{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:41:14Z","timestamp":1760550074890},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["onlinecjc.ca","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.cjca.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T10:35:22Z","timestamp":1466505322000},"page":"1513-1519","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab\u2013Mediated Cardiac Dysfunction"],"prefix":"10.1016","volume":"32","author":[{"given":"Vineet","family":"Goyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Bews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheena","family":"Premecz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soma","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Best","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Bhindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Thliveris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan K.","family":"Singal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Niraula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder S.","family":"Jassal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2016.06.002_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1470-2045(09)70042-7","article-title":"Cardiovascular toxicity caused by cancer treatment: strategies for early detection","volume":"10","author":"Altena","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cjca.2016.06.002_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1078-0432.CCR-07-1033","article-title":"Cardiac toxicity in breast cancer survivors: review of potential cardiac problems","volume":"14","author":"Bird","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cjca.2016.06.002_bib3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1200\/JCO.1999.17.2.460","article-title":"Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy","volume":"17","author":"Kuerer","year":"1999","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.cjca.2016.06.002_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2165\/00003495-200666040-00005","article-title":"Trastuzumab: a review of its use in the management of HER2-positive metastatic and early-stage breast cancer","volume":"66","author":"Plosker","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.cjca.2016.06.002_bib5","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJMoa052306","article-title":"Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer","volume":"353","author":"Piccart-Gebhart","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.06.002_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.echo.2011.01.018","article-title":"The cardioprotective role of probucol against anthracycline and trastuzumab-mediated cardiotoxicity","volume":"24","author":"Walker","year":"2011","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2016.06.002_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cjca.2013.11.013","article-title":"Congenital absence of nitric oxide synthase 3 potentiates cardiac dysfunction and reduces survival in doxorubicin- and trastuzumab-mediated cardiomyopathy","volume":"30","author":"Zeglinski","year":"2014","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2016.06.002_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1056\/NEJMc070065","article-title":"Cardiotoxicity of trastuzumab in clinical practice","volume":"357","author":"McArthur","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2016.06.002_bib9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cardfail.2009.04.011","article-title":"Trastuzumab-induced cardiomyopathy: not as benign as it looks? A retrospective study","volume":"15","author":"Guglin","year":"2009","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2016.06.002_bib10","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2010.11.063","volume":"57","author":"Fallah-Rad","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2016.06.002_bib11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.pcad.2006.10.002","article-title":"Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management","volume":"49","author":"Takemura","year":"2007","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.cjca.2016.06.002_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1749-6632.1999.tb09233.x","article-title":"Apoptosis in isolated adult cardiomyocytes exposed to adriamycin","volume":"874","author":"Kumar","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cjca.2016.06.002_bib13","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1074\/jbc.M804570200","article-title":"Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways","volume":"284","author":"Gordon","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cjca.2016.06.002_bib14","doi-asserted-by":"crossref","first-page":"C645","DOI":"10.1152\/ajpcell.00186.2012","article-title":"Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury","volume":"303","author":"Ludke","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.cjca.2016.06.002_bib15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1006\/abbi.1995.1091","article-title":"Doxorubicin reduces the iron(III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals","volume":"316","author":"Malisza","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.cjca.2016.06.002_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(08)60985-0","article-title":"N-acetylcysteine: pharmacological considerations and experimental and clinical applications","volume":"38","author":"Cotgreave","year":"1997","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.cjca.2016.06.002_bib17","first-page":"917","article-title":"Attempt to prevent doxorubicin-induced acute human myocardial morphologic damage with acetylcysteine","volume":"71","author":"Unverferth","year":"1983","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.cjca.2016.06.002_bib18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2004.09.025","article-title":"N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress","volume":"38","author":"Grinberg","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cjca.2016.06.002_bib19","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.freeradbiomed.2010.02.023","article-title":"HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide","volume":"48","author":"Banerjee","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cjca.2016.06.002_bib20","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1471-4159.2004.02428.x","article-title":"A\u00a0low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis","volume":"89","author":"Offen","year":"2004","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.cjca.2016.06.002_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2210-9-7","article-title":"N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes","volume":"9","author":"Shi","year":"2009","journal-title":"BMC Pharmacol"},{"key":"10.1016\/j.cjca.2016.06.002_bib22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.echo.2009.01.016","article-title":"Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline mediated cardiomyopathy","volume":"22","author":"Jassal","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2016.06.002_bib23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/CIRCULATIONAHA.106.652339","article-title":"Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin","volume":"116","author":"Neilan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.06.002_bib24","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ajpath.2011.01.036","article-title":"N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation","volume":"178","author":"Schimel","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cjca.2016.06.002_bib25","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3892\/mmr.2014.2292","article-title":"N-acetylcysteine reduces oxidative stress, nuclear factor-\u03baB activity and cardiomyocyte apoptosis in heart failure","volume":"10","author":"Wu","year":"2014","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.cjca.2016.06.002_bib26","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1161\/01.CIR.89.6.2829","article-title":"Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats","volume":"89","author":"Siveski-Iliskovic","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.06.002_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00280-003-0676-y","article-title":"New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity","volume":"52","author":"El-Demerdash","year":"2003","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.cjca.2016.06.002_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.7326\/0003-4819-88-2-168","article-title":"Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyocardial biopsy, and cardiac catheterization","volume":"88","author":"Bristow","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cjca.2016.06.002_bib29","doi-asserted-by":"crossref","first-page":"H1466","DOI":"10.1152\/ajpheart.00795.2008","article-title":"Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in\u00a0vivo and in\u00a0vitro","volume":"296","author":"Mukhopadhyay","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cjca.2016.06.002_bib30","first-page":"141","article-title":"Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure","volume":"148","author":"Sharov","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cjca.2016.06.002_bib31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2016.06.002_bib32","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1006\/jmcc.2002.2110","article-title":"Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in\u00a0vitro and in\u00a0vivo studies","volume":"34","author":"Wu","year":"2002","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cjca.2016.06.002_bib33","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.echo.2014.01.014","article-title":"Doxorubicin and trastuzumab regimen induces biventricular failure in mice","volume":"27","author":"Milano","year":"2014","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2016.06.002_bib34","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/eurheartj\/ehl013","article-title":"Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury","volume":"27","author":"Neilan","year":"2006","journal-title":"Eur Heart J"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X16301453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X16301453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:57:06Z","timestamp":1568077026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X16301453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0828282X16301453"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2016.06.002","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab\u2013Mediated Cardiac Dysfunction","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}