardi","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0425","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1038\/s41467-024-45537-z","article-title":"In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors","volume":"15","author":"Han","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0430","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1021\/acs.nanolett.7b02664","article-title":"Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA","volume":"17","author":"Patel","year":"2017","journal-title":"Nano Lett"},{"key":"10.1016\/j.cis.2026.103897_bb0435","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41541-017-0032-6","article-title":"Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines","volume":"2","author":"Lutz","year":"2017","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.cis.2026.103897_bb0440","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/adhm.201400039","article-title":"Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles","volume":"3","author":"Wang","year":"2014","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0445","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020401118","article-title":"Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3","volume":"118","author":"Qiu","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cis.2026.103897_bb0450","article-title":"Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response","volume":"119","author":"Chen","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cis.2026.103897_bb0455","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ymthe.2018.03.010","article-title":"A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates","volume":"26","author":"Sabnis","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0460","article-title":"A combinatorial library of lipid nanoparticles for cell type-specific mRNA delivery","volume":"10","author":"Naidu","year":"2023","journal-title":"Adv Sci Weinh"},{"key":"10.1016\/j.cis.2026.103897_bb0465","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1021\/acsnano.3c04507","article-title":"Fluorinated lipid nanoparticles for enhancing mRNA delivery efficiency","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.cis.2026.103897_bb0470","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1028","article-title":"Ionizable lipid nanoparticles for in utero mRNA delivery","volume":"7","author":"Riley","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.cis.2026.103897_bb0475","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1038\/s41467-020-16248-y","article-title":"Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver","volume":"11","author":"Miao","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0480","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1021\/acs.nanolett.0c01386","article-title":"Deconvoluting lipid nanoparticle structure for messenger RNA delivery","volume":"20","author":"Eygeris","year":"2020","journal-title":"Nano Lett"},{"key":"10.1016\/j.cis.2026.103897_bb0485","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1039\/D0BM01947J","article-title":"Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery","volume":"9","author":"Herrera","year":"2021","journal-title":"Biomater Sci"},{"key":"10.1016\/j.cis.2026.103897_bb0490","doi-asserted-by":"crossref","first-page":"E3351","DOI":"10.1073\/pnas.1720542115","article-title":"Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles","volume":"115","author":"Yanez Arteta","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cis.2026.103897_bb0495","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.ymthe.2019.07.018","article-title":"Endocytic profiling of cancer cell models reveals critical factors influencing LNP-mediated mRNA delivery and protein expression","volume":"27","author":"Sayers","year":"2019","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0500","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1038\/s41467-019-12275-6","article-title":"Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells","volume":"10","author":"Maugeri","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0505","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba5672","article-title":"Increased PIP3 activity blocks nanoparticle mRNA delivery","volume":"6","author":"Paunovska","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.cis.2026.103897_bb0510","doi-asserted-by":"crossref","first-page":"10571","DOI":"10.1128\/JVI.01041-09","article-title":"Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff","volume":"83","author":"Simmons","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.cis.2026.103897_bb0515","first-page":"867","article-title":"Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin","volume":"17","author":"Huysmans","year":"2019","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0520","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1038\/s41467-020-19486-2","article-title":"In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating t cells in vivo","volume":"11","author":"Parayath","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0525","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1021\/acs.nanolett.9b04246","article-title":"Ionizable lipid nanoparticle-mediated mRNA delivery for human CAR T cell engineering","volume":"20","author":"Billingsley","year":"2020","journal-title":"Nano Lett"},{"key":"10.1016\/j.cis.2026.103897_bb0530","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/thno.89913","article-title":"Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery","volume":"14","author":"Patel","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.cis.2026.103897_bb0535","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jconrel.2019.10.028","article-title":"Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening","volume":"316","author":"Guimaraes","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0540","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1021\/acs.nanolett.8b01101","article-title":"Lipid nanoparticle formulations for enhanced co-delivery of siRNA and mRNA","volume":"18","author":"Ball","year":"2018","journal-title":"Nano Lett"},{"key":"10.1016\/j.cis.2026.103897_bb0545","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02441-2","article-title":"Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration","volume":"4","author":"Carrasco","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.cis.2026.103897_bb0550","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41467-021-20903-3","article-title":"Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA","volume":"12","author":"Rizvi","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0555","series-title":"The mRNA-LNP platform\u2019s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory","author":"Ndeupen","year":"2021"},{"key":"10.1016\/j.cis.2026.103897_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010255","article-title":"Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses","volume":"18","author":"Ndeupen","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cis.2026.103897_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121570","article-title":"An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates","volume":"286","author":"Ripoll","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.cis.2026.103897_bb0570","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s10038-021-00938-6","article-title":"Cancer-associated miRNAs and their therapeutic potential","volume":"66","author":"Inoue","year":"2021","journal-title":"J Hum Genet"},{"key":"10.1016\/j.cis.2026.103897_bb0575","doi-asserted-by":"crossref","DOI":"10.3390\/mps4010010","article-title":"Recent advances in miRNA delivery systems","volume":"4","author":"Dasgupta","year":"2021","journal-title":"Methods Protoc"},{"key":"10.1016\/j.cis.2026.103897_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113834","article-title":"Nucleic acid delivery for therapeutic applications","volume":"178","author":"Gupta","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0585","first-page":"330","article-title":"Therapeutic potential of LNP-mediated delivery of miR-634 for cancer therapy","volume":"19","author":"Gokita","year":"2020","journal-title":"Mol Ther"},{"key":"10.1016\/j.cis.2026.103897_bb0590","doi-asserted-by":"crossref","first-page":"378","DOI":"10.21037\/atm.2018.06.29","article-title":"Ventilator-induced lung injury and lung mechanics","volume":"6","author":"Bates","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.cis.2026.103897_bb0595","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1096\/fj.11-199240","article-title":"MiR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium","volume":"26","author":"Huang","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.cis.2026.103897_bb0600","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41467-020-20449-w","article-title":"Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation","volume":"12","author":"Bobba","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.cis.2026.103897_bb0605","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35074604","article-title":"Activation of EphA receptor tyrosine kinase inhibits the Ras\/MAPK pathway","volume":"3","author":"Miao","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.cis.2026.103897_bb0610","first-page":"4481","article-title":"Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer","volume":"8","author":"Lee","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0615","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1172\/JCI63455","article-title":"MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cis.2026.103897_bb0620","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.nano.2013.05.007","article-title":"Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor","volume":"9","author":"Hsu","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0625","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40364-021-00272-1","article-title":"MiR-21: a non-specific biomarker of all maladies","volume":"9","author":"Jenike","year":"2021","journal-title":"Biomark Res"},{"key":"10.1016\/j.cis.2026.103897_bb0630","article-title":"MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu city, China","volume":"9","author":"Xu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.cis.2026.103897_bb0635","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/rna.8.5.16154","article-title":"Regulation and function of miRNA-21 in health and disease","volume":"8","author":"Kumarswamy","year":"2011","journal-title":"RNA Biol"},{"key":"10.1016\/j.cis.2026.103897_bb0640","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00210-013-0837-4","article-title":"MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines","volume":"386","author":"de Antonellis","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.cis.2026.103897_bb0645","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2018.05.038","article-title":"A novel lipidoid-microRNA formulation promotes calvarial bone regeneration","volume":"177","author":"Sui","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.cis.2026.103897_bb0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2021.105207","article-title":"Osteogenic effects of microRNA-335-5p\/lipidoid nanoparticles coated on titanium surface","volume":"129","author":"Wang","year":"2021","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.cis.2026.103897_bb0655","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202409812","article-title":"Simplified lipid nanoparticles for tissue- and cell-targeted mRNA delivery facilitate precision tumor therapy in a lung metastasis mouse model","volume":"36","author":"Fei","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0660","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2021.05.009","article-title":"Microneedles for gene and drug delivery in skin cancer therapy","volume":"335","author":"Zhi","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0665","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.NAN.0000264712.26219.67","article-title":"Liposomal drug delivery","volume":"30","author":"Allison","year":"2007","journal-title":"J Infus Nurs"},{"key":"10.1016\/j.cis.2026.103897_bb0670","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41565-019-0591-y","article-title":"The onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs","volume":"14","author":"Akinc","year":"2019","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cis.2026.103897_bb0675","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1021\/acsnano.8b07858","article-title":"Lipid-based DNA therapeutics: hallmarks of non-viral gene delivery","volume":"13","author":"Buck","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.cis.2026.103897_bb0680","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.cis.2026.103897_bb0685","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.copbio.2021.09.016","article-title":"Principles for designing an optimal mRNA lipid nanoparticle vaccine","volume":"73","author":"Kon","year":"2022","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.cis.2026.103897_bb0690","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.xphs.2020.12.006","article-title":"Addressing the cold reality of mRNA vaccine stability","volume":"110","author":"Crommelin","year":"2021","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.cis.2026.103897_bb0695","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41565-022-01071-x","article-title":"Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines","volume":"17","author":"Szebeni","year":"2022","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cis.2026.103897_bb0700","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cis.2026.103897_bb0705","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.actbio.2016.03.048","article-title":"Conjugates of small targeting molecules to non-viral vectors for the mediation of siRNA","volume":"36","author":"Zhi","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.cis.2026.103897_bb0710","doi-asserted-by":"crossref","first-page":"2202670","DOI":"10.1002\/adhm.202202670","article-title":"Targeting ligand independent tropism of siRNA-LNP by small molecules for directed therapy of liver or myeloid immune cells","volume":"13","author":"Lin","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.cis.2026.103897_bb0715","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.nano.2012.11.006","article-title":"Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA","volume":"9","author":"Tam","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.cis.2026.103897_bb0720","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jconrel.2022.06.052","article-title":"Targeted delivery of lipid nanoparticle to lymphatic endothelial cells via anti-podoplanin antibody","volume":"349","author":"Sakurai","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0725","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/acs.accounts.3c00172","article-title":"Functional ligand-enabled particle assembly for bio-nano interactions","volume":"56","author":"Ju","year":"2023","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.cis.2026.103897_bb0730","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.addr.2016.06.011","article-title":"Recent progress in development of siRNA delivery vehicles for cancer therapy","volume":"104","author":"Kim","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0735","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12943-023-01807-w","article-title":"The use of RNA-based treatments in the field of cancer immunotherapy","volume":"22","author":"Chehelgerdi","year":"2023","journal-title":"Mol Cancer"},{"key":"10.1016\/j.cis.2026.103897_bb0740","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jconrel.2020.06.032","article-title":"Photothermal therapy","volume":"325","author":"Zhi","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.cis.2026.103897_bb0745","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","article-title":"Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy","volume":"121","author":"Pham","year":"2021","journal-title":"Chem Rev"},{"key":"10.1016\/j.cis.2026.103897_bb0750","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/C8CS00618K","article-title":"Photothermal therapy and photoacoustic imaging nanotheranostics in fighting cancer","volume":"48","author":"Liu","year":"2019","journal-title":"Chem Soc Rev"}],"container-title":["Advances in Colloid and Interface Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001868626001223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001868626001223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:01:41Z","timestamp":1779249701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001868626001223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":150,"alternative-id":["S0001868626001223"],"URL":"https:\/\/doi.org\/10.1016\/j.cis.2026.103897","relation":{},"ISSN":["0001-8686"],"issn-type":[{"value":"0001-8686","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in lipids design for LNP-mediated DNA and RNA delivery","name":"articletitle","label":"Article Title"},{"value":"Advances in Colloid and Interface Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cis.2026.103897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103897"}}