{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:28:36Z","timestamp":1782944916840,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["onlinecjc.ca","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.cjca.2016.02.056","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T20:15:26Z","timestamp":1456344926000},"page":"1355.e9-1355.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cost-Effectiveness of Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation Patients With Contraindications to Anticoagulation"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-984X","authenticated-orcid":false,"given":"Jacqueline","family":"Saw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Bennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon M.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harindra C.","family":"Wijeysundera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2016.02.056_bib1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.amjcard.2013.05.063","article-title":"Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population","volume":"112","author":"Colilla","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib2","doi-asserted-by":"crossref","first-page":"e63479","DOI":"10.1371\/journal.pone.0063479","article-title":"Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD registry","volume":"8","author":"Kakkar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2016.02.056_bib3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jacc.2013.02.089","article-title":"Percutaneous left atrial appendage closure with the AMPLATZER cardiac plug device in patients with nonvalvular atrial fibrillation and contraindications to anticoagulation therapy","volume":"62","author":"Urena","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib4","doi-asserted-by":"crossref","first-page":"A18131","DOI":"10.1161\/circ.132.suppl_3.18131","article-title":"Canadian multi-center experience with WATCHMAN for percutaneous left atrial appendage closure","volume":"132","author":"Saw","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.02.056_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cjca.2015.09.008","article-title":"Left atrial appendage closure for atrial fibrillation: a story still being written","volume":"32","author":"Jaffer","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cjca.2013.11.008","article-title":"Cardiac procedures to prevent stroke: patent foramen ovale closure\/left atrial appendage occlusion","volume":"30","author":"Freixa","year":"2014","journal-title":"Can J\u00a0Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib7","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/CIRCULATIONAHA.112.000920","article-title":"Economic evaluation of percutaneous left atrial appendage occlusion, dabigatran, and warfarin for stroke prevention in patients with nonvalvular atrial fibrillation","volume":"127","author":"Singh","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.02.056_bib8","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1016\/j.jacc.2015.09.084","article-title":"Time to cost-effectiveness following stroke reduction strategies in AF: warfarin versus NOACs versus LAA closure","volume":"66","author":"Reddy","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0272989X15593083","article-title":"A\u00a0decision analysis of percutaneous left atrial appendage occlusion relative to novel and traditional oral anticoagulation for stroke prevention in patients with new-onset atrial fibrillation","volume":"36","author":"Micieli","year":"2016","journal-title":"Med Decis Making"},{"key":"10.1016\/j.cjca.2016.02.056_bib10","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.cjca.2014.08.001","article-title":"2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation","volume":"30","author":"Verma","year":"2014","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib11","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/eurheartj\/ehs253","article-title":"2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association","volume":"33","author":"Camm","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2016.02.056_bib12","series-title":"Guidelines for the Economic Evaluation of Health Technologies: Canada","year":"2006"},{"key":"10.1016\/j.cjca.2016.02.056_bib13","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.jacc.2013.03.035","article-title":"Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology)","volume":"61","author":"Reddy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib14","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/ehjci\/jev067","article-title":"Cardiac CT angiography for device surveillance after endovascular left atrial appendage closure","volume":"16","author":"Saw","year":"2015","journal-title":"Eur Heart J\u00a0Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2016.02.056_bib15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2016.02.056_bib16","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib17","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/archinte.1996.00440150083009","article-title":"The effect of stroke and stroke prophylaxis with aspirin or warfarin on quality of life","volume":"156","author":"Gage","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib18","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.112.114389","article-title":"Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3-year follow-up of the PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation) Trial","volume":"127","author":"Reddy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.02.056_bib19","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial","volume":"312","author":"Reddy","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2016.02.056_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-154-1-201101040-00289","article-title":"Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation","volume":"154","author":"Freeman","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib21","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/eurheartj\/ehq250","article-title":"Mortality predictors and effects of antithrombotic therapies in atrial fibrillation: insights from ACTIVE-W","volume":"31","author":"De Caterina","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2016.02.056_bib22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial","volume":"64","author":"Holmes","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib24","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/j.jacc.2015.04.025","article-title":"Left atrial appendage closure as an alternative to warfarin for stroke prevention in atrial fibrillation: a patient-level meta-analysis","volume":"65","author":"Holmes","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00005650-200006000-00004","article-title":"One thousand health-related quality-of-life estimates","volume":"38","author":"Tengs","year":"2000","journal-title":"Med Care"},{"key":"10.1016\/j.cjca.2016.02.056_bib26","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(00)90012-6","article-title":"Decision analysis and guidelines for anticoagulant therapy to prevent stroke in patients with atrial fibrillation","volume":"355","author":"Thomson","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2016.02.056_bib27","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.jacc.2008.01.042","article-title":"Balancing the risks of restenosis and stent thrombosis in bare-metal versus drug-eluting stents: results of a decision analytic model","volume":"51","author":"Garg","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.02.056_bib28","first-page":"678","article-title":"Live donor nephrectomy in patients with fibromuscular dysplasia of the renal arteries","volume":"162","author":"Indudhara","year":"1999","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.cjca.2016.02.056_bib29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/000331979905000911","article-title":"Successful stenting on tortuous coronary artery with accordion phenomenon: strategy\u2014a case report","volume":"50","author":"Asakura","year":"1999","journal-title":"Angiology"},{"key":"10.1016\/j.cjca.2016.02.056_bib30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ahj.2013.12.014","article-title":"Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry","volume":"167","author":"O'Brien","year":"2014","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjca.2016.02.056_bib31","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7326\/0003-4819-131-7-199910050-00003","article-title":"Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis","volume":"131","author":"Hart","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib32","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa1007432","article-title":"Apixaban in patients with atrial fibrillation","volume":"364","author":"Connolly","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib34","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.02.056_bib35","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"N\u00a0Engl J Med"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X16001641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X16001641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T01:59:28Z","timestamp":1654394368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X16001641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0828282X16001641"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2016.02.056","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cost-Effectiveness of Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation Patients With Contraindications to Anticoagulation","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2016.02.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}