{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:09:51Z","timestamp":1778544591060,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012589","name":"Fondation Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["399323"],"award-info":[{"award-number":["399323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cjca.2020.12.011","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T20:31:26Z","timestamp":1620937886000},"page":"968-979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pathophysiology, Diagnosis, and New Therapeutic Approaches for Ischemic Mitral Regurgitation"],"prefix":"10.1016","volume":"37","author":[{"given":"Sandra","family":"Hadjadj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ons","family":"Marsit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-6821","authenticated-orcid":false,"given":"Jonathan","family":"Beaudoin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2020.12.011_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2020.12.011_bib2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9149(91)90401-6","article-title":"Evaluation of transient mitral regurgitation in coronary artery disease","volume":"68","author":"Fehrenbacher","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/echo.14402","article-title":"Clinical and echocardiographic presentation of postmyocardial infarction papillary muscle rupture","volume":"36","author":"Leroux","year":"2019","journal-title":"Echocardiography"},{"key":"10.1016\/j.cjca.2020.12.011_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/01.CIR.63.3.565","article-title":"Incomplete mitral leaflet closure in patients with papillary muscle dysfunction","volume":"63","author":"Godley","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib5","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCULATIONAHA.110.977843","article-title":"Mitral regurgitation after anteroapical myocardial infarction: new mechanistic insights","volume":"123","author":"Yosefy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib6","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.jacc.2003.04.002","article-title":"Determinants of exercise-induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction","volume":"42","author":"Lancellotti","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/CIRCIMAGING.108.823732","article-title":"Mechanism of decrease in mitral regurgitation after cardiac resynchronization therapy: optimization of the force-balance relationship","volume":"2","author":"Solis","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/eurheartj\/ehn063","article-title":"Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy","volume":"29","author":"Ypenburg","year":"2008","journal-title":"Eur Heart J"},{"issue":"9 suppl","key":"10.1016\/j.cjca.2020.12.011_bib9","first-page":"I458","article-title":"Mitral annulus flattens in ischemic mitral regurgitation: geometric differences between inferior and anterior myocardial infarction: a real-time 3-dimensional echocardiographic study","volume":"112","author":"Watanabe","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.107.749440","article-title":"Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation","volume":"118","author":"Chaput","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.108.846782","article-title":"Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation","volume":"120","author":"Dal-Bianco","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jacc.2015.10.092","article-title":"Myocardial infarction alters adaptation of the tethered mitral valve","volume":"67","author":"Dal-Bianco","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jacc.2019.11.039","article-title":"Attenuated mitral leaflet enlargement contributes to functional mitral regurgitation after myocardial infarction","volume":"75","author":"Marsit","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib14","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacc.2017.07.734","article-title":"Effect of losartan on mitral valve changes after myocardial infarction","volume":"70","author":"Bartko","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jtcvs.2005.04.019","article-title":"Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation","volume":"130","author":"Grande-Allen","year":"2005","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2020.12.011_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.006512","article-title":"Mitral leaflet changes following myocardial infarction: clinical evidence for maladaptive valvular remodeling","volume":"10","author":"Beaudoin","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jacc.2007.07.093","article-title":"Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation","volume":"51","author":"Beeri","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib18","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"issue":"11 suppl 1","key":"10.1016\/j.cjca.2020.12.011_bib19","first-page":"S248","article-title":"Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair","volume":"128","author":"Beaudoin","year":"2013","journal-title":"Circulation"},{"issue":"11 suppl","key":"10.1016\/j.cjca.2020.12.011_bib20","first-page":"I288","article-title":"Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study","volume":"116","author":"Beeri","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib21","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.12.011_bib22","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.12.011_bib23","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/eurheartj\/ehx763","article-title":"Educational needs and application of guidelines in the management of patients with mitral regurgitation. A European mixed-methods study","volume":"39","author":"Iung","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.12.011_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ehjci\/jey117","article-title":"Comparison of mitral valve geometrical effect of percutaneous edge-to-edge repair between central and eccentric functional mitral regurgitation: clinical implications","volume":"20","author":"Utsunomiya","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.echo.2013.06.014","article-title":"Calcification of the mitral valve and annulus: systematic evaluation of effects on valve anatomy and function","volume":"26","author":"Movva","year":"2013","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.12.011_bib26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1540-8175.2011.01528.x","article-title":"Multiplane two-dimensional versus real time three-dimensional transesophageal echocardiography in ischemic mitral regurgitation","volume":"28","author":"Fattouch","year":"2011","journal-title":"Echocardiography"},{"key":"10.1016\/j.cjca.2020.12.011_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.12.011_bib28","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.echo.2008.02.003","article-title":"Direct assessment of size and shape of noncircular vena contracta area in functional versus organic mitral regurgitation using real-time three-dimensional echocardiography","volume":"21","author":"Kahlert","year":"2008","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.12.011_bib29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/CIRCIMAGING.110.961649","article-title":"Diagnostic value of vena contracta area in the quantification of mitral regurgitation severity by color Doppler 3D echocardiography","volume":"4","author":"Zeng","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/01.CIR.90.1.307","article-title":"Dynamics of mitral regurgitant flow and orifice area. Physiologic application of the proximal flow convergence method: clinical data and experimental testing","volume":"90","author":"Schwammenthal","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ejechocard\/jeq031","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease)","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.cjca.2020.12.011_bib32","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2020.12.011_bib33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib34","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.echo.2020.03.008","article-title":"In\u00a0vitro quantification of mitral regurgitation of complex geometry by the modified proximal isovelocity surface area method","volume":"33","author":"Papolla","year":"2020","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2020.12.011_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10554-019-01713-7","article-title":"Quantification of mitral valve regurgitation by 2D and 3D echocardiography compared with cardiac magnetic resonance a systematic review and meta-analysis","volume":"36","author":"Sk\u00f6ldborg","year":"2020","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib36","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0735-1097(01)01605-9","article-title":"Quantitation of functional mitral regurgitation during bicycle exercise in patients with heart failure","volume":"38","author":"Lebrun","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/CIRCULATIONAHA.108.795781","article-title":"Is it time to update the definition of functional mitral regurgitation?: structural changes in the mitral leaflets with left ventricular dysfunction","volume":"118","author":"Gillam","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.amjcard.2015.10.045","article-title":"Comparative assessment of mitral regurgitation severity by transthoracic echocardiography and cardiac magnetic resonance using an integrative and quantitative approach","volume":"117","author":"Lopez-Mattei","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib39","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1161\/CIRCULATIONAHA.115.017888","article-title":"Determination of clinical outcome in mitral regurgitation with cardiovascular magnetic resonance quantification","volume":"133","author":"Myerson","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib40","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.jcmg.2019.11.008","article-title":"Prognostic impact of ischemic mitral regurgitation severity and myocardial infarct quantification by cardiovascular magnetic resonance","volume":"13","author":"Cavalcante","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2020.12.011_bib41","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jacc.2019.12.024","article-title":"Prognostic value of left ventricular global longitudinal strain in patients with secondary mitral regurgitation","volume":"75","author":"Namazi","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib42","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1161\/CIRCULATIONAHA.108.842104","article-title":"Predictors of improvement of unrepaired moderate ischemic mitral regurgitation in patients undergoing elective isolated coronary artery bypass graft surgery","volume":"120","author":"Penicka","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jacc.2016.06.047","article-title":"Association of B-type natriuretic peptide with survival in patients with degenerative mitral regurgitation","volume":"68","author":"Clavel","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib44","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/CIRCULATIONAHA.118.037077","article-title":"Angiotensin receptor neprilysin inhibitor for functional mitral regurgitation","volume":"139","author":"Kang","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib45","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/CIRCULATIONAHA.110.009803","article-title":"Cardiac resynchronization therapy as a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk","volume":"124","author":"van Bommel","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib46","first-page":"1478","article-title":"Novel heart failure biomarkers predict improvement of mitral regurgitation in patients receiving cardiac resynchronization therapy\u2014the BIOCRT study","volume":"32","author":"Beaudoin","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2020.12.011_bib47","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jtcvs.2018.09.018","article-title":"Three-dimensional mitral valve structure in predicting moderate ischemic mitral regurgitation improvement after coronary artery bypass grafting","volume":"157","author":"Sun","year":"2019","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2020.12.011_bib48","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1161\/CIRCULATIONAHA.112.143818","article-title":"Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial","volume":"126","author":"Chan","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib49","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1056\/NEJMoa1602003","article-title":"Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation","volume":"374","author":"Michler","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.12.011_bib50","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/CIRCULATIONAHA.106.649236","article-title":"Preoperative posterior leaflet angle accurately predicts outcome after restrictive mitral valve annuloplasty for ischemic mitral regurgitation","volume":"115","author":"Magne","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib51","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.athoracsur.2007.04.106","article-title":"A\u00a0prospective study of predicting factors in ischemic mitral regurgitation recurrence after ring annuloplasty","volume":"84","author":"Roshanali","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2020.12.011_bib52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jtcvs.2012.09.042","article-title":"Mitral valve repair or replacement for ischemic mitral regurgitation? The Italian Study on the Treatment of Ischemic Mitral Regurgitation (ISTIMIR)","volume":"145","author":"Lorusso","year":"2013","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2020.12.011_bib53","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJMoa1512913","article-title":"Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation","volume":"374","author":"Goldstein","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.12.011_bib54","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/jocs.12843","article-title":"Combined papillary muscle sling and ring annuloplasty for moderate-to-severe secondary mitral regurgitation","volume":"31","author":"Mihos","year":"2016","journal-title":"J\u00a0Card Surg"},{"key":"10.1016\/j.cjca.2020.12.011_bib55","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2020.12.011_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/CIRCULATIONAHA.117.031733","article-title":"One-year outcomes after mitraclip for functional mitral regurgitation","volume":"139","author":"Ailawadi","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2020.12.011_bib57","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/ejhf.1616","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years","volume":"21","author":"Iung","year":"2019","journal-title":"Eur J Heart Fail"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20311466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X20311466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:22:46Z","timestamp":1778541766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X20311466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0828282X20311466"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2020.12.011","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiology, Diagnosis, and New Therapeutic Approaches for Ischemic Mitral Regurgitation","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2020.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}