{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:56:45Z","timestamp":1788919005563,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008093","name":"Schulich School of Medicine and Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinecjc.ca","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.cjca.2018.08.033","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T17:57:28Z","timestamp":1535479048000},"page":"1631-1640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Association of Kidney Function and Albuminuria With the Risk and Outcomes of Syncope: A Population-Based Cohort Study"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-2030","authenticated-orcid":false,"given":"David","family":"Massicotte-Azarniouch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"Kuwornu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber O","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit X.","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish M.","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2018.08.033_bib1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJMoa012407","article-title":"Incidence and prognosis of syncope","volume":"347","author":"Soteriades","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"suppl 1","key":"10.1016\/j.cjca.2018.08.033_bib2","article-title":"Epidemiology of reflex syncope","volume":"14","author":"Colman","year":"2004","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.cjca.2018.08.033_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.amjcard.2004.11.013","article-title":"Direct medical costs of syncope-related hospitalizations in the United States","volume":"95","author":"Sun","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijcard.2011.11.083","article-title":"Incidence, etiology and predictors of adverse outcomes in 43,315 patients presenting to the emergency department with syncope: an international meta-analysis","volume":"167","author":"D\u2019Ascenzo","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib5","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.amjcard.2005.07.047","article-title":"Relation of clinical presentation of syncope to the age of patients","volume":"96","author":"Del Rosso","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ajkd.2003.50007","article-title":"Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey","volume":"41","author":"Coresh","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.cjca.2018.08.033_bib7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1681\/ASN.2004070539","article-title":"Chronic kidney disease awareness: prevalence, and trends among US adults, 1999 to 2000","volume":"16","author":"Coresh","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.cjca.2018.08.033_bib8","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2018.08.033_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease - A systematic review and meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2018.08.033_bib10","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/aje\/kwn033","article-title":"Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population","volume":"167","author":"Astor","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib11","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2215\/CJN.09741110","article-title":"Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes","volume":"6","author":"Bello","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.cjca.2018.08.033_bib12","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib13","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1001\/archinte.167.22.2490","article-title":"Association of kidney function and albuminuria with cardiovascular mortality in older vs younger individuals: the HUNT II study","volume":"167","author":"Hallan","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2010.531","article-title":"Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes: a collaborative meta-analysis of general and high-risk population cohorts","volume":"80","author":"Gansevoort","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.cjca.2018.08.033_bib15","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2018.08.033_bib16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1525-139X.2008.00455.x","article-title":"Sudden cardiac death and dialysis patients","volume":"21","author":"Herzog","year":"2008","journal-title":"Semin Dial"},{"key":"10.1016\/j.cjca.2018.08.033_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/0735-1097(96)00018-6","article-title":"Characteristics and mortality outcomes of thrombolysis trial participants and nonparticipants: a population-based comparison","volume":"27","author":"Jha","year":"1996","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib19","first-page":"67","article-title":"Coding accuracy of administrative drug claims in the Ontario Drug Benefit database","volume":"10","author":"Levy","year":"2003","journal-title":"Can J Clin Pharmacol"},{"key":"10.1016\/j.cjca.2018.08.033_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40697-014-0026-5","article-title":"Canadian Organ Replacement Register (CORR): reflecting the past and embracing the future","volume":"1","author":"Moist","year":"2014","journal-title":"Can J Kidney Health Dis"},{"key":"10.1016\/j.cjca.2018.08.033_bib21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"suppl","key":"10.1016\/j.cjca.2018.08.033_bib22","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.cjca.2018.08.033_bib23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/europace\/eus359","article-title":"Accuracy of the ICD-10 discharge diagnosis for syncope","volume":"15","author":"Ruwald","year":"2013","journal-title":"Europace"},{"key":"10.1016\/j.cjca.2018.08.033_bib24","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.cjca.2018.08.033_bib25","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2215\/CJN.10301016","article-title":"Statistical methods for cohort studies of CKD: survival analysis in the setting of competing risks","volume":"12","author":"Hsu","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.cjca.2018.08.033_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11255-006-9088-3","article-title":"Prospective investigation of the incidence of falls, dizziness and syncope in haemodialysis patients","volume":"39","author":"Roberts","year":"2007","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.cjca.2018.08.033_bib27","first-page":"197","article-title":"The prevalence and prognostic significance of near syncope and syncope: a prospective study of 395 cases in an emergency department (the SPEED study)","volume":"111","author":"Greve","year":"2014","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.cjca.2018.08.033_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCEP.110.957100","article-title":"Association of chronic kidney disease with atrial fibrillation among adults in the United States REasons for Geographic and Racial Differences in Stroke (REGARDS) study","volume":"4","author":"Baber","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066036","article-title":"Prevalence of ventricular arrhythmia and its associated factors in nondialyzed chronic kidney disease patients","volume":"8","author":"Bonato","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2018.08.033_bib30","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1681\/ASN.2004090765","article-title":"High prevalence of occult coronary artery stenosis in patients with chronic kidney disease at the initiation of renal replacement therapy: an angiographic examination","volume":"16","author":"Ohtake","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.cjca.2018.08.033_bib31","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/sj.ki.5000249","article-title":"Redefinition of uremic cardiomyopathy by contrast-enhanced cardiac magnetic resonance imaging","volume":"69","author":"Mark","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.cjca.2018.08.033_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0895-7061(98)00232-5","article-title":"Blood pressure and the risk of complex arrhythmia in renal insufficiency, hemodialysis, and renal transplant patients","volume":"12","author":"De Lima","year":"1999","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cjca.2018.08.033_bib33","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2009.219","article-title":"Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease","volume":"76","author":"Pun","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.cjca.2018.08.033_bib34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.annemergmed.2007.02.001","article-title":"Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with syncope","volume":"49","author":"Huff","year":"2007","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib35","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0735-1097(01)01241-4","article-title":"Diagnostic value of history in patients with syncope with or without heart disease","volume":"37","author":"Alboni","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib36","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0002-9343(95)00052-6","article-title":"Is syncope a risk factor for poor outcomes? Comparison of patients with and without syncope","volume":"100","author":"Kapoor","year":"1996","journal-title":"Am J Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0196-0644(97)70217-8","article-title":"Risk stratification of patients with syncope","volume":"29","author":"Martin","year":"1997","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/archinte.159.4.375","article-title":"Do symptoms predict cardiac arrhythmias and mortality in patients with syncope?","volume":"159","author":"Oh","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.15420\/ecr.2014.9.1.28","article-title":"Syncope in the elderly","volume":"9","author":"Brien","year":"2014","journal-title":"Eur Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib40","article-title":"2017 ACC\/AHA\/HRS Guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"136","author":"Shen","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2018.08.033_bib41","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jacc.2009.09.049","article-title":"The ROSE (Risk Stratification of Syncope in the Emergency Department) study","volume":"55","author":"Reed","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2018.08.033_bib42","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.annemergmed.2005.11.019","article-title":"Prospective validation of the San Francisco syncope rule to predict patients with serious outcomes","volume":"47","author":"Quinn","year":"2006","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.cjca.2018.08.033_bib43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jacc.2007.08.059","article-title":"Short- and long-term prognosis of syncope, risk factors, and role of hospital admission: results from the STePS (Short-Term Prognosis of Syncope) Study","volume":"51","author":"Costantino","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X1831105X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X1831105X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T04:53:49Z","timestamp":1544072029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X1831105X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0828282X1831105X"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2018.08.033","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association of Kidney Function and Albuminuria With the Risk and Outcomes of Syncope: A Population-Based Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2018.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}