{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:14:49Z","timestamp":1786986889979,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015679","name":"Heart And Stroke Foundation Of Quebec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015679","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012727","name":"IUCPQ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cjcopen.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CJC Open"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.cjco.2021.11.010","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T17:59:25Z","timestamp":1638208765000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neutrophil-Lymphocyte Ratio as an Independent Predictor of Survival in Pulmonary Arterial Hypertension: An Exploratory Study"],"prefix":"10.1016","volume":"4","author":[{"given":"Naomie","family":"Jutras-Beaudoin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie Christine","family":"Lajoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Breuils-Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Paulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-6445","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Potus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjco.2021.11.010_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjco.2021.11.010_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1378\/chest.11-1460","article-title":"An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry","volume":"142","author":"Benza","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.cjco.2021.11.010_bib3","doi-asserted-by":"crossref","first-page":"j5492","DOI":"10.1136\/bmj.j5492","article-title":"Pulmonary arterial hypertension: pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.cjco.2021.11.010_bib4","first-page":"977","article-title":"Canadian Cardiovascular Society\/Canadian Thoracic Society position statement on pulmonary hypertension","volume":"36","author":"Hirani","year":"2020","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjco.2021.11.010_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","article-title":"Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension","volume":"115","author":"Rabinovitch","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.cjco.2021.11.010_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2703518","article-title":"Neutrophil lymphocyte ratio and cardiovascular disease risk: a systematic review and meta-analysis","volume":"2018","author":"Angkananard","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.cjco.2021.11.010_bib7","first-page":"661","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in pulmonary arterial hypertension","volume":"43","author":"\u00d6zpelit","year":"2015","journal-title":"J\u00a0Int Med Res"},{"key":"10.1016\/j.cjco.2021.11.010_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.5543\/tkda.2013.93385","article-title":"Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension","volume":"41","author":"Y\u0131ld\u0131z","year":"2013","journal-title":"Turk Kardiyol Dern Ars"},{"key":"10.1016\/j.cjco.2021.11.010_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12890-017-0407-5","article-title":"Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension","volume":"17","author":"Harbaum","year":"2017","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.cjco.2021.11.010_bib10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/bph.12281","article-title":"Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response","volume":"171","author":"Mair","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cjco.2021.11.010_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1378\/chest.10-3114","article-title":"Sex differences in the diagnosis, treatment, and outcome of patients with pulmonary arterial hypertension enrolled in the registry to evaluate early and long-term pulmonary arterial hypertension disease management","volume":"141","author":"Shapiro","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.cjco.2021.11.010_bib12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1158\/1055-9965.EPI-18-0408","article-title":"Sex differences in using systemic inflammatory markers to prognosticate patients with head and neck squamous cell carcinoma","volume":"27","author":"Lin","year":"2018","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.cjco.2021.11.010_bib13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1089\/end.2016.0143","article-title":"Use of the modification of diet in renal disease equation for estimating glomerular filtration rate in the urologic literature","volume":"30","author":"Zabell","year":"2016","journal-title":"J\u00a0Endourol"},{"key":"10.1016\/j.cjco.2021.11.010_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10654-018-0472-y","article-title":"The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study","volume":"34","author":"Fest","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.cjco.2021.11.010_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.21037\/jtd-20-2593","article-title":"The neutrophil-lymphocyte ratio is associated with postoperative mortality of cardiac surgery","volume":"13","author":"Wang","year":"2021","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.cjco.2021.11.010_bib16","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0113-2017","article-title":"Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives","volume":"27","author":"Paliogiannis","year":"2018","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.cjco.2021.11.010_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/jamacardio.2018.1042","article-title":"Association of neutrophil-to-lymphocyte ratio with mortality and cardiovascular disease in the Jackson Heart Study and modification by the Duffy antigen variant","volume":"3","author":"Kim","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.cjco.2021.11.010_bib18","doi-asserted-by":"crossref","first-page":"19673","DOI":"10.1038\/s41598-019-56218-z","article-title":"Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer","volume":"9","author":"Howard","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjco.2021.11.010_bib19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/ans.13036","article-title":"Neutrophil-lymphocyte ratio as predictor of mortality and morbidity in cardiovascular surgery: a systematic review","volume":"85","author":"Tan","year":"2015","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.cjco.2021.11.010_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5603\/CJ.a2015.0061","article-title":"Neutrophil\/lymphocyte ratio is associated with right ventricular dysfunction in patients with acute inferior ST-segment elevation myocardial infarction","volume":"23","author":"Yaylak","year":"2016","journal-title":"Cardiol J"},{"key":"10.1016\/j.cjco.2021.11.010_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13104-016-2335-5","article-title":"What is the normal value of the neutrophil-to-lymphocyte ratio?","volume":"10","author":"Forget","year":"2017","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.cjco.2021.11.010_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112361","article-title":"Average values and racial differences of neutrophil lymphocyte ratio among a nationally representative sample of United States subjects","volume":"9","author":"Azab","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cjco.2021.11.010_bib23","first-page":"123","article-title":"The effects of anesthesia and surgery on count and function of neutrophils","volume":"3","author":"Tabuchi","year":"1989","journal-title":"J\u00a0Anesth"},{"key":"10.1016\/j.cjco.2021.11.010_bib24","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1053\/jpsu.2002.32268","article-title":"Monocyte and neutrophil activity after minor surgical stress","volume":"37","author":"Romeo","year":"2002","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.cjco.2021.11.010_bib25","article-title":"Sex differences in right ventricular dysfunction: insights from the bench to bedside","volume":"11","author":"Keen","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.cjco.2021.11.010_bib26","first-page":"138","article-title":"Neutrophil-to-lymphocyte ratio in diagnosis of systemic sclerosis for prediction of interstitial lung disease","volume":"24","author":"Jung","year":"2017","journal-title":"J\u00a0Respir Dis"},{"key":"10.1016\/j.cjco.2021.11.010_bib27","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1378\/chest.15-0300","article-title":"Five-year outcomes of patients enrolled in the REVEAL Registry","volume":"148","author":"Farber","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.cjco.2021.11.010_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01889-2018","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"Gali\u00e8","year":"2019","journal-title":"Eur Respir J"}],"container-title":["CJC Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X21003486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X21003486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:07:05Z","timestamp":1762902425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589790X21003486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2589790X21003486"],"URL":"https:\/\/doi.org\/10.1016\/j.cjco.2021.11.010","relation":{},"ISSN":["2589-790X"],"issn-type":[{"value":"2589-790X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil-Lymphocyte Ratio as an Independent Predictor of Survival in Pulmonary Arterial Hypertension: An Exploratory Study","name":"articletitle","label":"Article Title"},{"value":"CJC Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjco.2021.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}