{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:17:34Z","timestamp":1781133454002,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012285","name":"BC Children&apos;s Hospital","doi-asserted-by":"publisher","award":["GR008110"],"award-info":[{"award-number":["GR008110"]}],"id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012285","name":"BC Children&apos;s Hospital","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RN380020-406814"],"award-info":[{"award-number":["RN380020-406814"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["152972"],"award-info":[{"award-number":["152972"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["81197"],"award-info":[{"award-number":["81197"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cjca.2023.10.007","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:06:07Z","timestamp":1697421967000},"page":"89-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Chronic Disease on the Corrected QT (QTc) Value in Women in a British Columbia First Nations Population"],"prefix":"10.1016","volume":"40","author":[{"given":"Miles","family":"Marchand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders C.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Gillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Haywood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Jaworsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Drouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Laksman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Krahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-0880","authenticated-orcid":false,"given":"Laura","family":"Arbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2023.10.007_bib1","first-page":"e241","volume":"119","author":"Rautaharju","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.hrthm.2008.05.008","article-title":"Keep the QT interval: it is a reliable predictor of ventricular arrhythmias","volume":"5","author":"Roden","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjca.2023.10.007_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(01)00243-4","article-title":"Molecular and cellular mechanisms of cardiac arrhythmias","volume":"104","author":"Keating","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cjca.2023.10.007_bib4","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1093\/eurheartj\/eht089","article-title":"The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy","volume":"34","author":"Schwartz","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2023.10.007_bib5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCULATIONAHA.119.043132","article-title":"An international, multicentered, evidence-based reappraisal of genes reported to cause congenital long QT syndrome","volume":"141","author":"Adler","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2023.10.007_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cpcardiol.2013.08.001","article-title":"Genotype-and phenotype-guided management of congenital long QT syndrome","volume":"38","author":"Giudicessi","year":"2013","journal-title":"Curr Prob Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0735-1097(00)01124-4","article-title":"A\u00a0founder mutation of the potassium channel KCNQ1 in long QT syndrome: implications for estimation of disease prevalence and molecular diagnostics","volume":"37","author":"Piippo","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib8","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1161\/CIRCULATIONAHA.105.572453","article-title":"Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population","volume":"112","author":"Brink","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2023.10.007_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/GIM.0b013e31817c6b19","article-title":"A\u00a0KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact","volume":"10","author":"Arbour","year":"2008","journal-title":"Genet Med"},{"key":"10.1016\/j.cjca.2023.10.007_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11096-016-0414-2","article-title":"Risk factors for QTc-prolongation: systematic review of the evidence","volume":"39","author":"Vandael","year":"2017","journal-title":"Int J Clin Pharm"},{"key":"10.1016\/j.cjca.2023.10.007_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jacc.2006.08.057","article-title":"Long QT Syndrome in Adults","volume":"49","author":"Sauer","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/jmedgenet-2016-104153","article-title":"KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1","volume":"54","author":"Kapplinger","year":"2017","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.cjca.2023.10.007_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.116.001537","article-title":"Novel variant in the ANK2 membrane-binding domain is associated with Ankyrin-B syndrome and structural heart disease in a first nations population with a high rate of long QT syndrome","volume":"10","author":"Swayne","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.cjca.2023.10.007_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00059-016-4469-6","article-title":"Alcoholic cardiomyopathy: the result of dosage and individual predisposition","volume":"41","author":"Maisch","year":"2016","journal-title":"Herz"},{"key":"10.1016\/j.cjca.2023.10.007_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0049-0172(99)80003-1","article-title":"Rheumatic diseases in North America\u2019s indigenous peoples","volume":"28","author":"Peschken","year":"1999","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.cjca.2023.10.007_bib16","series-title":"First Nations Regional Health Survey (RHS) 2008\/10: national report on adults, youth and children living in First Nations communities","year":"2012"},{"key":"10.1016\/j.cjca.2023.10.007_bib18","series-title":"National report of the First Nations Regional Health Survey (RHS)","year":"2018"},{"key":"10.1016\/j.cjca.2023.10.007_bib19","author":"Arriagada"},{"key":"10.1016\/j.cjca.2023.10.007_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.24095\/hpcdp.32.4.04","article-title":"Cardiovascular disease mortality among First Nations people in Canada 1991-2001","volume":"32","author":"Tjepkema","year":"2012","journal-title":"Chronic Dis Injur Can"},{"key":"10.1016\/j.cjca.2023.10.007_bib22","first-page":"3","article-title":"Acute myocardial infarction hospitalisation and treatment: areas with a high percentage of First Nations identity residents","volume":"24","author":"Wei-Randall","year":"2013","journal-title":"Health Rep"},{"key":"10.1016\/j.cjca.2023.10.007_bib23","first-page":"437","article-title":"The state of affairs for cardiovascular health research in Indigenous women in Canada: a scoping review","volume":"34","author":"Prince","year":"2018","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib24","first-page":"693","article-title":"Charting the course for women\u2019s heart health in Canada: recommendations from the first Canadian Women\u2019s Heart Health Summit","volume":"33","author":"Prince","year":"2017","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib25","first-page":"1077","article-title":"Confronting the growing crisis of cardiovascular disease and heart health among aboriginal peoples in Canada","volume":"31","author":"Reading","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib17","first-page":"1584","article-title":"A\u00a0call to action: optimizing indigenous cardiovascular health in Canada","volume":"38","author":"Aziz","year":"2022","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib26","first-page":"1124","article-title":"Preventing cardiovascular and renal disease in Canada\u2019s aboriginal populations","volume":"31","author":"Tobe","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib28","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/jama.289.16.2120","article-title":"What clinicians should know about the QT interval","volume":"289","author":"Al-Khatib","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2023.10.007_bib29","first-page":"855","article-title":"Determination of the QT interval in left bundle branch block: development of a novel formula","volume":"35","author":"Tang","year":"2019","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib30","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.hrthm.2008.03.037","article-title":"Accurate electrocardiographic assessment of the QT interval: teach the tangent","volume":"5","author":"Postema","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjca.2023.10.007_bib31","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazett","year":"1920","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2023.10.007_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/cge.12235","article-title":"LQTS in Northern BC: homozygosity for KCNQ1 V205M presents with a more severe cardiac phenotype but with minimal impact on auditory function","volume":"86","author":"Jackson","year":"2014","journal-title":"Clin Genet"},{"key":"10.1016\/j.cjca.2023.10.007_bib34","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/EDE.0000000000000168","article-title":"Evidence of heterogeneity by race\/ethnicity in genetic determinants of QT interval","volume":"25","author":"Seyerle","year":"2014","journal-title":"Epidemiology"},{"key":"10.1016\/j.cjca.2023.10.007_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12881-017-0435-2","article-title":"Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis","volume":"18","author":"Winbo","year":"2017","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.cjca.2023.10.007_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.CIR.99.4.529","article-title":"Low penetrance in the long-QT syndrome: clinical impact","volume":"99","author":"Priori","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2023.10.007_bib37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.clinbiochem.2004.10.004","article-title":"Prevalence and risk factors for prolonged QTc in a multiethnic cohort in rural Hawaii","volume":"38","author":"Grandinetti","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.cjca.2023.10.007_bib38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCULATIONAHA.115.015673","article-title":"Distinctive clinical profile of blacks versus whites presenting with sudden cardiac arrest","volume":"132","author":"Reinier","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2023.10.007_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.101.1.61","article-title":"Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart study","volume":"101","author":"Okin","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2023.10.007_bib40","doi-asserted-by":"crossref","first-page":"072","DOI":"10.23937\/2378-2951\/1410072","article-title":"Increased corrected QT interval (QTc) in First Nations women of northern British Columbia with systemic lupus erythematosus (SLE)","volume":"3","author":"Munday","year":"2016","journal-title":"Int J Clin Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib41","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.envpol.2018.04.129","article-title":"Association of low-moderate urine arsenic and QT interval: cross-sectional and longitudinal evidence from the Strong Heart Study","volume":"240","author":"Moon","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.cjca.2023.10.007_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1475-2840-11-23","article-title":"Low serum magnesium concentrations are associated with a high prevalence of premature ventricular complexes in obese adults with type 2 diabetes","volume":"11","author":"del Gobbo","year":"2012","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.cjca.2023.10.007_bib43","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/euhj.2000.2222","article-title":"Congenital and acquired long QT syndrome","volume":"21","author":"Camm","year":"2000","journal-title":"Eur Heart J"},{"issue":"9190","key":"10.1016\/j.cjca.2023.10.007_bib44","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/S0140-6736(99)02107-8","article-title":"Long QT syndromes and torsade de pointes","volume":"354","author":"Viskin","year":"1999","journal-title":"Lancet"},{"issue":"suppl 4","key":"10.1016\/j.cjca.2023.10.007_bib45","first-page":"iv1","article-title":"On the relationship among QT interval, atrial fibrillation, and torsade de pointes","volume":"9","author":"Roden","year":"2007","journal-title":"Europace"},{"key":"10.1016\/j.cjca.2023.10.007_bib46","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCEP.109.858894","article-title":"Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study","volume":"2","author":"Akylbekova","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib47","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jelectrocard.2008.01.010","article-title":"Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men","volume":"41","author":"Sohaib","year":"2008","journal-title":"J\u00a0Electrocardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/rheumatology\/ket338","article-title":"Prolonged QTc interval predicts all-cause mortality in patients with rheumatoid arthritis: an association driven by high inflammatory burden","volume":"53","author":"Panoulas","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.cjca.2023.10.007_bib49","first-page":"84","article-title":"Population-based study of QT interval prolongation in patients with rheumatoid arthritis","volume":"33","author":"Chauhan","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cjca.2023.10.007_bib50","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/art.20130","article-title":"Prolongation of the corrected QT interval in adult patients with anti-Ro\/SSA\u2013positive connective tissue diseases","volume":"50","author":"Lazzerini","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cjca.2023.10.007_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/acr.22370","article-title":"Electrocardiographic findings in systemic lupus erythematosus: data from an international inception cohort","volume":"67","author":"Bourr\u00e9-Tessier","year":"2015","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.cjca.2023.10.007_bib52","article-title":"Risk of QTc Interval prolongation associated with circulating anti-Ro\/SSA antibodies among US veterans: an observational cohort study","volume":"10","author":"Lazzerini","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2023.10.007_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcvm.2015.00026","article-title":"Long QT syndrome: an emerging role for inflammation and immunity","volume":"2","author":"Lazzerini","year":"2015","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cjca.2023.10.007_bib54","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.RES.87.12.1123","article-title":"Myocardial cell death in human diabetes","volume":"87","author":"Frustaci","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2023.10.007_bib55","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.amjcard.2016.07.033","article-title":"Relation of heavy alcohol consumption to QTc interval prolongation","volume":"118","author":"Li","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib56","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/aje\/kwr172","article-title":"Sex-steroid hormones and electrocardiographic QT-interval duration: findings from the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis","volume":"174","author":"Zhang","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cjca.2023.10.007_bib57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pbiomolbio.2005.05.010","article-title":"Recent advances in understanding sex differences in cardiac repolarisation","volume":"94","author":"James","year":"2007","journal-title":"Prog Biophys Mol Biol"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X23017622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X23017622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:30:47Z","timestamp":1778754647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X23017622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0828282X23017622"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2023.10.007","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Impact of Chronic Disease on the Corrected QT (QTc) Value in Women in a British Columbia First Nations Population","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2023.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}