{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:05:02Z","timestamp":1793412302231,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Journal of Traumatology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cjtee.2026.05.006","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:24:38Z","timestamp":1784647478000},"page":"478-486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma apolipoprotein A-IV deficiency as a proteomics-identified diagnostic biomarker for heat stroke: A prospective 2-center study"],"prefix":"10.1016","volume":"29","author":[{"given":"Ye","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-5077","authenticated-orcid":false,"given":"Jingchun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cjtee.2026.05.006_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.amepre.2008.08.021","article-title":"Climate change and extreme heat events","volume":"35","author":"Luber","year":"2008","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.cjtee.2026.05.006_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000239","article-title":"Exertional heat stroke: pathophysiology and risk factors","volume":"1","author":"Garcia","year":"2022","journal-title":"BMJ Med"},{"key":"10.1016\/j.cjtee.2026.05.006_bib3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(21)01208-3","article-title":"Hot weather and heat extremes: health risks","volume":"398","author":"Ebi","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cjtee.2026.05.006_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/j.2040-4603.2015.tb00612.x","article-title":"Heat stroke","volume":"5","author":"Leon","year":"2015","journal-title":"Compr Physiol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1056\/NEJMcp2210623","article-title":"Treatment and prevention of heat-related illness","volume":"387","author":"Sorensen","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjtee.2026.05.006_bib6","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1056\/NEJMra011089","article-title":"Heat stroke","volume":"346","author":"Bouchama","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cjtee.2026.05.006_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/medicina56110589","article-title":"Exertional heat stroke, modality cooling rate, and survival outcomes: a systematic review","volume":"56","author":"Filep","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.cjtee.2026.05.006_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/joim.13633","article-title":"Classic heat stroke in a desert climate: a systematic review of 2632 cases","volume":"294","author":"Yezli","year":"2023","journal-title":"J Intern Med"},{"key":"10.1016\/j.cjtee.2026.05.006_bib9","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1002\/mas.21781","article-title":"Advances in data-independent acquisition mass spectrometry towards comprehensive digital proteome landscape","volume":"42","author":"Kitata","year":"2023","journal-title":"Mass Spectrom Rev"},{"key":"10.1016\/j.cjtee.2026.05.006_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110489","article-title":"Proteomic analysis of extracellular vesicles released from heat-stroked hepatocytes reveals promotion of programmed cell death pathway","volume":"129","author":"Li","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.cjtee.2026.05.006_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170869","article-title":"Heat stroke-induced cerebral cortex nerve injury by mitochondrial dysfunction: a comprehensive multi-omics profiling analysis","volume":"919","author":"Fang","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.cjtee.2026.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1176998","article-title":"Proteomics analyses of acute kidney injury biomarkers in a rat exertional heat stroke model","volume":"14","author":"Wen","year":"2023","journal-title":"Front Physiol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib13","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41592-020-00998-0","article-title":"diaPASEF: parallel accumulation-serial fragmentation combined with data-independent acquisition","volume":"17","author":"Meier","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.cjtee.2026.05.006_bib14","first-page":"1","article-title":"Expert consensus on the diagnosis and treatment of heat stroke in China","volume":"7","author":"Liu","year":"2020","journal-title":"Mil Med Res"},{"key":"10.1016\/j.cjtee.2026.05.006_bib15","first-page":"2133","article-title":"Management of heatstroke and heat exhaustion","volume":"71","author":"Glazer","year":"2005","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.cjtee.2026.05.006_bib16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1515\/reveh-2023-0059","article-title":"Diagnosing and managing heat exhaustion: insights from a systematic review of cases in the desert climate of Mecca","volume":"39","author":"Yezli","year":"2024","journal-title":"Rev Environ Health"},{"key":"10.1016\/j.cjtee.2026.05.006_bib17","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1172\/JCI112081","article-title":"Studies on the in vivo and in vitro distribution of apolipoprotein A-IV in human plasma and lymph","volume":"76","author":"Ohta","year":"1985","journal-title":"J Clin Investig"},{"key":"10.1016\/j.cjtee.2026.05.006_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1432-1033.1979.tb13261.x","article-title":"Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification","volume":"99","author":"Utermann","year":"1979","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.cjtee.2026.05.006_bib19","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1074\/jbc.M502501200","article-title":"Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size","volume":"281","author":"Lu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cjtee.2026.05.006_bib20","doi-asserted-by":"crossref","first-page":"G472","DOI":"10.1152\/ajpgi.00098.2014","article-title":"ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety","volume":"308","author":"Kohan","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib21","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.3390\/nu15224840","article-title":"Apolipoprotein A-IV-Deficient mice in 129\/SvJ background are susceptible to obesity and glucose intolerance","volume":"15","author":"Wang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.cjtee.2026.05.006_bib22","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.M113.511766","article-title":"Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cjtee.2026.05.006_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101034","article-title":"Apolipoprotein A4 restricts diet-induced hepatic steatosis via SREBF1-Mediated lipogenesis and enhances IRS-PI3K-Akt signaling","volume":"66","author":"Cheng","year":"2022","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.cjtee.2026.05.006_bib24","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1007\/s00125-016-4024-2","article-title":"MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study","volume":"59","author":"von Toerne","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.cjtee.2026.05.006_bib25","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/ijms24010670","article-title":"Apolipoprotein A-IV has Bi-Functional actions in alcoholic hepatitis by regulating hepatocyte injury and immune cell infiltration","volume":"24","author":"Li","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cjtee.2026.05.006_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/MOL.0000000000000371","article-title":"Apolipoprotein L1 and apolipoprotein A-IV and their association with kidney function","volume":"28","author":"Kronenberg","year":"2017","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib27","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/01.ATV.0000119353.03690.22","article-title":"Human apolipoprotein A-IV reduces secretion of proinflammatory cytokines and atherosclerotic effects of a chronic infection mimicked by lipopolysaccharide","volume":"24","author":"Recalde","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib28","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1038\/s41467-018-05806-0","article-title":"Apolipoprotein A-IV binds \u03b1IIb\u03b23 integrin and inhibits thrombosis","volume":"9","author":"Xu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.cjtee.2026.05.006_bib29","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1182\/blood-2018-05-850859","article-title":"Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice","volume":"132","author":"Yago","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.cjtee.2026.05.006_bib30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/cells8040319","article-title":"Apolipoprotein A-IV: a multifunctional protein involved in protection against atherosclerosis and diabetes","volume":"8","author":"Qu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cjtee.2026.05.006_bib31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1172\/JCI200421233","article-title":"Apolipoprotein A-IV inhibits experimental colitis","volume":"114","author":"Vowinkel","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1016\/j.cjtee.2026.05.006_bib32","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.3390\/ijms24054605","article-title":"Plasma apolipoprotein concentrations are highly altered in severe intensive care unit COVID-19 patients: preliminary results from the LIPICOR cohort study","volume":"24","author":"Begue","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cjtee.2026.05.006_bib33","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3390\/idr16050062","article-title":"Lipid metabolism disorders as diagnostic biosignatures in sepsis","volume":"16","author":"Birner","year":"2024","journal-title":"Infect Dis Rep"},{"key":"10.1016\/j.cjtee.2026.05.006_bib34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/antiox7110149","article-title":"Heat sepsis precedes heat toxicity in the pathophysiology of heat Stroke-A new paradigm on an ancient disease","volume":"7","author":"Lim","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.cjtee.2026.05.006_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI118440","article-title":"Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation","volume":"97","author":"Pinsky","year":"1996","journal-title":"J Clin Investig"},{"key":"10.1016\/j.cjtee.2026.05.006_bib36","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/ATVBAHA.107.158709","article-title":"Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model","volume":"28","author":"Roberts","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib37","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","article-title":"von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","author":"Brill","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cjtee.2026.05.006_bib38","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.prostaglandins.2018.10.004","article-title":"Apolipoprotein A-IV: a potential therapeutic target for atherosclerosis","volume":"139","author":"Peng","year":"2018","journal-title":"Prostag Other Lipid Mediat"},{"key":"10.1016\/j.cjtee.2026.05.006_bib40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12950-015-0069-0","article-title":"TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells","volume":"12","author":"Li","year":"2015","journal-title":"J Inflamm (Lond)"},{"key":"10.1016\/j.cjtee.2026.05.006_bib41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1055\/s-2007-984466","article-title":"The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases","volume":"39","author":"Ors\u00f3","year":"2007","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.cjtee.2026.05.006_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110574","article-title":"Heat stress-induced intestinal epithelial cells necroptosis via TLR3-TRIF-RIP3 pathway was dependent on p53","volume":"122","author":"Zhou","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.cjtee.2026.05.006_bib43","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1152\/japplphysiol.00301.2010","article-title":"Heat stroke: role of the systemic inflammatory response","volume":"109","author":"Leon","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.cjtee.2026.05.006_bib44","article-title":"A potential driver of disseminated intravascular coagulation in heat stroke mice: neutrophil extracellular traps","volume":"19","author":"Zhang","year":"2022","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.cjtee.2026.05.006_bib45","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"}],"container-title":["Chinese Journal of Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1008127526001380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1008127526001380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:26:41Z","timestamp":1790886401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1008127526001380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1008127526001380"],"URL":"https:\/\/doi.org\/10.1016\/j.cjtee.2026.05.006","relation":{},"ISSN":["1008-1275"],"issn-type":[{"value":"1008-1275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma apolipoprotein A-IV deficiency as a proteomics-identified diagnostic biomarker for heat stroke: A prospective 2-center study","name":"articletitle","label":"Article Title"},{"value":"Chinese Journal of Traumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cjtee.2026.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Chinese Medical Association. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}