{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:06:47Z","timestamp":1789236407083,"version":"build-2803163510"},"reference-count":126,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cjcpc.ca","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["CJC Pediatric and Congenital Heart Disease"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.cjcpc.2023.10.009","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:04:53Z","timestamp":1697774693000},"page":"283-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"PA","title":["Tetralogy of Fallot Across the Lifespan: A Focus on the Right Ventricle"],"prefix":"10.1016","volume":"2","author":[{"given":"Elie","family":"Ganni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Yen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Therrien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lucy","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc L.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Bitterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Friedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Saraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-9951","authenticated-orcid":false,"given":"Rafael","family":"Alonso-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjcpc.2023.10.009_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/euhj.1998.1273","article-title":"Echocardiographic and morphological correlations in tetralogy of Fallot","volume":"20","author":"Gatzoulis","year":"1999","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib2","article-title":"Supraventricular crest: structure, function and implications for surgical resection in tetralogy of Fallot","volume":"4","author":"Ho","year":"2021","journal-title":"Int J Cardiol Congenit Heart Dis"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.carpath.2016.02.001","article-title":"Myocardial histopathology in late-repaired and unrepaired adults with tetralogy of Fallot","volume":"25","author":"Pradegan","year":"2016","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/ejechocard\/jep159","article-title":"Anatomy and myoarchitecture of the left ventricular wall in normal and in disease","volume":"10","author":"Ho","year":"2009","journal-title":"Eur J Echocardiogr"},{"issue":"suppl 1","key":"10.1016\/j.cjcpc.2023.10.009_bib5","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1136\/hrt.2005.077875","article-title":"Anatomy, echocardiography, and normal right ventricular dimensions","volume":"92","author":"Ho","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/hrt.76.3.280","article-title":"Ventricular myoarchitecture in tetralogy of Fallot","volume":"76","author":"Sanchez-Quintana","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.503054","article-title":"Polarized light imaging of the myoarchitecture in tetralogy of Fallot in the perinatal period","volume":"8","author":"Truong","year":"2020","journal-title":"Front Pediatr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib8","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1161\/CIRCULATIONAHA.117.032285","article-title":"Renin-angiotensin-aldosterone system inhibitors for right ventricular dysfunction in tetralogy of Fallot: quo vadis?","volume":"137","author":"Reddy","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jacc.2005.08.074","article-title":"Report of the National Heart, Lung, and Blood Institute working group on research in adult congenital heart disease","volume":"47","author":"Williams","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib10","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1136\/heartjnl-2017-312777","article-title":"Causes of death in a contemporary adult congenital heart disease cohort","volume":"104","author":"Yu","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.105.548727","article-title":"Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of Fallot and its relationship to adverse markers of clinical outcome","volume":"113","author":"Babu-Narayan","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10554-018-1435-9","article-title":"Risk of cardiac tachyarrhythmia in patients with repaired tetralogy of Fallot: a multicenter cardiac MRI based study","volume":"35","author":"Beurskens","year":"2019","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jtcvs.2015.09.106","article-title":"Mechanical stress is associated with right ventricular response to pulmonary valve replacement in patients with repaired tetralogy of Fallot","volume":"151","author":"Tang","year":"2016","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.638934","article-title":"A\u00a0novel pulmonary valve replacement surgery strategy using contracting band for patients with repaired tetralogy of Fallot: an MRI-based multipatient modeling study","volume":"9","author":"Yu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"issue":"Pt 1","key":"10.1016\/j.cjcpc.2023.10.009_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1113\/jphysiol.2005.101428","article-title":"Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform","volume":"571","author":"Kondo","year":"2006","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/CIRCULATIONAHA.113.001375","article-title":"Right versus left ventricular failure: differences, similarities, and interactions","volume":"129","author":"Friedberg","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib17","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/MOP.0000000000000268","article-title":"The vulnerable right ventricle","volume":"27","author":"Reddy","year":"2015","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijcard.2010.09.057","article-title":"Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)","volume":"154","author":"Babu-Narayan","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib19","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/CIRCULATIONAHA.117.031438","volume":"137","author":"Bokma","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91625","article-title":"miR-21 is associated with fibrosis and right ventricular failure","volume":"2","author":"Reddy","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib21","doi-asserted-by":"crossref","first-page":"H1314","DOI":"10.1152\/ajpheart.00776.2012","article-title":"Physiologic and molecular characterization of a murine model of right ventricular volume overload","volume":"304","author":"Reddy","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib22","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00109-010-0679-1","article-title":"Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure","volume":"88","author":"Piao","year":"2010","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib23","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/ehjci\/jez068","article-title":"Focal scar and diffuse myocardial fibrosis are independent imaging markers in repaired tetralogy of Fallot","volume":"20","author":"Cochet","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib24","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/heartjnl-2018-313961","article-title":"Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement","volume":"105","author":"Yamamura","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib25","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1165\/rcmb.2013-0149OC","article-title":"Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-beta1 signaling and is abrogated by angiotensin receptor blockade","volume":"49","author":"Friedberg","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0735-1097(01)01496-6","article-title":"Right ventricular ischemia in patients with primary pulmonary hypertension","volume":"38","author":"G\u00f3mez","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib27","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1164\/rccm.201702-0425LE","article-title":"Right ventricle vasculature in human pulmonary hypertension assessed by stereology","volume":"196","author":"Graham","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl_1","key":"10.1016\/j.cjcpc.2023.10.009_bib28","article-title":"Abstract 20371: non-cardiomyocyte microRNA-34a mediates dysregulation of angiogenesis in RV failure","volume":"134","author":"Reddy","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib29","article-title":"Transcriptomic and functional analyses of mitochondrial dysfunction in pressure overload-induced right ventricular failure","volume":"10","author":"Hwang","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib30","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/CIRCULATIONAHA.120.045470","article-title":"4HNE impairs myocardial bioenergetics in congenital heart disease-induced right ventricular failure","volume":"142","author":"Hwang","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCHEARTFAILURE.111.961474","article-title":"Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease","volume":"4","author":"Karamanlidis","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0003-4975(89)90671-1","article-title":"Effect of transannular patching on outcome after repair of tetralogy of Fallot","volume":"48","author":"Kirklin","year":"1989","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib33","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.athoracsur.2005.04.016","article-title":"Tetralogy of Fallot: results of a pulmonary valve-sparing strategy","volume":"80","author":"Stewart","year":"2005","journal-title":"Ann Thorac Surg"},{"issue":"Pt 2","key":"10.1016\/j.cjcpc.2023.10.009_bib34","first-page":"III14","article-title":"Long-term valvular function after total repair of tetralogy of Fallot. Relation to ventricular arrhythmias","volume":"78","author":"Zahka","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s002460010050","article-title":"Course of right and left ventricular function in patients with pulmonary insufficiency after repair of tetralogy of Fallot","volume":"21","author":"Schamberger","year":"2000","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2022.11.039","article-title":"Prevalence and determinants of tricuspid regurgitation after repair of tetralogy of Fallot","volume":"372","author":"Offen","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/01.CIR.92.2.231","article-title":"Mechanoelectrical interaction in tetralogy of Fallot. QRS prolongation relates to right ventricular size and predicts malignant ventricular arrhythmias and sudden death","volume":"92","author":"Gatzoulis","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib38","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0735-1097(00)00930-X","article-title":"Pulmonary valve replacement in adults late after repair of tetralogy of Fallot: are we operating too late?","volume":"36","author":"Therrien","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib39","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.amjcard.2004.11.037","article-title":"Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair","volume":"95","author":"Therrien","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib40","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1093\/eurheartj\/ehi581","article-title":"Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance","volume":"26","author":"Buechel","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib41","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/CIRCULATIONAHA.106.659664","article-title":"Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance","volume":"116","author":"Oosterhof","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib42","first-page":"862","article-title":"Canadian Cardiovascular Society 2022 guidelines for cardiovascular interventions in adults with congenital heart disease","volume":"38","author":"Marelli","year":"2022","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib43","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jacc.2023.02.052","article-title":"Improved outcomes after pulmonary valve replacement in repaired tetralogy of Fallot","volume":"81","author":"Bokma","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib44","first-page":"450","article-title":"Late homograft valve insertion after transannular patch repair of tetralogy of Fallot","volume":"7","author":"d'Udekem","year":"1998","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib45","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCULATIONAHA.104.523266","article-title":"Percutaneous pulmonary valve implantation in humans: results in 59 consecutive patients","volume":"112","author":"Khambadkone","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008320","article-title":"Three-year outcomes from the Harmony Native Outflow Tract Early Feasibility Study","volume":"13","author":"Benson","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib47","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCULATIONAHA.107.726372","article-title":"Implantable cardioverter-defibrillators in tetralogy of Fallot","volume":"117","author":"Khairy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib48","doi-asserted-by":"crossref","DOI":"10.1161\/HAE.0000000000000084","article-title":"Arrhythmias in repaired tetralogy of Fallot: a scientific statement from the American Heart Association","volume":"15","author":"Krieger","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib49","doi-asserted-by":"crossref","unstructured":"Toubat O, Wells WJ, Starnes VA, Kumar SR. Fate of the right ventricular outflow tract following valve-sparing repair of tetralogy of Fallot [e-pub ahead of print]. Semin Thorac Cardiovasc Surg https:\/\/doi.org\/10.1053\/j.semtcvs.2022.12.002, accessed December 23, 2022.","DOI":"10.1053\/j.semtcvs.2022.12.002"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib50","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1161\/01.CIR.103.20.2489","article-title":"Impact of pulmonary valve replacement on arrhythmia propensity late after repair of tetralogy of Fallot","volume":"103","author":"Therrien","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib51","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCULATIONAHA.106.183095","volume":"116","author":"Wilson","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib52","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1161\/01.CIR.100.14.1540","article-title":"Acute right ventricular restrictive physiology after repair of tetralogy of Fallot: association with myocardial injury and oxidative stress","volume":"100","author":"Chaturvedi","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib53","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ehjci\/jet009","article-title":"Restrictive right ventricular physiology after tetralogy of Fallot repair is associated with fibrosis of the right ventricular outflow tract visualized on cardiac magnetic resonance imaging","volume":"14","author":"Munkhammar","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib54","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1017\/S1047951100007988","article-title":"Antegrade diastolic pulmonary arterial flow as a marker of right ventricular restriction after complete repair of pulmonary atresia with intact septum and critical pulmonary valvar stenosis","volume":"2","author":"Redington","year":"1992","journal-title":"Cardiol Young"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib55","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1161\/01.CIR.91.6.1775","article-title":"Right ventricular diastolic function 15 to 35 years after repair of tetralogy of Fallot. Restrictive physiology predicts superior exercise performance","volume":"91","author":"Gatzoulis","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib56","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1161\/01.CIR.94.12.3276","article-title":"Relationship between type of outflow tract repair and postoperative right ventricular diastolic physiology in tetralogy of Fallot","volume":"94","author":"Norg\u00e5rd","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib57","first-page":"26","article-title":"Cardiopulmonary exercise testing in repaired tetralogy of Fallot: multiparametric overview and correlation with cardiac magnetic resonance and physical activity level","volume":"9","author":"Leonardi","year":"2022","journal-title":"J\u00a0Cardiovasc Dev Dis"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib58","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.011823","article-title":"Impaired exercise tolerance in repaired tetralogy of Fallot is associated with impaired biventricular contractile reserve: an exercise-stress real-time cardiovascular magnetic resonance study","volume":"14","author":"Steinmetz","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib59","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/CIRCULATIONAHA.111.058719","article-title":"Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term","volume":"125","author":"Inuzuka","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib60","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/eurheartj\/ehr461","article-title":"Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life--single centre experience and review of published data","volume":"33","author":"Kempny","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib61","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1161\/CIRCULATIONAHA.105.594218","article-title":"Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival","volume":"113","author":"Dimopoulos","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib62","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jacc.2006.05.051","article-title":"Heart rate response during exercise predicts survival in adults with congenital heart disease","volume":"48","author":"Diller","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib63","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.jacc.2018.08.1029","article-title":"2018 AHA\/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","volume":"73","author":"Stout","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib64","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1093\/eurheartj\/ehaa701","article-title":"The ESC clinical practice guidelines for the management of adult congenital heart disease 2020","volume":"41","author":"Baumgartner","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib65","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijcard.2014.09.014","article-title":"Impact of percutaneous pulmonary valve implantation for right ventricular outflow tract dysfunction on exercise recovery kinetics","volume":"177","author":"Lurz","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib66","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1093\/eurheartj\/ehaa501","volume":"41","author":"Budts","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib67","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCULATIONAHA.110.953380","article-title":"Heart rate response during exercise and pregnancy outcome in women with congenital heart disease","volume":"123","author":"Lui","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib68","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1253\/circj.CJ-12-0485","article-title":"Cardiopulmonary variables during exercise predict pregnancy outcome in women with congenital heart disease","volume":"77","author":"Ohuchi","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.echo.2013.11.009","volume":"27","author":"Valente","year":"2014","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib70","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.jacc.2021.09.010","article-title":"AHA\/ACC vs ESC guidelines for management of adults with congenital heart disease: JACC guideline comparison","volume":"78","author":"Egidy Assenza","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.amjcard.2007.07.080","article-title":"Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy of Fallot","volume":"101","author":"Sheehan","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib72","article-title":"Right ventricular flow vorticity relationships with biventricular shape in adult tetralogy of Fallot","volume":"8","author":"Elsayed","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib73","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1038\/s41598-023-28358-w","article-title":"Biventricular shape modes discriminate pulmonary valve replacement in tetralogy of Fallot better than imaging indices","volume":"13","author":"Govil","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib74","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.echo.2012.01.023","article-title":"Can simple echocardiographic measures reduce the number of cardiac magnetic resonance imaging studies to diagnose right ventricular enlargement in congenital heart disease?","volume":"25","author":"Alghamdi","year":"2012","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib75","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.echo.2011.08.006","article-title":"Echocardiographic assessment of right ventricular volumes after surgical repair of tetralogy of Fallot: clinical validation of a new echocardiographic method","volume":"24","author":"Dragulescu","year":"2011","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib76","doi-asserted-by":"crossref","unstructured":"Bitterman Y, Hui W, Fan CS, et\u00a0al. Electromechanical dyssynchrony is associated with right ventricular remodelling and dysfunction independently of pulmonary regurgitation late after tetralogy of Fallot repair [e-pub ahead of print]. J Am Soc Echocardiogr https:\/\/doi.org\/10.1016\/j.echo.2023.06.010, accessed June 24,\u00a02023.","DOI":"10.1016\/j.echo.2023.06.010"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib77","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/heartjnl-2013-304958","article-title":"Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort","volume":"100","author":"Valente","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib78","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/CIRCULATIONAHA.111.086983","article-title":"Left ventricular longitudinal function predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of Fallot","volume":"125","author":"Diller","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib79","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcm.2014.11.011","article-title":"Heart failure in adult congenital heart disease: emerging concepts with a focus on tetralogy of Fallot","volume":"25","author":"Wald","year":"2015","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib80","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib81","first-page":"77","article-title":"Critical care management of the patient with pulmonary hypertension","volume":"11","author":"Barnett","year":"2022","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib82","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijcard.2018.07.132","article-title":"Ramipril and left ventricular diastolic function in stable patients with pulmonary regurgitation after repair of tetralogy of Fallot","volume":"272","author":"Krupickova","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib83","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/01.CIR.59.6.1241","article-title":"The mechanism of apparent right bundle branch block after transatrial repair of tetralogy of Fallot","volume":"59","author":"Horowitz","year":"1979","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib84","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.echo.2018.03.012","article-title":"Quantification of right ventricular electromechanical dyssynchrony in relation to right ventricular function and clinical outcomes in children with repaired tetralogy of Fallot","volume":"31","author":"Yim","year":"2018","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib85","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1161\/CIRCULATIONAHA.107.688770","article-title":"Right ventricular mechanics and QRS duration in patients with repaired tetralogy of Fallot: implications of infundibular disease","volume":"116","author":"Uebing","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib86","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007141","article-title":"Right ventricular electrical activation in patients with repaired tetralogy of Fallots: insights from electroanatomical mapping and high-resolution magnetic resonance imaging","volume":"12","author":"Jalal","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib87","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ahj.2012.01.025","article-title":"Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages","volume":"163","author":"Risum","year":"2012","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib88","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ahj.2012.06.029","article-title":"Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair","volume":"165","author":"Friedberg","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib89","article-title":"Relative impact of right ventricular electromechanical dyssynchrony versus pulmonary regurgitation on right ventricular dysfunction and exercise intolerance in patients after repair of tetralogy of Fallot","volume":"8","author":"Lumens","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib90","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1161\/CIRCIMAGING.113.001483","article-title":"Mechanisms of right ventricular electromechanical dyssynchrony and mechanical inefficiency in children after repair of tetralogy of Fallot","volume":"7","author":"Hui","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib91","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jacc.2003.10.045","article-title":"Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging","volume":"43","author":"Geva","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib92","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study","volume":"356","author":"Gatzoulis","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib93","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0002-9149(97)00311-1","article-title":"QRS prolongation is associated with inducible ventricular tachycardia after repair of tetralogy of Fallot","volume":"80","author":"Balaji","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib94","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/heartjnl-2016-310068","article-title":"QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot","volume":"103","author":"Bokma","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib95","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/europace\/eun178","article-title":"Presence of ventricular dyssynchrony and haemodynamic impact of right ventricular pacing in adults with repaired tetralogy of Fallot and right bundle branch block","volume":"10","author":"Bordachar","year":"2008","journal-title":"Europace"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib96","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijcard.2011.06.005","article-title":"Biventricular pacing in patients with tetralogy of Fallot: non-invasive epicardial mapping and clinical impact","volume":"163","author":"Thambo","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib97","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.006424","article-title":"Pulmonary right ventricular resynchronization in congenital heart disease: acute improvement in right ventricular mechanics and contraction efficiency","volume":"10","author":"Janou\u0161ek","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib98","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1161\/01.CIR.0000070930.33499.9F","article-title":"Electrical resynchronization: a novel therapy for the failing right ventricle","volume":"107","author":"Dubin","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib99","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.hrthm.2010.12.044","article-title":"Electrical dyssynchrony and resynchronization in tetralogy of Fallot","volume":"8","author":"Thambo","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib100","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007157","article-title":"Cardiac resynchronization therapy for treatment of chronic subpulmonary right ventricular dysfunction in congenital heart disease","volume":"12","author":"Janou\u0161ek","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib101","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/europace\/euw414","article-title":"Acute right ventricular resynchronization improves haemodynamics in children after surgical repair of tetralogy of Fallot","volume":"20","author":"Vojtovic","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib102","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/europace\/euu281","article-title":"Haemodynamic consequences of targeted single- and dual-site right ventricular pacing in adults with congenital heart disease undergoing surgical pulmonary valve replacement","volume":"17","author":"Plymen","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/pace.12284","article-title":"Cardiac resynchronization therapy in adult patients with repaired tetralogy of Fallot and left ventricular systolic dysfunction","volume":"37","author":"Merchant","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib104","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.echo.2014.06.014","article-title":"Classic-pattern dyssynchrony and electrical activation delays in pediatric dilated cardiomyopathy","volume":"27","author":"Forsha","year":"2014","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib105","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/eurheartj\/ehn481","article-title":"Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms","volume":"30","author":"Parsai","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib106","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib107","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/MOP.0000000000000804","article-title":"Right ventricular failure in congenital heart disease","volume":"31","author":"Friedberg","year":"2019","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib108","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jelectrocard.2019.02.010","article-title":"The effects of pulmonary valve replacement on QRS duration in repaired tetralogy of Fallot patients with pulmonary regurgitation","volume":"54","author":"Aleligne","year":"2019","journal-title":"J\u00a0Electrocardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib109","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.15420\/cfr.2021.11","article-title":"Mechanical circulatory support for right ventricular failure","volume":"8","author":"DeFilippis","year":"2022","journal-title":"Card Fail Rev"},{"issue":"suppl 15","key":"10.1016\/j.cjcpc.2023.10.009_bib110","doi-asserted-by":"crossref","first-page":"S1834","DOI":"10.21037\/jtd.2018.05.35","article-title":"Successful HeartMate 3 implantation in isolated right heart failure-first in man experience of right heart configuration","volume":"10","author":"Ricklefs","year":"2018","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib111","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005537","article-title":"Preimplant phosphodiesterase-5 inhibitor use is associated with higher rates of severe early right heart failure after left ventricular assist device implantation","volume":"12","author":"Gulati","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib112","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.21037\/cdt-20-592","article-title":"Emerging therapies for right ventricular dysfunction and failure","volume":"10","author":"Klinke","year":"2020","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib113","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fphys.2018.00609","article-title":"Inflammatory mediators drive adverse right ventricular remodeling and dysfunction and serve as potential biomarkers","volume":"9","author":"Sydykov","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib114","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1183\/09031936.00151313","article-title":"Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension","volume":"43","author":"Cracowski","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib115","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","article-title":"Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension","volume":"122","author":"Soon","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib116","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1164\/ajrccm.151.5.7735624","article-title":"Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension","volume":"151","author":"Humbert","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib117","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1164\/rccm.201809-1631LE","article-title":"IL-1 blockade reduces inflammation in pulmonary arterial hypertension and right ventricular failure: a single-arm, open-label, phase IB\/II pilot study","volume":"199","author":"Trankle","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib118","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/1756-185X.12304","article-title":"Preventive and remedial application of etanercept attenuate monocrotaline-induced pulmonary arterial hypertension","volume":"19","author":"Zhang","year":"2016","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib119","doi-asserted-by":"crossref","DOI":"10.1177\/2045893217735820","article-title":"Clinical trial protocol for TRANSFORM-UK: a therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension","volume":"8","author":"Hern\u00e1ndez-S\u00e1nchez","year":"2018","journal-title":"Pulm Circ"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib120","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1165\/rcmb.2008-0132OC","article-title":"Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model","volume":"42","author":"Nisbet","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib121","doi-asserted-by":"crossref","DOI":"10.1038\/srep41605","article-title":"Dimethyl fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways","volume":"7","author":"Grzegorzewska","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib122","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1164\/rccm.201007-1106OC","article-title":"Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats","volume":"183","author":"Bogaard","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib123","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2016.08.003","article-title":"Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension","volume":"99","author":"Chen","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib124","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1086\/675986","article-title":"Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series)","volume":"4","author":"De Raaf","year":"2014","journal-title":"Pulm Circ"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib125","first-page":"1609","article-title":"The future of adult congenital heart disease research: precision health services delivery for the next decade","volume":"35","author":"Marelli","year":"2019","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.cjcpc.2023.10.009_bib126","article-title":"Recurrent disease progression networks for modelling risk trajectory of heart failure","volume":"16","author":"Lu","year":"2021","journal-title":"PLoS One"}],"container-title":["CJC Pediatric and Congenital Heart Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772812923001604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772812923001604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:02:19Z","timestamp":1757422939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772812923001604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":126,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2772812923001604"],"URL":"https:\/\/doi.org\/10.1016\/j.cjcpc.2023.10.009","relation":{},"ISSN":["2772-8129"],"issn-type":[{"value":"2772-8129","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetralogy of Fallot Across the Lifespan: A Focus on the Right Ventricle","name":"articletitle","label":"Article Title"},{"value":"CJC Pediatric and Congenital Heart Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjcpc.2023.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society.","name":"copyright","label":"Copyright"}]}}