{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:34:38Z","timestamp":1789583678557,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cjca.2025.04.015","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:12:37Z","timestamp":1745500357000},"page":"1503-1514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Temporal Trends in Transcatheter Aortic Valve Replacement Outcomes in Patients With Low-Flow, Low-Gradient Aortic Stenosis: Insights From the TOPAS-TAVI Registry"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-8794","authenticated-orcid":false,"given":"Siddhartha","family":"Mengi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cepas-Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stamatios","family":"Lerakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Babaliaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Barbosa","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Pelletier-Beaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2025.04.015_bib1","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/eurheartj\/ehw096","article-title":"Low-gradient aortic stenosis","volume":"37","author":"Clavel","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.04.015_bib2","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.jacc.2016.02.072","article-title":"The complex interaction between left ventricular ejection fraction, flow, and gradient in patients undergoing TAVR","volume":"67","author":"Pibarot","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib3","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jacc.2018.01.054","article-title":"Transcatheter aortic valve replacement in patients with low-flow, low-gradient aortic stenosis: the TOPAS-TAVI registry","volume":"71","author":"Ribeiro","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2014.11.047","article-title":"Impact of classic and paradoxical low flow on survival after aortic valve replacement for severe aortic stenosis","volume":"65","author":"Clavel","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029489","article-title":"Clinical outcomes in high-gradient, classical low-flow, low-gradient, and paradoxical low-flow, low-gradient aortic stenosis after transcatheter aortic valve implantation: a report from the SwissTAVI registry","volume":"12","author":"Wagener","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2025.04.015_bib6","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2012.06.051","article-title":"Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction","volume":"60","author":"Pibarot","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib7","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jacc.2007.10.067","article-title":"Aortic valve replacement for low-flow\/low-gradient aortic stenosis: operative risk stratification and long-term outcome: a European multicenter study","volume":"51","author":"Levy","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib8","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.jacc.2009.02.026","article-title":"Outcome after aortic valve replacement for low-flow\/low-gradient aortic stenosis without contractile reserve on dobutamine stress echocardiography","volume":"53","author":"Tribouilloy","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib9","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4244\/EIJV10I7A145","article-title":"TAVI for low-flow, low-gradient severe aortic stenosis with preserved or reduced ejection fraction: a subgroup analysis from the German Aortic Valve Registry (GARY)","volume":"10","author":"Lauten","year":"2014","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.04.015_bib10","first-page":"1481","article-title":"Impact of surgical and transcatheter aortic valve replacement in low-gradient aortic stenosis: a meta-analysis","volume":"14","author":"Hiroki Ueyama","year":"2021","journal-title":"Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.04.015_bib11","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.jacc.2014.09.026","article-title":"Multicenter evaluation of a next-generation balloon-expandable transcatheter aortic valve","volume":"64","author":"Webb","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib12","first-page":"2277","article-title":"Cardiac death after transcatheter aortic valve replacement with contemporary devices","volume":"16","author":"Mesnier","year":"2023","journal-title":"Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.04.015_bib13","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jacc.2012.09.001","article-title":"Updated standardized end point definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium 2 consensus document","volume":"60","author":"Kappetein","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib14","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.4244\/EIJY14M12_12","article-title":"Impact of left ventricular function and transaortic gradient on outcomes from transcatheter aortic valve implantation: data from the UK TAVI Registry","volume":"11","author":"Malkin","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.04.015_bib15","doi-asserted-by":"crossref","first-page":"e1428","DOI":"10.4244\/EIJ-D-17-00139","article-title":"Characteristics and outcome following transcatheter aortic valve replacement in patients with severe aortic stenosis with low flow","volume":"13","author":"Abramowitz","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.04.015_bib16","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.jacc.2016.03.514","article-title":"Impact of ejection fraction and aortic valve gradient on outcomes of transcatheter aortic valve replacement","volume":"67","author":"Baron","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib17","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2025.04.015_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ehjci\/jex019","article-title":"Patient-prosthesis mismatch in new generation trans-catheter heart valves: a propensity score analysis","volume":"19","author":"Theron","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2025.04.015_bib19","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4244\/EIJ-D-18-00827","article-title":"Prosthesis-patient mismatch after transcatheter aortic valve implantation: prevalence and prognostic impact with respect to baseline left ventricular function","volume":"14","author":"Schofer","year":"2019","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.04.015_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/ehjci\/jead243","article-title":"Transcatheter aortic valve replacement outcomes in patients with low-flow very low-gradient aortic stenosis","volume":"25","author":"Ueyama","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2025.04.015_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/ejechocard\/jeq014","article-title":"Impact of global left ventricular afterload on left ventricular function in asymptomatic severe aortic stenosis: a two-dimensional speckle-tracking study","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.cjca.2025.04.015_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jacc.2011.02.059","article-title":"Low-gradient aortic valve stenosis myocardial fibrosis and its influence on function and outcome","volume":"58","author":"Herrmann","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib23","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1001\/jamacardio.2024.3486","article-title":"Aortic stenosis, heart failure, and aortic valve replacement","volume":"9","author":"Mengi","year":"2024","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib24","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2025.04.015_bib25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/eurheartj\/ehu384","article-title":"Paravalvular regurgitation after transcatheter aortic valve replacement with the Edwards Sapien valve in the PARTNER trial: characterizing patients and impact on outcomes","volume":"36","author":"Kodali","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.04.015_bib26","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.jacc.2014.02.556","article-title":"Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery","volume":"63","author":"Popma","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2016.05.059","article-title":"Cardiovascular magnetic resonance to evaluate aortic regurgitation after transcatheter aortic valve replacement","volume":"68","author":"Ribeiro","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/CIRCINTERVENTIONS.113.000650","article-title":"Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the Placement of Aortic Transcatheter Valves (PARTNER) trial (cohort A)","volume":"6","author":"Elmariah","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.04.015_bib29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijcard.2014.06.017","article-title":"Increased mortality after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis and low ejection fraction: a meta-analysis of 6898 patients","volume":"176","author":"Sannino","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib30","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1161\/CIRCULATIONAHA.112.001290","article-title":"Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis","volume":"127","author":"Herrmann","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2025.04.015_bib31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4244\/EIJ-D-16-00801","article-title":"Long-term outcomes after TAVI in patients with different types of aortic stenosis: the conundrum of low flow, low gradient and low ejection fraction","volume":"13","author":"Puls","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.04.015_bib32","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Casta\u00f1o","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.04.015_bib33","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1001\/jama.2016.12347","article-title":"Association between transcatheter aortic valve replacement and subsequent infective endocarditis and in-hospital death","volume":"316","author":"Regueiro","year":"2016","journal-title":"Jama"},{"key":"10.1016\/j.cjca.2025.04.015_bib34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.04.015_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007146","article-title":"Computed tomography aortic valve calcium scoring in patients with aortic stenosis","volume":"11","author":"Pawade","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2025.04.015_bib36","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/eurheartj\/ehx785","article-title":"Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review","volume":"39","author":"van Rosendael","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.04.015_bib37","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/CIRCULATIONAHA.113.005479","article-title":"Permanent pacemaker implantation after transcatheter aortic valve implantation: impact on late clinical outcomes and left ventricular function","volume":"129","author":"Urena","year":"2014","journal-title":"Circulation"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25003186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25003186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:26:54Z","timestamp":1758133614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X25003186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0828282X25003186"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2025.04.015","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal Trends in Transcatheter Aortic Valve Replacement Outcomes in Patients With Low-Flow, Low-Gradient Aortic Stenosis: Insights From the TOPAS-TAVI Registry","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2025.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}