{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:33:15Z","timestamp":1781001195821,"version":"3.54.1"},"reference-count":91,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010619","name":"University of Ottawa Heart Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.cjca.2020.11.003","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T12:39:27Z","timestamp":1605616767000},"page":"572-584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pulmonary Hypertension Due to Left Heart Disease\u2014A Practical Approach to Diagnosis and Management"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3840-2385","authenticated-orcid":false,"given":"Felicity","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Mielniczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2020.11.003_bib1","doi-asserted-by":"crossref","first-page":"1801887","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","article-title":"A\u00a0global view of pulmonary hypertension","volume":"4","author":"Hoeper","year":"2016","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.cjca.2020.11.003_bib3","doi-asserted-by":"crossref","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib4","doi-asserted-by":"crossref","first-page":"D100","DOI":"10.1016\/j.jacc.2013.10.033","article-title":"Pulmonary hypertension due to left heart disease","volume":"62","author":"Vachi\u00e9ry","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1183\/09059180.00004612","article-title":"Pulmonary hypertension in left heart disease","volume":"21","author":"Guazzi","year":"2012","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.cjca.2020.11.003_bib7","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.amjmed.2017.05.003","article-title":"Pulmonary hypertension with left heart disease: prevalence, temporal shifts in etiologies and outcome","volume":"130","author":"Weitsman","year":"2017","journal-title":"Am J Med"},{"key":"10.1016\/j.cjca.2020.11.003_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/jamacardio.2018.0128","article-title":"Association between hemodynamic markers of pulmonary hypertension and outcomes in heart failure with preserved ejection fraction","volume":"3","author":"Vanderpool","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib9","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCULATIONAHA.115.020207","article-title":"Association of borderline pulmonary hypertension with mortality and hospitalization in a large patient cohort: insights from the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program","volume":"133","author":"Maron","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00380-015-0700-2","article-title":"Predictors of persistent pulmonary hypertension after mitral valve replacement","volume":"31","author":"Briongos Figuero","year":"2016","journal-title":"Heart Vessels"},{"key":"10.1016\/j.cjca.2020.11.003_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/heartjnl-2017-311978","article-title":"Outcomes of persistent pulmonary hypertension following transcatheter aortic valve replacement","volume":"104","author":"Masri","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2020.11.003_bib12","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1093\/eurheartj\/ehq245","article-title":"Determinants and prognostic value of pulmonary arterial pressure in patients with chronic heart failure","volume":"31","author":"Damy","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib13","doi-asserted-by":"crossref","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","article-title":"Definitions and diagnosis of pulmonary hypertension","volume":"62","author":"Hoeper","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1183\/09031936.00145608","article-title":"Pulmonary arterial pressure doing rest and exercise in healthy subjects: a systematic review","volume":"34","author":"Kovacs","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1001\/jamacardio.2017.3882","article-title":"Prognostic effect and longitudinal hemodynamic assessment of borderline pulmonary hypertension","volume":"2","author":"Assad","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib16","doi-asserted-by":"crossref","first-page":"1801897","DOI":"10.1183\/13993003.01897-2018","article-title":"Pulmonary hypertension due to left heart disease","volume":"53","author":"Vachi\u00e9ry","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib17","doi-asserted-by":"crossref","first-page":"1802148","DOI":"10.1183\/13993003.02148-2018","article-title":"An overview of the 6th World Symposium on Pulmonary Hypertension","volume":"53","author":"Gali\u00e8","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11897-016-0306-8","article-title":"Pulmonary hypertension in heart failure patients: pathophysiology and prognostic implications","volume":"13","author":"Guazzi","year":"2016","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.cjca.2020.11.003_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jchf.2014.07.010","article-title":"The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease","volume":"3","author":"Tampakakis","year":"2015","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijcard.2019.05.016","article-title":"Prognostic value and diagnostic properties of the diastolic pulmonary pressure gradient in patients with pulmonary hypertension and left heart disease","volume":"290","author":"Dragu","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib21","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.jacc.2016.09.942","article-title":"Clinical and biological insights into combined post- and pre-capillary pulmonary hypertension","volume":"68","author":"Assad","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.chest.2019.07.028","article-title":"Impact of the new pulmonary hypertension definition on heart transplant outcomes: expanding the hemodynamic risk profile","volume":"157","author":"Crawford","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2020.11.003_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/eurheartj\/ehv512","article-title":"Left ventricular heart failure and pulmonary hypertension","volume":"37","author":"Rosenkranz","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib24","first-page":"416","article-title":"Pathophysiology and clinical relevance of pulmonary remodelling in pulmonary hypertension due to left heart diseases","volume":"31","author":"Dupuis","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib25","first-page":"881","article-title":"Modulation of actin isoform expression in alveolar myofibroblasts (contractile interstitial cells) during pulmonary hypertension","volume":"136","author":"Kapanci","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cjca.2020.11.003_bib26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/CIRCULATIONAHA.111.085761","article-title":"Pulmonary hypertension due to left heart disease","volume":"126","author":"Guazzi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004082","article-title":"Hemodynamic phenotyping of pulmonary hypertension in left heart failure","volume":"10","author":"Naeije","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib28","doi-asserted-by":"crossref","first-page":"1801904","DOI":"10.1183\/13993003.01904-2018","article-title":"Diagnosis of pulmonary hypertension","volume":"53","author":"Frost","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.11.003_bib30","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/j.ijcard.2013.07.005","article-title":"Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension","volume":"168","author":"d\u2019Alto","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib31","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/ehjci\/jew190","article-title":"The clinical use of stress echocardiography in nonischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"17","author":"Lancellotti","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.11.003_bib32","doi-asserted-by":"crossref","first-page":"170134","DOI":"10.1183\/16000617.0134-2017","article-title":"The role of cardiopulmonary exercise tests in pulmonary arterial hypertension","volume":"27","author":"Farina","year":"2018","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.cjca.2020.11.003_bib33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cardfail.2013.05.005","article-title":"Cardiopulmonary exercise testing as a diagnostic tool for the detection of left-sided pulmonary hypertension in heart failure","volume":"19","author":"Guazzi","year":"2013","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cardfail.2016.10.002","article-title":"A\u00a0clinical and echocardiographic score to identify pulmonary hypertension due to HFpEF","volume":"23","author":"Berthelot","year":"2017","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1183\/09031936.00202814","article-title":"Noninvasive identification of left-sided heart failure in a population suspected of pulmonary arterial hypertension","volume":"46","author":"Jacobs","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib36","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.echo.2014.09.004","article-title":"Echocardiographic prediction of pre- versus postcapillary pulmonary hypertension","volume":"28","author":"d\u2019Alto","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.11.003_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.21693\/1933-088X-19.1.6","article-title":"Modern right heart catheterization: beyond simple hemodynamics","volume":"19","author":"Bonno","year":"2020","journal-title":"Adv Pulm Hypertens"},{"key":"10.1016\/j.cjca.2020.11.003_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.201402-0269PP","article-title":"Reading pulmonary vascular pressure tracings. How to handle the problems of zero levelling and respiratory swings","volume":"190","author":"Kovacs","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjca.2020.11.003_bib39","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib40","first-page":"E233","article-title":"SCAI\/HFSA clinical expert consensus document on the use of invasive hemodynamics for the diagnosis and management of cardiovascular disease","volume":"89","author":"Sorajja","year":"2017","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2020.11.003_bib41","doi-asserted-by":"crossref","first-page":"1700578","DOI":"10.1183\/13993003.00578-2017","article-title":"An official European Respiratory Society statement: pulmonary haemodynamics during exercise","volume":"50","author":"Kovacs","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib42","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1249\/MSS.0000000000001227","article-title":"Pulmonary artery wedge pressure relative to exercise work rate in older men and women","volume":"49","author":"Esfandiari","year":"2017","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cjca.2020.11.003_bib43","first-page":"337","article-title":"The influence of age on hemodynamic parameters during rest and exercise in healthy individuals","volume":"5","author":"Wolsk","year":"2017","journal-title":"JACC: Heart Failure"},{"key":"10.1016\/j.cjca.2020.11.003_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/CIRCHEARTFAILURE.114.001731","article-title":"Differential hemodynamic effects of exercise and volume expansion in people with and without heart failure","volume":"8","author":"Andersen","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib45","article-title":"Impaired myocardial oxygen availability contributes to abnormal exercise hemodynamics in heart failure with preserved ejection fraction","volume":"3","author":"van Empel","year":"2014","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2020.11.003_bib46","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cardfail.2012.06.530","article-title":"Hemodynamic determinants of the abnormal cardiopulmonary exercise response in heart failure with preserved left ventricular ejection fraction","volume":"18","author":"Maeder","year":"2012","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib47","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/CIRCHEARTFAILURE.112.967919","article-title":"Exercise hemodynamics in patients with and without diastolic dysfunction and preserved ejection fraction after myocardial infarction","volume":"5","author":"Andersen","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib48","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cardfail.2018.10.009","article-title":"Pulmonary arterial wedge pressure at rest and during exercise in healthy adults: a systematic review and meta-analysis","volume":"25","author":"Esfandiari","year":"2019","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cardfail.2019.07.547","article-title":"Hemodynamic effects of pulmonary arterial hypertension-specific therapy in patients with heart failure with preserved ejection fraction and with combined post- and precapillary pulmonary hypertension","volume":"26","author":"Huis in\u2019t Veld","year":"2020","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib50","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018819803","article-title":"Clinical and hemodynamic factors in predicting response to fluid challenge during right heart catheterization","volume":"9","author":"Moghaddam","year":"2019","journal-title":"Pulm Circ"},{"key":"10.1016\/j.cjca.2020.11.003_bib51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.chest.2016.08.1439","article-title":"Clinical relevance of fluid challenge in patients evaluated for pulmonary hypertension","volume":"151","author":"d\u2019Alto","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2020.11.003_bib52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/CIRCHEARTFAILURE.113.000468","article-title":"High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension","volume":"7","author":"Robbins","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCULATIONAHA.112.111302","article-title":"Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure","volume":"127","author":"Fujimoto","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib54","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1183\/09031936.00091212","article-title":"High prevalence of occult left heart disease in scleroderma-pulmonary hypertension","volume":"42","author":"Fox","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib55","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1086\/683815","article-title":"Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice","volume":"5","author":"Berry","year":"2015","journal-title":"Pulm Circ"},{"key":"10.1016\/j.cjca.2020.11.003_bib56","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.112.104463","article-title":"The invasive cardiopulmonary exercise test","volume":"127","author":"Maron","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib57","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/eurheartj\/ehx700","article-title":"Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial","volume":"39","author":"Bermejo","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib58","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1093\/eurheartj\/ehv336","article-title":"Effects of sildenafil on invasive haemodynamics and exercise capacity in heart failure patients with preserved ejection fraction and pulmonary hypertension: a randomized controlled trial","volume":"36","author":"Hoendermis","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib59","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/eurjhf\/hfr147","article-title":"Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study","volume":"14","author":"Guazzi","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.110.983866","article-title":"Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study","volume":"124","author":"Guazzi","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib61","doi-asserted-by":"crossref","first-page":"1701886","DOI":"10.1183\/13993003.01886-2017","article-title":"Macitentan in pulmonary hypertension due to left ventricular dysfunction","volume":"51","author":"Vachi\u00e9ry","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjca.2020.11.003_bib62","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.hlc.2016.09.004","article-title":"Pilot study of endothelin receptor blockade in heart failure with diastolic dysfunction and pulmonary hypertension (BADDHY-Trial)","volume":"26","author":"Koller","year":"2017","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.cjca.2020.11.003_bib63","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCULATIONAHA.113.001458","article-title":"Riociguat for patients with pulmonary hypertension caused by systolic left ventricular dysfunction: a phase IIb double-blind, randomized, placebo-controlled, dose-ranging hemodynamic study","volume":"128","author":"Bonderman","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib64","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/jama.2013.2024","article-title":"Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial","volume":"309","author":"Redfield","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2020.11.003_bib65","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/chf.12008","article-title":"Is chronic sildenafil therapy safe and clinically beneficial in patients with systolic heart failure?","volume":"19","author":"Amin","year":"2013","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/CIRCHEARTFAILURE.110.944694","article-title":"PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study","volume":"4","author":"Guazzi","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib67","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jchf.2017.02.021","article-title":"Long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure: primary results of the ENABLE trials","volume":"5","author":"Packer","year":"2017","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib68","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.2015.15734","article-title":"Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction: the SOCRATES-REDUCED randomized trial","volume":"314","author":"Gheorghiade","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2020.11.003_bib69","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/eurheartj\/ehw593","article-title":"Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the Soluble Guanylate Cyclase Stimulator in Heart Failure Patients with Preserved EF (SOCRATES-PRESERVED) study","volume":"38","author":"Pieske","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.11.003_bib70","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1915928","article-title":"Vericiguat in patients with heart failure and reduced ejection fraction","volume":"382","author":"Armstrong","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.11.003_bib71","first-page":"1342","article-title":"2017 Comprehensive update of the Canadian Cardiovascular Society guidelines for the management of heart failure","volume":"33","author":"Ezekowitz","year":"2017","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib72","first-page":"159","article-title":"CCS\/CHFS heart failure guidelines: clinical trial update on functional mitral regurgitation, SGLT2 inhibitors, ARNI in HFpEF, and tafamidis in amyloidosis","volume":"36","author":"O\u2019Meara","year":"2020","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib73","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.005819","article-title":"Treatment of pulmonary hypertension with angiotensin II receptor blocker and neprilysin inhibitor sacubitril\/valsartan","volume":"12","author":"Clements","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib74","article-title":"Angiotensin receptor-neprilysin inhibition attenuates right ventricular remodelling in pulmonary hypertension","volume":"9","author":"Kia","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2020.11.003_bib75","first-page":"A14392","article-title":"Effects of sacubitril-valsartan compared with enalapril on pulmonary artery pressure in patients with heart failure and reduced ejection fraction [abstract]","volume":"140","author":"Desai","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib76","first-page":"2165","article-title":"The effects of sacubitril\/valsartan on clinical, biochemical and echocardiographic parameters in patients with heart failure with reduced ejection fraction: the \u201chemodynamic recovery","volume":"8","author":"Romano","year":"2019","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.cjca.2020.11.003_bib77","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.jacc.2005.04.069","article-title":"Left ventricular dyssynchrony predicts right ventricular remodelling after cardiac resynchronization therapy","volume":"46","author":"Bleeker","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib78","doi-asserted-by":"crossref","first-page":"6817832","DOI":"10.1155\/2018\/6817832","article-title":"Acute and long-term hemodynamic effects of MitraClip implantation on a preexisting secondary right heart failure","volume":"2018","author":"H\u00fcnlich","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.cjca.2020.11.003_bib79","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.amjcard.2016.09.015","article-title":"Meta-analysis of outcomes and evolution of pulmonary hypertension before and after transcatheter aortic valve implantation","volume":"119","author":"Tang","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib80","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(11)60101-3","article-title":"Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial","volume":"377","author":"Abraham","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2020.11.003_bib81","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.healun.2014.04.014","article-title":"Pulmonary hypertension related to left heart disease: insight from a wireless implantable hemodynamic monitor","volume":"34","author":"Benza","year":"2015","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.cjca.2020.11.003_bib82","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCULATIONAHA.117.032094","article-title":"Transcatheter interatrial shunt device for the treatment of heart failure with preserved ejection fraction (REDUCE LAP-HF I [Reduce Elevated Left Atrial Pressure in Patients with Heart Failure]): a phase 2, randomized, sham-controlled trial","volume":"137","author":"Feldman","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.11.003_bib83","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jamacardio.2018.2936","volume":"3","author":"Shah","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjca.2020.11.003_bib84","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004540","article-title":"Impact of baseline hemodynamics on the effects of a transcatheter interatrial shunt device in heart failure with preserved ejection fraction","volume":"11","author":"Wessler","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib85","first-page":"1236","article-title":"Percutaneous atriotomy for levoatrial\u2013to\u2013coronary sinus shunting in symptomatic heart failure: first-in-human experience","volume":"13","author":"Simard","year":"2020","journal-title":"JACC: Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2020.11.003_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2015.10.023","article-title":"The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update","volume":"35","author":"Mehra","year":"2016","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.cjca.2020.11.003_bib87","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.athoracsur.2019.09.095","article-title":"Effect of pulmonary hypertension on transplant outcomes in patients with ventricular assist devices","volume":"110","author":"Ando","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2020.11.003_bib88","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.healun.2012.09.013","article-title":"The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary","volume":"32","author":"Feldman","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.cjca.2020.11.003_bib89","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.cardfail.2016.06.049","article-title":"SOPRANO: study of macitentan in patients with pulmonary hypertension (PH) post\u2013left ventricular assist device (LVAD) implantation","volume":"22","author":"Park","year":"2016","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib90","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004436","article-title":"Pulmonary effective arterial elastance as a measure of right ventricular afterload and its prognostic value in pulmonary hypertension due to left heart disease","volume":"11","author":"Tampakakis","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjca.2020.11.003_bib91","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.healun.2020.02.013","article-title":"Elevated pulmonary arterial elastance and right ventricular uncoupling are associated with greater mortality in advanced heart failure","volume":"39","author":"Wright","year":"2020","journal-title":"J\u00a0Heart Lung Transplant"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20311041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20311041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:46:06Z","timestamp":1760107566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X20311041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0828282X20311041"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2020.11.003","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary Hypertension Due to Left Heart Disease\u2014A Practical Approach to Diagnosis and Management","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2020.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}