{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:38:21Z","timestamp":1763552301746,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","onlinecjc.ca","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cjca.2024.03.009","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T21:07:19Z","timestamp":1710968839000},"page":"1690-1699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Angiotensin II Receptor Blockers Are Associated With Reduced Valvular Fibrosis in Women With Aortic Stenosis"],"prefix":"10.1016","volume":"40","author":[{"given":"Rasmus","family":"Carter-Storch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Le Nezet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulham","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9anne","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Haujir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolanne","family":"Demers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Couture","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Trahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Pag\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Dagenais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi S.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-740X","authenticated-orcid":false,"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2024.03.009_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2024.03.009_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.CIR.76.1.77","article-title":"Early postoperative changes in left ventricular chamber size, architecture, and function in aortic stenosis and aortic regurgitation and their relation to intraoperative changes in afterload: a prospective two-dimensional echocardiographic study","volume":"76","author":"Sutton","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.03.009_bib3","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1136\/heartjnl-2016-310894","article-title":"Epidemiology of valvular heart disease in a swedish nationwide hospital-based register study","volume":"103","author":"Andell","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2024.03.009_bib4","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1161\/ATVBAHA.114.304015","article-title":"Carotid plaque, intima-media thickness, and incident aortic stenosis: a prospective cohort study","volume":"34","author":"Martinsson","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cjca.2024.03.009_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/ehjcvp\/pvw027","article-title":"Is the use of renin-angiotensin system inhibitors in patients with aortic valve stenosis safe and of prognostic benefit? A systematic review and meta-analysis","volume":"3","author":"Andersson","year":"2017","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.cjca.2024.03.009_bib6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jacc.2019.05.055","article-title":"Renin-angiotensin system inhibition following transcatheter aortic valve replacement","volume":"74","author":"Rodriguez-Gabella","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.7326\/M13-1505","article-title":"Renin-angiotensin system blockade therapy after surgical aortic valve replacement for severe aortic stenosis: a cohort study","volume":"161","author":"Goel","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cjca.2024.03.009_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jacc.2011.01.063","article-title":"Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis","volume":"58","author":"Nadir","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.amjcard.2010.04.028","article-title":"Effect of candesartan treatment on left ventricular remodeling after aortic valve replacement for aortic stenosis","volume":"106","author":"Dahl","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib10","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1161\/01.CIR.89.5.2204","article-title":"Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in\u00a0vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in\u00a0vitro","volume":"89","author":"Kojima","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.03.009_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijcard.2011.08.056","article-title":"Prevention of atrial fibrillation in patients with aortic valve stenosis with candesartan treatment after aortic valve replacement","volume":"165","author":"Dahl","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib12","article-title":"Renin-angiotensin system blockade in aortic stenosis: implications before and after aortic valve replacement","volume":"9","author":"Goel","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2024.03.009_bib13","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/archinte.165.8.858","article-title":"Angiotensin-converting enzyme inhibitors and change in aortic valve calcium","volume":"165","author":"O\u2019Brien","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cjca.2024.03.009_bib14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/eci.12169","article-title":"Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis","volume":"43","author":"Capoulade","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cjca.2024.03.009_bib15","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jacc.2006.11.043","article-title":"Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits","volume":"49","author":"Arishiro","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000350896","article-title":"Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease","volume":"81","author":"C\u00f4t\u00e9","year":"2014","journal-title":"Pathobiology"},{"key":"10.1016\/j.cjca.2024.03.009_bib17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/CIRCRESAHA.116.309306","article-title":"Sex-related discordance between aortic valve calcification and hemodynamic severity of aortic stenosis: is valvular fibrosis the explanation?","volume":"120","author":"Simard","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2024.03.009_bib18","article-title":"Age, sex, and valve phenotype differences in fibro-calcific remodeling of calcified aortic valve","volume":"9","author":"Voisine","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjca.2024.03.009_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007146","article-title":"Computed tomography aortic valve calcium scoring in patients with aortic stenosis","volume":"11","author":"Pawade","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2024.03.009_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jacc.2014.05.066","article-title":"Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: results of an international registry study","volume":"64","author":"Clavel","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib21","first-page":"I3","article-title":"A\u00a0method of uniform stratification of risk for evaluating the results of surgery in acquired adult heart disease","volume":"79","author":"Parsonnet","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.03.009_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2024.03.009_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2024.03.009_bib24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/00313029700169315","article-title":"Calcification of the aortic valve: its progression and grading","volume":"29","author":"Warren","year":"1997","journal-title":"Pathology"},{"key":"10.1016\/j.cjca.2024.03.009_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.117.10094","article-title":"MicroRNA-221\/222 family counteracts myocardial fibrosis in pressure overload-induced heart failure","volume":"71","author":"Verjans","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.cjca.2024.03.009_bib26","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/01.RES.84.9.1073","article-title":"Angiotensin II\u2013induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-\u03b2 synthesis via transcriptional and posttranscriptional mechanisms","volume":"84","author":"Moriguchi","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2024.03.009_bib27","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib28","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1161\/01.CIR.0000035655.45453.D2","article-title":"Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma","volume":"106","author":"O\u2019Brien","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.03.009_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/01.RES.80.2.219","article-title":"Functional and biochemical analysis of angiotensin II\u2013forming pathways in the human heart","volume":"80","author":"Wolny","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2024.03.009_bib30","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.jacc.2004.07.054","article-title":"Induction of local angiotensin II\u2013producing systems in stenotic aortic valves","volume":"44","author":"Helske","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib31","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/eurheartj\/ehi706","article-title":"Possible role for mast cell\u2013derived cathepsin G in the adverse remodelling of stenotic aortic valves","volume":"27","author":"Helske","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2024.03.009_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039980","article-title":"Sex-related differences in gene expression by porcine aortic valvular interstitial cells","volume":"7","author":"McCoy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2024.03.009_bib33","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/01.CIR.102.15.1828","article-title":"Differential effects of estrogen and progesterone on AT1 receptor gene expression in vascular smooth muscle cells","volume":"102","author":"Nickenig","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.03.009_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijcard.2014.07.077","article-title":"Androgen attenuates cardiac fibroblasts activations through modulations of transforming growth factor-\u03b2 and angiotensin II signaling","volume":"176","author":"Chung","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.1365-2796.2003.01179.x","article-title":"Oestrogen receptor \u03b1 gene polymorphism is related to aortic valve sclerosis in postmenopausal women","volume":"254","author":"Nordstr\u00f6m","year":"2003","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.cjca.2024.03.009_bib36","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15433","article-title":"Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model","volume":"10","author":"Fleury","year":"2022","journal-title":"Physiol Rep"},{"key":"10.1016\/j.cjca.2024.03.009_bib37","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.jacc.2013.08.1621","article-title":"The complex nature of discordant severe calcified aortic valve disease grading: new insights from combined Doppler echocardiographic and computed tomographic study","volume":"62","author":"Clavel","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2024.03.009_bib38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/heart.88.4.348","article-title":"T\u00a0lymphocyte infiltration in nonrheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves","volume":"88","author":"Wallby","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2024.03.009_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/heartjnl-2016-309665","article-title":"Effect of age and aortic valve anatomy on calcification and haemodynamic severity of aortic stenosis","volume":"103","author":"Shen","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2024.03.009_bib40","article-title":"Ex\u00a0vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease","volume":"7","author":"Sun","year":"2012","journal-title":"PLoS One"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X24002708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X24002708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T14:27:33Z","timestamp":1725632853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X24002708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0828282X24002708"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2024.03.009","relation":{},"ISSN":["0828-282X"],"issn-type":[{"type":"print","value":"0828-282X"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II Receptor Blockers Are Associated With Reduced Valvular Fibrosis in Women With Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2024.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}