{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:21:37Z","timestamp":1790706097550,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007177","name":"CRC Health Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["143348"],"award-info":[{"award-number":["143348"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.cjca.2020.02.003","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T20:10:10Z","timestamp":1581106210000},"page":"648-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["How Structure, Mechanics, and Function of the Vasculature Contribute to Blood Pressure Elevation in Hypertension"],"prefix":"10.1016","volume":"36","author":[{"given":"Ernesto L.","family":"Schiffrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2020.02.003_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/01.HYP.8.3.181","article-title":"Localization of vascular resistance changes during hypertension","volume":"8","author":"Bohlen","year":"1986","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jash.2006.11.003","article-title":"The vascular phenotypes in hypertension: relation to the natural history of hypertension","volume":"1","author":"Schiffrin","year":"2007","journal-title":"J\u00a0Am Soc Hypertens"},{"issue":"Suppl II","key":"10.1016\/j.cjca.2020.02.003_bib3","article-title":"Reactivity of small blood vessels in hypertension: relation with structural changes","volume":"19","author":"Schiffrin","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib4","doi-asserted-by":"crossref","first-page":"H126","DOI":"10.1152\/ajpheart.1989.256.1.H126","article-title":"Microvascular rarefaction and tissue vascular resistance in hypertension","volume":"256","author":"Greene","year":"1989","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJMoa1803180","article-title":"Effect of systolic and diastolic blood pressure on cardiovascular outcomes","volume":"381","author":"Flint","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.02.003_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1161\/CIRCULATIONAHA.108.797936","article-title":"Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart Study","volume":"119","author":"Franklin","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib7","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/CIRCULATIONAHA.116.026687","article-title":"Systolic blood pressure trajectory, frailty, and all-cause mortality >80 years of age","volume":"135","author":"Ravindrarajah","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib8","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1152\/japplphysiol.90549.2008","article-title":"Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage","volume":"105","author":"Mitchell","year":"2008","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib9","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.jacc.2012.07.054","article-title":"Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis)","volume":"60","author":"Chirinos","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00004872-199503000-00010","article-title":"Media:lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance","volume":"13","author":"Rosei","year":"1995","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib11","first-page":"505","article-title":"Vascular remodeling","volume":"28","author":"Mulvany","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib12","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.amjhyper.2004.05.023","article-title":"Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment","volume":"17","author":"Schiffrin","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib13","first-page":"H88","article-title":"Effect of endothelin antagonism on blood pressure and vascular structure in renovascular hypertensive rats","volume":"40","author":"Li","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1161\/01.RES.43.6.854","article-title":"Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrower lumen, a thicker media and a greater number of smooth muscle cell layers","volume":"43","author":"Mulvany","year":"1978","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004872-198310000-00007","article-title":"Correlations and otherwise between blood pressure, cardiac mass and resistance vessel characteristics in hypertensive, normotensive and hypertensive\/normotensive hybrid rats","volume":"1","author":"Mulvany","year":"1983","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/01.RES.61.2.181","article-title":"Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitation-contraction coupling in isolated resistance vessels from essential hypertensives","volume":"61","author":"Aalkjaer","year":"1987","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib18","first-page":"177","article-title":"Morphology of resistance arteries and comparison of effects of vasoconstrictors in mild essential hypertensive patients","volume":"16","author":"Schiffrin","year":"1993","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.cjca.2020.02.003_bib19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.HYP.22.4.523","article-title":"Histology of subcutaneous small arteries from patients with essential hypertension","volume":"22","author":"Korsgaard","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.HYP.23.1.83","article-title":"Effects of a beta blocker or a converting enzyme inhibitor on resistance arteries in essential hypertension","volume":"23","author":"Schiffrin","year":"1994","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib21","first-page":"H1171","article-title":"Morphologic and functional alterations of mesenteric small resistance arteries in early renal hypertension in the rat","volume":"261","author":"Deng","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib22","first-page":"H1782","article-title":"Schiffrin EL Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats","volume":"262","author":"Deng","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/01.HYP.30.4.905","article-title":"Structure and function of small arteries in salt-induced hypertension\u2014effects of chronic endothelin-subtype-a-receptor blockade","volume":"30","author":"d\u2019Uscio","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib24","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1161\/01.CIR.0000144462.08345.B9","article-title":"Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction","volume":"110","author":"Amiri","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.HYP.28.5.785","article-title":"Vascular hypertrophy and remodeling in secondary hypertension","volume":"28","author":"Rizzoni","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib26","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1210\/jc.2006-0101","article-title":"Changes in extracellular matrix in subcutaneous small resistance arteries of patients with primary aldosteronism","volume":"91","author":"Rizzoni","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.cjca.2020.02.003_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1161\/01.HYP.0000114604.52270.95","article-title":"Acromegalic patients show the presence of hypertrophic remodeling of subcutaneous small resistance arteries","volume":"43","author":"Rizzoni","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib28","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1210\/jc.2009-1588","article-title":"Hypertrophic remodeling of subcutaneous small resistance arteries in patients with Cushing\u2019s syndrome","volume":"94","author":"Rizzoni","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.cjca.2020.02.003_bib29","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.HYP.13.6.968","article-title":"Remodeling of cerebral arterioles in chronic hypertension","volume":"13","author":"Baumbach","year":"1989","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.HYP.21.4.391","article-title":"Small artery structure in hypertension: dual processes of remodeling and growth","volume":"21","author":"Heagerty","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib31","first-page":"H933","article-title":"Alterations in the microvasculature of one-kidney, one-clip hypertensive rats","volume":"253","author":"Hashimoto","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.HYP.14.1.36","article-title":"Arteriolar changes in developing and chronic stages of two-kidney, one clip hypertension","volume":"14","author":"Ono","year":"1989","journal-title":"Hypertension"},{"issue":"part 2","key":"10.1016\/j.cjca.2020.02.003_bib33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/01.HYP.34.4.795","article-title":"Cardiac microvasculature in DOCA-salt hypertensive rats: effect of endothelin ETA receptor antagonism","volume":"34","author":"Larouche","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib34","first-page":"H243","article-title":"Development of microvascular rarefaction in the spontaneously hypertensive rat","volume":"243","author":"Prewitt","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib35","first-page":"143","article-title":"Microvascular changes associated with high salt intake and hypertension in Dahl rats","volume":"12","author":"Boegehold","year":"1993","journal-title":"Int J Microcirc Clin Exp"},{"key":"10.1016\/j.cjca.2020.02.003_bib36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/01.HYP.38.2.238","article-title":"Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction","volume":"38","author":"Sern\u00e9","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib37","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/hrt.31.5.570","article-title":"Cardiac output and distribution of blood volume in central and peripheral circulations in hypertensive and normotensive man","volume":"31","author":"Ulrych","year":"1969","journal-title":"Brit Heart J"},{"key":"10.1016\/j.cjca.2020.02.003_bib38","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/01.CIR.43.3.382","article-title":"Relationship between cardiac output and peripheral resistance in borderline hypertension","volume":"43","author":"Julius","year":"1971","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib39","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/01.HYP.34.4.655","article-title":"Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality","volume":"34","author":"Antonios","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/hrt.28.2.184","article-title":"Morphology of the intestinal arterioles in chronic human hypertension","volume":"28","author":"Short","year":"1966","journal-title":"Brit Heart J"},{"key":"10.1016\/j.cjca.2020.02.003_bib41","doi-asserted-by":"crossref","first-page":"113S","DOI":"10.1016\/0895-7061(96)00287-7","article-title":"Sympathetic overactivity in hypertension","volume":"9","author":"Julius","year":"1996","journal-title":"Amer J Hypert"},{"key":"10.1016\/j.cjca.2020.02.003_bib42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00005344-199707000-00011","article-title":"Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR","volume":"30","author":"Li","year":"1997","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.cjca.2020.02.003_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/01.HYP.0000078357.92682.EC","article-title":"Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling","volume":"42","author":"Pu","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib44","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/01.CIR.101.14.1653","article-title":"Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan","volume":"101","author":"Schiffrin","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib45","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/HYPERTENSIONAHA.107.103267","article-title":"The selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients","volume":"51","author":"Savoia","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib46","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.HYP.21.3.294","article-title":"Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate\u2013salt hypertensive but not in spontaneously hypertensive rats","volume":"21","author":"Larivi\u00e8re","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00004872-199601000-00008","article-title":"Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension","volume":"14","author":"Sventek","year":"1996","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.HYP.24.2.183","article-title":"Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate\u2013salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy","volume":"24","author":"Li","year":"1994","journal-title":"Hypertension"},{"issue":"part 1","key":"10.1016\/j.cjca.2020.02.003_bib49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/01.HYP.25.4.495","article-title":"Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist","volume":"25","author":"Li","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/HYPERTENSIONAHA.115.05168","article-title":"Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors","volume":"66","author":"Rautureau","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib51","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/HYPERTENSIONAHA.117.09925","article-title":"Three-month endothelial human endothelin-1 overexpression causes blood pressure elevation and vascular and kidney injury","volume":"71","author":"Coelho","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00004872-199715010-00005","article-title":"Enhanced expression of endothelin-1 gene in resistance arteries in severe human essential hypertension","volume":"15","author":"Schiffrin","year":"1997","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib53","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1161\/01.ATV.0000181743.28028.57","article-title":"Reduced vascular remodeling, endothelial dysfunction and oxidative stress in resistance arteries of angiotensin II\u2013infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury","volume":"25","author":"de Ciuceis","year":"2005","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"10.1016\/j.cjca.2020.02.003_bib54","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/CIRCULATIONAHA.111.034470","article-title":"Lysozyme M\u2013positive monocytes mediate angiotensin II\u2013induced arterial hypertension and vascular dysfunction","volume":"124","author":"Wenzel","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib55","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.cjca.2020.02.003_bib56","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/HYPERTENSIONAHA.110.162941","article-title":"T\u00a0regulatory lymphocytes prevent angiotensin II\u2013induced hypertension and vascular injury","volume":"57","author":"Barhoumi","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib57","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/HYPERTENSIONAHA.111.181123","article-title":"T\u00a0regulatory lymphocytes prevent aldosterone-induced vascular injury","volume":"59","author":"Kasal","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib58","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1161\/CIRCULATIONAHA.116.027058","article-title":"Gamma delta T cells mediate angiotensin II\u2013induced hypertension and vascular injury","volume":"135","author":"Caillon","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib59","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cjca.2020.02.003_bib60","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/HYPERTENSIONAHA.109.138305","article-title":"Endothelial NO synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome","volume":"54","author":"Marchesi","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib61","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1476-5381.2011.01479.x","article-title":"Perivascular adipose tissue from human systemic and coronary vessels: the emergence of a new pharmacotherapeutic target","volume":"165","author":"Aghamohammadzadeh","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cjca.2020.02.003_bib62","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ng.361","article-title":"Genome-wide association study identifies eight loci associated with blood pressure","volume":"41","author":"Newton-Cheh","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.cjca.2020.02.003_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","author":"Ehret","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cjca.2020.02.003_bib64","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/HYPERTENSIONAHA.119.12619","article-title":"MiR-431-5p knockdown protects against angiotensin II\u2013induced hypertension and vascular injury","volume":"73","author":"Huo","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib65","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/00004872-199715120-00011","article-title":"Apoptosis in aorta of deoxycorticosterone acetate-salt hypertensive rats: effect of endothelin receptor antagonism","volume":"15","author":"Sharifi","year":"1997","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/01.HYP.34.4.617","article-title":"In\u00a0vivo study of AT(1) and AT(2) angiotensin receptors in apoptosis in rat blood vessels","volume":"34","author":"Diep","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib67","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1097\/00004872-199917100-00008","article-title":"Apoptosis in the muscular arteries from young spontaneously hypertensive rats","volume":"17","author":"Dickhout","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib68","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1161\/01.CIR.100.22.2267","article-title":"Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats. Effects of angiotensin receptor antagonism and converting enzyme inhibition","volume":"100","author":"Intengan","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib69","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.HYP.36.3.312","article-title":"Structure and mechanical properties of resistance arteries in hypertension. Role of adhesion molecules and extracellular matrix determinants","volume":"36","author":"Intengan","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib70","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/01.ATV.18.7.1027","article-title":"Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats","volume":"28","author":"B\u00e9zie","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cjca.2020.02.003_bib71","first-page":"105","article-title":"Vascular changes at the prehypertensive phase in the mesenteric arteries from spontaneously hypertensive rats","volume":"22","author":"Lee","year":"1985","journal-title":"Blood Vessels"},{"key":"10.1016\/j.cjca.2020.02.003_bib72","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/01.RES.57.5.794","article-title":"Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector","volume":"57","author":"Mulvany","year":"1985","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib73","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.HYP.12.2.162","article-title":"Cellular hypertrophy in mesenteric resistance vessels from renal hypertensive rats","volume":"12","author":"Korsgaard","year":"1988","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib74","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/01.HYP.32.2.305","article-title":"Effects of losartan and enalapril on small artery structure in hypertensive rats","volume":"32","author":"Rizzoni","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib75","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/01.RES.82.5.548","article-title":"Inhibition of vascular smooth muscle cell growth by inhibition of fibronectin matrix assembly","volume":"82","author":"Mercurius","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib76","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.ATV.13.1.120","article-title":"Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in\u00a0vitro","volume":"13","author":"Gadeau","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.cjca.2020.02.003_bib77","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/01.RES.74.2.214","article-title":"Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in\u00a0vitro","volume":"74","author":"Liaw","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib78","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s004180050113","article-title":"Changes in osteopontin mRNA expression during phenotypic transition of rabbit arterial smooth muscle cells","volume":"107","author":"Yamamoto","year":"1997","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.cjca.2020.02.003_bib79","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/00004872-199917080-00009","article-title":"Contribution of synthetic phenotype on the enhanced angiotensin II\u2013generating system in vascular smooth muscle cells from spontaneously hypertensive rats","volume":"27","author":"Fukuda","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib80","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00004872-199816040-00007","article-title":"Effects of enalapril and amlodipine on small-artery structure and composition, and on endothelial dysfunction in spontaneously hypertensive rats","volume":"16","author":"Sharifi","year":"1998","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib81","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/01.HYP.33.1.569","article-title":"Mechanics and composition of human subcutaneous resistance arteries in essential hypertension","volume":"33","author":"Intengan","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib82","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00004872-199109010-00003","article-title":"Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells","volume":"9","author":"Kato","year":"1991","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib83","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/01.HYP.37.2.574","article-title":"P38 MAP kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY","volume":"37","author":"Touyz","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib84","first-page":"47","article-title":"Growth factors increase pericellular proteoglycans independently of their mitogenic effects on A10 vascular smooth muscle cells","volume":"30","author":"Emoto","year":"1998","journal-title":"Int J Biochem"},{"key":"10.1016\/j.cjca.2020.02.003_bib85","first-page":"433","article-title":"Vascular smooth muscle phenotype influences glycosaminoglycan composition and growth effects of extracellular matrix","volume":"33","author":"Hein","year":"1996","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib86","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0934-8832(11)80083-1","article-title":"Proteoglycan synthesis in normotensive and spontaneously hypertensive rat arteries in\u00a0vitro","volume":"12","author":"Walker-Capriologlio","year":"1992","journal-title":"Matrix"},{"key":"10.1016\/j.cjca.2020.02.003_bib87","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.HYP.34.4.893","article-title":"Proteoglycan production by vascular smooth muscle cells from resistance arteries of hypertensive rats","volume":"34","author":"Castro","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib88","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0174-173X(85)80024-8","article-title":"Rukosuev VS Distribution of type I, III, IV, and V collagen in normal and atherosclerotic human arterial wall: immunomorphological characteristics","volume":"5","author":"Shekhonin","year":"1985","journal-title":"Coll Relat Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib89","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000025637","article-title":"Collagen I and III and mechanical properties of conduit arteries in rats with genetic hypertension","volume":"36","author":"Chamiot Clerc","year":"1999","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib90","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/01.CIR.93.5.1026","article-title":"Serum markers of collagen type I metabolism in spontaneously hypertensive rats: relation to myocardial fibrosis","volume":"93","author":"Diez","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib91","first-page":"2998","article-title":"Is the extracellular degradation of collagen type I fibers depressed in spontaneously hypertensive rats with myocardial fibrosis?","volume":"94","author":"Diez","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib92","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/01.CIR.91.5.1450","article-title":"Increased serum concentrations of procollagen peptides in essential hypertension. Relation to cardiac alterations","volume":"91","author":"Diez","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib93","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/01.CIR.98.6.535","article-title":"Abnormalities of the extracellular degradation of collagen type I in essential hypertension","volume":"98","author":"Laviades","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib94","first-page":"604","article-title":"Changes in collagen biosynthesis, types, and mechanics of aorta in hypertensive rats","volume":"113","author":"Bashey","year":"1989","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.cjca.2020.02.003_bib95","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.HYP.0000176744.15592.7d","article-title":"Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries","volume":"46","author":"Brassard","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib96","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/00005344-200206000-00015","article-title":"Endothelin A receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats","volume":"39","author":"Tostes","year":"2002","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.cjca.2020.02.003_bib97","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/HYPERTENSIONAHA.112.191270","article-title":"Chronic matrix metalloproteinase inhibition retards age-associated arterial proinflammation and increase in blood pressure","volume":"60","author":"Wang","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib98","first-page":"H1027","article-title":"Mechanics of large and small cerebral arteries in chronic hypertension","volume":"266","author":"Hadju","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib99","first-page":"117","article-title":"Effect of pressurization on mechanical properties of mesenteric small arteries from spontaneously hypertensive rats","volume":"34","author":"Laurant","year":"1997","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib100","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/00004872-199816121-00009","article-title":"Mechanical properties of mesenteric resistance arteries from Dahl salt-resistant and salt-sensitive rats: role of endothelin-1","volume":"16","author":"Intengan","year":"1998","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib101","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1161\/01.HYP.32.4.770","article-title":"Effect of vasopressin antagonism on structure and mechanics of small arteries and vascular expression of endothelin-1 in deoxycorticosterone acetate salt hypertensive rats","volume":"32","author":"Intengan","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib102","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/01.HYP.26.1.48","article-title":"Effects of hypertension on viscoelasticity of carotid and femoral arteries in humans","volume":"26","author":"Armentano","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib103","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/00004872-199608000-00009","article-title":"Some pharmacological and elastic characteristics of isolated subcutaneous small arteries from patients with essential hypertension","volume":"14","author":"Thybo","year":"1996","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib104","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00004872-200105000-00013","article-title":"Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension","volume":"19","author":"Park","year":"2001","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/01.RES.62.1.56","article-title":"Mechanics of cerebral arterioles in hypertensive rats","volume":"62","author":"Baumbach","year":"1988","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib106","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.HYP.21.6.816","article-title":"Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats","volume":"21","author":"Baumbach","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004872-199501000-00002","article-title":"Hypertension and the vasculature. Arterioles and the myogenic response","volume":"13","author":"Izzard","year":"1995","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib108","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.004979","article-title":"Microvascular function contributes to the relation between aortic stiffness and cardiovascular events: the Framingham Heart Study","volume":"9","author":"Cooper","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.02.003_bib109","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1469-7793.1999.0239r.x","article-title":"Impaired flow-dependent dilatation in distal mesenteric arteries from the spontaneously hypertensive rat","volume":"518","author":"Izzard","year":"1999","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib110","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/01.HYP.8.4.344","article-title":"Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat","volume":"8","author":"Luscher","year":"1986","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib111","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/cs0880611","article-title":"Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats","volume":"88","author":"Deng","year":"1995","journal-title":"Clin Sci"},{"key":"10.1016\/j.cjca.2020.02.003_bib112","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.1996.270.1.H1","article-title":"Myogenic tone in mesenteric arteries from spontaneously hypertensive rats","volume":"270","author":"Izzard","year":"1996","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib113","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1152\/physrev.1982.62.2.347","article-title":"Physiological aspects of primary hypertension","volume":"62","author":"Folkow","year":"1982","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cjca.2020.02.003_bib114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00004872-199205000-00006","article-title":"Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients","volume":"10","author":"Schiffrin","year":"1992","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib115","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/ajh\/5.11.817","article-title":"Effects of endothelin-1 and vasopressin on resistance arteries of spontaneously hypertensive rats","volume":"5","author":"Deng","year":"1992","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib116","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1097\/00004872-199917120-00005","article-title":"Enhanced total peripheral vascular responsiveness in hypertension accords with the amplifier hypothesis","volume":"17","author":"Wright","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib117","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.HYP.28.4.604","article-title":"Increased wall-lumen ratio of mesenteric vessels from the spontaneously hypertensive rat is not associated with increased contractility under isobaric conditions","volume":"28","author":"Izzard","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib118","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1097\/00004872-199917120-00002","article-title":"The amplifier hypothesis: permission to dissent?","volume":"17","author":"Izzard","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib119","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004872-200018020-00016","article-title":"Structure and the resistance amplifier in hypertension: reply to the dissenters","volume":"18","author":"Korner","year":"2000","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib120","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/00004872-199406000-00006","article-title":"Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin II but not to endothelin-1","volume":"12","author":"Touyz","year":"1994","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib121","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00004872-199715120-00010","article-title":"Role of calcium influx and intracellular calcium stores in angiotensin II\u2013mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats","volume":"15","author":"Touyz","year":"1997","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib122","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.CIR.99.3.392","article-title":"Role of extracellular signal-regulated kinases in angiotensin II\u2013stimulated contraction of smooth muscle cells from human resistance arteries","volume":"99","author":"Touyz","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib123","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.RES.84.5.505","article-title":"Mitogen-activated protein extracellular signal-regulated kinase inhibition attenuates angiotensin II mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells","volume":"84","author":"Touyz","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib124","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0167-0115(96)00020-1","article-title":"RGD-containing peptides induce endothelium-dependent and independent vasorelaxations of rat aortic rings","volume":"63","author":"Lipke","year":"1996","journal-title":"Regul Pept"},{"key":"10.1016\/j.cjca.2020.02.003_bib125","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.RES.79.4.821","article-title":"Vascular smooth muscle \u03b1v\u03b23 integrin mediates arteriolar vasodilation in response to RGD peptides","volume":"79","author":"Mogford","year":"1996","journal-title":"Circ Res"},{"issue":"41","key":"10.1016\/j.cjca.2020.02.003_bib126","first-page":"H2065","article-title":"Integrin-mediated reduction in vascular smooth muscle [Ca2+]i induced by RGD-containing peptide","volume":"272","author":"d\u2019Angelo","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib127","first-page":"H1449","article-title":"Role of K+ channels in arteriolar vasodilation mediated by integrin interaction with RGD-containing peptide","volume":"44","author":"Platts","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib128","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1083\/jcb.143.1.241","article-title":"Modulation of calcium current in arteriolar smooth muscle by \u03b1v\u03b23 and \u03b15\u03b21 integrin ligands","volume":"143","author":"Wu","year":"1998","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.cjca.2020.02.003_bib129","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1172\/JCI119689","article-title":"RGDN peptide interaction with endothelial \u03b15\u03b21 integrin causes sustained endothelin-dependent vasoconstriction of rat skeletal muscle arterioles","volume":"100","author":"Mogford","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cjca.2020.02.003_bib130","first-page":"H76","article-title":"Extracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility","volume":"274","author":"Lee","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cjca.2020.02.003_bib131","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.RES.85.10.906","article-title":"Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor","volume":"85","author":"Fernandez-Patron","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2020.02.003_bib132","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.CIR.0000157159.39889.EC","article-title":"Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study","volume":"111","author":"Franklin","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib133","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.HYP.26.2.301","article-title":"Pulse pressure and resistance artery structure in the elderly","volume":"26","author":"James","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib134","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00004872-199917030-00011","article-title":"Relationship of small artery structure with systolic, diastolic and pulse pressure in essential hypertension","volume":"17","author":"Schiffrin","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib135","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1161\/CIRCULATIONAHA.105.551168","article-title":"Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study","volume":"112","author":"Mitchell","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.02.003_bib136","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.HYP.0000167992.80876.26","article-title":"Vascular development, pulse pressure, and the mechanisms of hypertension","volume":"46","author":"Safar","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2020.02.003_bib137","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/HYPERTENSIONAHA.117.09279","article-title":"Hemodynamic and mechanical properties of the proximal aorta in young and middle-aged adults with isolated systolic hypertension: the Dallas Heart Study","volume":"70","author":"Yano","year":"2017","journal-title":"Hypertension"},{"issue":"suppl 5","key":"10.1016\/j.cjca.2020.02.003_bib138","first-page":"S7","article-title":"Resistance vessel structure and the pathogenesis of hypertension","volume":"11","author":"Mulvany","year":"1993","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.cjca.2020.02.003_bib139","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1172\/JCI23378","article-title":"Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system","volume":"115","author":"Crowley","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cjca.2020.02.003_bib140","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa060838","article-title":"Feasibility of treating prehypertension with an angiotensin-receptor blocker","volume":"354","author":"Julius","year":"2006","journal-title":"N\u00a0Engl J Med"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20300751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20300751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:23:05Z","timestamp":1778541785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X20300751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":140,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0828282X20300751"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2020.02.003","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How Structure, Mechanics, and Function of the Vasculature Contribute to Blood Pressure Elevation in Hypertension","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2020.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}