{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:48:19Z","timestamp":1780645699604,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.cjca.2012.02.003","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T22:54:04Z","timestamp":1335999244000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Cardiovascular Risk Factors Significantly Correlate With Autonomic Nervous System Activity in Children"],"prefix":"10.1016","volume":"28","author":[{"given":"Yan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2012.02.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4070\/kcj.2010.40.1.1","article-title":"Atherosclerotic cardiovascular disease beginning in childhood","volume":"40","author":"Hong","year":"2010","journal-title":"Korean Circ J"},{"key":"10.1016\/j.cjca.2012.02.003_bib2","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM199806043382302","article-title":"Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults","volume":"338","author":"Berenson","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2012.02.003_bib3","first-page":"114","article-title":"Prevalence of nonalcoholic fatty liver disease and metabolic syndrome in obese children [in Chinese]","volume":"47","author":"Shi","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.cjca.2012.02.003_bib4","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jacc.2008.04.013","article-title":"Cardiac markers of pre-clinical disease in adolescents with the metabolic syndrome: the strong heart study","volume":"52","author":"Chinali","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2012.02.003_bib5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jpeds.2005.07.020","article-title":"Underdiagnosis of pediatric obesity and underscreening for fatty liver disease and metabolic syndrome by pediatricians and pediatric subspecialists","volume":"147","author":"Riley","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.cjca.2012.02.003_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","article-title":"The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors","volume":"141","author":"Thayer","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2012.02.003_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.cjca.2012.02.003_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/01.RES.0000147962.01036.bb","article-title":"Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle","volume":"95","author":"Zhang","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2012.02.003_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1797","article-title":"The vagus nerve and the nicotinic anti-inflammatory pathway","volume":"4","author":"Ulloa","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.cjca.2012.02.003_bib10","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/01.CIR.101.14.1665","article-title":"Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries","volume":"101","author":"Laine","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2012.02.003_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1006\/pmed.1995.1097","article-title":"The emergence of clinically abnormal levels of cardiovascular disease risk factor variables among young adults: the Bogalusa Heart Study","volume":"24","author":"Wattigney","year":"1995","journal-title":"Prev Med"},{"key":"10.1016\/j.cjca.2012.02.003_bib12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1540-8159.2008.01045.x","article-title":"The impact of the components of metabolic syndrome on heart rate variability: using the NCEP-ATP III and IDF definitions","volume":"31","author":"Min","year":"2008","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjca.2012.02.003_bib13","first-page":"426","article-title":"Experts consensus for prevention and treatment of dyslipidemia in children and adolescents","volume":"47","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.cjca.2012.02.003_bib14","first-page":"417","article-title":"Metabolic syndrome in overweight and obese school children in Beijing","volume":"6","author":"Wan","year":"2007","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.cjca.2012.02.003_bib15","first-page":"493","article-title":"Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years","volume":"47","author":"Li","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"suppl 2","key":"10.1016\/j.cjca.2012.02.003_bib16","first-page":"555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2012.02.003_bib17","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpedi.157.8.821","article-title":"Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994","volume":"157","author":"Cook","year":"2003","journal-title":"Arch Pediatr Adolsc Med"},{"key":"10.1016\/j.cjca.2012.02.003_bib18","first-page":"201","article-title":"Dose-response relationship between physical activity and dyslipidemia in youth","volume":"26","author":"LeBlanc","year":"2010","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2012.02.003_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MED.0b013e3283424b37","article-title":"Metabolic effects of obesity causing disease in childhood","volume":"18","author":"Abrams","year":"2011","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.cjca.2012.02.003_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1058-9813(00)00069-2","article-title":"Obesity in the pediatric patient: cardiovascular complications","volume":"12","author":"Daniels","year":"2001","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2012.02.003_bib21","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.amepre.2009.04.006","article-title":"Nutrient intake, physical activity, and CVD risk factors in children: Project HeartBeat!","volume":"37","author":"Day","year":"2009","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.cjca.2012.02.003_bib22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.mehy.2007.01.066","article-title":"Is atherosclerosis a neurogenic phenomenon?","volume":"69","author":"Marwah","year":"2007","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.cjca.2012.02.003_bib23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsycho.2005.11.013","article-title":"The role of vagal function in the risk for cardiovascular disease and mortality","volume":"74","author":"Thayer","year":"2007","journal-title":"Biol Psychol"},{"key":"10.1016\/j.cjca.2012.02.003_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/oby.2003.6","article-title":"Autonomic nervous system activity and the state and development of obesity in Japanese school children","volume":"11","author":"Nagai","year":"2003","journal-title":"Obes Res"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X12000517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X12000517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:36:27Z","timestamp":1760106987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X12000517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0828282X12000517"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2012.02.003","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular Risk Factors Significantly Correlate With Autonomic Nervous System Activity in Children","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2012.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}