{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:51:46Z","timestamp":1791255106905,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cjca.2025.11.028","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:34:52Z","timestamp":1763969692000},"page":"699-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Packaged Red Blood Cells Administration on Long-term Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2497-7587","authenticated-orcid":false,"given":"Jakob Johannes","family":"Reichl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorald","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stortecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wagener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raban","family":"Jeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Reuthebuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wenaweser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Nietlispach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Roffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"Heg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-5738","authenticated-orcid":false,"given":"Thomas","family":"Nestelberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2025.11.028_bib1","first-page":"524","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"75","author":"Vahanian","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.cjca.2025.11.028_bib2","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/CIRCRESAHA.121.318040","article-title":"Current therapeutic options in aortic stenosis","volume":"128","author":"Boskovski","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.cjca.2025.11.028_bib3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jacc.2022.11.050","article-title":"Bleeding events after transcatheter aortic valve replacement","volume":"81","author":"Avvedimento","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.11.028_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/CIRCULATIONAHA.110.946533","article-title":"Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis","volume":"123","author":"Tamburino","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2025.11.028_bib6","first-page":"640","article-title":"Predictors and outcomes after transcatheter aortic valve implantation using different approaches according to the Valve Academic Research Consortium definitions","volume":"82","author":"Seiffert","year":"2013","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.amjcard.2011.10.034","article-title":"Usefulness of periprocedural bleeding to predict outcome after transcatheter aortic valve implantation","volume":"109","author":"Halliday","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2025.11.028_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1536\/ihj.16-131","article-title":"Association between blood transfusions and 12-month mortality after transcatheter aortic valve implantation","volume":"58","author":"Kleczynski","year":"2017","journal-title":"Int Heart J"},{"key":"10.1016\/j.cjca.2025.11.028_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029489","article-title":"Clinical outcomes in high-gradient, classical low-flow, low-gradient, and paradoxical low-flow, low-gradient aortic stenosis after transcatheter aortic valve implantation: a report from the SwissTAVI Registry","volume":"12","author":"Wagener","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2025.11.028_bib10","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jcin.2021.01.042","article-title":"Age-related outcomes after transcatheter aortic valve replacement","volume":"14","author":"Attinger-Toller","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib11","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1016\/j.jcin.2023.10.021","article-title":"Long-term risk of stroke after transcatheter aortic valve replacement: insights from the SwissTAVI Registry","volume":"16","author":"Okuno","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/j.seminhematol.2015.07.006","article-title":"Anemia in clinical practice-definition and classification: does hemoglobin change with aging?","volume":"52","author":"Cappellini","year":"2015","journal-title":"Semin Hematol"},{"key":"10.1016\/j.cjca.2025.11.028_bib13","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.2023.12914","article-title":"Red blood cell transfusion: 2023 AABB International guidelines","volume":"330","author":"Carson","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2025.11.028_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-2141.2001.02701.x","article-title":"Guidelines for the clinical use of red cell transfusions","volume":"113","author":"Murphy","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cjca.2025.11.028_bib15","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/eurheartj\/ehs255","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"33","author":"Kappetein","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.11.028_bib16","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1177\/0962280218784726","article-title":"Sample size for binary logistic prediction models: beyond events per variable criteria","volume":"28","author":"van Smeden","year":"2019","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.cjca.2025.11.028_bib17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.athoracsur.2020.10.023","article-title":"Long-term impact of perioperative red blood cell transfusion on patients undergoing cardiac surgery","volume":"112","author":"Sultan","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2025.11.028_bib18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.athoracsur.2020.09.031","article-title":"The impact of transfusions on mortality after transcatheter or surgical aortic valve replacement","volume":"112","author":"Mumtaz","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjca.2025.11.028_bib19","article-title":"Impact of hemoglobin drop, bleeding events, and red blood cell transfusions on long-term mortality in patients undergoing transaortic valve implantation","volume":"32","author":"Konigstein","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2025.11.028_bib20","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/bjs.9898","article-title":"Patient blood management to reduce surgical risk","volume":"102","author":"Clevenger","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.cjca.2025.11.028_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tracli.2015.04.001","article-title":"The scientific basis for patient blood management","volume":"22","author":"Murphy","year":"2015","journal-title":"Transfus Clin Biol J"},{"key":"10.1016\/j.cjca.2025.11.028_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008227","article-title":"Incidence, temporal trends, and associated outcomes of vascular and bleeding complications in patients undergoing transfemoral transcatheter aortic valve replacement","volume":"13","author":"Sherwood","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib23","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jcin.2017.04.034","article-title":"Frequency, timing, and impact of access-site and non-access-site bleeding on mortality among patients undergoing transcatheter aortic valve replacement","volume":"10","author":"Piccolo","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib24","first-page":"1225","article-title":"Radial versus femoral secondary access for transcatheter aortic valve replacement: a systematic review and meta-analysis","volume":"99","author":"Das","year":"2022","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib25","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/j.jcin.2024.09.020","article-title":"Femoral or radial secondary access in TAVR: a subanalysis from the multicenter PULSE registry","volume":"17","author":"Grundmann","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031953","article-title":"Gastrointestinal bleeding during the transcatheter aortic valve replacement perioperative period: a review","volume":"101","author":"Lu","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cjca.2025.11.028_bib27","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.amjcard.2023.11.024","article-title":"Temporal trends in patient characteristics and outcomes of transcatheter aortic valve implantation and surgical aortic valve replacement: a nationwide study","volume":"211","author":"Lundahl","year":"2024","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjca.2025.11.028_bib30","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","article-title":"Transcatheter aortic-valve replacement with a self-expanding prosthesis","volume":"370","author":"Adams","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib31","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib28","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcin.2016.08.050","article-title":"Early clinical outcomes after transcatheter aortic valve replacement using a novel self-expanding bioprosthesis in patients with severe aortic stenosis who are suboptimal for surgery: results of the Evolut R U.S. Study","volume":"10","author":"Popma","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib33","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.116.003287","article-title":"Quantifying the shift toward transcatheter aortic valve replacement in low-risk patients: a meta-analysis","volume":"10","author":"De Sciscio","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.cjca.2025.11.028_bib34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jcin.2020.10.016","article-title":"Single versus dual antiplatelet therapy following TAVR: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Guedeney","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib35","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/jcm11082190","article-title":"Antithrombotic therapy following transcatheter aortic valve replacement","volume":"11","author":"Granger","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib36","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1056\/NEJMoa2017815","article-title":"Aspirin with or without clopidogrel after transcatheter aortic-valve implantation","volume":"383","author":"Brouwer","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib37","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/eurheartj\/ehac242","article-title":"Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial","volume":"43","author":"Collet","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.11.028_bib38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1056\/NEJMoa2407794","article-title":"Continuation versus interruption of oral anticoagulation during TAVI","volume":"392","author":"van Ginkel","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib39","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1056\/NEJMsa1901109","article-title":"Procedural volume and outcomes for transcatheter aortic-valve replacement","volume":"380","author":"Vemulapalli","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjca.2025.11.028_bib40","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1093\/eurheartj\/ehu175","article-title":"Advanced chronic kidney disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes and prognostic markers from a large cohort of patients","volume":"35","author":"Allende","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2025.11.028_bib41","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jcin.2010.09.009","article-title":"Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation","volume":"3","author":"Sinning","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2025.11.028_bib42","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jacc.2013.04.057","article-title":"Prognostic value of chronic kidney disease after transcatheter aortic valve implantation","volume":"62","author":"Yamamoto","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2025.11.028_bib43","article-title":"Mortality at one year after transcatheter aortic valve replacement - relation of age and comorbidities","volume":"43","author":"Strange","year":"2022","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.cjca.2025.11.028_bib44","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.12659\/MSM.916185","article-title":"Preoperative anemia and postoperative mortality in patients with aortic stenosis treated with transcatheter aortic valve implantation (TAVI): a systematic review and meta-analysis","volume":"25","author":"Lv","year":"2019","journal-title":"Med Sci Monit"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25014369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X25014369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:05Z","timestamp":1791252785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X25014369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0828282X25014369"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2025.11.028","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Packaged Red Blood Cells Administration on Long-term Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2025.11.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}