{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:31:20Z","timestamp":1777501880047,"version":"3.51.4"},"reference-count":146,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.cjca.2022.04.028","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T22:29:46Z","timestamp":1652308186000},"page":"930-945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hypoplastic Left Heart Syndrome Across the Lifespan: Clinical Considerations for Care of the Fetus, Child, and Adult"],"prefix":"10.1016","volume":"38","author":[{"given":"Rachel M.","family":"Wald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-1268","authenticated-orcid":false,"given":"Luc L.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2022.04.028_bib1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1136\/heartjnl-2013-305336","article-title":"The single-ventricle patient population: a current and future concern\u2014a population-based study in the north of England","volume":"100","author":"Coats","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2022.04.028_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/bdra.20169","article-title":"Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001","volume":"73","author":"McBride","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.cjca.2022.04.028_bib3","article-title":"Changing epidemiology of hypoplastic left heart syndrome: results of a national Swedish cohort study","volume":"8","author":"\u00d6hman","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2022.04.028_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2016.05.035","article-title":"The Fontan epidemic: population projections from the Australia and New Zealand Fontan Registry","volume":"219","author":"Schilling","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.113.008396","article-title":"Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010","volume":"130","author":"Marelli","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.635776","article-title":"The improved prognosis of hypoplastic left heart: a population-based register study of 343 cases in England and Wales","volume":"9","author":"Best","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.cjca.2022.04.028_bib7","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1161\/CIRCULATIONAHA.117.029375","article-title":"Transplant-free survival and interventions at 6 years in the SVR Trial","volume":"137","author":"Newburger","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib8","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/CIRCULATIONAHA.117.031282","article-title":"Outcomes of patients with hypoplastic left heart syndrome reaching adulthood after fontan palliation: multicenter study","volume":"137","author":"Wilson","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1017\/S1047951106000291","article-title":"The nomenclature, definition and classification of hypoplastic left heart syndrome","volume":"16","author":"Tchervenkov","year":"2006","journal-title":"Cardiol Young"},{"key":"10.1016\/j.cjca.2022.04.028_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41569-020-00500-5","article-title":"Clarification of the definition of hypoplastic left heart syndrome","volume":"18","author":"Anderson","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib11","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0003-4975(98)00803-0","article-title":"Biventricular repair in neonates with hypoplastic left heart complex","volume":"66","author":"Tchervenkov","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib12","article-title":"Hypoplastic left heart syndrome: a new paradigm for an old disease?","volume":"6","author":"Grossfeld","year":"2019","journal-title":"J\u00a0Cardiovasc Dev Dis"},{"key":"10.1016\/j.cjca.2022.04.028_bib13","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2011.04.046","article-title":"Left ventricular hypoplasia: a spectrum of disease involving the left ventricular outflow tract, aortic valve, and aorta","volume":"59","author":"Hickey","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib14","article-title":"Genetic etiology of left-sided obstructive heart lesions: a story in development","volume":"10","author":"Parker","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2022.04.028_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.281.5373.108","article-title":"Congenital heart disease caused by mutations in the transcription factor NKX2-5","volume":"281","author":"Schott","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cjca.2022.04.028_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng0398-271","article-title":"The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis","volume":"18","author":"Riley","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.cjca.2022.04.028_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.01562","article-title":"The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage\u2013dependent manner","volume":"132","author":"McFadden","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cjca.2022.04.028_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1050-1738(98)00033-4","article-title":"Hand proteins: molecular mediators of cardiac development and congenital heart disease","volume":"9","author":"Srivastava","year":"1999","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.cjca.2022.04.028_bib19","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/hmg\/ddn027","article-title":"A\u00a0loss-of-function mutation in the binding domain of Hand1 predicts hypoplasia of the human hearts","volume":"17","author":"Reamon-Buettner","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cjca.2022.04.028_bib20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1152\/physiolgenomics.00091.2016","article-title":"Impact of MYH6 variants in hypoplastic left heart syndrome","volume":"48","author":"Tomita-Mitchell","year":"2016","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.cjca.2022.04.028_bib21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCGENETICS.115.001070","article-title":"Recessive MYH6 mutations in hypoplastic left heart with reduced ejection fraction","volume":"8","author":"Theis","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.cjca.2022.04.028_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9149(73)90810-2","article-title":"Experimental production of hypoplastic left heart syndrome in the chick embryo","volume":"31","author":"Harh","year":"1973","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib23","first-page":"14","article-title":"A\u00a0mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow","author":"Rahman","year":"2021","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.cjca.2022.04.028_bib24","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1161\/CIRCULATIONAHA.121.056198","article-title":"Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome","volume":"144","author":"Krane","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/chd.12413","article-title":"A\u00a0population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry","volume":"12","author":"Lara","year":"2017","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.cjca.2022.04.028_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0167-5273(89)90226-X","article-title":"The natural history of the hypoplastic left heart syndrome","volume":"25","author":"Allan","year":"1989","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/hrt.77.3.205","article-title":"Natural history and outcome of aortic stenosis diagnosed prenatally","volume":"77","author":"Simpson","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2022.04.028_bib28","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/0002-8703(92)90834-I","article-title":"Hypoplastic left heart syndrome: progression of left ventricular dilation and dysfunction to left ventricular hypoplasia in utero","volume":"123","author":"Danford","year":"1992","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjca.2022.04.028_bib29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/hrt.65.5.256","article-title":"Balloon dilatation of the aortic valve in the fetus: a report of two cases","volume":"65","author":"Maxwell","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.cjca.2022.04.028_bib30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/CIRCULATIONAHA.105.588194","article-title":"Fetal aortic valve stenosis and the evolution of hypoplastic left heart syndrome: patient selection for fetal intervention","volume":"113","author":"M\u00e4kikallio","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib31","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/CIRCULATIONAHA.114.009032","article-title":"Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome: postnatal outcomes of the first 100 patients","volume":"130","author":"Freud","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/uog.15876","article-title":"Natural history of 107 cases of fetal aortic stenosis from a European multicenter retrospective study","volume":"48","author":"Gardiner","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.cjca.2022.04.028_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/uog.18913","article-title":"Fetal hemodynamic response to aortic valvuloplasty and postnatal outcome: a European multicenter study","volume":"52","author":"Kovacevic","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.cjca.2022.04.028_bib34","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.athoracsur.2007.06.061","article-title":"Hypoplastic left heart syndrome with atrial level restriction in the era of prenatal diagnosis","volume":"84","author":"Glatz","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib35","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1161\/01.CIR.0000128690.35860.C5","article-title":"Hypoplastic left heart syndrome with intact or highly restrictive atrial septum: outcome after neonatal transcatheter atrial septostomy","volume":"109","author":"Vlahos","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.athoracsur.2007.04.017","article-title":"Hypoplastic left heart syndrome with intact or highly restrictive atrial septum: surgical experience from a single center","volume":"84","author":"Vida","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib37","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.ijcard.2013.01.173","article-title":"Fetal stenting of the atrial septum: technique and initial results in cardiac lesions with left atrial hypertension","volume":"168","author":"Chaturvedi","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib38","first-page":"195","article-title":"Pulmonary vasoreactivity to materno-fetal hyperoxygenation testing in fetuses with hypoplastic left heart","volume":"37","author":"Enzensberger","year":"2016","journal-title":"Ultraschall Med"},{"key":"10.1016\/j.cjca.2022.04.028_bib39","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.21037\/tp-20-226","article-title":"Maternal hyperoxygenation in congenital heart disease","volume":"10","author":"Lee","year":"2021","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.cjca.2022.04.028_bib40","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/CIRCIMAGING.109.848432","article-title":"Vasoreactive response to maternal hyperoxygenation in the fetus with hypoplastic left heart syndrome","volume":"3","author":"Szwast","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2022.04.028_bib41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00246-009-9600-5","article-title":"Chronic intermittent materno-fetal hyperoxygenation in late gestation may improve on hypoplastic cardiovascular structures associated with cardiac malformations in human fetuses","volume":"31","author":"Kohl","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/uog.15846","article-title":"Pilot study of chronic maternal hyperoxygenation and effect on aortic and mitral valve annular dimensions in fetuses with left heart hypoplasia","volume":"48","author":"Lara","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.cjca.2022.04.028_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000489123","article-title":"Chronic maternal hyperoxygenation and effect on cerebral and placental vasoregulation and neurodevelopment in fetuses with left heart hypoplasia","volume":"46","author":"Edwards","year":"2019","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.cjca.2022.04.028_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejogrb.2020.12.054","article-title":"Calling into question the future of hyperoxygenation in pregnancy","volume":"258","author":"McHugh","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.cjca.2022.04.028_bib45","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.21037\/tp-20-267","article-title":"Impacts of prenatal diagnosis of congenital heart diseases on outcomes","volume":"10","author":"Bonnet","year":"2021","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.cjca.2022.04.028_bib46","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/jp.2016.20","article-title":"Fetal cardiology: changing the definition of critical heart disease in the newborn","volume":"36","author":"S\u0142odki","year":"2016","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.cjca.2022.04.028_bib47","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jtcvs.2010.11.060","article-title":"Atrioventricular valve repair in patients with functional single-ventricle physiology: impact of ventricular and valve function and morphology on survival and reintervention","volume":"142","author":"Honjo","year":"2011","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jtcvs.2011.09.076","article-title":"Biventricular strategies for neonatal critical aortic stenosis: high mortality associated with early reintervention","volume":"144","author":"Hickey","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib49","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1161\/01.CIR.84.6.2325","article-title":"Predictors of survival in neonates with critical aortic stenosis","volume":"84","author":"Rhodes","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1067\/mtc.2001.111207","article-title":"Critical aortic stenosis in the neonate: a multi-institutional study of management, outcomes, and risk factors. Congenital Heart Surgeons Society","volume":"121","author":"Lofland","year":"2001","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib51","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jtcvs.2008.04.027","article-title":"Borderline hypoplasia of the left ventricle in neonates: insights for decision-making from functional assessment with magnetic resonance imaging","volume":"136","author":"Grosse-Wortmann","year":"2008","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib52","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.athoracsur.2018.05.048","article-title":"The evolution of therapeutic strategies: niche apportionment for hybrid palliation","volume":"106","author":"Haller","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12968-014-0073-1","article-title":"Cardiovascular magnetic resonance parameters associated with early transplant-free survival in children with small left hearts following conversion from a univentricular to biventricular circulation","volume":"16","author":"Banka","year":"2014","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2022.04.028_bib54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0002-9149(80)90224-6","article-title":"Hypoplastic left heart syndrome: experience with palliative surgery","volume":"45","author":"Norwood","year":"1980","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM198301063080106","article-title":"Physiologic repair of aortic atresia-hypoplastic left heart syndrome","volume":"308","author":"Norwood","year":"1983","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2022.04.028_bib56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/j.pcsu.2004.02.023","article-title":"Right ventricle\u2013pulmonary artery shunt in first-stage palliation of hypoplastic left heart syndrome","volume":"7","author":"Sano","year":"2004","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"10.1016\/j.cjca.2022.04.028_bib57","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/ejcts\/ezr190","article-title":"Use of surveillance criteria reduces interstage mortality after the Norwood operation for hypoplastic left heart syndrome","volume":"41","author":"Hansen","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib58","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.jtcvs.2014.02.038","article-title":"Improving interstage survival after Norwood operation: outcomes from 10 years of home monitoring","volume":"148","author":"Rudd","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib59","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jtcvs.2013.04.006","article-title":"Home monitoring program reduces interstage mortality after the modified Norwood procedure","volume":"147","author":"Siehr","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib60","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jtcvs.2020.04.098","article-title":"Low preoperative superior vena cava blood flow predicts bidirectional cavopulmonary shunt failure","volume":"160","author":"Luo","year":"2020","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib61","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1056\/NEJMoa0912461","article-title":"Comparison of shunt types in the Norwood procedure for single-ventricle lesions","volume":"362","author":"Ohye","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cjca.2022.04.028_bib62","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/CIRCULATIONAHA.113.006191","article-title":"Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial","volume":"129","author":"Newburger","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib63","article-title":"High risk status for stage I palliation increases mortality after stage II but not stage III [e-pub ahead of print]","author":"Coyan","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib64","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/CIRCULATIONAHA.120.046962","article-title":"National variation in congenital heart surgery outcomes","volume":"142","author":"Pasquali","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib65","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/hrt.69.6.551","article-title":"Stenting of the arterial duct combined with banding of the pulmonary arteries and atrial septectomy or septostomy: a new approach to palliation for the hypoplastic left heart syndrome","volume":"69","author":"Gibbs","year":"1993","journal-title":"Br Heart J"},{"key":"10.1016\/j.cjca.2022.04.028_bib66","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/hc0902.104709","article-title":"Stenting of the arterial duct and banding of the pulmonary arteries: basis for combined Norwood stage I and II repair in hypoplastic left heart","volume":"105","author":"Akintuerk","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib67","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00246-014-1015-2","article-title":"Fifteen-year single center experience with the \u201cGiessen hybrid\u201d approach for hypoplastic left heart and variants: current strategies and outcomes","volume":"36","author":"Schranz","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib68","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.athoracsur.2008.02.009","article-title":"Hybrid approach for hypoplastic left heart syndrome: intermediate results after the learning curve","volume":"85","author":"Galantowicz","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib69","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jtcvs.2012.11.029","article-title":"\u201cReverse Blalock-Taussig shunt\u201d: application in single ventricle hybrid palliation","volume":"146","author":"Baba","year":"2013","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib70","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jtcvs.2013.10.038","article-title":"Bilateral pulmonary arterial banding results in an increased need for subsequent pulmonary artery interventions","volume":"147","author":"Davies","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib71","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jtcvs.2015.06.069","article-title":"Survival and right ventricular performance for matched children after stage-1 Norwood: modified Blalock-Taussig shunt versus right-ventricle\u2013to\u2013pulmonary-artery conduit","volume":"150","author":"Wilder","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib72","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.pcsu.2013.01.002","article-title":"The Norwood procedure: in favour of the RV-PA conduit","volume":"16","author":"Barron","year":"2013","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"10.1016\/j.cjca.2022.04.028_bib73","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.athoracsur.2011.07.081","article-title":"The complex relationship between center volume and outcome in patients undergoing the Norwood operation","volume":"93","author":"Pasquali","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib74","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.athoracsur.2017.09.001","article-title":"Cost variation across centers for the Norwood operation","volume":"105","author":"McHugh","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib75","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s00246-018-1885-9","article-title":"Longitudinal health care cost in hypoplastic left heart syndrome palliation","volume":"39","author":"Hansen","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib76","doi-asserted-by":"crossref","first-page":"e1181","DOI":"10.1542\/peds.2010-3742","article-title":"Inpatient costs and charges for surgical treatment of hypoplastic left heart syndrome","volume":"128","author":"Dean","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2022.04.028_bib77","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0974-2069.107226","article-title":"Treating hypoplastic left heart syndrome in emerging economies: heading the wrong way?","volume":"6","author":"Iyer","year":"2013","journal-title":"Ann Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib78","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacc.2011.09.022","article-title":"Hypoplastic left heart syndrome: current considerations and expectations","volume":"59","author":"Feinstein","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib79","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jtcvs.2016.02.035","article-title":"Neurodevelopmental outcome in hypoplastic left heart syndrome: Impact of perioperative cerebral tissue oxygenation of the Norwood procedure","volume":"151","author":"Hansen","year":"2016","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib80","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1161\/CIRCULATIONAHA.111.064113","article-title":"Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial","volume":"125","author":"Newburger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib81","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-014589","article-title":"Six-year neurodevelopmental outcomes for children with single-ventricle physiology","volume":"147","author":"Sananes","year":"2021","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2022.04.028_bib82","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1542\/peds.105.5.1082","article-title":"Neurodevelopmental outcome and lifestyle assessment in school-aged and adolescent children with hypoplastic left heart syndrome","volume":"105","author":"Mahle","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2022.04.028_bib83","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-1010","article-title":"Behaviour and quality of life at 6 years for children with hypoplastic left heart syndrome","volume":"144","author":"Goldberg","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2022.04.028_bib84","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/ejcts\/ezt062","article-title":"Risk factors for adverse neurocognitive outcomes in school-aged patients after the Fontan operation","volume":"44","author":"Sugimoto","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib85","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1542\/peds.2005-0575","article-title":"Relationship of surgical approach to neurodevelopmental outcomes in hypoplastic left heart syndrome","volume":"117","author":"Mahle","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.cjca.2022.04.028_bib86","article-title":"Survival, neurocognitive, and functional outcomes after completion of staged surgical palliation in a cohort of patients with hypoplastic left heart syndrome","volume":"9","author":"Atallah","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2022.04.028_bib87","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jpeds.2017.01.034","article-title":"Neurodevelopmental outcome in children after fetal cardiac intervention for aortic stenosis with evolving hypoplastic left heart syndrome","volume":"184","author":"Laraja","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cjca.2022.04.028_bib88","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5761\/atcs.lte.16-00106","article-title":"Neurodevelopmental outcome of children with hypoplastic left heart syndrome at one and four years of age comparing hybrid and Norwood procedure","volume":"22","author":"Knirsch","year":"2016","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib89","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/CIRCGENETICS.113.000189","article-title":"Effect of copy number variants on outcomes for infants with single ventricle heart defects","volume":"6","author":"Carey","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.cjca.2022.04.028_bib90","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/CIRCULATIONAHA.120.048202","article-title":"Neurocognitive dysfunction and smaller brain volumes in adolescents and adults with a Fontan circulation","volume":"143","author":"Verrall","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib91","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1161\/CIRCULATIONAHA.115.017202","article-title":"Survival prospects and circumstances of death in contemporary adult congenital heart disease patients under follow-up at a large tertiary centre","volume":"132","author":"Diller","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib92","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1161\/CIRCULATIONAHA.116.022816","article-title":"Current therapy for hypoplastic left heart syndrome and related single ventricle lesions","volume":"134","author":"Ohye","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib93","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jacc.2011.11.049","article-title":"Predictors of survival after single-ventricle palliation: the impact of right ventricular dominance","volume":"59","author":"d\u2019Udekem","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib94","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1161\/CIRCULATIONAHA.113.007764","article-title":"Redefining expectations of long-term survival after the Fontan procedure: twenty-five years of follow-up from the entire population of Australia and New Zealand","volume":"130","author":"d\u2019Udekem","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib95","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.110.946343","article-title":"Temporal trends in survival to adulthood among patients born with congenital heart disease from 1970 to 1992 in Belgium","volume":"122","author":"Moons","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib96","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jtcvs.2013.09.074","article-title":"Trends in Fontan surgery and risk factors for early adverse outcomes after Fontan surgery: the Australia and New Zealand Fontan Registry experience","volume":"148","author":"Iyengar","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib97","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ejcts\/ezz052","article-title":"The impact of morphological characteristics on late outcomes in patients born with hypoplastic left heart syndromedagger","volume":"56","author":"Newland","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijcard.2019.02.018","article-title":"Implications of atrial volumes in surgical corrected tetralogy of Fallot on clinical adverse events","volume":"283","author":"Ait Ali","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib99","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1586\/erc.11.75","article-title":"The failing Fontan: etiology, diagnosis and management","volume":"9","author":"Goldberg","year":"2011","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.cjca.2022.04.028_bib100","article-title":"Health-related quality of life in children, adolescents, and adults with a Fontan circulation: a meta-analysis","volume":"9","author":"Marshall","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2022.04.028_bib101","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S1355617714001027","article-title":"Executive function in children and adolescents with critical cyanotic congenital heart disease","volume":"21","author":"Cassidy","year":"2015","journal-title":"J\u00a0Int Neuropsychol Soc"},{"key":"10.1016\/j.cjca.2022.04.028_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.765380","article-title":"Sexual function in men living with a Fontan circulation","volume":"9","author":"Rubenis","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.cjca.2022.04.028_bib103","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijcard.2017.10.064","article-title":"Patient-reported outcomes in adults with congenital heart disease: inter-country variation, standard of living and healthcare system factors","volume":"251","author":"Moons","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib104","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/ehjqcco\/qcab009","article-title":"Development of an international standard set of clinical and patient-reported outcomes for children and adults with congenital heart disease: a report from the International Consortium for Health Outcomes Measurement Congenital Heart Disease Working Group","volume":"7","author":"Hummel","year":"2021","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.cjca.2022.04.028_bib105","doi-asserted-by":"crossref","first-page":"S205","DOI":"10.1161\/CIRCULATIONAHA.112.000380","article-title":"Surgical palliation strategy does not affect interstage ventricular dysfunction or atrioventricular valve regurgitation in children with hypoplastic left heart syndrome and variants","volume":"128","author":"Chetan","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib106","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00246-018-1845-4","article-title":"Survival to stage II with ventricular dysfunction: secondary analysis of the Single Ventricle Reconstruction Trial","volume":"39","author":"Jean-St-Michel","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib107","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.echo.2018.02.001","article-title":"Reduced right ventricular fractional area change, strain, and strain rate before bidirectional cavopulmonary anastomosis is associated with medium-term mortality for children with hypoplastic left heart syndrome","volume":"31","author":"Lin","year":"2018","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib108","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00246-018-1974-9","article-title":"Immediate postnatal ventricular performance is associated with mortality in hypoplastic left heart syndrome","volume":"40","author":"Altit","year":"2019","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib109","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s00246-021-02624-y","article-title":"Longitudinal assessment of right ventricular function in hypoplastic left heart syndrome","volume":"42","author":"Balasubramanian","year":"2021","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijcard.2020.03.085","article-title":"Serial changes in longitudinal strain are associated with outcome in children with hypoplastic left heart syndrome","volume":"317","author":"Borrelli","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib111","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.echo.2019.01.006","article-title":"Serial strain analysis identifies hypoplastic left heart syndrome infants at risk for cardiac morbidity and mortality: a pilot study","volume":"32","author":"Colquitt","year":"2019","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib112","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/chd.12834","article-title":"Trajectory of right ventricular indices is an early predictor of outcomes in hypoplastic left heart syndrome","volume":"14","author":"Kim","year":"2019","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.cjca.2022.04.028_bib113","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.008006","article-title":"prognostic value of serial echocardiography in hypoplastic left heart syndrome: smaller hearts, better results","volume":"11","author":"mercer-rosa","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2022.04.028_bib114","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.jacc.2014.08.033","article-title":"Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial","volume":"64","author":"Frommelt","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib115","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.007865","article-title":"Impact of initial shunt type on echocardiographic indices in children after single right ventricle palliations","volume":"12","author":"Frommelt","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2022.04.028_bib116","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/heartjnl-2015-308787","article-title":"Impact of Norwood versus hybrid palliation on cardiac size and function in hypoplastic left heart syndrome","volume":"102","author":"Grotenhuis","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2022.04.028_bib117","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.echo.2015.01.018","article-title":"Impact of initial Norwood shunt type on right ventricular deformation: the Single Ventricle Reconstruction Trial","volume":"28","author":"Hill","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib118","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/heartjnl-2017-311532","article-title":"Ventricular function and vascular dimensions after Norwood and hybrid palliation of hypoplastic left heart syndrome","volume":"104","author":"Latus","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2022.04.028_bib119","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00246-020-02482-0","article-title":"Right ventricular remodelling in hypoplastic left heart syndrome is minimally impacted by cardiopulmonary bypass: a comparison of Norwood vs hybrid","volume":"42","author":"Mah","year":"2021","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib120","article-title":"Association of digoxin with preserved echocardiographic indices in the interstage period: a possible mechanism to explain improved survival?","volume":"10","author":"Batsis","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2022.04.028_bib121","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial","volume":"116","author":"Ishigami","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2022.04.028_bib122","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yjmcc.2019.08.005","article-title":"Hypoplastic left heart syndrome: from bedside to bench and back","volume":"135","author":"Saraf","year":"2019","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib123","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jtcvs.2015.06.076","article-title":"Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: three-year follow-up of the Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single-Ventricle Physiology (TICAP) trial","volume":"150","author":"Tarui","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib124","article-title":"Systemic ventricular assist device support of the Fontan circulation yields promising outcomes: an analysis of the Society of Thoracic Surgeons Pedimacs and Intermacs Databases [e-pub ahead of print]","author":"Bedzra","year":"2021","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.pcsu.2021.04.004","article-title":"Mechanical support for the failing single ventricle at pre-Fontan stage: current state of the field and future directions","volume":"24","author":"Puri","year":"2021","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"10.1016\/j.cjca.2022.04.028_bib126","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jtcvs.2019.04.037","article-title":"An in\u00a0vitro analysis of the PediMag and CentriMag for right-sided failing Fontan support","volume":"158","author":"Trusty","year":"2019","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib127","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1016\/j.jbiomech.2015.07.039","article-title":"The effect of resolution on viscous dissipation measured with 4D flow MRI in patients with Fontan circulation: evaluation using computational fluid dynamics","volume":"48","author":"Cibis","year":"2015","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.cjca.2022.04.028_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.athoracsur.2022.01.017","article-title":"Fontan geometry and hemodynamics are associated with quality of life in adolescents and young adults [e-pub ahead of print]","author":"Mercer-Rosa","year":"2022","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib129","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12968-022-00854-4","article-title":"4D flow cardiovascular magnetic resonance derived energetics in the Fontan circulation correlate with exercise capacity and CMR-derived liver fibrosis\/congestion","volume":"24","author":"Rijnberg","year":"2022","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2022.04.028_bib130","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.jtcvs.2017.11.068","article-title":"Virtual surgical planning, flow simulation, and 3-dimensional electrospinning of patient-specific grafts to optimise Fontan hemodynamics","volume":"155","author":"Siallagan","year":"2018","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib131","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/s41598-022-05985-3","article-title":"Parametric investigation of an injection-jet self-powered Fontan circulation","volume":"12","author":"Prather","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjca.2022.04.028_bib132","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezac111","article-title":"A\u00a0potential future Fontan modification: preliminary in\u00a0vitro data of a pressure-generating tube from engineered heart tissue [e-pub ahead of print]","author":"K\u00f6hne","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib133","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jtcvs.2014.06.044","article-title":"Mechanisms of tricuspid regurgitation in patients with hypoplastic left heart syndrome undergoing tricuspid valvuloplasty","volume":"148","author":"Bautista-Hernandez","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2022.04.028_bib134","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ehjci\/jes123","article-title":"Mechanisms of tricuspid valve regurgitation in hypoplastic left heart syndrome: a case-matched echocardiographic-surgical comparison study","volume":"14","author":"Bharucha","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2022.04.028_bib135","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.echo.2020.12.010","article-title":"Tricuspid regurgitation in hypoplastic left heart syndrome: three-dimensional echocardiography provides additional information in describing jet location","volume":"34","author":"Mah","year":"2021","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib136","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.echo.2021.06.007","article-title":"Tricuspid valve tethering is associated with residual regurgitation after valve repair in hypoplastic left heart syndrome: a three-dimensional echocardiographic study","volume":"34","author":"Shigemitsu","year":"2021","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib137","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/CIRCULATIONAHA.119.044352","article-title":"Results of the FUEL Trial","volume":"141","author":"Goldberg","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib138","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCULATIONAHA.110.981746","article-title":"Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: a randomised, double-blind, placebo-controlled, crossover trial","volume":"123","author":"Goldberg","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib139","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.113.008441","article-title":"Bosentan improves exercise capacity in adolescents and adults after Fontan operation: the TEMPO (Treatment With Endothelin Receptor Antagonist in Fontan Patients, a Randomised, Placebo-Controlled, Double-Blind Study Measuring Peak Oxygen Consumption) study","volume":"130","author":"Hebert","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2022.04.028_bib140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00246-015-1238-x","article-title":"Effect of tadalafil on myocardial and endothelial function and exercise performance after modified Fontan operation","volume":"37","author":"Sabri","year":"2016","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib141","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/eurjhf\/hft017","article-title":"Impact of bosentan on exercise capacity in adults after the Fontan procedure: a randomised controlled trial","volume":"15","author":"Schuuring","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cjca.2022.04.028_bib142","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.amjcard.2016.02.024","article-title":"Effect of ambrisentan on exercise capacity in adult patients after the Fontan procedure","volume":"117","author":"Cedars","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2022.04.028_bib143","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.echo.2018.11.010","article-title":"Global left ventricular relaxation: a useful echocardiographic marker of heart transplant rejection and recovery in children","volume":"32","author":"Hernandez","year":"2019","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2022.04.028_bib144","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/heartjnl-2020-316613","article-title":"Augmentation of pulmonary blood flow and cardiac output by non-invasive external ventilation late after Fontan palliation","volume":"107","author":"Charla","year":"2021","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2022.04.028_bib145","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/CIR.0000000000000696","article-title":"Evaluation and management of the child and adult with Fontan circulation: a scientific statement from the American Heart Association","volume":"140","author":"Rychik","year":"2019","journal-title":"Circulation"},{"issue":"9689","key":"10.1016\/j.cjca.2022.04.028_bib146","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0140-6736(09)60563-8","article-title":"Hypoplastic left heart syndrome","volume":"374","author":"Barron","year":"2009","journal-title":"Lancet"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X22002902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X22002902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:49:45Z","timestamp":1760107785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X22002902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":146,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0828282X22002902"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2022.04.028","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoplastic Left Heart Syndrome Across the Lifespan: Clinical Considerations for Care of the Fetus, Child, and Adult","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2022.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}