{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:18:45Z","timestamp":1790417925690,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["onlinecjc.ca","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.cjca.2015.04.012","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T22:13:38Z","timestamp":1430000018000},"page":"1313-1324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Pathogenesis of Arrhythmogenic Cardiomyopathy"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-5504","authenticated-orcid":false,"given":"Angeliki","family":"Asimaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre G.","family":"Kleber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Saffitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2015.04.012_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","article-title":"Right ventricular dysplasia: a report of 24 adult cases","volume":"65","author":"Marcus","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/hrt.71.3.215","volume":"71","author":"McKenna","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.cjca.2015.04.012_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.med.052208.130419","article-title":"Arrhythmogenic cardiomyopathy: etiology, diagnosis and treatment","volume":"61","author":"Sen-Chowdhry","year":"2010","journal-title":"Ann Rev Med"},{"key":"10.1016\/j.cjca.2015.04.012_bib4","first-page":"599","article-title":"Diagnostic criteria for arrhythmogenic right ventricular cardiomyopathy","volume":"65","author":"Quartaa","year":"2012","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.carpath.2009.10.006","article-title":"Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease","volume":"19","author":"Saffitz","year":"2010","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.cjca.2015.04.012_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.carpath.2004.12.001","article-title":"Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat?","volume":"14","author":"Basso","year":"2005","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.cjca.2015.04.012_bib7","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.CIR.94.5.983","article-title":"Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis?","volume":"94","author":"Basso","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib8","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/CIRCULATIONAHA.108.840827","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria","volume":"121","author":"Marcus","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib9","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1111\/pace.12463","article-title":"Electrocardiographic difference between ventricular arrhythmias from the right ventricular outflow tract and idiopathic right ventricular arrhythmias","volume":"37","author":"Ren","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib10","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.febslet.2014.02.008","article-title":"Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome","volume":"588","author":"Agullo-Pascual","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cjca.2015.04.012_bib11","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1540-8167.2005.50040.x","article-title":"The \u201cshort-coupled\u201d variant of right ventricular outflow ventricular tachycardia: a not-so-benign form of benign ventricular tachycardia?","volume":"16","author":"Viskin","year":"2005","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib12","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/eurheartj\/ehp252","article-title":"Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities","volume":"30","author":"Catalano","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2015.04.012_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.hfc.2009.12.003","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"6","author":"Ellinor","year":"2010","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.cjca.2015.04.012_bib14","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1046\/j.1460-9592.2003.t01-1-00217.x","article-title":"Cardiac sarcoidosis masquerading as right ventricular dysplasia","volume":"26","author":"Ott","year":"2003","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tcm.2014.10.007","article-title":"Present understanding of the relationship between exercise and arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"25","author":"Rojas","year":"2015","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.cjca.2015.04.012_bib16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1540-8159.1995.tb06971.x","article-title":"Arrhythmogenic right ventricular dysplasia\/cardiomyopathy: a review","volume":"18","author":"Marcus","year":"1995","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib17","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.hrthm.2009.03.013","article-title":"Arrhythmogenic right ventricular cardiomyopathy\/dysplasia, clinical presentation and diagnostic evaluation: results from the North American multidisciplinary study","volume":"6","author":"Marcus","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjca.2015.04.012_bib18","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1161\/CIRCULATIONAHA.105.542266","article-title":"Arrhythmogenic right ventricular dysplasia: a United States experience","volume":"112","author":"Dalal","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCGENETICS.109.858217","article-title":"Comprehensive desmosome mutation analysis in North Americans with Arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"2","author":"den Haan","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.cjca.2015.04.012_bib20","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jacc.2013.06.033","article-title":"Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"62","author":"James","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib21","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCULATIONAHA.111.025528","article-title":"Sudden death from genetic and acquired cardiomyopathies","volume":"125","author":"Sen-Chowdhry","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/35043032","article-title":"Are desmosomes more than tethers for intermediate filaments","volume":"1","author":"Green","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cjca.2015.04.012_bib23","doi-asserted-by":"crossref","first-page":"207835","DOI":"10.1155\/2010\/207835","article-title":"A\u00a0new perspective on intercalated disk organization: implications for heart disease","volume":"2010","author":"Li","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"10.1016\/j.cjca.2015.04.012_bib24","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1161\/01.CIR.97.20.2049","article-title":"Gene for arrhythmogenic right ventricular cardiomyopathy with diffuse nonepidermolytic palmoplantar keratoderma and woolly hair (Naxos disease) maps to 17q21","volume":"97","author":"Coonar","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib25","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0140-6736(00)02379-5","article-title":"Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)","volume":"355","author":"McKoy","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2015.04.012_bib26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/humu.22765","article-title":"The ARVD\/C Genetic Variants Database: 2014 Update","volume":"36","author":"Lazzarini","year":"2015","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cjca.2015.04.012_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/hmg\/10.3.189","article-title":"Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)","volume":"10","author":"Tiso","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cjca.2015.04.012_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/01.RES.0000091335.07574.86","article-title":"Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes","volume":"93","author":"George","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ajhg.2008.01.010","article-title":"Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene","volume":"82","author":"Merner","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cjca.2015.04.012_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2350-13-21","article-title":"Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy","volume":"13","author":"Rajkumar","year":"2012","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.cjca.2015.04.012_bib31","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/eurjhf\/hfs119","article-title":"Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy","volume":"14","author":"van der Zwaag","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cjca.2015.04.012_bib32","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cardiores.2004.10.005","article-title":"Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1","volume":"65","author":"Beffagna","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.amjcard.2012.10.017","article-title":"Desmin mutations and arrhythmogenic right ventricular cardiomyopathy","volume":"111","author":"Lorenzon","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/cge.12458","article-title":"A mutation in the Z-line Cypher\/ZASP protein is associated with arrhythmogenic right ventricular cardiomyopathy","volume":"88","author":"Lopez-Ayala","year":"2015","journal-title":"Clin Genet"},{"key":"10.1016\/j.cjca.2015.04.012_bib35","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2013.01.073","article-title":"Genetics of arrhythmogenic right ventricular cardiomyopathy: a practical guide for physicians","volume":"61","author":"Marcus","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00441-012-1402-z","article-title":"The changing spectrum of arrhythmogenic (right ventricular) cardiomyopathy","volume":"348","author":"Rizzo","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"suppl D","key":"10.1016\/j.cjca.2015.04.012_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/eurheartj\/10.suppl_D.95","article-title":"Histological diagnosis of right ventricular dysplasia: a role for electron microscopy?","volume":"10","author":"Guiraudon","year":"1989","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2015.04.012_bib38","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/eurheartj\/ehl095","article-title":"Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies","volume":"27","author":"Basso","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2015.04.012_bib39","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1084\/jem.20090641","article-title":"Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy","volume":"206","author":"Pilichou","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.cjca.2015.04.012_bib40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/CIRCRESAHA.111.247023","article-title":"Interactions between ankyrin-G, plakophilin-2, and connexin43 at the cardiac intercalated disc","volume":"109","author":"Sato","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/cvr\/cvu212","article-title":"Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion","volume":"104","author":"Hariharan","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib42","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1056\/NEJMoa0808138","article-title":"A\u00a0new diagnostic test for arrhythmogenic right ventricular cardiomyopathy","volume":"360","author":"Asimaki","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2015.04.012_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12024-014-9644-6","article-title":"Plakoglobin: a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology?","volume":"11","author":"Munkholm","year":"2015","journal-title":"Forensic Sci Med Pathol"},{"key":"10.1016\/j.cjca.2015.04.012_bib44","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/pace.12492","article-title":"Plakoglobin immunolocalization as a diagnostic test for arrhythmogenic right ventricular cardiomyopathy","volume":"37","author":"Ermakov","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib45","doi-asserted-by":"crossref","first-page":"e109128","DOI":"10.1371\/journal.pone.0109128","article-title":"TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy","volume":"9","author":"Siragam","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2015.04.012_bib46","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCEP.111.964890","article-title":"Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy","volume":"4","author":"Asimaki","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib47","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1172\/JCI27751","article-title":"Suppression of canonical Wnt\/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy","volume":"116","author":"Garcia-Gras","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cjca.2015.04.012_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cellsig.2012.09.025","article-title":"Beyond cell adhesion: the role of armadillo proteins in the heart","volume":"25","author":"Swope","year":"2013","journal-title":"Cell Signal"},{"key":"10.1016\/j.cjca.2015.04.012_bib49","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1083\/jcb.139.5.1325","article-title":"Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system","volume":"139","author":"Salomon","year":"1997","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.cjca.2015.04.012_bib50","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0955-0674(98)80039-2","article-title":"Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer","volume":"10","author":"Ben-Ze\u2019ev","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.cjca.2015.04.012_bib51","doi-asserted-by":"crossref","first-page":"31776","DOI":"10.1074\/jbc.M109.047928","article-title":"Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes","volume":"284","author":"Choi","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cjca.2015.04.012_bib52","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1242\/jcs.113.10.1737","article-title":"The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2","volume":"113","author":"Wahl","year":"2000","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.cjca.2015.04.012_bib53","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1038\/sj.onc.1203519","article-title":"Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system","volume":"19","author":"Sadot","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cjca.2015.04.012_bib54","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1242\/jcs.113.18.3127","article-title":"Plakoglobin and beta-catenin: protein interactions, regulation and biological roles","volume":"113","author":"Zhurinsky","year":"2000","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.cjca.2015.04.012_bib55","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1038\/sj.onc.1203921","article-title":"A\u00a0comparative evaluation of beta-catenin and plakoglobin signaling activity","volume":"19","author":"Williams","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cjca.2015.04.012_bib56","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/CIRCRESAHA.111.255075","article-title":"Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy","volume":"109","author":"Lombardi","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib57","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1196\/annals.1341.030","article-title":"Dependence of electrical coupling on mechanical coupling in cardiac myocytes \u2013 insights gained from cardiomyopathies caused by defects in cell-cell communication","volume":"1047","author":"Saffitz","year":"2005","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.cjca.2015.04.012_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ppedcard.2014.10.001","article-title":"Arrhythmogenic cardiomyopathy - new insights into disease mechanisms and drug discovery","volume":"37","author":"Asimaki","year":"2014","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2015.04.012_bib59","doi-asserted-by":"crossref","first-page":"240ra74","DOI":"10.1126\/scitranslmed.3008008","article-title":"Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy","volume":"6","author":"Asimaki","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.cjca.2015.04.012_bib60","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/cvr\/cvs218","article-title":"Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency","volume":"95","author":"Cerrone","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib61","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1152\/physrev.00025.2003","article-title":"Basic mechanisms of cardiac impulse propagation and associated arrhythmias","volume":"84","author":"Kl\u00e9ber","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cjca.2015.04.012_bib62","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.hrthm.2012.11.018","article-title":"Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy","volume":"10","author":"Noorman","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjca.2015.04.012_bib63","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cell.2006.12.037","article-title":"Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions","volume":"128","author":"Shaw","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cjca.2015.04.012_bib64","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/CIRCRESAHA.111.257964","article-title":"Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane","volume":"110","author":"Smyth","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-12-388448-0.00018-8","article-title":"Visualizing cardiac ion channel trafficking pathways","volume":"505","author":"Smyth","year":"2012","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cjca.2015.04.012_bib66","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.201312110","article-title":"Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions","volume":"206","author":"Patel","year":"2014","journal-title":"J\u00a0Cell Biol"},{"issue":"suppl","key":"10.1016\/j.cjca.2015.04.012_bib67","first-page":"A15042","article-title":"Arrhythmogenic cardiomyopathy mutations cause disassembly of the Cx43 forward trafficking machinery which can be rescued by GSK-3\u03b2 inhibition [abstract 15042]","volume":"130","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib68","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/CIRCRESAHA.110.228312","article-title":"SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes","volume":"108","author":"Petitprez","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib69","doi-asserted-by":"crossref","first-page":"E2134","DOI":"10.1073\/pnas.1109370109","article-title":"Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia","volume":"109","author":"Milstein","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cjca.2015.04.012_bib70","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/CIRCULATIONAHA.113.007852","article-title":"PDZ domain-binding motif regulates cardiomyocyte compartment-specific Nav1.5 channel expression and function","volume":"130","author":"Shy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2015.04.012_bib71","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.hrthm.2014.09.057","article-title":"Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current","volume":"12","author":"Gillet","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjca.2015.04.012_bib72","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/CIRCRESAHA.109.196899","article-title":"Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy","volume":"104","author":"Lombardi","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib73","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.114.302810","article-title":"The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy","volume":"114","author":"Chen","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2015.04.012_bib74","doi-asserted-by":"crossref","first-page":"e23341","DOI":"10.1371\/journal.pone.0023341","article-title":"Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2015.04.012_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature11799","article-title":"Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs","volume":"494","author":"Kim","year":"2013","journal-title":"Nature"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X15003001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X15003001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T03:00:23Z","timestamp":1651806023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X15003001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0828282X15003001"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2015.04.012","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenesis of Arrhythmogenic Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2015.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}