{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:53:43Z","timestamp":1787939623636,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL158517"],"award-info":[{"award-number":["R01 HL158517"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL160761"],"award-info":[{"award-number":["R01 HL160761"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cjcopen.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CJC Open"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.cjco.2024.08.006","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:39:33Z","timestamp":1724395173000},"page":"1386-1394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex Differences in Outcomes of Adults with Repaired Coarctation of Aorta and Concomitant Aortic Valve Disease"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-3631","authenticated-orcid":false,"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Karnakoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjco.2024.08.006_bib1","first-page":"E191","article-title":"A\u00a0comparison of hemodynamic and clinical outcomes after transcatheter versus surgical therapy in adults in coarctation of aorta","volume":"33","author":"Egbe","year":"2021","journal-title":"J\u00a0Invasive Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib2","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.jcmg.2020.01.016","article-title":"Left ventricular remodeling after transcatheter versus surgical therapy in adults with coarctation of aorta","volume":"13","author":"Egbe","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib3","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.jacc.2011.08.053","article-title":"Comparison of surgical, stent, and balloon angioplasty treatment of native coarctation of the aorta: an observational study by the CCISC (Congenital Cardiovascular Interventional Study Consortium)","volume":"58","author":"Forbes","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ahj.2021.07.005","article-title":"Coarctation of aorta is associated with left ventricular stiffness, left atrial dysfunction and pulmonary hypertension","volume":"241","author":"Egbe","year":"2021","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjco.2024.08.006_bib5","first-page":"100530","article-title":"Increased prevalence of left ventricular diastolic dysfunction in adults with repaired coarctation of aorta","volume":"28","author":"Egbe","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"key":"10.1016\/j.cjco.2024.08.006_bib6","doi-asserted-by":"crossref","first-page":"e009672","DOI":"10.1161\/CIRCIMAGING.119.009672","article-title":"Doppler-derived arterial load indices better reflect left ventricular afterload than systolic blood pressure in coarctation of aorta","volume":"13","author":"Egbe","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib7","doi-asserted-by":"crossref","first-page":"e006651","DOI":"10.1161\/CIRCHEARTFAILURE.119.006651","article-title":"Determinants of left ventricular diastolic function and exertional symptoms in adults with coarctation of aorta","volume":"13","author":"Egbe","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjco.2024.08.006_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ahj.2022.10.008","article-title":"On-treatment blood pressure and cardiovascular mortality in adults with repaired coarctation of aorta","volume":"255","author":"Egbe","year":"2023","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjco.2024.08.006_bib9","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.amjcard.2013.07.052","article-title":"Aortic stiffness and left ventricular diastolic function in children following early repair of aortic coarctation","volume":"112","author":"Lombardi","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/HYPERTENSIONAHA.121.17515","article-title":"Persistent hypertension and left ventricular hypertrophy after repair of native coarctation of aorta in adults","volume":"78","author":"Egbe","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.cjco.2024.08.006_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MBP.0000000000000573","article-title":"Paradoxical increase in ambulatory SBP in coarctation of aorta as compared to essential hypertension","volume":"27","author":"Egbe","year":"2022","journal-title":"Blood Press Monit"},{"key":"10.1016\/j.cjco.2024.08.006_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jtcvs.2007.04.027","article-title":"Coarctation long-term assessment (COALA): significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material","volume":"134","author":"Hager","year":"2007","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjco.2024.08.006_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ahj.2016.07.012","article-title":"Hypertension in adults with repaired coarctation of the aorta","volume":"181","author":"Rinnstrom","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjco.2024.08.006_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijcard.2016.05.033","article-title":"Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range","volume":"218","author":"Rinnstrom","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2017.05.075","article-title":"Elevated sympathetic activity, endothelial dysfunction, and late hypertension after repair of coarctation of the aorta","volume":"243","author":"Lee","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib16","doi-asserted-by":"crossref","first-page":"I165","DOI":"10.1161\/hc37t1.094900","article-title":"Vascular dysfunction after repair of coarctation of the aorta: impact of early surgery","volume":"104","author":"de Divitiis","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cjco.2024.08.006_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10554-015-0827-3","article-title":"Serial assessment of arterial structure and function in patients with coarctation of the aorta undergoing stenting","volume":"32","author":"Jesus","year":"2016","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCIMAGING.121.013383","article-title":"Cardiac remodeling and disease progression in patients with repaired coarctation of aorta and aortic stenosis","volume":"14","author":"Egbe","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijcard.2023.04.061","article-title":"Left ventricular adaptation to aortic regurgitation in adults with repaired coarctation of aorta","volume":"383","author":"Egbe","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib20","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jcmg.2022.02.007","article-title":"Sex differences in LV remodeling and hemodynamics in aortic stenosis: sex-specific criteria for severe stenosis?","volume":"15","author":"Ito","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib21","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/ehjci\/jew288","article-title":"Impact of left ventricular remodelling patterns on outcomes in patients with aortic stenosis","volume":"18","author":"Capoulade","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjco.2024.08.006_bib23","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","article-title":"Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American Society of Echocardiography","volume":"32","author":"Mitchell","year":"2019","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjco.2024.08.006_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jacc.2023.05.045","article-title":"Prognostic performance of right ventricular global longitudinal strain measurements in patients with Ebstein anomaly","volume":"82","author":"Egbe","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jcmg.2021.09.016","article-title":"Prognostic implications of progressive systemic ventricular dysfunction in congenitally corrected transposition of great arteries","volume":"15","author":"Egbe","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjco.2024.08.006_bib28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jcmg.2022.12.012","article-title":"Prognostic value of cardiac remodeling staging in adults with repaired coarctation of aorta","volume":"16","author":"Egbe","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2010.10.024","article-title":"Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction","volume":"57","author":"Kasner","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjco.2024.08.006_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jcmg.2019.06.014","article-title":"Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis","volume":"13","author":"Tastet","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.cjco.2024.08.006_bib31","article-title":"Excess mortality and undertreatment of women with severe aortic stenosis","volume":"10","author":"Tribouilloy","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjco.2024.08.006_bib32","article-title":"Sex differences in the utilization and outcomes of surgical aortic valve replacement for severe aortic stenosis","volume":"6","author":"Chaker","year":"2017","journal-title":"J\u00a0Am Heart Assoc"}],"container-title":["CJC Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X2400372X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X2400372X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:54:30Z","timestamp":1761843270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589790X2400372X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2589790X2400372X"],"URL":"https:\/\/doi.org\/10.1016\/j.cjco.2024.08.006","relation":{},"ISSN":["2589-790X"],"issn-type":[{"value":"2589-790X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex Differences in Outcomes of Adults with Repaired Coarctation of Aorta and Concomitant Aortic Valve Disease","name":"articletitle","label":"Article Title"},{"value":"CJC Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjco.2024.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}