{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:38:00Z","timestamp":1788781080199,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["onlinecjc.ca","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.cjca.2017.09.005","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T15:31:17Z","timestamp":1505230277000},"page":"1708-1715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study"],"prefix":"10.1016","volume":"33","author":[{"given":"Stephen P.","family":"Hoole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Hern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan C.","family":"McNab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Calvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra S.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard M.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2017.09.005_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0025-6196(12)60336-X","article-title":"Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts","volume":"59","author":"Hagen","year":"1984","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.cjca.2017.09.005_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM198805053181802","article-title":"Prevalence of patent foramen ovale in patients with stroke","volume":"318","author":"Lechat","year":"1988","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1525-2167(03)00076-3","article-title":"Transthoracic echocardiography using second harmonic imaging with Valsalva manoeuvre for the detection of right to left shunts","volume":"5","author":"Clarke","year":"2004","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.cjca.2017.09.005_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S1808-86942009000300024","article-title":"Use of Muller's maneuver in the evaluation of patients with sleep apnea\u2014literature review","volume":"75","author":"Soares","year":"2009","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.cjca.2017.09.005_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2273.1991.tb00974.x","article-title":"A\u00a0comparison of sleep nasendoscopy and the Muller manoeuvre","volume":"16","author":"Pringle","year":"1991","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.cjca.2017.09.005_bib6","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1152\/jappl.1985.59.5.1364","article-title":"Physiological determinants of nocturnal arterial oxygenation in patients with obstructive sleep apnea","volume":"59","author":"Bradley","year":"1985","journal-title":"J\u00a0Appl Physiol"},{"issue":"8","key":"10.1016\/j.cjca.2017.09.005_bib7","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/sleep\/25.8.21","article-title":"Obstructive sleep apnea can be provocative for right-to-left shunting through a patent foramen ovale","volume":"25","author":"Beelke","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.cjca.2017.09.005_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1378\/chest.113.1.91","article-title":"Prevalence of patent foramen ovale and its contribution to hypoxemia in patients with obstructive sleep apnea","volume":"113","author":"Shanoudy","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2017.09.005_bib9","first-page":"1257","article-title":"Ventilatory responses to hypercapnia during wakefulness and sleep in obese adolescents with and without obstructive sleep apnea syndrome","volume":"35","author":"Yuan","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.cjca.2017.09.005_bib10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1540-8183.2005.00072.x","article-title":"Obstructive sleep apnea and patent foramen ovale: successful treatment of symptoms by percutaneous foramen ovale closure","volume":"18","author":"Agnoletti","year":"2005","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5664\/jcsm.26802","article-title":"Improvement in sleep apnea associated with closure of a patent foramen ovale","volume":"3","author":"Silver","year":"2007","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/thx.2010.152272","article-title":"Effectiveness of home respiratory polygraphy for the diagnosis of sleep apnea and hypopnea syndrome","volume":"66","author":"Masa","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.cjca.2017.09.005_bib13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.cjca.2017.09.005_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005650-199303000-00006","article-title":"The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs","volume":"31","author":"McHorney","year":"1993","journal-title":"Med Care"},{"key":"10.1016\/j.cjca.2017.09.005_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1164\/ajrccm.158.2.9712036","article-title":"Development of a disease-specific health-related quality of life questionnaire for sleep apnea","volume":"158","author":"Flemons","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib16","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.cjca.2017.09.005_bib17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1164\/rccm.201106-0964OC","article-title":"Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial","volume":"184","author":"Kohler","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib18","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1378\/chest.127.6.2076","article-title":"Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome","volume":"127","author":"Doherty","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2017.09.005_bib19","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1183\/09031936.04.00100203","article-title":"Night-to-night variation of the oxygen desaturation index in sleep apnea syndrome","volume":"24","author":"Fietze","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2017.09.005_bib20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cjca.2015.04.020","article-title":"When to suspect sleep apnea and what to do about it","volume":"31","author":"Kimoff","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib22","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib23","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.cjca.2017.09.005_bib24","first-page":"246","article-title":"Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study","volume":"108","author":"Young","year":"2009","journal-title":"WMJ"},{"key":"10.1016\/j.cjca.2017.09.005_bib25","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cjca.2015.03.011","article-title":"Epidemiology of sleep disturbances and cardiovascular consequences","volume":"31","author":"Badran","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0165-1838(95)00062-3","article-title":"Role of hypoxemia in sleep apnea-induced sympathoexcitation","volume":"56","author":"Smith","year":"1996","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.cjca.2017.09.005_bib27","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1152\/jappl.1992.72.3.821","article-title":"Repetitive apneas induce periodic hypertension in normal subjects through hypoxia","volume":"72","author":"van den Aardweg","year":"1992","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)74229-X","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnea-hypopnea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2017.09.005_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1183\/09031936.00035906","article-title":"The influence of patent foramen ovale on oxygen desaturation in obstructive sleep apnea","volume":"29","author":"Johansson","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2017.09.005_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1378\/chest.12-0334","article-title":"Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure","volume":"143","author":"Shaikh","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2017.09.005_bib31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1378\/chest.12-2216","article-title":"No closure for patent foramen ovale in obstructive sleep apnea?","volume":"143","author":"Hoole","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2017.09.005_bib32","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.jacc.2015.01.062","article-title":"Effect of patent foramen ovale closure on obstructive sleep apnea","volume":"65","author":"Rimoldi","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2017.09.005_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hs0102.100883","article-title":"Transesophageal echocardiography for quantifying size of patent foramen ovale in patients with cryptogenic cerebrovascular events","volume":"33","author":"Schuchlenz","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.cjca.2017.09.005_bib34","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/0735-1097(93)90789-4","article-title":"Femoral vein delivery of contrast medium enhances transthoracic echocardiographic detection of patent foramen ovale","volume":"22","author":"Gin","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X17309923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X17309923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T10:36:52Z","timestamp":1602931012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X17309923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0828282X17309923"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2017.09.005","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Patent Foramen Ovale Closure on Obstructive Sleep Apnea Syndrome: PCOSA Study","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2017.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}