{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:48:17Z","timestamp":1793965697800,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CIBC World Market"},{"name":"Child Health Research"},{"name":"Labatt Family Heart Centre"},{"name":"SickKids Hospital"},{"name":"International Kawasaki Disease Registry"},{"name":"les Fonds BoBeau Coeur of the Ste-Justine Hospital Foundation"},{"DOI":"10.13039\/100001244","name":"McCance Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001244","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vella Fund"},{"name":"Children\u2019s Health Foundation of London"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.cjca.2020.01.016","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T08:23:45Z","timestamp":1593591825000},"page":"1598-1607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children With Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-7681","authenticated-orcid":false,"given":"Cedric","family":"Manlhiot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-3703","authenticated-orcid":false,"given":"Tisiana","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagib","family":"Dahdah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Mackie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Raghuveer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese M.","family":"Giglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-2523","authenticated-orcid":false,"given":"Frederic","family":"Dallaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-6361","authenticated-orcid":false,"given":"Mathew","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-4700","authenticated-orcid":false,"given":"Kyle","family":"Runeckles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfriede","family":"Pahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf S.","family":"Harahsheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Norozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah D.","family":"de Ferranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anji T.","family":"Yetman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"McCrindle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Braunlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0345-0341","authenticated-orcid":false,"given":"Michael R.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine F.","family":"Choueiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica H.","family":"Colyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-9178","authenticated-orcid":false,"given":"Andrew","family":"Crean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8602-9864","authenticated-orcid":false,"given":"Adam","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-2764","authenticated-orcid":false,"given":"Laurent","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane","family":"Dillenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2864-1830","authenticated-orcid":false,"given":"Audrey","family":"Dionne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Grcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Greenway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Hamel-Perrault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hayden-Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ni","family":"Jone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Kimball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-7137","authenticated-orcid":false,"given":"Ming-Tai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Mahle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"McHugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Portman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-8820","authenticated-orcid":false,"given":"Claudia","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Kristen","family":"Sexson Tejitel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline R.","family":"Szmuszkovicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Texter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Thacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Seda","family":"Selamet Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana H.","family":"Tremoulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Wagner-Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2020.01.016_bib1","first-page":"79","article-title":"Epidemiology of Kawasaki disease in Asia, Europe, and the United States","volume":"22","author":"Uehara","year":"2012","journal-title":"J\u00a0Epidemiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib2","first-page":"303","article-title":"Epidemiology of Kawasaki disease in Canada 2004 to 2014: comparison of surveillance using administrative data vs periodic medical record review","volume":"34","author":"Manlhiot","year":"2018","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib3","first-page":"519","article-title":"Size of coronary aneurysm as a determinant factor of the prognosis in Kawasaki disease: clinicopathologic study of coronary aneurysms","volume":"250","author":"Fujiwara","year":"1987","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.cjca.2020.01.016_bib4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0022-3476(87)80246-9","article-title":"Long-term prognosis of giant coronary aneurysm in Kawasaki disease: an angiographic study","volume":"111","author":"Tatara","year":"1987","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cjca.2020.01.016_bib5","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.01.016_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ppedcard.2004.08.012","article-title":"Anticoagulation in the acute and long-term management of Kawasaki disease","volume":"19","author":"Richard","year":"2004","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib7","series-title":"Oral Anticoagulants","first-page":"9","article-title":"Structure and mechanism of activation of vitamin K antagonists","author":"Sadowski","year":"1996"},{"key":"10.1016\/j.cjca.2020.01.016_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2011.01.061","article-title":"A\u00a0multicenter, randomized trial comparing heparin\/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children","volume":"58","author":"Monagle","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpeds.2017.04.051","article-title":"Safety and efficacy of warfarin therapy in Kawasaki disease","volume":"189","author":"Baker","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cjca.2020.01.016_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-3476(00)90005-2","article-title":"The use of low molecular weight heparin in pediatric patients: a prospective cohort study","volume":"136","author":"Dix","year":"2000","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cjca.2020.01.016_bib11","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/j.thromres.2010.05.026","article-title":"Development and preliminary evaluation of the KIDCLOT PAC QL: a new health-related quality of life measure for pediatric long-term anticoagulation therapy","volume":"126","author":"Bruce","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.cjca.2020.01.016_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11606-016-3603-8","article-title":"Effects of long-term low-molecular-weight heparin on fractures and bone density in non-pregnant adults: a systematic review with meta-analysis","volume":"31","author":"Gajic-Veljanoski","year":"2016","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.cjca.2020.01.016_bib13","first-page":"1120","article-title":"Difference between persistent aneurysm, regressed aneurysm, and coronary dilation in Kawasaki disease: an optical coherence tomography study","volume":"34","author":"Dionne","year":"2018","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00246-010-9715-8","article-title":"Long-term anticoagulation in Kawasaki disease: Initial use of low molecular weight heparin is a viable option for patients with severe coronary artery abnormalities","volume":"31","author":"Manlhiot","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib15","doi-asserted-by":"crossref","first-page":"e016440","DOI":"10.1161\/JAHA.119.016440","article-title":"International Kawasaki Disease Registry. Medium-term complications associated with coronary artery aneurysms after Kawasaki Disease: a study from the International Kawasaki Disease Registry","volume":"9","author":"McCrindle","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2020.01.016_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.cjca.2020.01.016_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/CIRCULATIONAHA.107.690875","article-title":"Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements","volume":"116","author":"McCrindle","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.01.016_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00246-007-9132-9","article-title":"Warfarin therapy for giant aneurysm prevents myocardial infarction in Kawasaki disease","volume":"29","author":"Sugahara","year":"2008","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2020.01.016_bib19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1253\/circj.CJ-08-0931","article-title":"Multicenter and retrospective case study of warfarin and aspirin combination therapy in patients with giant coronary aneurysms caused by Kawasaki disease","volume":"73","author":"Suda","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.cjca.2020.01.016_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000363732","article-title":"Safety and efficacy of warfarin plus aspirin combination therapy for giant coronary artery aneurysm secondary to Kawasaki disease: a meta-analysis","volume":"129","author":"Su","year":"2014","journal-title":"Cardiology"},{"key":"10.1016\/j.cjca.2020.01.016_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1503\/cmaj.070186","article-title":"Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding","volume":"177","author":"Delaney","year":"2007","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.cjca.2020.01.016_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/JMDH.S54324","article-title":"Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment","volume":"7","author":"Cryer","year":"2014","journal-title":"J\u00a0Multidiscip Healthc"},{"key":"10.1016\/j.cjca.2020.01.016_bib23","author":"Crader"},{"key":"10.1016\/j.cjca.2020.01.016_bib24","doi-asserted-by":"crossref","first-page":"e44S","DOI":"10.1378\/chest.11-2292","article-title":"Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Ageno","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2020.01.016_bib25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pedhc.2016.11.007","article-title":"Kawasaki disease with coronary artery aneurysms: psychosocial impact on parents and children","volume":"31","author":"Chahal","year":"2017","journal-title":"J\u00a0Pediatr Health Care"},{"key":"10.1016\/j.cjca.2020.01.016_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/01.fpc.0000184955.08453.a8","article-title":"Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans","volume":"16","author":"Takahashi","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.cjca.2020.01.016_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MBC.0b013e3283494b3c","article-title":"Protamine reversal of low molecular weight heparin: clinically effective?","volume":"22","author":"van Veen","year":"2011","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.cjca.2020.01.016_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.11622\/smedj.2015184","article-title":"Novel oral anticoagulants for atrial fibrillation","volume":"56","author":"How","year":"2015","journal-title":"Singapore Med J"},{"key":"10.1016\/j.cjca.2020.01.016_bib29","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2147\/TCRM.S84210","article-title":"New oral anticoagulants: their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events","volume":"11","author":"Mekaj","year":"2015","journal-title":"Ther Clin Risk Manag"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20300519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20300519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:44:18Z","timestamp":1760107458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X20300519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0828282X20300519"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2020.01.016","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children With Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2020.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}