{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T20:41:51Z","timestamp":1763757711746,"version":"3.45.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cjca.2025.08.326","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:30:36Z","timestamp":1755649836000},"page":"2221-2231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombosis Risk in Patients With Mitral Paravalvular Leak: A New Phenomenon in Mechanical Prosthetic Valves"],"prefix":"10.1016","volume":"41","author":[{"given":"Semih","family":"Kalkan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Guner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Ozan","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabahattin","family":"Gunduz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Yesin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macit","family":"Kal\u00e7\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"\u0130nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"Bayam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2025.08.326_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0002-9149(99)80081-2","article-title":"Influence of mitral regurgitation on left atrial thrombus and spontaneous echocardiographic contrast in patients with rheumatic mitral valve disease","volume":"76","author":"Karatasakis","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib2","first-page":"e35","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2025.08.326_bib3","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jtcvs.2015.06.047","article-title":"Paravalvular regurgitation after conventional aortic and mitral valve replacement: a benchmark for alternative approaches","volume":"150","author":"Duncan","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjca.2025.08.326_bib4","first-page":"350","article-title":"A comprehensive review of the diagnosis and management of mitral paravalvular leakage","volume":"24","author":"G\u00fcrsoy","year":"2020","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib5","first-page":"307","article-title":"Cardiac imaging in prosthetic paravalvular leaks","volume":"4","author":"L\u00e1zaro","year":"2014","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.cjca.2025.08.326_bib6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.amjcard.2022.02.050","article-title":"Serum levels of cholesterol and lipoproteins in patients with symptomatic paravalvular leaks","volume":"173","author":"G\u00fcner","year":"2022","journal-title":"Am J Cardiol"},{"issue":"suppl Q","key":"10.1016\/j.cjca.2025.08.326_bib7","doi-asserted-by":"crossref","first-page":"Q41","DOI":"10.4244\/EIJV8SQA9","article-title":"Paravalvular leaks: mechanisms, diagnosis and management","volume":"8","author":"Garc\u00eda","year":"2012","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.08.326_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032262","article-title":"Transcatheter closure or surgery for symptomatic paravalvular leaks: the multicenter KiSS registry","volume":"13","author":"G\u00fcner","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2025.08.326_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2005.06.051","article-title":"Prosthetic heart valve thrombosis: pathogenesis, diagnosis and management","volume":"110","author":"C\u00e1ceres-L\u00f3riga","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2021.12.027","article-title":"Thrombolysis or surgery in patients with obstructive mechanical valve thrombosis: the multicenter HATTUSHA study","volume":"79","author":"\u00d6zkan","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9149(03)00481-8","article-title":"Effect of paravalvular mitral regurgitation on left atrial thrombus formation in patients with mechanical mitral valves","volume":"92","author":"Kaymaz","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1536\/jhj.43.495","article-title":"Severe mitral regurgitation may prevent mural thrombus formation within the left ventricle with systolic dysfunction","volume":"43","author":"Ozdemir","year":"2002","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.cjca.2025.08.326_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(09)60040-4","article-title":"Mechanisms of thrombogenesis in atrial fibrillation: Virchow\u2019s triad revisited","volume":"373","author":"Watson","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2025.08.326_bib14","doi-asserted-by":"crossref","first-page":"xvii","DOI":"10.1016\/S0889-8588(05)70134-9","article-title":"Blood stasis, thrombosis and fibrinolysis","volume":"14","author":"Hassouna","year":"2000","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.cjca.2025.08.326_bib15","first-page":"566","article-title":"Improvement of endothelial function early after thrombolytic therapy in patients with prosthetic heart valve thrombosis","volume":"48","author":"\u00c7akal","year":"2020","journal-title":"Turk Kardiyol Dern Ars"},{"key":"10.1016\/j.cjca.2025.08.326_bib16","first-page":"278","article-title":"Mitral regurgitation reduces systemic coagulation activity in patients with rheumatic heart disease","volume":"18","author":"Cevik","year":"2009","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.cjca.2025.08.326_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2459\/JCM.0000000000000838","article-title":"Does mitral regurgitation reduce the risks of thrombosis in atrial fibrillation and flutter?","volume":"20","author":"Cresti","year":"2019","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.cjca.2025.08.326_bib18","article-title":"\u201cPropulsion method in a fluid.\u201d","author":"Coanda","year":"1932","journal-title":"Invent. patent Gr"},{"key":"10.1016\/j.cjca.2025.08.326_bib19","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1378\/chest.128.2.998","article-title":"A mystery featuring right-to-left shunting despite normal intracardiac pressure","volume":"128","author":"Zanchetta","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2025.08.326_bib20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1378\/chest.130.1.300","article-title":"The Coanda effect and preferential right atrial streaming","volume":"130","author":"Ashrafian","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.cjca.2025.08.326_bib21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1213\/ANE.0000000000001474","article-title":"The Coanda effect","volume":"123","author":"Bardia","year":"2016","journal-title":"Anesth Analg"},{"key":"10.1016\/j.cjca.2025.08.326_bib22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/heartjnl-2012-303498","article-title":"Quantification of mitral regurgitation by echocardiography","volume":"101","author":"Zamorano","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2025.08.326_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s13239-017-0316-z","article-title":"3D experimental and computational analysis of eccentric mitral regurgitant jets in a mock imaging heart chamber","volume":"8","author":"Wang","year":"2017","journal-title":"Cardiovasc Eng Technol"},{"key":"10.1016\/j.cjca.2025.08.326_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005207","article-title":"Beyond Bernoulli: improving the accuracy and precision of noninvasive estimation of peak pressure drops","volume":"10","author":"Donati","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2025.08.326_bib25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0002-8703(90)90101-3","article-title":"Transmitral flow velocity in symptomatic severe aortic regurgitation: utility of Doppler for determination of preclosure of the mitral valve","volume":"120","author":"Marcus","year":"1990","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjca.2025.08.326_bib26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.4244\/EIJ-D-18-00348L","article-title":"Leaflet thrombosis and clinical events after TAVR: are paravalvular leaks a crucial trigger?","volume":"14","author":"Deutsch","year":"2018","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.08.326_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2014-208243","article-title":"Prosthetic mitral valve obstruction: role of real-time three-dimensional transesophageal echocardiography in diagnosis","volume":"2015","author":"Kannan","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.cjca.2025.08.326_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/17434440.2020.1733972","article-title":"Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations","volume":"17","author":"G\u00fcnd\u00fcz","year":"2020","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.cjca.2025.08.326_bib29","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4244\/EIJ-D-16-00581","article-title":"Outcomes and predictors of success and complications for paravalvular leak closure: an analysis of the SpanisH real-wOrld paravalvular LEaks closure (HOLE) registry","volume":"12","author":"Garc\u00eda","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2025.08.326_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCINTERVENTIONS.110.960955","article-title":"Percutaneous repair of paravalvular prosthetic regurgitation: acute and 30-day outcomes in 115 patients","volume":"4","author":"Sorajja","year":"2011","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.08.326_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010920","article-title":"Silent brain infarcts following cardiac procedures: a systematic review and meta-analysis","volume":"8","author":"Indja","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2025.08.326_bib32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0735-1097(99)00598-7","article-title":"Early and long-term (one-year) effects of the association of aspirin and oral anticoagulant on thrombi and morbidity after replacement of the mitral valve with the St. Jude medical prosthesis: a clinical and transesophageal echocardiographic study","volume":"35","author":"Laffort","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.08.326_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.131968","article-title":"Management of prosthetic valve thrombosis with unfractionated heparin","volume":"404","author":"Kalkan","year":"2024","journal-title":"Int J Cardiol"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25009833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25009833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T20:38:32Z","timestamp":1763757512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X25009833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0828282X25009833"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2025.08.326","relation":{},"ISSN":["0828-282X"],"issn-type":[{"type":"print","value":"0828-282X"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombosis Risk in Patients With Mitral Paravalvular Leak: A New Phenomenon in Mechanical Prosthetic Valves","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2025.08.326","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}