{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:31:41Z","timestamp":1786566701589,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinecjc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Cardiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cjca.2026.07.004","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:01:55Z","timestamp":1783954915000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extra-Mitral Abnormalities in Nonsyndromic Mitral Valve Prolapse Assessed By Means of Cardiovascular Magnetic Resonance"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-1548","authenticated-orcid":false,"given":"Stefano","family":"Figliozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Stankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Donia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cambini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arosh","family":"Shavinda Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Catapano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Stefanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Imbriaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier-Giorgio","family":"Masci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Francone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjca.2026.07.004_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrcardio.2015.161","article-title":"Mitral valve disease\u2014morphology and mechanisms","volume":"12","author":"Levine","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cjca.2026.07.004_bib2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/eurheartj\/ehq258","article-title":"Cardiovascular manifestations in men and women carrying a FBN1 mutation","volume":"31","author":"D\u00e9taint","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.07.004_bib3","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1161\/CIRCULATIONAHA.109.887042","article-title":"Comparison of clinical presentations and outcomes between patients with TGFBR2 and FBN1 mutations in Marfan syndrome and related disorders","volume":"120","author":"Attias","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2026.07.004_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jama.1989.03430040095032","article-title":"Association of mitral valve prolapse and systemic abnormalities of connective tissue. A phenotypic continuum","volume":"262","author":"Glesby","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/j.cjca.2026.07.004_bib5","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/heartjnl-2017-312420","article-title":"Genetics of syndromic and nonsyndromic mitral valve prolapse","volume":"104","author":"Le Tourneau","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.cjca.2026.07.004_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1077788","article-title":"Genetics and pathophysiology of mitral valve prolapse","volume":"10","author":"Delwarde","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cjca.2026.07.004_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2024.101137","article-title":"Cardiovascular magnetic resonance in patients with mitral valve prolapse","volume":"27","author":"Figliozzi","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2026.07.004_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation","volume":"30","author":"Zoghbi","year":"2017","journal-title":"Journal of the American Society of Echocardiography"},{"key":"10.1016\/j.cjca.2026.07.004_bib9","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1093\/ehjci\/jeab253","article-title":"Multi-modality imaging assessment of native valvular regurgitation: an EACVI and ESC council of valvular heart disease position paper","volume":"23","author":"Lancellotti","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J Med Genet"},{"key":"10.1016\/j.cjca.2026.07.004_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1742-1241.2003.tb10455.x","article-title":"A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain","volume":"57","author":"Hakim","year":"2003","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.cjca.2026.07.004_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12968-020-00607-1","article-title":"Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update","volume":"22","author":"Kramer","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2026.07.004_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12968-020-00610-6","article-title":"Standardized image interpretation and post-processing in cardiovascular magnetic resonance\u20142020 update","volume":"22","author":"Schulz-Menger","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2026.07.004_bib14","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jacc.2018.07.070","article-title":"The mitral annulus disjunction arrhythmic syndrome","volume":"72","author":"Dejgaard","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2026.07.004_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2024.101413","article-title":"True- and pseudo-mitral annular disjunction in patients undergoing cardiovascular magnetic resonance","volume":"27","author":"Stankowski","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2026.07.004_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1148\/radiol.220454","article-title":"Myocardial fibrosis at cardiac MRI helps predict adverse clinical outcome in patients with mitral valve prolapse","volume":"306","author":"Figliozzi","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.cjca.2026.07.004_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19461-5","article-title":"Comparison of cine cardiac magnetic resonance and echocardiography derived diameters of the aortic root in a large population-based cohort","volume":"12","author":"Wenzel","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjca.2026.07.004_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/joa.12499","article-title":"The measurement of the normal thorax using the Haller index methodology at multiple vertebral levels","volume":"229","author":"Archer","year":"2016","journal-title":"J Anat"},{"key":"10.1016\/j.cjca.2026.07.004_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fendo.2020.00005","article-title":"The clinical relevance of hyperkyphosis: a narrative review","volume":"11","author":"Koel\u00e9","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cjca.2026.07.004_bib20","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/ehjci\/jead024","article-title":"Multimodality imaging in thoracic aortic diseases: a clinical consensus statement from the European Association of Cardiovascular Imaging and the European Society of Cardiology working group on aorta and peripheral vascular diseases","volume":"24","author":"Evangelista","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2025.101853","article-title":"Society for Cardiovascular Magnetic Resonance reference values (\u201cnormal values\u201d) in cardiovascular magnetic resonance: 2025 update","volume":"27","author":"Kawel-Boehm","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.cjca.2026.07.004_bib22","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/eurheartj\/ehac049","article-title":"Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse","volume":"43","author":"Roselli","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.07.004_bib23","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ng.3383","article-title":"Genetic association analyses highlight biological pathways underlying mitral valve prolapse","volume":"47","author":"Dina","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.cjca.2026.07.004_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.carpath.2015.07.009","article-title":"TGF-\u03b21 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse","volume":"24","author":"Rizzo","year":"2015","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.cjca.2026.07.004_bib25","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/eurjhf\/hfq127","article-title":"Evidence for Marfan cardiomyopathy","volume":"12","author":"Alpendurada","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cjca.2026.07.004_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1540-8175.2011.01544.x","article-title":"Classic mitral valve prolapse causes enlargement in left ventricle even in the absence of significant mitral regurgitation","volume":"29","author":"Yiginer","year":"2012","journal-title":"Echocardiography"},{"key":"10.1016\/j.cjca.2026.07.004_bib27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.echo.2020.01.016","article-title":"Mitral valve prolapse patients with less than moderate mitral regurgitation exhibit early cardiac chamber remodeling","volume":"33","author":"Yang","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.cjca.2026.07.004_bib28","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjca.2026.07.004_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jacc.2018.06.048","article-title":"Myocardial fibrosis in patients with primary mitral regurgitation with and without prolapse","volume":"72","author":"Kitkungvan","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2026.07.004_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022332","article-title":"Mitral valve prolapse induces regionalized myocardial fibrosis","volume":"10","author":"Morningstar","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjca.2026.07.004_bib31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jcmg.2020.08.029","article-title":"Resolving the disproportionate left ventricular enlargement in mitral valve prolapse due to Barlow disease","volume":"14","author":"El-Tallawi","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib32","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/ehjci\/jeae121","article-title":"Structural and functional abnormalities of left-sided cardiac chambers in Barlow\u2019s disease without significant mitral regurgitation","volume":"25","author":"Meucci","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.053033","article-title":"Evidence-based assessment of genes in dilated cardiomyopathy","volume":"144","author":"Jordan","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2026.07.004_bib34","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jacc.2022.11.052","article-title":"Prevalence and clinical implications of tricuspid valve prolapse based on magnetic resonance diagnostic criteria","volume":"81","author":"Guta","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.cjca.2026.07.004_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/echo.70017","article-title":"Early right heart remodeling in patients with mitral valve prolapse","volume":"41","author":"Donia","year":"2024","journal-title":"Echocardiography"},{"key":"10.1016\/j.cjca.2026.07.004_bib36","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.jcmg.2022.07.015","article-title":"Mitral annular disjunction assessed using cmr imaging: insights from the UK Biobank population study","volume":"15","author":"Zugwitz","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib37","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005030","article-title":"Morphofunctional abnormalities of mitral annulus and arrhythmic mitral valve prolapse","volume":"9","author":"Perazzolo Marra","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/echo.70132","article-title":"To each imaging modality, their own MAD","volume":"42","author":"Stankowski","year":"2025","journal-title":"Echocardiography"},{"key":"10.1016\/j.cjca.2026.07.004_bib39","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ehjci\/jeab022","article-title":"Prevalence and extent of mitral annular disjunction in structurally normal hearts: comprehensive 3D analysis using cardiac computed tomography","volume":"22","author":"Toh","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjca.2026.07.004_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.carpath.2017.05.008","article-title":"Histopathologic differences partially distinguish syndromic aortic diseases","volume":"30","author":"Waters","year":"2017","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.cjca.2026.07.004_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.111.054676","article-title":"Aortic event rate in the Marfan population","volume":"125","author":"Jondeau","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjca.2026.07.004_bib42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/ejechocard\/jep219","article-title":"Isolated mitral valve prolapse is an independent predictor of aortic root size in a general population","volume":"11","author":"Matos-Souza","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.cjca.2026.07.004_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/ped.15582","article-title":"Increased incidence of mitral valve prolapse in children with pectus chest wall deformity","volume":"65","author":"Karabulut","year":"2023","journal-title":"Pediatr Int"},{"key":"10.1016\/j.cjca.2026.07.004_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212165","article-title":"Characteristics of mitral valve leaflet length in patients with pectus excavatum: a single center cross-sectional study","volume":"14","author":"Nomura","year":"2019","journal-title":"PLoS One"},{"issue":"9458","key":"10.1016\/j.cjca.2026.07.004_bib45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(05)17869-6","article-title":"Mitral valve prolapse","volume":"365","author":"Hayek","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cjca.2026.07.004_bib46","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ocl.2007.04.003","article-title":"Spinal deformities in Marfan syndrome","volume":"38","author":"Demetracopoulos","year":"2007","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.cjca.2026.07.004_bib47","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/humu.24456","article-title":"Kyphoscoliotic Ehlers-Danlos syndrome caused by pathogenic variants in FKBP14: further insights into the phenotypic spectrum and pathogenic mechanisms","volume":"43","author":"Colman","year":"2022","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cjca.2026.07.004_bib48","doi-asserted-by":"crossref","first-page":"e-1235","DOI":"10.1097\/BRS.0b013e31829ef890","article-title":"Position of the aorta relative to the spine in patients with thoracolumbar\/lumbar kyphosis secondary to ankylosing spondylitis","volume":"38","author":"Feng","year":"2013","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Canadian Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X26006598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0828282X26006598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:05:38Z","timestamp":1786565138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0828282X26006598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["S0828282X26006598"],"URL":"https:\/\/doi.org\/10.1016\/j.cjca.2026.07.004","relation":{},"ISSN":["0828-282X"],"issn-type":[{"value":"0828-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extra-Mitral Abnormalities in Nonsyndromic Mitral Valve Prolapse Assessed By Means of Cardiovascular Magnetic Resonance","name":"articletitle","label":"Article Title"},{"value":"Canadian Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjca.2026.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}