{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:12:22Z","timestamp":1778544742421,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2022CRD044"],"award-info":[{"award-number":["SHDC2022CRD044"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91949128"],"award-info":[{"award-number":["91949128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370316"],"award-info":[{"award-number":["82370316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270447"],"award-info":[{"award-number":["82270447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["XHEC-F-2024-024"],"award-info":[{"award-number":["XHEC-F-2024-024"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["XHEC-NSFC-2019-327"],"award-info":[{"award-number":["XHEC-NSFC-2019-327"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.cjca.2024.10.011","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T18:21:09Z","timestamp":1729275669000},"page":"224-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["NDRG1 Regulates Iron Metabolism and Inhibits Pathologic Cardiac Hypertrophy"],"prefix":"10.1016","volume":"41","author":[{"given":"Jiali","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengye","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojian","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binfeng","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiji","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengshuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuepeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-400X","authenticated-orcid":false,"given":"Qunshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2024.10.011_bib1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.2021.5469","article-title":"The leading causes of death in the US for 2020","volume":"325","author":"Ahmad","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2024.10.011_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41569-022-00806-6","article-title":"Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential","volume":"20","author":"Martin","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1139\/cjpp-2019-0566","article-title":"Mechanisms for the transition from physiological to pathological cardiac hypertrophy","volume":"98","author":"Oldfield","year":"2020","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.cjca.2024.10.011_bib5","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J"},{"key":"10.1016\/j.cjca.2024.10.011_bib6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cjca.2024.10.011_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cjca.2024.10.011_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115765","article-title":"Ferroptosis in cardiac hypertrophy and heart failure","volume":"168","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.cjca.2024.10.011_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.yjmcc.2022.10.004","article-title":"Ferroptosis in heart failure","volume":"173","author":"Yang","year":"2022","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib11","first-page":"1712","article-title":"YAP facilitates NEDD4L-mediated ubiquitination and degradation of ACSL4 to alleviate ferroptosis in myocardial ischemia-reperfusion injury","volume":"39","author":"Qiu","year":"2023","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib12","first-page":"1728","article-title":"Leashing ferroptosis in myocardial ischemia\/reperfusion injury: role of the YAP\/NEDD4L\/ACSL4 pathway, knowledge gaps, and potential therapeutic application","volume":"39","author":"Zheng","year":"2023","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188871","article-title":"The role of the NDRG1 in the pathogenesis and treatment of breast cancer","volume":"1878","author":"Zhao","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.cjca.2024.10.011_bib14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1124\/pharmrev.122.000795","article-title":"The Myc family and the metastasis suppressor NDRG1: targeting key molecular interactions with innovative therapeutics","volume":"75","author":"Deng","year":"2023","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.cjca.2024.10.011_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2019.05.020","article-title":"Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer","volume":"157","author":"Park","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cjca.2024.10.011_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbcan.2013.11.002","article-title":"Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy","volume":"1845","author":"Fang","year":"2014","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.cjca.2024.10.011_bib17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1124\/mol.112.083097","article-title":"Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1\/pMLC2 signaling pathway","volume":"83","author":"Sun","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.cjca.2024.10.011_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jnci\/djab222","article-title":"NDRG1 in aggressive breast cancer progression and brain metastasis","volume":"114","author":"Villodre","year":"2022","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.cjca.2024.10.011_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202201605","article-title":"CRISPR\/Cas9 screen in gastric cancer patient-derived organoids reveals KDM1A-NDRG1 axis as a targetable vulnerability","volume":"7","author":"Mircetic","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.cjca.2024.10.011_bib20","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-019-03406-9","article-title":"Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases","volume":"77","author":"Li","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.cjca.2024.10.011_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/geno.2000.6496","article-title":"Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart","volume":"73","author":"Zhou","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.cjca.2024.10.011_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114891","article-title":"Genetic factors contribute to medication-induced QT prolongation: a review","volume":"317","author":"Toba-Oluboka","year":"2022","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.cjca.2024.10.011_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00395-015-0519-0","article-title":"N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-\u03b1 and nuclear factor kappa B, aggravates cardiac ischemia\/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway","volume":"111","author":"Xing","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ydbio.2008.02.044","article-title":"Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish","volume":"317","author":"Qu","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.cjca.2024.10.011_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057273","article-title":"N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion","volume":"8","author":"Lane","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2024.10.011_bib26","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100443R","article-title":"Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family","volume":"35","author":"Le","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.cjca.2024.10.011_bib27","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.3390\/cancers14235739","article-title":"NDRG1 in cancer: a suppressor, promoter, or both?","volume":"14","author":"Joshi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cjca.2024.10.011_bib28","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/blood-2004-05-1866","article-title":"Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation","volume":"104","author":"Le","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cjca.2024.10.011_bib29","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1074\/jbc.M112.350470","article-title":"The iron chelators Dp44mT and DFO inhibit TGF-\u03b2-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)","volume":"287","author":"Chen","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.cjca.2024.10.011_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCRESAHA.122.321837","article-title":"NDRG1 signaling is essential for endothelial inflammation and vascular remodeling","volume":"132","author":"Zhang","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2024.10.011_bib31","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.115.013894","article-title":"Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload","volume":"131","author":"Schiattarella","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.10.011_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yjmcc.2019.08.003","article-title":"EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation","volume":"135","author":"Song","year":"2019","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.cjca.2024.10.011_bib33","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1161\/CIRCULATIONAHA.112.115592","article-title":"Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling","volume":"126","author":"Das","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.10.011_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/CIRCULATIONAHA.122.061557","article-title":"Noncanonical form of ERAD regulates cardiac hypertrophy","volume":"147","author":"Blackwood","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.10.011_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166724","article-title":"GSK-3 at the heart of cardiometabolic diseases: isoform-specific targeting is critical to therapeutic benefit","volume":"1869","author":"Umbarkar","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.cjca.2024.10.011_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2156-5-27","article-title":"Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers","volume":"5","author":"Cangul","year":"2004","journal-title":"BMC Genet"},{"key":"10.1016\/j.cjca.2024.10.011_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/taap.1999.8759","article-title":"Role of Ca(2+) in the regulation of nickel-inducible Cap43 gene expression","volume":"160","author":"Salnikow","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cjca.2024.10.011_bib38","article-title":"Construction and validation of a prognostic model for hepatocellular carcinoma: Inflammatory ferroptosis and mitochondrial metabolism indicate a poor prognosis","volume":"12","author":"Han","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.cjca.2024.10.011_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12575-023-00199-x","article-title":"TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC","volume":"25","author":"Tang","year":"2023","journal-title":"Biol Proced Online"},{"key":"10.1016\/j.cjca.2024.10.011_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000844","article-title":"The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin","volume":"2","author":"Kachhap","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2024.10.011_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087268","article-title":"Global gene expression analysis reveals a link between NDRG1 and vesicle transport","volume":"9","author":"Askautrud","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cjca.2024.10.011_bib42","first-page":"3961","article-title":"NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation","volume":"126","author":"Pieti\u00e4inen","year":"2013","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.cjca.2024.10.011_bib43","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1038\/s41388-021-01962-8","article-title":"NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer","volume":"40","author":"Yang","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.cjca.2024.10.011_bib44","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1182\/blood.2020006987","article-title":"Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts","volume":"137","author":"Petit","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.cjca.2024.10.011_bib45","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.3390\/ijms23147977","article-title":"Emerging roles of the iron chelators in inflammation","volume":"23","author":"Di Paola","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cjca.2024.10.011_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.123.004181","article-title":"Cardiovascular disease knowledge portal: a community resource for cardiovascular disease research","volume":"16","author":"Costanzo","year":"2023","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.cjca.2024.10.011_bib47","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"GTEx Consortium. The genotype-tissue expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.cjca.2024.10.011_bib48","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.111.050773","article-title":"Iron overload cardiomyopathy in clinical practice","volume":"124","author":"Kremastinos","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2024.10.011_bib49","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.cardfail.2010.05.009","article-title":"Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment","volume":"16","author":"Murphy","year":"2010","journal-title":"J\u00a0Card Fail"},{"issue":"Suppl 2","key":"10.1016\/j.cjca.2024.10.011_bib50","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/S0268-960X(08)70004-3","article-title":"Cardiac iron across different transfusion-dependent diseases","volume":"22","author":"Wood","year":"2008","journal-title":"Blood Rev"},{"key":"10.1016\/j.cjca.2024.10.011_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2023.02.018","article-title":"Iron chelation alleviates multiple pathophysiological pathways in a rat model of cardiac pressure overload","volume":"200","author":"Lupu","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cjca.2024.10.011_bib52","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbrc.2017.03.127","article-title":"Deferiprone attenuates inflammation and myocardial fibrosis in diabetic cardiomyopathy rats","volume":"486","author":"Zou","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cjca.2024.10.011_bib53","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/nu15030591","article-title":"Targeting iron metabolism and ferroptosis as novel therapeutic approaches in cardiovascular diseases","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.cjca.2024.10.011_bib54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/eurheartj\/ehi028","article-title":"Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance","volume":"26","author":"Paraskevaidis","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2024.10.011_bib55","first-page":"IV390","article-title":"Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans","volume":"82","author":"Menasch\u00e9","year":"1990","journal-title":"Circulation"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X24010298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X24010298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:29:20Z","timestamp":1778542160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X24010298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0828282X24010298"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2024.10.011","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NDRG1 Regulates Iron Metabolism and Inhibits Pathologic Cardiac Hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2024.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}