{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:28:12Z","timestamp":1786415292225,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cjcopen.ca","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CJC Open"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cjco.2026.03.008","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:22:54Z","timestamp":1775197374000},"page":"925-938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preprocedural CALLY Index As a Novel Predictor of Pacemaker Requirement After Transcatheter Aortic Valve Replacement"],"prefix":"10.1016","volume":"8","author":[{"given":"Haitham Abu","family":"Khadija","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar Abu","family":"Hamdeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Masu'd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duha","family":"Najajra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jebrin","family":"Alkrinawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-432X","authenticated-orcid":false,"given":"Alena","family":"Kirzhner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"Sinnokrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Jofa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Besharieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashed","family":"Saed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-2903","authenticated-orcid":false,"given":"Tal","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-8499","authenticated-orcid":false,"given":"Mohammad","family":"Alnees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjco.2026.03.008_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258963","article-title":"Differential systemic inflammatory responses after TAVI: the role of self versus balloon expandable devices","volume":"16","author":"Abu Khadija","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.cjco.2026.03.008_bib2","first-page":"E139","article-title":"Contemporary transcatheter aortic valve implantation related thrombocytopenia","volume":"98","author":"Abu Khadija","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4330\/wjc.v16.i2.49","article-title":"Risk of permanent pacemaker implantation following transcatheter aortic valve replacement: Which factors are most relevant?","volume":"16","author":"Batta","year":"2024","journal-title":"World J Cardiol"},{"key":"10.1016\/j.cjco.2026.03.008_bib4","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0088","article-title":"Association of clinical and economic outcomes with permanent pacemaker implantation after transcatheter aortic valve replacement","volume":"1","author":"Aljabbary","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.cjco.2026.03.008_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jcin.2025.03.028","article-title":"Long-term outcomes of patients requiring pacemaker implantation after transcatheter aortic valve replacement: the SwissTAVI Registry","volume":"18","author":"Badertscher","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.14797\/mdcvj.1230","article-title":"What\u2019s new with TAVR? An update on device technology","volume":"19","author":"Zaid","year":"2023","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"10.1016\/j.cjco.2026.03.008_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31083\/j.rcm2504111","article-title":"Association between the C-reactive protein-albumin-lymphocyte (CALLY) index and adverse clinical outcomes in CAD patients after PCI: findings of a real-world study","volume":"25","author":"Pan","year":"2024","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.cjco.2026.03.008_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12872-025-04596-w","article-title":"Associations of the C-reactive protein-albumin-lymphocyte index with all-cause and cardiovascular mortality among individuals with cardiovascular disease: evidence from the NHANES 2001-2010","volume":"25","author":"Han","year":"2025","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.cjco.2026.03.008_bib9","article-title":"The relationship between C-reactive protein-albumin-lymphocyte index and peripheral artery disease","volume":"15","author":"Wu","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjco.2026.03.008_bib10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.hroo.2025.03.003","article-title":"Preprocedural neutrophil-to-lymphocyte ratio: a novel predictor of permanent pacemaker implantation in self-expandable vs balloon-expandable valve cohorts following transcatheter aortic valve implantation","volume":"6","author":"Khadija","year":"2025","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.cjco.2026.03.008_bib11","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.3390\/jcm10184148","article-title":"Comparative analysis of the kinetic behavior of systemic inflammatory markers in patients with depressed versus preserved left ventricular function undergoing transcatheter aortic valve implantation","volume":"10","author":"Khadija","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.cjco.2026.03.008_bib12","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjco.2026.03.008_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.010543","article-title":"Real-world experience with the SAPIEN 3 Ultra Transcatheter Heart Valve: a propensity-matched analysis from the United States","volume":"14","author":"Nazif","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4244\/EIJY14M11_06","article-title":"Unravelling the (arte)fact of increased pacemaker rate with the Edwards SAPIEN 3 valve","volume":"11","author":"Tarantini","year":"2015","journal-title":"EuroIntervention"},{"key":"10.1016\/j.cjco.2026.03.008_bib17","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.jcin.2025.09.023","article-title":"The inflammatory response to transcatheter aortic valve replacement","volume":"18","author":"Maznyczka","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022095","article-title":"Unravelling atrioventricular block risk in inflammatory diseases: systemic inflammation acutely delays atrioventricular conduction via a cytokine-mediated inhibition of connexin43 expression","volume":"10","author":"Lazzerini","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjco.2026.03.008_bib19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.amjcard.2016.11.019","article-title":"Prognostic value of hypoalbuminemia after transcatheter aortic valve implantation (from the Japanese Multicenter OCEAN-TAVI Registry)","volume":"119","author":"Yamamoto","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjco.2026.03.008_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.118.007213","article-title":"Prognostic value of hs-CRP after transcatheter aortic valve implantation","volume":"11","author":"Iglesias-\u00c1lvarez","year":"2018","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib21","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","volume":"34","author":"Brignole","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjco.2026.03.008_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112744","article-title":"Long-term prognostic value of CRP\u2013albumin\u2013lymphocyte index in elderly patients with heart failure with preserved ejection fraction","volume":"204","author":"He","year":"2025","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.cjco.2026.03.008_bib23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4330\/wjc.v15.i11.582","article-title":"Novel predictors of permanent pacemaker implantation following transcatheter aortic valve replacement","volume":"15","author":"Nwaedozie","year":"2023","journal-title":"World J Cardiol"},{"key":"10.1016\/j.cjco.2026.03.008_bib24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s40001-023-01237-w","article-title":"A prediction model for permanent pacemaker implantation after transcatheter aortic valve replacement","volume":"28","author":"Qi","year":"2023","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.cjco.2026.03.008_bib25","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1111\/jocs.17212","article-title":"Neutrophil to lymphocyte ratio predicts permanent pacemaker implantation in TAVR patients","volume":"37","author":"Totaro","year":"2022","journal-title":"J Card Surg"},{"key":"10.1016\/j.cjco.2026.03.008_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3949\/ccjm.77a.09158","article-title":"Left ventricular hypertrophy: an overlooked cardiovascular risk factor","volume":"77","author":"Bauml","year":"2010","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.cjco.2026.03.008_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.cjco.2026.03.008_bib28","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/CIRCULATIONAHA.117.028352","article-title":"Conduction disturbances after transcatheter aortic valve replacement","volume":"136","author":"Auffret","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.cjco.2026.03.008_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCULATIONAHA.114.014508","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD)","volume":"131","author":"Collins","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.cjco.2026.03.008_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"10.1016\/j.cjco.2026.03.008_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/aje\/kwy250","article-title":"Some desirable properties of the Bonferroni correction: Is the Bonferroni correction really so bad?","volume":"188","author":"VanderWeele","year":"2019","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cjco.2026.03.008_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s12872-024-04302-2","article-title":"Predicting new-onset persistent conduction disturbance following transcatheter aortic valve replacement: the usefulness of FEOPS finite element analysis","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.cjco.2026.03.008_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1671841","article-title":"Association of preoperative systemic inflammation with postoperative conduction block in TAVI patients","volume":"12","author":"Shi","year":"2025","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cjco.2026.03.008_bib35","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1038\/s41467-025-61916-6","article-title":"Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: a double-blind randomized trial","volume":"16","author":"Ryffel","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.cjco.2026.03.008_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcin.2020.09.063","article-title":"Incidence, predictors, and implications of permanent pacemaker requirement after transcatheter aortic valve replacement","volume":"14","author":"Sammour","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib37","article-title":"C-Reactive protein-albumin-lymphocyte (CALLY) index as an independent risk factor for postoperative atrial fibrillation recurrence","volume":"48","author":"Deng","year":"2025","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.cjco.2026.03.008_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.020906","article-title":"Predictors of permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement\u2014a systematic review and meta-analysis","volume":"10","author":"Ullah","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.cjco.2026.03.008_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.21470\/1678-9741-2020-0482","article-title":"C-reactive protein to albumin ratio as a novel inflammatory-based marker for 30-day mortality in patients undergoing transcatheter aortic valve replacement","volume":"37","author":"Katkat","year":"2022","journal-title":"Braz J Cardiovasc Surg"},{"key":"10.1016\/j.cjco.2026.03.008_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112860","article-title":"Prognostic significance of C-reactive protein-albumin-lymphocyte (CALLY) index after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction","volume":"141","author":"Ji","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.cjco.2026.03.008_bib41","first-page":"1111","article-title":"The prognostic value of C-reactive protein-albumin-lymphocyte (CALLY) index in predicting in-hospital mortality after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction (STEMI)","volume":"106","author":"Demir","year":"2025","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib42","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.jcin.2023.05.020","article-title":"Incidence, predictors, and prognostic impact of new permanent pacemaker implantation after TAVR with self-expanding valves","volume":"16","author":"Pagnesi","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.cjco.2026.03.008_bib43","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/eurheartj\/ehx785","article-title":"Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review","volume":"39","author":"van Rosendael","year":"2018","journal-title":"Eur Heart J"}],"container-title":["CJC Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X26001010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589790X26001010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:35:58Z","timestamp":1786412158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589790X26001010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2589790X26001010"],"URL":"https:\/\/doi.org\/10.1016\/j.cjco.2026.03.008","relation":{},"ISSN":["2589-790X"],"issn-type":[{"value":"2589-790X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preprocedural CALLY Index As a Novel Predictor of Pacemaker Requirement After Transcatheter Aortic Valve Replacement","name":"articletitle","label":"Article Title"},{"value":"CJC Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjco.2026.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}