{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:50:21Z","timestamp":1791841821638,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2025CCS001"],"award-info":[{"award-number":["SHDC2025CCS001"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470340"],"award-info":[{"award-number":["82470340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008838","name":"Shanghai Municipal Commission of Economy and Informatization","doi-asserted-by":"publisher","award":["23SHS04900"],"award-info":[{"award-number":["23SHS04900"]}],"id":[{"id":"10.13039\/501100008838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.cjca.2026.05.003","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:30:19Z","timestamp":1778754619000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Changes and Prognostic Value of Angio-derived Index of Microcirculatory Resistance in Acute Myocardial Infarction: A Cohort Study"],"prefix":"10.1016","author":[{"given":"Jingpu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rende","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2026.05.003_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2026.05.003_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.05.003_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41569-023-00953-4","article-title":"Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction","volume":"21","author":"Galli","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011058","article-title":"Dynamic changes in microvascular flow conductivity and perfusion after myocardial infarction shown by image-based modeling","volume":"8","author":"Gkontra","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2026.05.003_bib5","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1093\/eurheartj\/ehx414","article-title":"Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials","volume":"38","author":"de Waha","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.05.003_bib6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jcmg.2017.05.023","article-title":"Long-term incremental prognostic value of cardiovascular magnetic resonance after ST-segment elevation myocardial infarction: a study of the Collaborative Registry on CMR in STEMI","volume":"11","author":"Symons","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.05.003_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.124.017645","article-title":"Clinical impact of persistent microvascular obstruction in CMR after reperfused STEMI","volume":"18","author":"Troger","year":"2025","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.05.003_bib8","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.jcmg.2021.02.023","article-title":"Coronary microvascular dysfunction assessed by pressure wire and CMR after STEMI predicts long-term outcomes","volume":"14","author":"Scarsini","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.05.003_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jcmg.2023.01.021","article-title":"Impact of persistent microvascular obstruction late after STEMI on adverse LV remodeling: a CMR study","volume":"16","author":"Bodi","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.05.003_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3346\/jkms.2012.27.9.1044","article-title":"Index of microcirculatory resistance as predictor for microvascular functional recovery in patients with anterior myocardial infarction","volume":"27","author":"Yoo","year":"2012","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.cjca.2026.05.003_bib11","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jcin.2023.08.030","article-title":"The index of microcirculatory resistance after primary PCI: a pooled analysis of individual patient data","volume":"16","author":"El Farissi","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2026.05.003_bib12","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.4244\/EIJ-D-18-00378","volume":"14","author":"De Maria","year":"2018","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjca.2026.05.003_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jcmg.2018.02.018","article-title":"Index of microcirculatory resistance as a tool to characterize microvascular obstruction and to predict infarct size regression in patients With STEMI undergoing primary PCI","volume":"12","author":"De Maria","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.05.003_bib14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3390\/biomedicines13061289","article-title":"Coronary microvascular disease early after myocardial infarction: diagnostic approach and prognostic value-a narrative review","volume":"13","author":"Sokratous","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.cjca.2026.05.003_bib15","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jcin.2021.05.027","article-title":"Functional coronary angiography-derived index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction","volume":"14","author":"Choi","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2026.05.003_bib16","first-page":"786","article-title":"Functional angiography-derived index of microcirculatory resistance validated with microvascular obstruction in cardiac magnetic resonance after STEMI","volume":"75","author":"Shin","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.cjca.2026.05.003_bib17","first-page":"434","article-title":"Coronary angiography-derived index of microcirculatory resistance associated with new-onset atrial fibrillation in patients with STEMI","volume":"40","author":"Chen","year":"2024","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejim.2021.05.027","article-title":"Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries","volume":"92","author":"Abdu","year":"2021","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.cjca.2026.05.003_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036033","article-title":"Microcirculatory resistance after primary percutaneous coronary intervention predicts residual myocardial damage and scar formation","volume":"14","author":"Candreva","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2026.05.003_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0735-1097(00)01101-3","article-title":"Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion","volume":"37","author":"Roe","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.11152\/mu-941","article-title":"Serial transthoracic coronary Doppler shows complete reversibility of microvascular obstruction pattern at one month after reperfused acute myocardial infarction","volume":"19","author":"Ober","year":"2017","journal-title":"Med Ultrason"},{"key":"10.1016\/j.cjca.2026.05.003_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrcardio.2009.103","article-title":"Targeting angiogenesis to restore the microcirculation after reperfused MI","volume":"6","author":"van der Laan","year":"2009","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib23","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/eurheartj\/eht434","article-title":"Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction","volume":"35","author":"Cuculi","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.05.003_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1051174","article-title":"One-year results from the Assessing MICRO-vascular resistances via IMR to predict outcome in ST-elevation myocardial infarction patients with multivessel disease undergoing primary PCI (AMICRO) trial","volume":"9","author":"Fineschi","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cjca.2026.05.003_bib25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/CIRCINTERVENTIONS.122.012081","article-title":"The dynamic relationship between invasive microvascular function and microvascular injury indicators, and their association with left ventricular function and infarct size at 1-month after reperfused ST-segment-elevation myocardial infarction","volume":"15","author":"Demirkiran","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2026.05.003_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015507","article-title":"Different microcirculation response between culprit and non-culprit vessels in patients with acute coronary syndrome","volume":"9","author":"Jo","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2026.05.003_bib27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ahj.2010.02.019","article-title":"Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging","volume":"159","author":"Eitel","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjca.2026.05.003_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10557-016-6641-x","article-title":"Design and rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (ENDORA-PCI) trial","volume":"30","author":"Liou","year":"2016","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.cjca.2026.05.003_bib29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/eurheartj\/ehv484","article-title":"Coronary microvascular obstruction in acute myocardial infarction","volume":"37","author":"Niccoli","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.05.003_bib30","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1172\/JCI107898","article-title":"The \u201cno-reflow\u201d phenomenon after temporary coronary occlusion in the dog","volume":"54","author":"Kloner","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cjca.2026.05.003_bib31","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.jacc.2009.12.037","article-title":"Microvascular obstruction: underlying pathophysiology and clinical diagnosis","volume":"55","author":"Bekkers","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib32","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1001\/jamacardio.2019.2138","article-title":"Temporal changes in coronary hyperemic and resting hemodynamic indices in nonculprit vessels of patients with ST-segment elevation myocardial infarction","volume":"4","author":"van der Hoeven","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjca.2026.05.003_bib33","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jcin.2018.06.045","article-title":"Fractional flow reserve and instantaneous wave-free ratio for nonculprit stenosis in patients with acute myocardial infarction","volume":"11","author":"Choi","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjca.2026.05.003_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.31083\/j.rcm2502069","article-title":"Coronary microvascular function assessment using the coronary angiography-derived index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"25","author":"Li","year":"2024","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.cjca.2026.05.003_bib35","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/cvr\/cvz301","article-title":"Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction","volume":"116","author":"Konijnenberg","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cjca.2026.05.003_bib36","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1161\/CIRCULATIONAHA.116.022603","article-title":"Comparative prognostic utility of indexes of microvascular function alone or in combination in patients with an acute ST-segment-elevation myocardial infarction","volume":"134","author":"Carrick","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2026.05.003_bib37","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1161\/CIRCULATIONAHA.112.000298","article-title":"Prognostic value of the index of microcirculatory resistance measured after primary percutaneous coronary intervention","volume":"127","author":"Fearon","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2026.05.003_bib38","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.jcin.2016.08.018","article-title":"Index of Microvascular Resistance and microvascular obstruction in patients with acute myocardial infarction","volume":"9","author":"Bulluck","year":"2016","journal-title":"JACC Cardiovasc Interv"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X2600406X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X2600406X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:35:32Z","timestamp":1791840932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X2600406X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":38,"alternative-id":["S0828282X2600406X"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2026.05.003","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic Changes and Prognostic Value of Angio-derived Index of Microcirculatory Resistance in Acute Myocardial Infarction: A Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2026.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}